Find 4 Star Hotels in Texas Medical Center, TX from AED 322

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Check availability on Texas Medical Center 4 Star Hotels

Tonight
4 Dec - 5 Dec
Tomorrow
5 Dec - 6 Dec
This weekend
5 Dec - 7 Dec
Next weekend
12 Dec - 14 Dec

Compare Texas Medical Center 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Exterior detail
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4.0 star property
Greater Uptown
8.2 out of 10, Very Good, (3022)
"Wonderful property will be booking again"
United States
Tyanna
The price is AED 458
AED 540 total
includes taxes & fees
2 Jan - 3 January 2026
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Exterior
The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria

4.0 star property
The Galleria
8.4 out of 10, Very Good, (1437)
"Great place to stay!"
United States
Curtis
The price is AED 474
AED 554 total
includes taxes & fees
19 Dec - 20 Dec
The Royal Sonesta Houston Galleria
Banquet hall
The Westin Galleria Houston

The Westin Galleria Houston

4.5 star property
The Galleria
9.0 out of 10, Wonderful, (1000)
"Excellent property. Great location next to shopping mall. "
Canada
Paul
The price is AED 585
AED 800 total
includes taxes & fees
6 Dec - 7 Dec
The Westin Galleria Houston
Lobby
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4.0 star property
Downtown Houston
8.4 out of 10, Very Good, (3920)
"Hotel was beautiful, room was great for the price"
United States
Sonya
The price is AED 307
AED 359 total
includes taxes & fees
6 Dec - 7 Dec
Club Quarters Hotel Downtown, Houston
Premium bedding, minibar, in-room safe, individually decorated
Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

4.0 star property
Texas Medical Center
9.0 out of 10, Wonderful, (3588)
"Everything about our stay was excellent. "
United States
Clarence
The price is AED 484
AED 566 total
includes taxes & fees
2 Jan - 3 January 2026
Blossom Hotel Houston, Curio Collection by Hilton
Premium bedding, pillowtop beds, minibar, in-room safe
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 star property
South Central Houston
9.0 out of 10, Wonderful, (1838)
"Very nice room, great staff, excellent food & drink."
United States
Mary
Hotel Zaza Houston Museum District
View from property
Magnolia Hotel Houston, A Tribute Portfolio Hotel

Magnolia Hotel Houston, A Tribute Portfolio Hotel

4.0 star property
Downtown Houston
9.2 out of 10, Wonderful, (1309)
"Good location, beautiful room and seamless checkin"
United States
kanchana
The price is AED 459
AED 549 total
includes taxes & fees
22 Dec - 23 Dec
Magnolia Hotel Houston, A Tribute Portfolio Hotel
Interior
Omni Houston Hotel

Omni Houston Hotel

4.0 star property
Greater Uptown
9.0 out of 10, Wonderful, (1002)
"Great location! "
United States
Fletcher
The price is AED 585
AED 694 total
includes taxes & fees
6 Dec - 7 Dec
Omni Houston Hotel
Business center
DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza

4.0 star property
Greenway Plaza-Upper Kirby
8.4 out of 10, Very Good, (1364)
"Great service, clean room, lots of amenities. Very pleasant stay"
Canada
Andrea
The price is AED 332
AED 388 total
includes taxes & fees
18 Dec - 19 Dec
DoubleTree by Hilton Hotel Houston - Greenway Plaza
Lunch, dinner, brunch served; Italian cuisine
C. Baldwin, Curio Collection by Hilton

C. Baldwin, Curio Collection by Hilton

4.0 star property
Downtown Houston
8.6 out of 10, Excellent, (1000)
"Great staff and great location"
United States
Anna
The price is AED 531
AED 718 total
includes taxes & fees
20 Dec - 21 Dec
C. Baldwin, Curio Collection by Hilton
Exterior
Hilton Americas-Houston

Hilton Americas-Houston

4.0 star property
Downtown Houston
9.4 out of 10, Exceptional, (1593)
"Clean, great location and super convenient food options!"
United States
Valerie
The price is AED 541
AED 641 total
includes taxes & fees
19 Dec - 20 Dec
Hilton Americas-Houston
Cocktail bar
Le Meridien Houston Downtown

Le Meridien Houston Downtown

4.0 star property
Downtown Houston
8.8 out of 10, Excellent, (1005)
"Great amenities "
United States
Larry
The price is AED 460
AED 538 total
includes taxes & fees
20 Dec - 21 Dec
Le Meridien Houston Downtown
City view from property
The Whitehall Houston

