A gazebo with columns, a large tree with hanging roots, and a building in the background.

Find hotels in Santa Ana, Panama City

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Santa Ana hotels

1. Casco View Life Residences

Casco View Life Residences
4.0 star property
Santa Ana
9.0 out of 10, Wonderful, (106 reviews)
"Always an amazing stay"
United States
chris
The price is AED 206
AED 337 total
includes taxes & fees
23 Sep - 24 Sep
Casco View Life Residences

2. Hotel Caracas - Casco Viejo

Hotel Caracas - Casco Viejo
3.0 star property
Santa Ana
7.6 out of 10, Good, (14 reviews)
"great staff"
United States
Keith
The price is AED 134
AED 147 total
includes taxes & fees
12 Oct - 13 Oct
Hotel Caracas - Casco Viejo

3. ART CASCO The Hotel

ART CASCO The Hotel
2.0 star property
Santa Ana
6.0 out of 10, (13 reviews)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
United States
Eldris
The price is AED 90
AED 99 total
includes taxes & fees
18 Sep - 19 Sep
ART CASCO The Hotel

4. Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.6 out of 10, Good, (73 reviews)
"Excellent staff, close to metro and embassies. A good location, good room for a great price. I would stay again. "
United Kingdom
Mark
The price is AED 98
AED 109 total
includes taxes & fees
19 Sep - 20 Sep
Hostal La Cigarra

5. Hotel República

Hotel República
2.0 star property
Santa Ana
6.8 out of 10, (197 reviews)
"Good location. Walking distance to shops and public transport."
Canada
Danilo
The price is AED 98
AED 329 total
includes taxes & fees
18 Oct - 19 Oct
Hotel República

6. La Manzana Barrio Vivo by Wynwood

La Manzana Barrio Vivo by Wynwood
3.0 star property
Santa Ana
7.6 out of 10, Good, (19 reviews)
"Very clean and safe property"
United States
Javier Alberto Lindauer
The price is AED 259
AED 386 total
includes taxes & fees
20 Sep - 21 Sep
La Manzana Barrio Vivo by Wynwood

7. Hotel Riazor

Hotel Riazor
3.0 star property
Santa Ana
3.8 out of 10, (11 reviews)
"Rough neighborhood "
Canada
Del
The price is AED 91
AED 101 total
includes taxes & fees
18 Oct - 19 Oct
Hotel Riazor

8. Room-sofa Bed Stay Rooftop Pool & Gym, A

Room-sofa Bed Stay Rooftop Pool & Gym, A
2.0 star property
Santa Ana
2.0 out of 10, (1 review)
"You pay for a space in the apartment, it’s not the whole apartment be careful. The owner or whoever manages doesn’t give care about you as costumers they just want the money"
United States
Cristian Camilo Betancur
The price is AED 382
AED 420 total
includes taxes & fees
18 Oct - 19 Oct
Room-sofa Bed Stay Rooftop Pool & Gym, A

9. La Concordia Boutique Hotel

La Concordia Boutique Hotel
4.0 star property
San Felipe, 0.5 km from Santa Ana
9.6 out of 10, Exceptional, (237 reviews)
"Such a beautiful and highly curated and very helpful staff."
United States
Jadah
The price is AED 740
AED 814 total
includes taxes & fees
8 Oct - 9 Oct
La Concordia Boutique Hotel

10. Hotel Casa Panamá

Hotel Casa Panamá
4.0 star property
San Felipe, 0.6 km from Santa Ana
7.6 out of 10, Good, (756 reviews)
"Overall a good place to stay for exploring Panama. Lots of restaurants and activities walking distance."
United States
Naveera Jyoti
The price is AED 205
AED 227 total
includes taxes & fees
18 Oct - 19 Oct
Hotel Casa Panamá

