Cheap Flights from Columbia (COU) to Knoxville (TYS)

Popular airlines from Columbia, MO (COU-Columbia Regional) to McGhee Tyson Airport (TYS)

    notification illustration

    Be in the know

    Get alerts if flight prices drop or rise*
    deals illustration

    Book smarter

    Save on select hotels after you book a flight*
    trophy illustration

    Find the right fit

    We search billions of combinations of flights to help you find your next adventure

Frequently asked questions

Is it cheaper to buy a plane ticket from COU to Knoxville Airport last minute?
Being the spontaneous type is a great way to see the world, but it isn't always the smartest way to pick up a bargain fare. Consider booking your Columbia Regional Airport to Knoxville Airport trip ahead of time instead of waiting till the last minute. Based on flight pricing and demand studies in 2022, we have found that the best time to book domestic flights is between 28 – 35 days ahead of the departure date, and international flights three to four months in advance. Leave your spontaneous side for when you're discovering Knoxville Airport!
What airports do you fly into for Knoxville from Columbia?
With McGhee Tyson Airport (TYS), Gatlinburg, TN (GKT-Gatlinburg - Pigeon Forge) and Morristown, TN (MOR-Moore-Murrell) to choose from, connecting from Columbia to Knoxville is simple. The city's busiest terminal, McGhee Tyson Airport (TYS), is approximately 19 kilometers south of the downtown area. Apart from ticket prices, consider factors like transportation options from the airport and the distance to your hotel before making your decision. Get your Knoxville adventure off to an awesome start by visiting Ijams Nature Center and Women's Basketball Hall of Fame.
Can I change the date of my flight from COU to Knoxville Airport?
Life can throw a spanner in your plans, so Expedia is here to help make things as simple as possible. To start, access your COU to McGhee Tyson Airport (TYS) itinerary through the Expedia Trips portal and browse the ticket rules and conditions to see if change fees apply. If you booked in the last 24 hours, some carriers will let you cancel for free and organize new flights. If you bought your ticket more than 24 hours ago, get in touch with us via our Customer Service portal to run through your options.

Travel information

Travel information

Origin airport
Columbia Regional
Destination airport
McGhee Tyson
Distance
796 km

Book with confidence

Book with confidence

Columbia to Knoxville Flights

Whether you’re looking for a grand adventure or just want to get away for a last-minute break, flights from Columbia to Knoxville offer the perfect respite. Not only does exploring Knoxville provide the chance to make some magical memories, dip into delectable dishes, and tour the local landmarks, but the cheap airfare means you won’t bust your budget. So no matter whether your ideal itinerary involves flying one way, non-stop, or round trip, you’re bound to find flights that match your schedule on Expedia, and at prices that won’t shock your wallet.

Bagging a cheap flight from Columbia to Knoxville may mean more dollars to spend on for one-of-a-kind souvenirs when you arrive, but it doesn’t mean you have to skimp on your travel experience, as Expedia offers a sizzling selection of cheap airlines that’ll put you in your happy place on their planes, whether that’s getting lost in a hair-raising airport thriller, dreaming on the passing landscape over a glass of bubbly, or jotting down your vacation bucket list at 38,000 feet. There’s also bound to be plenty of opportunities to snap a few photos of the high life that will make your friends green with envy. After all, enjoying the journey is part of the fun.

With so many affordable flights and so many wonderful adventures awaiting you, there’s no reason to put off booking a fantastic flight from to today. So don’t leave it to the last minute to make your dream trip a reality: pack your bags with your go-to travel accessories, put together your list of must-see attractions and can’t-miss activities, and get ready to broaden your horizons – with Expedia, the wonders of Knoxville are only a plane trip away. Book your travel arrangements with us today!

If you would like to book flights to Knoxville more flexibly many prefer to purchase one-way tickets with options to take different airlines. A one way ticket to Knoxville is now!

Columbia to Knoxville Flights

Explore a world of travel with Expedia

Explore a world of travel with Expedia