Photo by Cameron Abbott

Find 5 Star Hotels in Upper Matecumbe Key, FL from AED 1,018
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Check availability on Upper Matecumbe Key 5 Star Hotels
Our top choices for Upper Matecumbe Key 5-star hotels

1. Cheeca Lodge & Spa
Cheeca Lodge & SpaMatecumbe
9.2 out of 10, Wonderful, (1,503 reviews)
The price is AED 666
AED 1,018 total
includes taxes & fees
29 Nov - 30 Nov

2. The Islands of Islamorada
The Islands of IslamoradaMatecumbe
9.6 out of 10, Exceptional, (83 reviews)
The price is AED 2,437
AED 3,010 total
includes taxes & fees
30 Nov - 1 Dec
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 4-star hotels
Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Upper Matecumbe Key.

Hawks Cay Resort
61 Hawks Cay Blvd Marathon FL
The price is AED 800 per night from Nov 15 to Nov 16
AED 800
AED 1,236 total
15 Nov - 16 Nov
includes taxes & fees
8.2/10 Very Good! (1,003 reviews)
Still don't see what you're looking for?
See all properties in Upper Matecumbe Key.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about Upper Matecumbe Key
Check out the local area in Upper Matecumbe Key—home to attractions like Bud n' Mary's Dive Center and Florida Keys Brewing Co..

Top Upper Matecumbe Key Hotel Reviews

Cheeca Lodge & Spa
10/10 Excellent
Explore a world of travel with Expedia
- Wyndham Hotels in Long Key
- Motels in Tavernier
- Business Hotels in Grassy Key
- Aparthotels in Tavernier
- Hotel Wedding Venues Hotels in Tavernier
- Cabin Rentals in Marathon
- Houseboats in Marathon
- Marriott Hotels & Resorts in Islamorada
- Pet-Friendly Hotels in Islamorada
- Condo Rentals in Key Largo
- Resorts & Hotels with Spas in Marathon
- 5 Star Hotels in Florida City
- 3 Star Hotels in Naranja
- 4 Star Hotels in Key Largo
- Adults Only Resorts & in Islamorada
- 4 Star Hotels in Downtown Homestead
- 5 Star Hotels in Grassy Key
- Beach Hotels in Key Largo
- Best Western Hotels in Islamorada
- Houseboats in Islamorada
- Shopping Hotels in Islamorada
- Resorts in Marathon
- Independent Hotels in Plantation Key Colony
- Aimbridge Hospitality Hotels in Islamorada
- Scuba Diving Hotels in Tavernier
- 4 Star Hotels in Homestead
- Hersha Hospitality Hotels in Lignumvitae Key Botanical State Park
- Casino Hotels in Key Largo
- 3 Star Hotels in Conch Key
- Benchmark Hotels in Duck Key
- Bluegreen Resorts in Marathon
- Wyndham Hotels in Key Largo
- Resorts in Islamorada
- 5 Star Hotels in Tavernier
- 5 Star Hotels in Plantation Key Colony
- Houseboats in Grassy Key
- Luxury Hotels in Islamorada
- Hotels with a Pool in Key Largo
- Florida City Hotels
- Cheap Hotels in Islamorada
- Villas in Tavernier
- Historic Hotels in Tavernier
- Boutique Hotels in Key Largo
- 5 Star Hotels in No Name Key
- 2 Star Hotels in Homestead
- Condo Rentals in Grassy Key
- 5 Star Hotels in Conch Key
- Hotels near Bluefin Rock Harbor Marina
- Hotels near Ernest F. Coe Visitor Center
- Cottages in Key Largo
- Hotels with Hot Tubs in Key Largo
- Villas in Duck Key
- Houseboats in Key Largo
- Hilton Hotels in Grassy Key
- Cheap Hotels in Key Largo
- 3 Star Hotels in Islamorada
- 5 Star Hotels in Islamorada
- Cottages in Marathon
- Hyatt Hotels in Marathon
- Vacation Homes in Duck Key
- 4 Star Hotels in Naranja
- Hilton Hotels in Key Colony Beach
- Equity Lifestyle Hotels in Marathon
- Luxury Hotels in Key Colony Beach
- Aparthotels in Key Largo
- Motels in Marathon
- Vacation Homes in Marathon
- Resorts in Key Largo
- 3 Star Hotels in Marathon
- 4 Star Hotels in Lignumvitae Key Botanical State Park
- Romantic Hotels in Key Colony Beach
- Hotel Wedding Venues Hotels in Key Largo
- 5 Star Hotels in Homestead
- Flights from Savannah (SAV) to Marathon (MTH)
- Flights from Valdosta (VLD) to Marathon (MTH)
- Flights from Key West (EYW) to Ocean Reef Club (OCA)
- Flights from Florida Keys Marathon
- Flights from Grassy Key
- Flights from Manzini (SHO) to Marathon (MTH)
- Flights from Grand Rapids (GRR) to Marathon (MTH)
- Flights from Marathon
- Flights from Key Colony Beach
- Flights from Chiang Rai (CEI) to Marathon (MTH)
- Flights from Knoxville (TYS) to Marathon (MTH)
- Flights from Ocean Reef Club
- Flights from Niue (IUE) to Marathon (MTH)
- Flights from Lakeland Intl. Airport (LAL) to Marathon (MTH)
- Flights from Aspen (ASE) to Marathon (MTH)
- Flights from Lancaster (LNS) to Marathon (MTH)
- Flights from Layton
- Flights from Key Largo
- Flights from Brownsville (BRO) to Marathon (MTH)
- Flights from Raleigh (RDU) to Marathon (MTH)
- Flights from Knoxville (TYS) to Ocean Reef Club (OCA)
- Flights from Florence (FLR) to Marathon (MTH)
- Flights from Fargo (FAR) to Marathon (MTH)
- Flights from Vilnius (VNO) to Marathon (MTH)







