Find 4 Star Hotels in Vandalia, MO
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Check availability on Vandalia 4 Star Hotels
Compare Vandalia 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Garth Woodside Mansion B&B
Hannibal
9.6 out of 10, Exceptional, (21)
Save an average of 15% on thousands of hotels when you're signed in
Top Vandalia Hotel Reviews

Garth Woodside Mansion B&B
10/10 Excellent
Frequently asked questions
Explore a world of travel with Expedia
Vandalia Hotels by Star Rating
Stay near popular Vandalia attractions
- Hotels near Mississippi River
- Hotels near Mark Twain Cave
- Hotels near Mark Twain State Park
- Hotels near Graham Cave State Park
- Hotels near Mark Twain Birthplace State Historic Site
- Hotels near Lakeview Park
- Hotels near Presser Performing Arts Center
- Hotels near Audrain County Historical Society
- Hotels near New Florence United Methodist Church
- Hotels near Hillside Mini Golf
- Hotels near Sodalis Nature Preserve
More Accommodation Types in Vandalia
Explore more hotels
- Kennedys Red Barn Inn
- Budget Inn Mexico MO on US 54
- 3 Bedroom 2 Bath Cabin nestled in the woods minutes from Mark Twain Lake.
- Garth Woodside Mansion B&B
- MTL HUNTING LAYAWAY & OUTDOOR HANGOUT
- “Peaceful Retreat” @ MTL
- Family Cabin by a private fishing lake
- Charming 2-bedroom 2-bath condo with WiFi in Monroe City by Mark Twain Lake
- Newly Built Shouse Near Mark Twain Lake!
- Brady Hotel
- “The Stoutsville Cabin” offers you a peaceful and secluded getaway!
- Deluxe two queen bed motel room packed with amenities.
- Luxury condo at Mark Twain Lake
- Holder House at Beautiful Mark Twain Lake.
- Family-Friendly Home. Sleeps 14. Just minutes away from Mark Twain Lake.
- Charming 2-bedroom house at Mark Twain Lake
- A real charmer built in 1915 , pet friendly , located next to Mark Twain lake.
- Mark Twain Lake Condo
- 2 bedroom house near Mark Twain Lake on Salt River! WiFi and Boat parking!
- 1 Mi to Mark Twain Lake: Cabin w/ Community Pool



