A bench, a bicycle, and a lake surrounded by trees.

Find 4 Star Hotels in Upstate South Carolina, SC from AED 372

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Check availability on Upstate South Carolina 4 Star Hotels

Tonight
24 Oct - 25 Oct
Tomorrow
25 Oct - 26 Oct
Next weekend
30 Oct - 1 Nov
In two weeks
6 Nov - 8 Nov

Our top choices for Upstate South Carolina 4-star hotels

A large, multi-story house with a prominent waterfall in the foreground, surrounded by lush greenery.
An outdoor dining area with multiple tables and chairs, large windows, and a view of greenery.
A modern interior with a stone fireplace, leather sofas, and a wooden ceiling.
A modern interior with a fireplace, plush seating, and a stone accent wall.

1. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
United States
colleen
AED 1,286
AED 1,457 total
includes taxes & fees
15 Nov - 16 Nov
Grand Bohemian Lodge Greenville, Autograph Collection
A dining area with a wooden table, chairs, and a vase of white flowers.
A bar with multiple shelves of liquor bottles and glasses hanging above.
A modern living room with a fireplace, seating area, and a bar with shelves of bottles.
A large, two-story house with a symmetrical facade, large windows, and a central entrance.

2. Hotel Hartness

Hotel Hartness
Greenville
United States
Nicole
AED 604
AED 805 total
includes taxes & fees
25 Oct - 26 Oct
Hotel Hartness
A hotel facade with arched windows, a fountain, and a sign for "The Westin."
A banquet hall with round tables, chandeliers, and ornate windows.
A grand lobby with a chandelier, multiple seating areas, and a checkered floor pattern.
Meeting facility

3. The Westin Poinsett Greenville

The Westin Poinsett Greenville
Greenville Downtown
United States
BRITTANY
AED 584
AED 673 total
includes taxes & fees
22 Nov - 23 Nov
The Westin Poinsett Greenville
A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.
A modern kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, and a granite countertop. There are three white bar stools and two pendant lights.
A modern kitchen with white cabinets, a stainless steel refrigerator, and a bar area with white stools.
A modern kitchen with granite countertops, double sinks, and a built-in dishwasher.

4. Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
Greenville Downtown
United States
Michelle
AED 347
AED 382 total
includes taxes & fees
23 Nov - 24 Nov
Mint House Greenville Downtown by Kasa
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.
A bar area with a counter, multiple chairs, and a display of bottles and glasses.
A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.

5. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
United States
Amy
AED 525
AED 583 total
includes taxes & fees
15 Nov - 16 Nov
The Abernathy of Clemson
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.
A spacious living area with a sofa, ottoman, and chairs, a dining area with a table, and a kitchen in the background.
A modern bar area with a wooden ceiling, green bar stools, and a bar counter.

6. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
United States
Laurrie
AED 768
AED 852 total
includes taxes & fees
26 Oct - 27 Oct
The Shepherd Hotel Downtown Clemson
A white BMW with "BMW Performance Driving School" text on the side, driving on a road with a cloud-covered sky in the background.
A modern building with a large illuminated logo reading "TOPGOLF" on the facade.
A spacious indoor venue with rows of white chairs adorned with purple sashes, large windows, and a modern ceiling design.
A banquet hall with round tables set for dining, large windows, and a stage with curtains.

7. Greenville Marriott

Greenville Marriott
Greenville
United States
John
AED 419
AED 474 total
includes taxes & fees
31 Oct - 1 Nov
Greenville Marriott
Bar (on property)
Bar (on property)
Snack bar
Room

8. Doubletree By Hilton Greenville Airport

Doubletree By Hilton Greenville Airport
Greer
United States
Stephanie
AED 407
AED 461 total
includes taxes & fees
16 Nov - 17 Nov
Doubletree By Hilton Greenville Airport
A white, two-story house with a front porch, surrounded by trees and shrubs.
A two-story building with a white exterior, a front door, and a balcony.
A bedroom with two beds, a TV, and a fireplace.
A hallway with a wooden bench, a chair, a cabinet, and a painting on the wall.

9. Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
Pendleton
United States
Christine
AED 335
AED 372 total
includes taxes & fees
9 Nov - 10 Nov
Liberty Hall Bed and Breakfast
A modern building with outdoor seating and a garden.
A modern kitchen with white cabinetry, a wooden dining table, and a black chair. There is a window with a view of greenery outside.
A modern living room with a sofa, coffee table, and dining table. There is a TV mounted on the wall, a coffee machine, and a bookshelf.
A row of modern, two-story buildings with a covered patio area.

10. The Station by Compo Hotels

The Station by Compo Hotels
Travelers Rest
United States
Anonymous traveler
AED 871
AED 1,261 total
includes taxes & fees
22 Nov - 23 Nov
The Station by Compo Hotels
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A restaurant with a stone fireplace, hanging crystal chandelier, and multiple dining tables set with white tablecloths and wine glasses.
A spacious room with wooden beams, a large chandelier, and a cozy seating area with orange chairs and a white sofa.
A swimming pool with lounge chairs and a building with balconies.

11. Hotel Domestique

Hotel Domestique
Travelers Rest
United States
Chuck
AED 1,539
AED 1,693 total
includes taxes & fees
1 Nov - 2 Nov
Hotel Domestique
A spacious living room with a stone fireplace, wooden beams, and a chandelier.
A multi-story residential building with balconies, a stone archway entrance, and a sign indicating it is part of Century Park at Taft Community.
A modern kitchen with dark wood cabinets, a black refrigerator, a microwave, and a stainless steel sink. There are two bar stools at the island, and a flat-screen TV mounted on the wall.
A modern kitchen with white cabinetry, dark blue walls, and a patterned floor.

12. Landing Apartments Greer - Sugar Creek

Landing Apartments Greer - Sugar Creek
Greer
United States
Amanda
Landing Apartments Greer - Sugar Creek
A bedroom with a bed, a chair, and a potted aloe plant on a table.
A modern living room with a flat-screen TV, two leather chairs, a wooden dining table, and a potted plant.
A modern kitchen with stainless steel appliances, a dining area with a table and chairs, and a TV mounted on a wooden cabinet.
A multi-story building with a symmetrical facade, large windows, and two flags on top.

13. Landing Furnished Apartments - Spartanburg, SC

Landing Furnished Apartments - Spartanburg, SC
Spartanburg
Landing Furnished Apartments - Spartanburg, SC
A cozy living room with a fireplace, leather armchair, and a large window.
A wooden gazebo with a roof, surrounded by trees, overlooking a lake.
A modern kitchen with stainless steel appliances, a granite countertop, and large windows offering a view of the outdoors.
A covered outdoor deck with wicker furniture and large windows offering views of a forest and a lake.

14. Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!
Salem
United States
Anonymous traveler
Designer Retreat w/ Pool, Golf + Beach Access!
A two-story yellow house with a front porch, a small garden, and a pathway leading to the entrance.
An indoor swimming pool with clear lanes, a covered roof, and a bench area.
Interior
Interior

15. Wooded Keowee Key Retreat Near Golf & Trails

Wooded Keowee Key Retreat Near Golf & Trails
Salem
Wooded Keowee Key Retreat Near Golf & Trails
A swimming pool with a view of a lake and docked boats.
A marina with boats docked, a lifeguard station, and a dock with lounge chairs.
A sandy beach with a calm lake surrounded by trees.
A spacious dining area with a wooden table, chairs, and a chandelier. A cozy seating area with a sofa and chairs is visible in the background.

