Picayune Vacations

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    Save up to AEDĀ 5,000 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

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Find the Best Picayune Vacation Packages

Picayune Hotel Deals

Holiday Inn Express Picayune-Stennis Space Center by IHG

Holiday Inn Express Picayune-Stennis Space Center by IHG

2.5 out of 5
1001 Dauphin Street Picayune MS
Fully refundable
The price is AEDĀ 393 per night from Dec 12 to Dec 13
AEDĀ 393
AEDĀ 428 total
12 Dec - 13 Dec
includes taxes & fees
8.8/10 Excellent! (719 reviews)
"Check in they could not get the computer figured out to check me in stood there for 30 them the manager happened to walk in he got it fixed"

Reviewed on 8 November 2026

Holiday Inn Express Picayune-Stennis Space Center by IHG
Days Inn by Wyndham Picayune

Days Inn by Wyndham Picayune

2 out of 5
450 S Lofton Avenue Picayune MS
Fully refundableReserve now, pay when you stay
The price is AEDĀ 203 per night from Nov 16 to Nov 17
AEDĀ 203
AEDĀ 221 total
16 Nov - 17 Nov
includes taxes & fees
6/10 (397 reviews)
"I had just had femur/hip surgery 8 days prior, and was only able to bear weight on one leg. With this in mind, I booked a room explaining that I needed a room on the bottom floor and handicapped accessible. At arrival, I had been assigned a room on the 2nd floor. After being told that would not work, ..."

Reviewed on 11 November 2026

Days Inn by Wyndham Picayune
Hollywood Casino Gulf Coast

Hollywood Casino Gulf Coast

3.5 out of 5
711 Hollywood Blvd Bay St Louis MS
Fully refundableReserve now, pay when you stay
The price is AEDĀ 138 per night from Nov 15 to Nov 16
AEDĀ 138
AEDĀ 197 total
15 Nov - 16 Nov
includes taxes & fees
Hollywood Casino Gulf Coast
See all 1,048 properties in Picayune
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Picayune attractions

Crosby Arboretum

7.8/10 (8 reviews)
The Crosby Arboretum showcases native Mississippi ecosystems across pine savannas, wetlands, and woodlands. Experience the award-winning Pinecote Pavilion and follow trails through the Pearl River Basin's natural heritage.
See properties

Frequently asked questions

How much does a Picayune vacation package cost?
Offering great value package deals on Expedia, you'll be thrilled with how little a vacation to Picayune costs! Expedia's packages make travel planning easier and save you more.
What are the cheapest months to go to Picayune?
January, June and December are great times to look for cheap Picayune vacation packages. Opting to travel in quieter periods means you can typically find reduced prices on accommodations and flights.
How to find the best Picayune package deals?
Use Expedia's filter tool to find some of the best Picayune package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your break for midweek, or browse for Picayune package deals in the off-peak season. Play around with your travel dates and you may score even better discounts. As a rule of thumb, it's usually best to book your vacation package as soon as possible.
Is it cheaper to book a Picayune vacation as a package?
An Expedia vacation package could land you significant savings when compared to booking flights and accommodations separately. Better still, you can customize your Picayune escape to fit your exact style. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
When to book a vacation package to Picayune?
If you're considering a spur-of-the-moment Picayune trip, check out our last-minute deals that can be booked up to one week before you go. Prefer not to wait until the last minute? You can score sensational deals on your hotels and flights by booking ahead.
How to plan a trip to Picayune?

  1. Pick the perfect time to travel: Your schedule, favorite season and the type of weather you like can all influence your decision on when to travel to Picayune.
  2. Plan your budget wisely: On top of the price of your hotel, you should consider other expenses too. These include transportation, flights and food. Also, put aside some extra funds for unexpected costs that could arise during your trip to Picayune.
  3. Decide how long to go for: Now that you're more familiar with Picayune, you can figure out the ideal length of your break. Put together a draft itinerary and give yourself enough time to cover everything you want to do.
  4. Combine your hotel and flights: Epic destination, check. Length of stay, check. Now all that's left is to choose a Picayune vacation package that brings all your bookings together.