The Whitehall Houston

4.0 star property
Downtown Houston
8.6 out of 10, Excellent, (1895)
"Great stay."
United States
Anita
The price is AED 409
AED 478 total
includes taxes & fees
1 Jan - 2 January 2026
The Whitehall Houston
Daily buffet breakfast for a fee
DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4.0 star property
Texas Medical Center
8.4 out of 10, Very Good, (467)
"Staff was helpful in getting me back & forth to MD Anderson Cancer Hospital. "
United States
Patricia
The price is AED 309
AED 361 total
includes taxes & fees
22 Dec - 23 Dec
DoubleTree by Hilton Houston Medical Center Hotel & Suites
Sundeck
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 star property
Texas Medical Center
8.4 out of 10, Very Good, (1719)
"Clean rooms, comfortable bed, & friendly staff"
United States
Thomas
The price is AED 344
AED 407 total
includes taxes & fees
21 Dec - 22 Dec
Hilton Houston Plaza/Medical Center
Exterior
The Moran CITYCENTRE

The Moran CITYCENTRE

4.0 star property
Memorial
9.0 out of 10, Wonderful, (1001)
"Location was perfect and very nice and clean hotel was "
United States
Hamik
The price is AED 460
AED 648 total
includes taxes & fees
25 Dec - 26 Dec
The Moran CITYCENTRE
Meeting facility
The Westin Oaks Houston at the Galleria

The Westin Oaks Houston at the Galleria

4.0 star property
The Galleria
9.0 out of 10, Wonderful, (1001)
"Todo excelente!"
Mexico
patricia
The price is AED 585
AED 800 total
includes taxes & fees
5 Dec - 6 Dec
The Westin Oaks Houston at the Galleria
Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, sun loungers
Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria

4.0 star property
The Galleria
9.0 out of 10, Wonderful, (1160)
"Confortable bed, quiet ron and nice breakfast!"
United States
Juan
The price is AED 473
AED 665 total
includes taxes & fees
12 Dec - 13 Dec
Hyatt Regency Houston/Galleria
Reception
InterContinental Houston by IHG

InterContinental Houston by IHG

4.0 star property
Texas Medical Center
9.2 out of 10, Wonderful, (1000)
"Clean room, excellent staff, kind and respectful."
United States
DIANA
The price is AED 431
AED 578 total
includes taxes & fees
7 Dec - 8 Dec
InterContinental Houston by IHG
Outdoor pool, free cabanas, pool umbrellas
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4.0 star property
Texas Medical Center
9.2 out of 10, Wonderful, (1000)
"Perfect location & amazing staff at the hotel"
United States
Orlando
The price is AED 503
AED 626 total
includes taxes & fees
19 Dec - 20 Dec
The Westin Houston Medical Center/Museum District
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Texas Medical Center.
The Post Oak Hotel at Uptown Houston

The Post Oak Hotel at Uptown Houston

1600 West Loop South Houston TX
The price is AED 1,898 per night from Jan 4 to Jan 5
AED 1,898
AED 2,221 total
4 Jan - 5 January 2026
includes taxes & fees
9.6/10 Exceptional! (878 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Texas Medical Center Hotel Reviews

Magnolia Hotel Houston, A Tribute Portfolio Hotel

Magnolia Hotel Houston, A Tribute Portfolio Hotel

10/10 Excellent
"I have never slept so good and felt more relaxed. I would recommend this hotel a million times over. Great Southern Hospitality from the moment of check in at the front desk to the time I checked out. Beautiful place with clean rooms and hallways. A second level with a piano and buffet bar too was the cherry on top. I will definitely stay at this hotel again."
Michelle 3-night trip
Posted 17 hours ago
Magnolia Hotel Houston, A Tribute Portfolio Hotel

Frequently asked questions

What are the best 4-star hotels in Texas Medical Center?
Blossom Hotel Houston and DoubleTree by Hilton Houston Medical Center Hotel & Suites are two highly recommended getaways located in or near Texas Medical Center. Both have a 4-star rating and promise high-end comfort alongside an unrivaled guest experience. Check in to the first and get access to designer toiletries and a rooftop terrace. The second features premium bedding and a swimming pool, among other amenities.
How much does it cost to stay in a 4-star hotel in Texas Medical Center?
With Expedia's handy search filters, scoring a top deal on a 4-star hotel in Texas Medical Center just got simpler. Start by entering your chosen travel dates and length of your stay. Then sort the results by price and pick the option that best matches your style and budget.

  • Search for the lowest price from AED 322

What's the difference between 5-star and 4-star hotels in Texas Medical Center?
Offering a welcoming guest experience and upmarket décor, 4-star hotels are a fantastic option for your Texas Medical Center getaway. These types of stays generally come with loads of handy amenities that make it easy to unpack and unwind — think large beds, bathrobes, pools and restaurants. Or enjoy even more lavishness at a 5-star hotel designed to pamper with high-end perks and amenities. Full-service health clubs, complimentary toiletries and fine dining are typically featured at these swanky properties.

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