Find hotels in Defiance, MO from AED 253

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Compare 845 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

The Wildwood Hotel

3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1612)
"Great hotel in a great neighborhood "
United States
Linda
The Wildwood Hotel

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3.0 star property
Fenton
8.0 out of 10, Very Good, (1030)
"Very friendly staff "
United States
Amber
The price is AED 312
AED 361 total
includes taxes & fees
7 Dec - 8 Dec
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Best Western Plus St. Louis West-Westport

2.5 star property
Maryland Heights
8.0 out of 10, Very Good, (1032)
"The room was great and the bed was very comfortable "
United States
Joyce
The price is AED 364
AED 422 total
includes taxes & fees
3 Dec - 4 Dec
Best Western Plus St. Louis West-Westport

Baymont by Wyndham Warrenton

2.5 star property
Warrenton
7.4 out of 10, Good, (1003)
"Great service and nice rooms. 5 Star staff as well. Over all a great experience! "
United States
Justin
The price is AED 307
AED 352 total
includes taxes & fees
8 Dec - 9 Dec
Baymont by Wyndham Warrenton

Sonesta ES Suites St. Louis - Chesterfield

3.0 star property
Chesterfield
8.0 out of 10, Very Good, (1032)
"Clean room,Friendly staff, Good location and Good Breakfast options"
United States
Micheal
The price is AED 341
AED 395 total
includes taxes & fees
11 Dec - 12 Dec
Sonesta ES Suites St. Louis - Chesterfield

AC Hotel by Marriott St. Louis Chesterfield

3.5 star property
Chesterfield
9.2 out of 10, Wonderful, (233)
"Newer hotel, very clean, up to date and in nice area. "
United States
Johnny
The price is AED 437
AED 507 total
includes taxes & fees
21 Dec - 22 Dec
AC Hotel by Marriott St. Louis Chesterfield

WoodSpring Suites St Peters-OFallon

2.5 star property
St. Peters
10.0 out of 10, Exceptional, (14)
"Very nice:) "
United States
Alicia
The price is AED 272
AED 312 total
includes taxes & fees
3 Dec - 4 Dec
WoodSpring Suites St Peters-OFallon

Holiday Inn Express St. Louis West - O'Fallon by IHG

2.5 star property
O'Fallon
8.6 out of 10, Excellent, (827)
"The staff was so friendly and helpful! The hotel was exceptionally clean. Breakfast was very good with lots of variety!"
United States
Millie
The price is AED 350
AED 412 total
includes taxes & fees
4 Dec - 5 Dec
Holiday Inn Express St. Louis West - O'Fallon by IHG

Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 star property
O'Fallon
8.8 out of 10, Excellent, (1019)
"Nice breakfast, friendly staff"
United States
Damon
The price is AED 324
AED 382 total
includes taxes & fees
28 Dec - 29 Dec
Sleep Inn & Suites O'Fallon MO - Technology Drive

Holiday Inn Express & Suites Wentzville St Louis West by IHG

2.5 star property
Wentzville
9.4 out of 10, Exceptional, (829)
"Good all around stay "
United States
Chad
The price is AED 379
AED 456 total
includes taxes & fees
2 Jan - 3 January 2026
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Drury Plaza Hotel St. Louis St. Charles

3.0 star property
St. Charles
9.6 out of 10, Exceptional, (1012)
"Hotel was very clean."
United States
christine
The price is AED 422
AED 490 total
includes taxes & fees
7 Dec - 8 Dec
Drury Plaza Hotel St. Louis St. Charles

Hampton Inn St. Charles St. Peters

2.5 star property
St. Charles
8.0 out of 10, Very Good, (1021)
"Room was very clean. Staff were nice."
United States
Susann
The price is AED 320
AED 368 total
includes taxes & fees
14 Dec - 15 Dec
Hampton Inn St. Charles St. Peters

Days Inn by Wyndham St Peters/St Charles

2.0 star property
St. Peters
6.2 out of 10, (1003)
"Staff was very friendly. Room was kept clean."
United States
Sandra
The price is AED 222
AED 255 total
includes taxes & fees
1 Jan - 2 January 2026
Days Inn by Wyndham St Peters/St Charles

Best Western Plus Washington Hotel

2.5 star property
Washington
9.2 out of 10, Wonderful, (632)
"Would stay again. "
United States
Alisa
The price is AED 474
AED 539 total
includes taxes & fees
3 Dec - 4 Dec
Best Western Plus Washington Hotel

