The Best Hotels Closest to Mayo Clinic Florida in Jacksonville for 2026

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Mayo Clinic Florida hotels

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

1.1 km from Mayo Clinic Florida

Devonta

AED 570 total

includes taxes & fees

8 Aug - 9 Aug

2. TownePlace Suites by Marriott Jacksonville East

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

Miriam

AED 496 total

includes taxes & fees

9 Aug - 10 Aug

3. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.6 km from Mayo Clinic Florida

Jorge

AED 459 total

includes taxes & fees

16 Aug - 17 Aug

4. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

0.4 km from Mayo Clinic Florida

Troy

AED 634 total

includes taxes & fees

8 Aug - 9 Aug

5. The Hotel Palms Poolside

7.8 km from Mayo Clinic Florida

Caitlin

AED 711 total

includes taxes & fees

2 Aug - 3 Aug

6. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Southside, 7.7 km from Mayo Clinic Florida

Christopher

AED 571 total

includes taxes & fees

31 Aug - 1 Sep

7. Hyatt Studios Jacksonville/St Johns Town Center

Deerwood, 7.8 km from Mayo Clinic Florida

Althia

AED 471 total

includes taxes & fees

11 Aug - 12 Aug

Standard Room, 2 Queen Beds, Non Smoking | Down comforters, minibar, iron/ironing board (on request), WiFi

8. The Hotel Palms Courtyard

7.8 km from Mayo Clinic Florida

Angela

AED 688 total

includes taxes & fees

31 Aug - 1 Sep

9. TownePlace Suites by Marriott® Jacksonville Mayport

10.8 km from Mayo Clinic Florida

Audra

AED 596 total

includes taxes & fees

16 Aug - 17 Aug

Couples treatment rooms, sauna, hot tub, steam room, body treatments

10. Ponte Vedra Inn & Club

6.3 km from Mayo Clinic Florida

Michael

AED 1,945 total

includes taxes & fees

18 Aug - 19 Aug

11. AC Hotel Jacksonville St Johns Town Center

Southside, 8.1 km from Mayo Clinic Florida

Dawn

AED 746 total

includes taxes & fees

1 Aug - 2 Aug

12. Hotel Indigo Jacksonville-Deerwood Park by IHG

Southside, 10.8 km from Mayo Clinic Florida

Jasmine

AED 529 total

includes taxes & fees

30 Aug - 31 Aug

13. Courtyard by Marriott Jacksonville I-295/East Beltway

Arlington, 13.2 km from Mayo Clinic Florida

Virnilito Nambayan

AED 422 total

includes taxes & fees

13 Aug - 14 Aug

Outdoor pool, pool umbrellas, sun loungers

14. Four Points by Sheraton Jacksonville Beachfront

5.6 km from Mayo Clinic Florida

John

AED 730 total

includes taxes & fees

23 Aug - 24 Aug

15. Best Western Oceanfront

5.7 km from Mayo Clinic Florida

Jasmine

AED 587 total

includes taxes & fees

19 Aug - 20 Aug

16. Holiday Inn Express Jacksonville South Bartram Prk by IHG

17.1 km from Mayo Clinic Florida

Jose

AED 417 total

includes taxes & fees

10 Aug - 11 Aug

17. Springhill Suites By Marriott Jacksonville Beach Oceanfront

5.8 km from Mayo Clinic Florida

STEPHEN

AED 776 total

includes taxes & fees

16 Aug - 17 Aug

Studio Suite, 2 Queen Beds | Down comforters, desk, laptop workspace, blackout drapes

18. Candlewood Suites Jacksonville - Mayport by IHG

9.2 km from Mayo Clinic Florida

Christopher

AED 492 total

includes taxes & fees

31 Aug - 1 Sep

19. Sheraton Jacksonville Hotel

Deerwood, 9.6 km from Mayo Clinic Florida

keren

AED 516 total

includes taxes & fees

14 Aug - 15 Aug

20. Aloft by Marriott Jacksonville Tapestry Park

Southside, 11 km from Mayo Clinic Florida

Debra

AED 484 total

includes taxes & fees

21 Aug - 22 Aug

View all properties

Compare popular hotels close to Mayo Clinic Florida

Property	Property class	Guest rating
Residence Inn By Marriott Jacksonville - Mayo Clinic Area	3.0 star property	9.4 Exceptional 568 reviews	View
TownePlace Suites by Marriott Jacksonville East	3.0 star property	9.2 Wonderful 642 reviews	View
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG	2.5 star property	9.0 Wonderful 1,000 reviews	View
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches	3.0 star property	8.4 Very Good 790 reviews	View
The Hotel Palms Poolside	2.5 star property	9.8 Exceptional 484 reviews	View

