Cheap Flights from Myrtle Beach (MYR) to Knoxville (TYS)

Popular airlines from Myrtle Beach Intl. Airport (MYR) to McGhee Tyson Airport (TYS)

    notification illustration

    Be in the know

    Get alerts if flight prices drop or rise*
    deals illustration

    Book smarter

    Save on select hotels after you book a flight*
    trophy illustration

    Find the right fit

    We search billions of combinations of flights to help you find your next adventure

Frequently asked questions

Is it cheaper to buy a plane ticket from MYR to Knoxville Airport last minute?
Being a spontaneous soul is a terrific way to travel the globe, but it's not necessarily the smartest method to track down a bargain plane ticket. Consider booking your MYR to Knoxville Airport trip in advance instead of leaving it till the last minute. Based on flight pricing and demand studies in 2022, we have found that the best time to book domestic flights is between 28 – 35 days ahead of the departure date, and international flights three to four months in advance. You can unleash your spontaneous side when you reach Knoxville Airport!
What airports do you fly into for Knoxville from Myrtle Beach?
McGhee Tyson Airport (TYS), Gatlinburg, TN (GKT-Gatlinburg - Pigeon Forge) and Morristown, TN (MOR-Moore-Murrell) are your choices when flying from Myrtle Beach to Knoxville. Around 19 kilometers south of downtown Knoxville, McGhee Tyson Airport (TYS) is the city's main gateway. Keep in mind factors like flight departure and arrival times and the distance to your hotel before you select an airport. Ijams Nature Center and Women's Basketball Hall of Fame are two awesome attractions to put on your itinerary when you arrive at your destination.
Can I change the date of my flight from MYR to Knoxville Airport?
We know plans can change, so Expedia is here to help make amending your journey as easy as possible. First, find your Myrtle Beach Intl. Airport to Knoxville Airport itinerary through the Expedia Trips portal and read the fare conditions about what changes can be made. If you booked your ticket in the last 24 hours, some airlines will let you cancel without charge and book new flights. If you bought your fare more than 24 hours ago, connect with us through our Customer Service portal to find out your options.

Travel information

Travel information

Origin airport
Myrtle Beach Intl.
Destination airport
McGhee Tyson
Distance
516 km

Book with confidence

Book with confidence