Find Resorts & Hotels with Spas in Upstate South Carolina, SC
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Pick from 26 Upstate South Carolina Resorts & Hotels with Spas and compare room rates, reviews, and availability. Most hotels are fully refundable.
Hotel Domestique
Hotel Domestique
9.6 out of 10, Exceptional, (25)
The price is AED 1,429
AED 1,572 total
includes taxes & fees
2 Jul - 3 Jul
Drury Inn & Suites Greenville
Drury Inn & Suites Greenville
9.4 out of 10, Exceptional, (1007)
The price is AED 397
AED 436 total
includes taxes & fees
9 Jun - 10 Jun
Hampton Inn & Suites Seneca-Clemson Area
Hampton Inn & Suites Seneca-Clemson Area
9.4 out of 10, Exceptional, (522)
The price is AED 418
AED 460 total
includes taxes & fees
13 Jun - 14 Jun
Hampton Inn Easley
Hampton Inn Easley
9.4 out of 10, Exceptional, (557)
The price is AED 465
AED 516 total
includes taxes & fees
16 Jun - 17 Jun
Courtyard Marriott Clemson
Courtyard Marriott Clemson
9.2 out of 10, Wonderful, (460)
The price is AED 434
AED 482 total
includes taxes & fees
29 Jun - 30 Jun
The Westin Poinsett Greenville
The Westin Poinsett Greenville
9.2 out of 10, Wonderful, (1003)
The price is AED 590
AED 669 total
includes taxes & fees
16 Jun - 17 Jun
Holiday Inn Express & Suites Greenville-Spartanburg (Duncan), an IHG Hotel
Holiday Inn Express & Suites Greenville-Spartanburg (Duncan), an IHG Hotel
9.0 out of 10, Wonderful, (157)
The price is AED 457
AED 514 total
includes taxes & fees
23 Jun - 24 Jun
Hampton Inn Simpsonville
Hampton Inn Simpsonville
9.0 out of 10, Wonderful, (464)
The price is AED 524
AED 586 total
includes taxes & fees
14 Jun - 15 Jun
Hilton Garden Inn Greenville
Hilton Garden Inn Greenville
9.0 out of 10, Wonderful, (833)
The price is AED 403
AED 443 total
includes taxes & fees
16 Jun - 17 Jun
Embassy Suites Greenville Golf Resort & Conference Center
Embassy Suites Greenville Golf Resort & Conference Center
8.8 out of 10, Excellent, (1013)
The price is AED 449
AED 508 total
includes taxes & fees
16 Jun - 17 Jun
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent reviews of Upstate South Carolina hotelsExpedia verified reviews
5/5 Excellent
Friendly and clean
"Always a pleasant experience at a Drury Hotel. The one in Greenville, SC, is really clean. The ladies at the desk are very friendly and accommodating. The other workers are also very friendly. Even the people staying at the hotel are friendly!!"
A verified traveler stayed at Drury Inn & Suites Greenville
Posted 3 days ago
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Hotels near popular Upstate South Carolina Attractions
- Hotels near Clemson University
- Hotels near Bon Secours Wellness Arena
- Hotels near Lake Jocassee
- Hotels near Haywood Mall
- Hotels near Falls Park on the Reedy
- Hotels near Prisma Health Greenville Memorial Hospital
- Hotels near Greenville Convention Center
- Hotels near The Peace Center
- Hotels near Wofford College
- Hotels near Fred W. Symmes Chapel
Upstate South Carolina Hotels by Star Rating
Explore more hotels
- Sleep Inn
- Embassy Suites Greenville Golf Resort & Conference Center
- Drury Inn & Suites Greenville
- Grand Bohemian Lodge Greenville, Autograph Collection
- Quality Inn & Suites Greenville - Haywood Mall
- Comfort Suites At WestGate Mall
- Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd
- Hyatt Place Greenville/Downtown
- Best Western Greenville Airport Inn
- Wingate by Wyndham - Greenville-Airport
- Hampton Inn Spartanburg-North I-85
- Best Western Spartanburg Northwest
- Days Inn by Wyndham Anderson
- Spartanburg Marriott
- Extended Stay America Premier Suites - Greenville - Spartanburg - I-85
- Holiday Inn Express & Suites Greenville Airport, an IHG Hotel
- Fairfield Inn & Suites by Marriott Greenville Simpsonville
- Quality Inn Simpsonville - Greenville
- Comfort Suites Greenville South
- Best Western Travelers Rest Greenville