Photo by Joe Kubitschek
Find all hotels by Best Western in Mark Twain, MO from AED 317
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Check prices for these dates
Compare rooms and suites by Best Western in Mark Twain with rates, reviews, and availability. Most hotels are fully refundable.

Best Western Coach House
Doling
8.6 out of 10, Excellent, (1007)
The price is AED 279
AED 317 total
includes taxes & fees
23 Nov - 24 Nov

Best Western Route 66 Rail Haven
Walnut Street
8.8 out of 10, Excellent, (1003)
The price is AED 304
AED 345 total
includes taxes & fees
19 Nov - 20 Nov
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Top Mark Twain Hotel Reviews

Baymont by Wyndham Springfield I-44
10/10 Excellent
Explore a world of travel with Expedia
Mark Twain Hotels by Brand
Hotels in Mark Twain Neighborhoods
Hotels near popular Springfield Attractions
- Hotels near Wonders of Wildlife Museum & Aquarium
- Hotels near Bass Pro Shops Outdoor World
- Hotels near Mercy Hospital Springfield
- Hotels near Missouri State University
- Hotels near Lester E. Cox Medical Center South
- Hotels near Ozark Empire Fairgrounds & Events Center
- Hotels near Fantastic Caverns
- Hotels near Springfield Expo Center
- Hotels near Hammons Field
- Hotels near Battlefield Mall
More Accommodation Types in Mark Twain
Explore more hotels
- Greenstay Inn & Suites CourtView
- Vīb Best Western Springfield
- Best Western Coach House
- The Bradford Hotel, an Ascend Collection Hotel
- Holiday Inn Hotel & Suites Springfield - I-44 by IHG
- Holiday Inn Express & Suites Springfield North by IHG
- Tru by Hilton Springfield Downtown
- Hotel Vandivort
- Days Inn by Wyndham Battlefield Rd/Hwy 65
- Super 8 by Wyndham Nixa/Springfield Area
- Extended Stay America Select Suites Springfield South
- Lamplighter Inn & Suites - South
- Quality Inn Ozark-Springfield South
- Red Roof Inn Springfield, MO
- DoubleTree by Hilton Springfield
- Moxy Springfield Downtown
- Homewood Suites by Hilton Springfield Medical District
- Hampton Inn & Suites Springfield, MO
- SpringHill Suites by Marriott Springfield North
- Fairfield Inn & Suites by Marriott Springfield North