11. Oasis Hotel

Oasis Hotel
3.0 star property
San Felipe, 0.6 km from Santa Ana
8.6 out of 10, Excellent, (154 reviews)
"Great stay! Highly recommend"
United States
Gregg
The price is AED 216
AED 238 total
includes taxes & fees
30 Sep - 1 Oct
Oasis Hotel

12. American Trade Hotel

American Trade Hotel
4.5 star property
San Felipe, 0.7 km from Santa Ana
9.4 out of 10, Exceptional, (809 reviews)
"Wonderful building and location. Spacious room. Wish we could have stayed longer"
United States
James
The price is AED 739
AED 813 total
includes taxes & fees
4 Oct - 5 Oct
American Trade Hotel

13. Tantalo Hotel

Tantalo Hotel
3.5 star property
San Felipe, 0.7 km from Santa Ana
8.8 out of 10, Excellent, (333 reviews)
"Great location, friendly and helpful staff, very spacious room, very clean, Great breakfast because we could order straight from the in-house restaurant’s menu. Would definitely stay again."
United States
Cassondra
The price is AED 333
AED 370 total
includes taxes & fees
18 Oct - 19 Oct
Tantalo Hotel

14. Hotel San Felipe

Hotel San Felipe
4.0 star property
San Felipe, 0.7 km from Santa Ana
9.4 out of 10, Exceptional, (452 reviews)
"Everything was excellent"
United States
ORLANDO RICARDO
The price is AED 508
AED 559 total
includes taxes & fees
25 Sep - 26 Sep
Hotel San Felipe

15. Hotel Magnolia Boutique

Hotel Magnolia Boutique
2.0 star property
San Felipe, 0.7 km from Santa Ana
8.8 out of 10, Excellent, (516 reviews)
"Super nice hotel, very clean and location is amazing"
United States
Boris
The price is AED 284
AED 312 total
includes taxes & fees
4 Oct - 5 Oct
Hotel Magnolia Boutique

16. Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo
4.0 star property
San Felipe, 0.9 km from Santa Ana
9.0 out of 10, Wonderful, (999 reviews)
"Great location and nice hotel."
United States
Olga
The price is AED 674
AED 741 total
includes taxes & fees
17 Oct - 18 Oct
Central Hotel Panama Casco Viejo

17. Amarla Boutique Hotel Casco Viejo Adults Only

Amarla Boutique Hotel Casco Viejo Adults Only
3.0 star property
San Felipe, 1 km from Santa Ana
9.6 out of 10, Exceptional, (143 reviews)
"Unit 8 was great!! Beautiful architecture, nicely decorated, fun to sleep in the loft. Very friendly front desk that offered excellent restaurant tips. On site restaurant was also nice to have. We would definitely come back."
United States
Cynthia
The price is AED 850
AED 937 total
includes taxes & fees
27 Sep - 28 Sep
Amarla Boutique Hotel Casco Viejo Adults Only

18. Hotel Bardot Boutique

Hotel Bardot Boutique
3.0 star property
San Felipe, 1.1 km from Santa Ana
8.8 out of 10, Excellent, (52 reviews)
"Clean room, nice staff!!"
United States
justin
The price is AED 308
AED 339 total
includes taxes & fees
27 Sep - 28 Sep
Hotel Bardot Boutique

19. Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
San Felipe, 1.1 km from Santa Ana
9.8 out of 10, Exceptional, (747 reviews)
"Amazing service and beautiful hotel"
United States
Jose
The price is AED 1,240
AED 1,364 total
includes taxes & fees
20 Sep - 21 Sep
Sofitel Legend Casco Viejo, Panama City

20. Hotel Caribe

Hotel Caribe
3.0 star property
Calidonia, 1.2 km from Santa Ana
7.6 out of 10, Good, (335 reviews)
"Hotel clean and staff is great the facilities need a little updating there is no good bilingual help closed to everything my stay was great"
United States
dave
The price is AED 153
AED 169 total
includes taxes & fees
30 Sep - 1 Oct
Hotel Caribe
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in Santa Ana

