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7 Nov - 8 Nov
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8 Nov - 9 Nov
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Our top choices for Lake Issaqueena hotels

A spacious hallway with a wooden ceiling, a sofa, a chair, and a lamp.

1. The Inn at Patrick Square

The Inn at Patrick Square
3.5 star property
9.2 km from Lake Issaqueena
9.8 out of 10, Exceptional, (938 reviews)
"Lovely place to stay."
United States
Jennifer
The price is AEDĀ 547
AEDĀ 608 total
includes taxes & fees
8 Nov - 9 Nov
The Inn at Patrick Square
An outdoor patio area with a fire pit, seating, and string lights.

2. Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
5.8 km from Lake Issaqueena
9.2 out of 10, Wonderful, (902 reviews)
"Great stay!"
United States
Melissa
The price is AEDĀ 367
AEDĀ 404 total
includes taxes & fees
8 Dec - 9 Dec
Tru by Hilton Seneca Clemson
A golf course with a water body, trees, and a distant view of a bridge.

3. Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
3.0 star property
8.7 km from Lake Issaqueena
9.4 out of 10, Exceptional, (1,006 reviews)
"Great property!"
United States
Lilllian
The price is AEDĀ 511
AEDĀ 567 total
includes taxes & fees
30 Nov - 1 Dec
Clemson University's James F. Martin Inn
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.

4. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
6.7 km from Lake Issaqueena
9.8 out of 10, Exceptional, (908 reviews)
"Lovely spot with a boutique offering"
United States
Janet
The price is AEDĀ 768
AEDĀ 852 total
includes taxes & fees
8 Nov - 9 Nov
The Shepherd Hotel Downtown Clemson
A cabin with a cozy interior, a wooden exterior, and a view of the forest.

5. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
15.8 km from Lake Issaqueena
9.8 out of 10, Exceptional, (119 reviews)
"If you're looking to "get away from it all", this is the place for you. Tiny home in the woods is how I'd describe this oasis in nature."
United States
Christopher
The price is AEDĀ 309
AEDĀ 501 total
includes taxes & fees
7 Dec - 8 Dec
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.

6. The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
6.7 km from Lake Issaqueena
9.6 out of 10, Exceptional, (659 reviews)
"Great place."
United States
John
The price is AEDĀ 526
AEDĀ 583 total
includes taxes & fees
25 Nov - 26 Nov
The Abernathy of Clemson
A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.

7. Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
5.6 km from Lake Issaqueena
9.0 out of 10, Wonderful, (1,001 reviews)
"Friendly front desk and bar staff. We had a really nice overnight stay."
United States
Sherry
The price is AEDĀ 400
AEDĀ 497 total
includes taxes & fees
8 Nov - 9 Nov
Lakeside Lodge Clemson
A poolside area with outdoor seating and a view of a lake and forested hills.

8. Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
3.0 star property
10.6 km from Lake Issaqueena
9.2 out of 10, Wonderful, (291 reviews)
"nice,clean hotel."
United States
Steve
The price is AEDĀ 441
AEDĀ 485 total
includes taxes & fees
22 Nov - 23 Nov
Fairfield Inn & Suites Seneca Clemson Univ Area
A modern bar area with a menu board, bar stools, and a countertop with various items.

9. Courtyard Marriott Clemson

Courtyard Marriott Clemson
3.0 star property
7.3 km from Lake Issaqueena
9.0 out of 10, Wonderful, (596 reviews)
"Exactly what I needed and was a clean hotel"
United States
Riley
The price is AEDĀ 379
AEDĀ 421 total
includes taxes & fees
22 Nov - 23 Nov
Courtyard Marriott Clemson
A reception area with a reception desk, a sofa, a staircase, and a wall with artwork.

10. Inn @ Clemson

Inn @ Clemson
2.5 star property
6.5 km from Lake Issaqueena
8.0 out of 10, Very good, (1,005 reviews)
"Clean room, comfortable beds, good breakfast, great price!"
United States
Kristi
The price is AEDĀ 285
AEDĀ 317 total
includes taxes & fees
8 Nov - 9 Nov
Inn @ Clemson
A modern kitchen with a microwave, coffee maker, and bar stools.

11. Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
2.5 star property
6.6 km from Lake Issaqueena
8.4 out of 10, Very good, (1,003 reviews)
"Clean, walkable to downtown!"
United States
melissa
The price is AEDĀ 372
AEDĀ 412 total
includes taxes & fees
29 Nov - 30 Nov
Comfort Inn & Suites Clemson - University Area
A hotel dining area with a long table, multiple chairs, and a bar in the background.

12. Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
2.5 star property
8.6 km from Lake Issaqueena
9.2 out of 10, Wonderful, (765 reviews)
"Great place to stay when visiting Clemson!"
United States
Lloyd
The price is AEDĀ 436
AEDĀ 479 total
includes taxes & fees
3 Dec - 4 Dec
Hampton Inn & Suites Seneca-Clemson Area
A Holiday Inn Express hotel with a stone facade, large windows, and a parking lot.

13. Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
2.5 star property
7.1 km from Lake Issaqueena
8.8 out of 10, Excellent, (999 reviews)
"Wonderful place to stay."
United States
John
The price is AEDĀ 474
AEDĀ 526 total
includes taxes & fees
8 Nov - 9 Nov
Holiday Inn Express & Suites Clemson by IHG
A restaurant interior with a counter, seating area, and a TV mounted on the wall.

14. Quality Inn Seneca US-123

Quality Inn Seneca US-123
2.5 star property
13.5 km from Lake Issaqueena
8.0 out of 10, Very good, (769 reviews)
"Clean rooms clean parking area nice staff all good"
United States
Barry
The price is AEDĀ 294
AEDĀ 346 total
includes taxes & fees
1 Dec - 2 Dec
Quality Inn Seneca US-123
A spacious indoor dining area with multiple tables and chairs, a food service counter, and a modern architectural design with balconies.

15. Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
2.5 star property
6.8 km from Lake Issaqueena
8.0 out of 10, Very good, (1,002 reviews)
"I have stayed here several times and it has always been a great experience. The rooms are clean and the staff is friendly."
United States
Alyssa
The price is AEDĀ 372
AEDĀ 412 total
includes taxes & fees
30 Nov - 1 Dec
Best Western Plus Clemson Hotel & Conference Center
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.

16. Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
9.7 km from Lake Issaqueena
8.4 out of 10, Very good, (699 reviews)
"The room was clean and had no odors. But the place is seriously dated even though it was clean."
United States
Greg
The price is AEDĀ 343
AEDĀ 378 total
includes taxes & fees
1 Dec - 2 Dec
Best Western Seneca-Clemson
A modern dining area with a high ceiling, large windows, and a buffet setup.

17. Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
2.0 star property
12.7 km from Lake Issaqueena
6.8 out of 10, (794 reviews)
"Very clean room, recently renovated. Comfy bed!"
United States
Rhiannon
The price is AEDĀ 262
AEDĀ 288 total
includes taxes & fees
1 Dec - 2 Dec
Days Inn by Wyndham Seneca / Clemson Area
A hotel lobby with a reception desk, seating area, and a view of the street outside.

18. Econo Lodge Clemson - University Area

Econo Lodge Clemson - University Area
2.0 star property
7.6 km from Lake Issaqueena
7.2 out of 10, Good, (160 reviews)
"Good location . Good price. Nice and quiet. Unusually good tv show choices. (Much better than last 4 or 5 hotels that I stayed at!)"
United States
Ruth
The price is AEDĀ 278
AEDĀ 314 total
includes taxes & fees
29 Nov - 30 Nov
Econo Lodge Clemson - University Area
A dining area with a table and chairs, large windows with a view of the outside, and a green sofa.

