Midtown, MO

St. Louis

Midtown
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Photo by Karissa Krull
Photo by Linda Garrison
Photo by Sophie R

Popular places to visit


Midtown Hotel Deals

Residence Inn by Marriott St Louis Downtown

Residence Inn by Marriott St Louis Downtown

3 out of 5
525 S Jefferson Ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
The price is AED 404 per night from Nov 27 to Nov 28
AED 404
AED 481 total
27 Nov - 28 Nov
includes taxes & fees
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free WiFi, a 24-hour fitness center, and parking (surcharge). Our guests praise the breakfast ...
7.8/10 Good! (1,001 reviews)
Enjoyed our room
Love the 2 bedroom reservation: one bedroom with a king bed as well as a bathroom with the 2nd bedroom with 2 double beds as well with a bathroom. Love the couch, TV area as well as a kitchen. With my daughter having celiac, we must carry food safe for her to eat. The full sized fridge was great ...

Reviewed on 14 October 2025

Residence Inn by Marriott St Louis Downtown
Element St. Louis Midtown

Element St. Louis Midtown

3 out of 5
3763 Forest Park Avenue, St. Louis, MO
The price is AED 514 per night from Nov 23 to Nov 24
AED 514
AED 601 total
23 Nov - 24 Nov
includes taxes & fees
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
9/10 Wonderful! (622 reviews)
The breakfast was good, timely and organized well. The room was clean and noise levels across rooms were not high. The location was ideal for my business trip. I also used the Gym and felt it was sufficient for my daily needs. The staff at the desk day/night were awake alert and well mannered. Would ...

Reviewed on 1 November 2025

Element St. Louis Midtown
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue, St. Louis, MO
The price is AED 365 per night from Nov 9 to Nov 10
AED 365
AED 426 total
9 Nov - 10 Nov
includes taxes & fees
Stay at this 3.5-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.8/10 Excellent! (2,982 reviews)
Clean room. Quiet & restful. The bed is very firm. I appreciate the accessible outlets everywhere and the furniture in the room is actually useful. The free breakfast is more than most hotels and the staff is gracious. They really can't help the bizarre layout of the building & maze of hallways , ...

Reviewed on 1 November 2025

Clayton Plaza Hotel & Extended Stay
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

3 out of 5
2 South 4th Street, St. Louis, MO
The price is AED 529 per night from Nov 9 to Nov 10
AED 529
AED 618 total
9 Nov - 10 Nov
includes taxes & fees
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
9.4/10 Exceptional! (3,247 reviews)
Clean room, awesome pool, great location and you can’t beat kick back or breakfast

Reviewed on 4 November 2025

Drury Plaza Hotel St. Louis at the Arch
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

4 out of 5
9801 Natural Bridge Road, St. Louis, MO
The price is AED 433 per night from Nov 21 to Nov 22
AED 433
AED 507 total
21 Nov - 22 Nov
includes taxes & fees
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
8.4/10 Very Good! (1,034 reviews)
Fast easy check in and helpful staff

Reviewed on 2 November 2025

Renaissance St. Louis Airport Hotel
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St, St. Louis, MO
The price is AED 322 per night from Nov 9 to Nov 10
AED 322
AED 382 total
9 Nov - 10 Nov
includes taxes & fees
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the bar and the helpful ...
8.6/10 Excellent! (1,079 reviews)
The app to pay for the valet was hard to get into.

Reviewed on 31 October 2025

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around Midtown

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The Gate

While there might not be top attractions in The Gate, you can explore the larger area and discover places like St. Louis Union Station and Busch Stadium.

The Gate
St. Louis which includes interior views

Downtown West

If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

Downtown West
Lafayette Square which includes a house and a garden

Lafayette Square

The restaurants and shopping are a few reasons travelers visit Lafayette Square. Though there aren't many top sights in the neighborhood, you can visit St. Louis Union Station and Busch Stadium, a few notable attractions nearby.

Lafayette Square
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Shaw

4.5/5(3 area reviews)

While there might not be top attractions in Shaw, you can explore the larger area and discover places like Missouri Botanical Gardens and Arboretum and St. Louis Science Center.

Shaw
Central West End

Central West End

4.5/5(450 area reviews)

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

Central West End
Not just bars but also loft apartments are lit in rainbow lights for Pride weekend in the Grove neighborhood in St. Louis! #LifeAtExpedia

The Grove

The Grove might not have many top sights, but St. Louis Science Center and Missouri Botanical Gardens and Arboretum are two attractions nearby that you can check out.

The Grove