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
Outdoor pool, open 7:00 AM to 10:00 PM, pool umbrellas, sun loungers
Casco View Life Residences
4.0 star property
9.0
Wonderful
106 reviews
View
Bar (on property)
Hostal La Cigarra
2.0 star property
7.6
Good
73 reviews
View
Interior
Hotel Caracas - Casco Viejo
3.0 star property
7.6
Good
14 reviews
View
Apartment (20) | Iron/ironing board, WiFi (free), bed sheets
La Manzana Barrio Vivo by Wynwood
3.0 star property
7.6
Good
19 reviews
View
Double Room | View from room
Hotel República
2.0 star property
6.8
197 reviews
View

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

San Felipe

If you're spending some time in San Felipe, Independence Square and Interoceanic Canal Museum are top sights worth seeing.

Top Santa Ana Hotel Reviews

Find out more about Santa Ana

Top reasons to visit Santa Ana

  • Vibrant Nightlife: Experience the lively bar scene in Santa Ana, perfect for those looking to enjoy Panama City's nightlife.
  • Cultural Attractions: Visit historical sites such as Santa Ana Casco Viejo and local museums to immerse yourself in Panama's rich heritage.
  • Stunning Views: Enjoy picturesque hilltop views that provide a breathtaking backdrop for your vacation.
  • Family-Friendly Activities: Explore various attractions and parks that cater to visitors of all ages.
  • Diverse Accommodations: Choose from a range of hotels and apartments that meet different needs and preferences.

Find great hotels near Santa Ana

Santa Ana offers a diverse selection of accommodations, including hotels and apartments, perfect for every traveler. Whether you seek a pet-friendly stay, a business-friendly environment, or a relaxed vacation experience, you'll find suitable options. With popular choices like Hotel El Panama and various city-themed hotels, Santa Ana is an ideal base for exploring Panama City while enjoying modern amenities and a welcoming atmosphere.

  • Central Hotel Panama Casco Viejo: Experience romance and luxury at the Central Hotel Panama Casco Viejo, a 4-star gem located a mere 805m from Santa Ana. This hotel is an ideal choice for couples seeking a romantic getaway, featuring enticing romance packages and exquisite food and beverage services, including 24-hour room service and champagne service. Guests can indulge in rejuvenating spa treatments, with amenities like facial treatments and a full-service spa available. The hotel’s central location makes it a perfect base for exploring the vibrant city while enjoying a serene retreat.
  • American Trade Hotel: The American Trade Hotel, a stylish 4.5-star property located 644m from Santa Ana, caters to business travelers and pet owners alike. This city-themed hotel provides a blend of comfort and convenience, allowing some pets on-site with waived fees for service animals. Guests can enjoy modern amenities and a prime location in the heart of the city, making it easy to conduct business or explore nearby attractions. With its elegant design and thoughtful services, the American Trade Hotel is perfect for those combining work and leisure.
  • Innfiniti Hotel & Suites: Offering a welcoming atmosphere, the Innfiniti Hotel & Suites is a 3.5-star accommodation located 1.4km from Santa Ana. This city-themed hotel is tailored for business travelers, providing essential amenities and a convenient location in the bustling city center. With comfortable rooms and a focus on guest satisfaction, Innfiniti is an excellent choice for those looking to balance work and relaxation during their stay in Panama City.

Where to stay near Santa Ana

Santa Ana, a vibrant neighborhood in Panama City, offers a unique blend of family-friendly attractions and business opportunities. Visitors can enjoy the welcoming atmosphere and explore nearby areas that showcase the rich culture of Panama. From local markets to luxurious accommodations, Santa Ana caters to all types of travelers seeking relaxation or adventure. Immerse yourself in the charm of this lively neighborhood while discovering the diverse experiences that Panama City has to offer.