Top Mayo Clinic Florida Hotel Reviews

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

8/10 Good

"Overall the staff was overly pleasant, both upon check in and checkout. The room was clean, a little chilly upon entering, but I am sure very acceptable to someone from out of town. My only negative takeaway were minor cosmetic issues. Vanity had small chips in the wood, tub spout not sealed to shower wall and screw holes that were not fixed in bathroom wall. Other than that wonderful stay."

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

8/10 Good

"It’s the only game in town if you’re there for a surgery the following day at the Mayo Clinic. The only issue I had was that the water in the shower and the sink were definitely very chlorinated and smelled really bad. I did find purified water at the icemaker and was able to fill my water bottle with that for drinking and for brushing my teeth but the rest for the rest of it my skin turned very dry and I wasn’t supposed to put lotion on my skin because I was having surgery the next day. At the front desk, there was a very nice young lady and she was totally awesome. I wish I could remember her name and that’s my fault. I really enjoyed your company chatting with her and trying to get my mind wrapped around what was gonna happen to me the following day so she was really helpful and I appreciated that so Five Stats for her."

Private Pool Getaway • 5min Beach • Sleeps 9

10/10 Excellent

"We had a wonderful stay at this VRBO! The home was beautifully decorated and in a great location, making it easy to get everywhere we wanted to go. The host was very responsive and attentive. We had a small issue with the outdoor fan, and it was fixed within an hour, which we really appreciated.The pool was clean and well maintained, and there was plenty of comfortable outdoor furniture for relaxing. The large TVs in every room were a nice bonus. Overall, this was a great place to stay, and we would definitely book it again!"

Frequently asked questions

What's the area like around Mayo Clinic Florida?

Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, check out the 46 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Mayo Clinic Florida?

Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville At Mayo Clinic and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.

How many hotels will I find near Mayo Clinic Florida?

Expedia has 46 hotels and other accommodations within a mile from Mayo Clinic Florida.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to review the best deals available near Mayo Clinic Florida.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic Florida?

To access more information about picking new dates or cancelling your stay near Mayo Clinic Florida, head over to our customer service page.

What can I see and do near Mayo Clinic Florida?

You can catch a show at Players by the Sea, SeaWalk Pavillion, and SeaWalk Pavillion. Spend some time exploring the natural beauty of Cradle Creek Preserve, Huguenot Park, and Oceanfront Park. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

Find hotels near Mayo Clinic Florida, Jacksonville from AED 417

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Mayo Clinic Florida hotels

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

2. TownePlace Suites by Marriott Jacksonville East

3. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

4. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

5. The Hotel Palms Poolside

6. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

7. Hyatt Studios Jacksonville/St Johns Town Center

8. The Hotel Palms Courtyard

9. TownePlace Suites by Marriott® Jacksonville Mayport

10. Ponte Vedra Inn & Club

11. AC Hotel Jacksonville St Johns Town Center

12. Hotel Indigo Jacksonville-Deerwood Park by IHG

13. Courtyard by Marriott Jacksonville I-295/East Beltway

14. Four Points by Sheraton Jacksonville Beachfront

15. Best Western Oceanfront

16. Holiday Inn Express Jacksonville South Bartram Prk by IHG

17. Springhill Suites By Marriott Jacksonville Beach Oceanfront

18. Candlewood Suites Jacksonville - Mayport by IHG

19. Sheraton Jacksonville Hotel

20. Aloft by Marriott Jacksonville Tapestry Park

Compare popular hotels close to Mayo Clinic Florida

Top Mayo Clinic Florida Hotel Reviews

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Frequently asked questions