Hollywood Casino & Hotel St. Louis

3.5 star property
Maryland Heights
8.4 out of 10, Very Good, (2219)
"Decent room. Well priced and centrally located for out soccer tournament we were in town for"
United States
Travis
The price is AED 283
AED 383 total
includes taxes & fees
15 Dec - 16 Dec
Hollywood Casino & Hotel St. Louis

Wingate by Wyndham St. Louis/Fenton Route 66

3.0 star property
Fenton
7.8 out of 10, Good, (1111)
"The young lady that checked us in was very friendly and helpful."
United States
Wenona
The price is AED 290
AED 335 total
includes taxes & fees
7 Dec - 8 Dec
Wingate by Wyndham St. Louis/Fenton Route 66

Super 8 by Wyndham Warrenton

2.0 star property
Warrenton
7.4 out of 10, Good, (617)
"I have stayed several times at this hotel, it is always very clean, the staff are super nice and very convenient to I-70; would recommend this hotel and I will definitely stay there again."
United States
Kimberly
The price is AED 222
AED 254 total
includes taxes & fees
28 Dec - 29 Dec
Super 8 by Wyndham Warrenton

Hilton Garden Inn Chesterfield

3.0 star property
Chesterfield
8.2 out of 10, Very Good, (782)
"Just a really nice hotel tucked away from everything, but still close to get whereevre you need to go!"
United States
Roy
The price is AED 358
AED 417 total
includes taxes & fees
14 Dec - 15 Dec
Hilton Garden Inn Chesterfield

Super 8 by Wyndham Eureka/Six Flags Nearby

2.0 star property
Eureka
7.0 out of 10, Good, (1007)
"A much needed comfortable bed and hot shower, staff was lovely. "
United States
Rachel
The price is AED 226
AED 264 total
includes taxes & fees
15 Dec - 16 Dec
Super 8 by Wyndham Eureka/Six Flags Nearby

Super 8 by Wyndham St. Clair MO

2.0 star property
St. Clair
7.2 out of 10, Good, (939)
"Was what I needed after a long drive."
United States
Michael
The price is AED 231
AED 253 total
includes taxes & fees
3 Dec - 4 Dec
Super 8 by Wyndham St. Clair MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

More cheap stays in Defiance

Hotels in Defiance with star-rating

Find out more about Defiance

Top reasons to visit Defiance

  • Scenic Outdoor Adventures: Enjoy hiking trails and beautiful recreational areas perfect for outdoor enthusiasts.
  • Charming Downtown Area: Explore quaint shops and local eateries that capture the town's unique character.
  • Family-Friendly Activities: Engage in a variety of attractions including urban parks and amusement parks.
  • Romantic Getaways: Experience picturesque landscapes ideal for leisurely walks and intimate moments.
  • Comfortable Accommodations: Find diverse lodging options that cater to families, pets, and business travelers alike.

Find great hotels near Defiance

Discover the charming accommodations in Defiance, Missouri, where a variety of hotels and apartments await your arrival. Whether you’re seeking a pet-friendly option, a family-friendly retreat, or a convenient place for business travel, Defiance has something to suit every traveler’s needs. Explore top hotels and available lodging that promise comfort and warmth during your stay in this picturesque town.

  • Sonesta ES Suites St. Louis - Chesterfield: Experience warm hospitality and a pet-friendly atmosphere at Sonesta ES Suites St. Louis - Chesterfield. Located 19.3km from Defiance, this 3-star hotel is ideal for travelers seeking comfort and convenience with their furry friends. The hotel features spacious suites equipped with full kitchens, making it perfect for extended stays. Guests can enjoy complimentary breakfast and a cozy outdoor space, as well as amenities like food and water bowls for pets. With a welcoming environment, this hotel ensures a delightful stay for both you and your pets.
  • The Wildwood Hotel: Embrace adventure and nature at The Wildwood Hotel, just 14.5km from Defiance. This 3.5-star hotel is perfect for business travelers and outdoor enthusiasts alike, offering a range of adventure sports and recreation activities nearby. Whether you’re into skiing, mountain biking, or snowboarding, this hotel serves as an excellent base for your excursions. Guests appreciate the unique blend of rustic charm and modern conveniences, including a well-equipped fitness center and meeting facilities, making it a great choice for work and play.
  • Hyatt Place St. Louis/Chesterfield: A family-friendly and business-oriented retreat, Hyatt Place St. Louis/Chesterfield is located 19.3km from Defiance. This 3-star hotel offers spacious rooms with modern amenities, including a 24/7 business center and kid-friendly services. The pet-friendly policy ensures that your furry companions are welcome too, with specific amenities designed for dogs. Enjoy a complimentary breakfast and relax by the outdoor pool after a busy day exploring the area. With its convenient location and accommodating services, this hotel is perfect for families and professionals on the go.