16. Lake Keowee Condo: Resort Pools & Lake Access!

Lake Keowee Condo: Resort Pools & Lake Access!
Salem
United States
Shawn
Lake Keowee Condo: Resort Pools & Lake Access!
A swimming pool with a view of the lake and docked boats.
A modern living room with a large window, a flat-screen TV, a leather sofa, a coffee table, and a bookshelf.
A spacious living area with a high ceiling, a large window with a view of trees, a kitchen with a bar, and a comfortable seating area with a sofa and ottomans.
A marina with boats docked, surrounded by greenery and trees.

17. Keowee Key Condo w/ Lake Access & Community Pools!

Keowee Key Condo w/ Lake Access & Community Pools!
Salem
Keowee Key Condo w/ Lake Access & Community Pools!
A wooden deck with a table and chairs, large windows, and a view of trees.
A marina with boats docked, surrounded by greenery and trees.
A swimming pool with a view of a lake and docked boats.
A dining area with a wooden table and chairs, a kitchen with white cabinets, and a staircase with a white railing.

18. Salem Vacation Rental w/ Lake Keowee Access!

Salem Vacation Rental w/ Lake Keowee Access!
Salem
Salem Vacation Rental w/ Lake Keowee Access!
A swimming pool with a view of the lake and docked boats.
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
An aerial view of a residential area with houses, a golf course, and a lake in the background.
A marina with boats docked, a lifeguard station, and a view of a lake surrounded by trees.

19. Views, Pools & Marina: Lake Keowee Condo!

Views, Pools & Marina: Lake Keowee Condo!
Salem
Views, Pools & Marina: Lake Keowee Condo!
A multi-story wooden building with balconies, large windows, and a landscaped area with trees.
A modern building with a prominent wooden entrance canopy, stone pillars, and a clear sky.
A spacious hotel lobby with a bar area, seating arrangements, and large windows offering views.
A modern kitchen with a stainless steel sink, pendant lighting, and a view to a living area with a sofa and a staircase.

20. Tee Times & Lake Days! Luxe Keowee Key Living

Tee Times & Lake Days! Luxe Keowee Key Living
Salem
Tee Times & Lake Days! Luxe Keowee Key Living
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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina
An aerial view of a park with a winding path, trees in autumn colors, and a bridge.
Photo by Visit Greenville, South Carolina

Top Upstate South Carolina Hotel Reviews

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

10/10 Excellent
"Beautiful property and city!"
Barbara 1-night trip
Posted 3 hours ago
Grand Bohemian Lodge Greenville, Autograph Collection
Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa

8/10 Good
"Great location and in vicinity/walking to Reedy Falls, shops, food & ice cream, and Grand Bohemian Lodge, too! Walk the pathway along the river and seeing the boulder water falls was exceptionally special! Balcony was a nice view of city life. Parking for a fee was conveniently located for access to the property. Kitchen was large and equipped well for simple dinner. The Laundry room with detergent was useful, too!"
Melissa 2-night trip
Posted 4 days ago
Mint House Greenville Downtown by Kasa

Frequently asked questions

What are the best 4-star hotels in Upstate South Carolina?
Greenville Marriott is rated highly by many Expedia guests. Located in Greer, Upstate South Carolina, this 4-star hotel features lots of amenities to help make your stay comfortable and convenient.
How much does it cost to stay in a 4-star hotel in Upstate South Carolina?
Expedia can help you quickly locate the perfect 4-star hotel for your getaway in Upstate South Carolina. Use our handy filter tool to tailor your search by things like amenities, budget and property star rating and get access to fabulous deals in a few clicks.
  • Search for the lowest price from AED 372
What's the difference between 5-star and 4-star hotels in Upstate South Carolina?
Offering a friendly guest experience and upmarket décor, 4-star hotels are a wonderful option for your Upstate South Carolina trip. These kinds of accommodations generally come with loads of handy amenities that make it simple to kick back and relax — think large beds, bathrobes, restaurants and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. Full-service health clubs, premium toiletries and fine dining are typically featured at these deluxe retreats.

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