  • Panama City: The vibrant heart of Panama, Panama City boasts a unique blend of modern skyscrapers and historic neighborhoods. Santa Ana is situated within its bustling limits, making it a convenient base for your adventures. Travelers flock here year-round, with peak visits in January, July, and September, drawn by its family-friendly atmosphere and urban experiences. Don't miss the chance to explore shopping centers and malls, while local attractions like beaches, parks, and lively streets offer a perfect backdrop for relaxation and exploration.
  • Casco Viejo: Just 644m from Santa Ana, Casco Viejo is a historic neighborhood filled with charming cobblestone streets and colonial architecture. This area is particularly popular in January and the spring months, catering to families and outdoor enthusiasts alike. Visitors can indulge in shopping at local markets and enjoy the vibrant atmosphere of cafes and restaurants. With close proximity to beautiful parks and stunning beachfront views, Casco Viejo is a must-visit for those looking to soak in the culture and history of Panama City.
  • San Felipe: Also located 644m from Santa Ana, San Felipe is known for its rich history and cultural landmarks. This neighborhood attracts families and outdoor lovers, especially during peak seasons in February, March, and December. Explore local resorts and shopping areas, and take a leisurely stroll through picturesque parks or along the beach. With historic sites nearby, San Felipe offers a delightful mix of recreation and education, making it an enriching stop on your Panama journey.

Things to do near Santa Ana

Santa Ana offers a vibrant mix of family-friendly and business-themed activities perfect for any traveler. Explore nearby shopping malls and centers, or indulge in the local bar crawl to experience Panama City's lively nightlife. Whether you're looking to shop or enjoy entertainment, Santa Ana provides a variety of options to make your vacation enjoyable and memorable.

Shopping

For a great shopping experience in Santa Ana, visit Albrook Shopping Mall, just 1.6km away, offering a mix of entertainment and family vibes. Avenida Central, only 483m away, features a lively atmosphere, while Uruguay Street, 3.2km away, is perfect for exploring local shops.

Recreation

In Santa Ana, you can visit Maracana Stadium for an energetic atmosphere, perfect for sports enthusiasts. Estadio Rommel Fernandez and Estadio Nacional Rod Carew offer vibrant sports experiences, making them excellent spots to enjoy local games and immerse yourself in Panama's sports culture.

Adventure

Explore the Honeycreeper Ridge Trail, a stunning hiking trail 43.5km from Santa Ana, offering breathtaking scenery and a chance to connect with nature. For an adrenaline rush, visit Gatun Eco Adventures, a thrilling zipline ropes course located 48.3km away, perfect for adventure seekers.

Nightlife

In Santa Ana, the vibrant nightlife features venues like the National Theater, Anita Villalaz Theater, and Amador Theater, all within 1.6km's reach. Each offers a unique blend of romance, culture, and entertainment, making for an enchanting evening in Panama City.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Santa Ana

To save money on your trip to Santa Ana, consider visiting between September and November, when prices are lower. Book your stay on a Tuesday for the best rates, as Saturdays tend to be the most expensive. Use Expedia’s search tool to filter options by budget and location, and arrange results from lowest to highest price. Additionally, combining hotel reservations with flights and activities through an Expedia package deal can lead to significant savings. Don't forget to look for expedia coupons to maximize your budget.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Santa Ana are September to November, where the prices are slightly lower. This is in comparison to January and March to April, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Santa Ana is Tuesday. The most expensive day to stay around Santa Ana is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia’s search tool to refine your preferences, such as your budget, desired location, and the type of hotel you’re looking for. To find the best prices and deals, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel reservations in Santa Ana with your flights and activities through an Expedia package deal.

Find the best attractions near Santa Ana

Santa Ana offers a delightful mix of family-friendly, city-themed, and business vacation options. Visitors can explore fascinating attractions like hilltop views, history museums, and cathedrals. Key points of interest include Santa Ana Casco Viejo, Plaza Santa Ana, Panama City Beach, Santa Ana Square, and Playa Bonita. These sites provide a rich cultural experience, stunning scenery, and a taste of local history, ensuring a memorable visit for travelers.