Where to stay near Defiance

Defiance, Missouri, offers a delightful blend of outdoor adventures and romantic getaways. Stroll through the quaint downtown area, where charming shops and local eateries await. Nearby, families can enjoy recreational activities while basking in the friendly atmosphere. For a relaxing break, explore the scenic landscapes that define the region, perfect for leisurely walks and unforgettable moments. Experience the rich history and vibrant community that make Defiance a unique destination for every traveler.

  • Chesterfield: Located 19.3km from Defiance, Chesterfield is a vibrant city known for its family-friendly atmosphere and diverse entertainment options. Visitors can enjoy a variety of activities, such as catching a live performance at a local theater or having a blast at the arcade adventure zone. The city thrives with seasonal visitors, particularly in April and from June to July, making it a lively hub during these months. Don’t miss the chance to explore local landmarks like the theme park or sports stadium, ensuring an exciting experience for everyone in the family.
  • Saint Albans: Just 6.4km from Defiance, Saint Albans is a charming city perfect for those seeking outdoor adventures and romantic getaways. The city welcomes travelers year-round, with peak visits occurring in April, July, and September. Engage in a range of activities from enjoying the rides at the amusement park to relaxing in the picturesque recreational areas. With urban parks and a serene lake nearby, visitors can embrace the natural beauty and tranquility that Saint Albans has to offer, making it an appealing destination for both couples and families alike.
  • O'Fallon: Situated 20.9km from Defiance, O'Fallon is a bustling city that attracts families and entertainment seekers throughout the year. With a peak in visitors during April and the summer months, the city boasts a variety of attractions such as an arena entertainment facility and shopping mall center. Visitors can indulge in various activities, including arcade adventures and local events at the convention center. With a vibrant atmosphere and numerous venues, O'Fallon promises a fulfilling travel experience filled with excitement and fun.

Things to do in and around Defiance

Defiance, Missouri, offers a perfect blend of outdoor adventure and romantic escapades. Visitors can explore scenic hiking trails and enjoy access to beautiful recreational areas, making it an ideal destination for memorable stays and outdoor activities. Whether you're looking to hike through nature or simply relax in a charming setting, Defiance provides a delightful experience for all who visit.

Shopping

In Defiance, visit the St. Louis Premium Outlets, just 11.3km away, for a variety of shops and entertainment vibes. If you're up for a drive, check out the Wentzville Flea Market, located 20.9km away, offering unique finds in a bustling atmosphere, or Taubman Prestige Outlets, 16.1km away, for more shopping options.

Recreation

Explore Broemmelsiek Park for a serene retreat amidst nature, featuring walking trails and picnic areas for relaxation. Enjoy a lively evening at The Factory, where live music creates an energetic atmosphere. For outdoor enthusiasts, the Missouri Bluffs Golf Course offers a challenging game with picturesque views.

Adventure

Hidden Valley Ski Resort offers thrilling winter sports only 14.5km from Defiance, perfect for skiing enthusiasts. For a splash of fun, Hurricane Harbor, located 16.1km away, features exciting water rides and family-friendly attractions. Enjoy the scenic beauty of Matson Hill Park Trailhead right in Defiance, ideal for hiking adventures.

Nightlife

Experience the fun at Chesterfield Sports Fusion, an arcade adventure zone featuring family-friendly activities, just 14.5km from Defiance. For a cultural night out, visit the New Jewish Theatre, 32.2km away, offering romance and entertainment. Jump into excitement at Sky Zone Indoor Trampoline Park, 16.1km from Defiance.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Defiance

To save money on your trip to Defiance, Missouri, consider visiting between December and February for lower accommodation rates. Mondays are the cheapest days to stay, while Saturdays tend to be pricier. Use Expedia's search tool to filter hotels by price and type, including eco-friendly options. Additionally, booking a package that includes flights, hotel stays, and activities can lead to significant savings. Look for flexible booking options and exclusive deals on beverages and last-minute offers to further cut costs during your visit.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Defiance are December to February, where the prices are slightly lower. This is in comparison to May to July, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Defiance is Monday. The most expensive day to stay in Defiance is Saturday.
  • Find cheap hotels on Expedia: Expedia's search tool enables you to customize your search based on your budget, preferred location, and additional criteria. You can easily arrange the results by price, starting with the most affordable hotels. Additionally, you have the option to refine your choices by hotel type; for instance, selecting the Eco-certified filter will display sustainable and environmentally-friendly hotels that you can reserve.
  • Consider bundling your trip: You can save money by booking an Expedia package that combines your hotel stay in Defiance with your flights and activities.