19. Days Inn by Wyndham Clemson

Days Inn by Wyndham Clemson
3.5 star property
7.1 km from Lake Issaqueena
6.8 out of 10, (237 reviews)
"While the hotel is close to Clemson, the property/ rooms were GROSS!! The bathroom had been wiped down, but whoever cleaned it missed the soap and shampoo left up top on the rim. The AC smelt so strongly of mildew/ mold that we could NOT turn it on. The whole room smelled like wet towels"
United States
Stephanie
The price is AEDĀ 311
AEDĀ 345 total
includes taxes & fees
10 Nov - 11 Nov
Days Inn by Wyndham Clemson
A hotel room with a large bed, a bedside table, a nightstand, and a wall-mounted lamp.

20. Rodeway Inn & Suites Walhalla

Rodeway Inn & Suites Walhalla
2.0 star property
17.7 km from Lake Issaqueena
7.6 out of 10, Good, (199 reviews)
"The room was clean and the bed was comfortable"
United States
Donna
The price is AEDĀ 293
AEDĀ 327 total
includes taxes & fees
6 Dec - 7 Dec
Rodeway Inn & Suites Walhalla
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Compare popular hotels close to Lake Issaqueena

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A spacious hallway with a wooden ceiling, a sofa, a chair, and a lamp.
The Inn at Patrick Square
3.5 star property
9.8
Exceptional
938 reviews
View
An outdoor patio area with a fire pit, seating, and string lights.
Tru by Hilton Seneca Clemson
2.5 star property
9.2
Wonderful
902 reviews
View
A golf course with a water body, trees, and a distant view of a bridge.
Clemson University's James F. Martin Inn
3.0 star property
9.4
Exceptional
1,006 reviews
View
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
The Shepherd Hotel Downtown Clemson
4.0 star property
9.8
Exceptional
908 reviews
View
A cabin with a cozy interior, a wooden exterior, and a view of the forest.
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
9.8
Exceptional
119 reviews
View

Other attractions near Lake Issaqueena

Larry W. Abernathy Waterfront Park

8.6/10 (58 reviews)
Larry W. Abernathy Waterfront Park is just one of the places to see in Clemson, so why not enjoy the other things to explore during your travels? Experience the area's theater scene or attend a football game.
See properties

Top Lake Issaqueena Hotel Reviews

A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson

10/10 Excellent

We had an amazing stay. From the beautifully decorated, relaxing room, to the restaurant decor and excellent service and food, to the cute coffee stations on each floor, to the bar and deck, it was all fantastic!
United States
Amy
Reviewed July 14, 2025
The Shepherd Hotel Downtown Clemson

Frequently Asked Questions

What's the area like around Lake Issaqueena?

Lake Issaqueena is located in Central. You'll find 209 hotels and other accommodations within a few miles for a convenient home base.

What's the best place to stay near Lake Issaqueena?

Lakeside Lodge Clemson is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and free parking. It's located 3.5 mi (5.6 km) from Lake Issaqueena. Other good choices within a few miles include Best Western Plus Clemson Hotel & Conference Center and Comfort Inn & Suites Clemson - University Area.

How many hotels are there close to Lake Issaqueena?

Expedia has 209 hotels and other accommodations a few miles from Lake Issaqueena.

If I need to cancel the hotel reservation for my stay near Lake Issaqueena, will I receive a refund?

Yes! Most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you might be able to still cancel and get a refund within 24 hours of booking. Add dates, click "Search", then you can filter by "fully refundable" to review the top deals on offer near Lake Issaqueena.

Where can I learn more about changing or cancelling my trip in the area near Lake Issaqueena?

For more details about updating your stay near Lake Issaqueena or cancelling it, head over to our customer service page.

What can I see and do near Lake Issaqueena?

You'll want to browse the exhibits at Fort Hill and Clemson Area African American Museum. Explore nature at Keowee Reservoir and Larry W. Abernathy Waterfront Park. If you've got some time to explore the area around Lake Issaqueena, you may want to make a stop by Littlejohn Coliseum, Memorial Stadium, and Sloan Tennis Center.