  • Metropolitan Cathedral of Panama: An architectural marvel, this cathedral features stunning colonial design and intricate details. Visitors can immerse themselves in the rich history and vibrant cultural atmosphere that surrounds this sacred space.
  • Interoceanic Canal Museum: Delve into the fascinating history of the Panama Canal at this engaging museum. With interactive exhibits and informative displays, you'll gain insights into the canal's significance and impact on global trade and travel.
  • Ancon Hill: Offering breathtaking panoramic views of Panama City and the canal, Ancon Hill is perfect for outdoor enthusiasts. Enjoy a scenic hike or leisurely stroll amidst lush greenery and diverse wildlife, making it a peaceful retreat from urban life.

Best time to go to Santa Ana

The best time to visit Santa Ana can depend on the weather and when visitor numbers rise and fall. The hottest average temperature around Santa Ana falls in April, when visitor numbers are average and weather is mostly sunny with light rain. The coolest average temperature around Santa Ana falls in November, visitor numbers are average and weather is mostly cloudy with frequent rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January78.8°F (26.0°C)No RainMostly SunnyAverageSlightly High
February79.2°F (26.2°C)No RainMostly SunnySlightly HighAverage
March79.7°F (26.5°C)No RainMostly SunnySlightly HighSlightly High
April80.4°F (26.9°C)Light RainMostly SunnyAverageSlightly High
May80.2°F (26.8°C)Frequent RainMostly CloudySlightly LowAverage
June79.9°F (26.6°C)Frequent RainMostly CloudySlightly LowAverage
July79.3°F (26.3°C)Frequent RainMostly CloudyAverageAverage
August79.2°F (26.2°C)Frequent RainMostly CloudyAverageAverage
September79.3°F (26.3°C)Frequent RainMostly CloudySlightly LowSlightly Low
October78.6°F (25.9°C)Frequent RainMostly CloudyAverageSlightly Low
November78.3°F (25.7°C)Frequent RainMostly CloudyAverageSlightly Low
December78.6°F (25.9°C)Light RainMostly CloudySlightly HighAverage

The nearest major airports for your trip to Santa Ana

Traveling to Santa Ana, Panama is convenient with access to major airports. Panama City (PTY-Tocumen Intl.) is located 20.9km away, with nearby hotels like The Santa Maria, a Luxury Collection Hotel, 8.0km from the airport, and JW Marriott Panama, 16.1km away. Alternatively, Panama City (PAC-Marcos A. Gelabert Intl.) is only 3.2km from Santa Ana, featuring excellent accommodations such as Waldorf Astoria Panama and Sofitel Legend Casco Viejo, both within 3.2km of the airport. For a more remote option, Rio Hato (RIH-Scarlett Martinez Intl.) is 91.7km away, with resorts like The Buenaventura Golf & Beach Resort offering transport services to the airport.

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighborhood that travelers like for its seafood restaurants, shopping, and parks. Are you looking for Santa Ana travel tips? Be sure to check out Avenida Balboa and El Machetazo Santa Ana while you're in the neighborhood.
Where is the best hotel for a stay in Santa Ana?
Based on our traveler data, Hotel Caracas - Casco Viejo is one of the top choices for your stay in Santa Ana. This hotel is a short 7-minute walk from Avenida Balboa, and it offers a restaurant and a bar. Another good choice for your stay in the area is Casco View Life Residences.
How many hotels can I expect to find in Santa Ana?
Expedia has 134 hotels and other accommodations in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! Most hotel room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Add dates, click "Search", then use the "fully refundable" filter to get top deals in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about picking new dates or cancelling your trip to Santa Ana, head over to our customer service page.
What is there to do in this Panama City neighborhood?
If you're looking forward to a day of shopping in Santa Ana, consider El Machetazo Santa Ana or Avenida Balboa, and pick out the perfect souvenir. When you're sightseeing in Panama City, Albrook Shopping Mall and Avenida Central are also worth a stop.