Find the best attractions in and around Defiance

Defiance, Missouri, is a perfect destination for outdoor enthusiasts and those seeking a romantic getaway. Visitors can explore a variety of attractions, including urban parks, national state parks, and amusement parks. Whether you’re looking for family-friendly activities, a vibrant city experience, or just some time in nature, Defiance offers a diverse range of points of interest to make your vacation memorable.

  • Six Flags St. Louis: Experience thrill-seeking adventures at Six Flags St. Louis, just 16.1km from Defiance. This amusement park boasts exhilarating rides, family-friendly attractions, and lively entertainment, making it perfect for all ages.
  • August A. Busch Memorial Conservation Area: Explore the beauty of nature at the August A. Busch Memorial Conservation Area, located within Defiance. This serene preserve offers family-friendly excursions, wildlife viewing, and scenic trails while promoting a welcoming atmosphere among visitors.
  • Historic Daniel Boone Home and Heritage Center: Step back in time at the Historic Daniel Boone Home and Heritage Center, also situated in Defiance. Discover the rich cultural heritage of early American settlers and enjoy informative exhibits that celebrate the life of this legendary frontiersman.

Best time to go to Defiance

The best time to visit Defiance is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are moderately high and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are moderately low and weather is mostly cloudy with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January31.6°F (-0.2°C)Light RainMostly CloudyModerately LowSlightly Low
February34.7°F (1.5°C)Light RainMostly SunnyAverageSlightly Low
March46.4°F (8.0°C)Light RainMostly SunnyAverageAverage
April55.9°F (13.3°C)Light RainMostly SunnyModerately HighAverage
May66.2°F (19.0°C)Light RainMostly SunnyAverageSlightly High
June75.9°F (24.4°C)Light RainMostly SunnyAverageSlightly High
July79.0°F (26.1°C)Light RainMostly SunnyModerately HighSlightly High
August77.2°F (25.1°C)Light RainMostly SunnyAverageAverage
September70.9°F (21.6°C)Light RainMostly SunnyModerately HighAverage
October58.5°F (14.7°C)Light RainMostly SunnyAverageAverage
November46.2°F (7.9°C)Light RainMostly SunnyModerately LowAverage
December37.6°F (3.1°C)Light RainMostly SunnyModerately LowSlightly Low

The nearest major airports for your trip to Defiance

If you're planning a trip to Defiance, Missouri, the nearest airports are St. Louis Lambert International Airport (STL), located 37.0km away, and Spirit of St. Louis Airport (SUS), situated 11.3km from Defiance. For accommodations near STL, consider The Ritz-Carlton, St. Louis, a 5-star hotel 11.3km from the airport, or the 4.5-star Royal Sonesta Chase Park Plaza, which is 14.5km away. Near SUS, the DoubleTree by Hilton Hotel St. Louis - Chesterfield, a 4-star option, is just 6.4km away, while the Wildwood Hotel, a 3.5-star establishment, is 9.7km away. Both airports are easily accessible from these hotels.

Frequently asked questions

What's the best place to stay in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are Hollywood Casino & Hotel St. Louis and The Wildwood Hotel. See all available top hotels, or vacation rentals in Defiance.
What's the top vacation rental in Defiance?
Stunning 1890's Home - Sleeps 8!: Visitors like this Defiance vacation home rental. It is equipped with a barbecue grill, air-conditioning, and laundry facilities to help you feel comfortable during your stay. It has 4 bedrooms as well as a kitchen with a dishwasher, a stovetop, and a microwave, so you can cook with friends or family. See all vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
Where can I learn more about changing or cancelling my trip to Defiance?
For more information about changing or cancelling your trip to Defiance, head over to our customer service page.
Where is the best hotel to stay with easy access to August A. Busch Memorial Conservation Area?
Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.
What about the best place to stay near Chandler Hill Vineyards?
One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.
What are some accommodations with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool, and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels that offer an onsite pool. View all hotels with pools in Defiance.
What's the best place to stay near Lambert-St. Louis International Airport (STL)?
Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.
What's it like to stay in Defiance?
Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights in the area include St. Louis Union Station and Gateway Arch. In Defiance, there are 20 hotels and other accommodations to choose from. Find out more about Defiance.
What is there to see in Defiance?
Natural beauty is on display at Matson Hill Park Trailhead, August A. Busch Memorial Conservation Area, and Missouri River. A couple of additional sights to add to your agenda are Yellow Farmhouse Winery and Chandler Hill Vineyards. Check out what more to see and do in Expedia's Defiance guide.
What's the seasonal weather like in Defiance?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.

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