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Compare 291 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (346)
"Accommodating staff, comfortable rooms, wonderful pool"
Canada
Jay
The price is AED 493
AED 493 total
14 Dec - 15 Dec
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Ibis Santa Cruz DE LA Sierra

3.0 star property
Santa Cruz
9.6 out of 10, Exceptional, (72)
"Great Spot"
United States
Jose
The price is AED 140
AED 140 total
22 Dec - 23 Dec
Ibis Santa Cruz DE LA Sierra

Sun Hotel

3.5 star property
Santa Cruz
8.4 out of 10, Very Good, (329)
"Staff spoke English. Airport pickup beat any US hotel. Rooms nice. Restaurant was ok"
United States
Peter
The price is AED 329
AED 329 total
12 Dec - 13 Dec
Sun Hotel

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (253)
"Nice hotel "
United States
Narciso Lorenzo
The price is AED 235
AED 235 total
14 Dec - 15 Dec
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Camino Real Hotel

4.5 star property
Santa Cruz
8.8 out of 10, Excellent, (407)
"The parrots. Unique"
United States
Juan P
The price is AED 661
AED 661 total
25 Dec - 26 Dec
Camino Real Hotel

HOTEL OSHO

3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (33)
"Excellent"
United States
Neysa
HOTEL OSHO

Hotel Cortez

3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (122)
"The staff and property are second to none! "
United States
Cynthia
The price is AED 463
AED 463 total
23 Dec - 24 Dec
Hotel Cortez

Marriott Santa Cruz de la Sierra Hotel

5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (210)
"Great hotel, food and location albeit a little expensive "
United States
Reinaldo
The price is AED 408
AED 408 total
13 Dec - 14 Dec
Marriott Santa Cruz de la Sierra Hotel

Delfines Collection Hotel By Mercure

3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (71)
"Clean comfortable rooms "
United States
mary
The price is AED 171
AED 171 total
12 Dec - 13 Dec
Delfines Collection Hotel By Mercure

Novotel Santa Cruz De La Sierra

5.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (103)
"Great location and very clean hotel. Will stay again soon."
United States
William
The price is AED 367
AED 367 total
22 Dec - 23 Dec
Novotel Santa Cruz De La Sierra

Apart Hotel Premium Suites Santa Cruz

3.5 star property
Santa Cruz
8.6 out of 10, Excellent, (93)
"Come and go easily, intellectual and kind owners who are working hard to make the property improvements that will bring this hotel up to the next level. A family friendly environment with easy walking distance to everything you need. Bed was not the best, but I know they are upgrading so I appreciate the ongoing process. For a few nights stay, the deals are very fair prices. "
United States
Andrew
Apart Hotel Premium Suites Santa Cruz

Chairú Eco Hotel

3.5 star property
Santa Cruz
9.6 out of 10, Exceptional, (46)
"Nice property. Would definitely stay there again and again. Only negative was on our last night there was a really noisy party next door that lasted until 2am. "
United States
Andrew
Chairú Eco Hotel

Lido Hotel

3.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (30)
"Very helpful and nice staff. Quiet location. near the central plaza. Great value "
United Kingdom
David
The price is AED 168
AED 168 total
14 Dec - 15 Dec
Lido Hotel

TRYP by Wyndham Santa Cruz

4.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (145)
"Nice stay with good service "
United States
Jianyuan
The price is AED 364
AED 364 total
9 Dec - 10 Dec
TRYP by Wyndham Santa Cruz

Hotel Las Américas

3.0 star property
Santa Cruz
6.0 out of 10, (1)
"O chuveiro foi impossível tomar um.banho de qualidade "
Brazil
Jean
The price is AED 141
AED 141 total
10 Dec - 11 Dec
Hotel Las Américas

Hotel LP Santa Cruz Centro

3.0 star property
Santa Cruz
8.0 out of 10, Very Good, (280)
"Clean, friendly staff"
United States
Giovanna
Hotel LP Santa Cruz Centro

Premium Suites Deluxe Aparthotel Equipetrol

3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (81)
"Good price, great hotel!"
United States
James
The price is AED 143
AED 143 total
12 Dec - 13 Dec
Premium Suites Deluxe Aparthotel Equipetrol

Hotel Arenal

3.5 star property
Santa Cruz
7.6 out of 10, Good, (59)
"Perfect hotel in a central location!"
United States
Max
The price is AED 216
AED 216 total
8 Jan - 9 January 2026
Hotel Arenal

Swissôtel Santa Cruz De La Sierra

4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (81)
"Beautiful hotel"
Australia
Joanna
The price is AED 544
AED 544 total
1 Jan - 2 January 2026
Swissôtel Santa Cruz De La Sierra

Hotel LP Equipetrol

3.5 star property
Santa Cruz
8.2 out of 10, Very Good, (201)
"Nice place to stay"
United States
Ricardo
Hotel LP Equipetrol
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most.

Hamacas

While Hamacas isn't home to many top sights, Santa Cruz Zoo and Las Brisas Shopping Center are some notable places to visit nearby.

Stay near popular Santa Cruz attractions

Learn more about Santa Cruz

Tropical energy pulses through Plaza 24 de Septiembre, where locals gather under palm trees and the Metropolitan Cathedral's twin towers stand watch. Biocentro Güembé offers rainforest trails with butterfly gardens, while the massive Ventura Mall provides air-conditioned shopping when afternoon temperatures climb.

San Lorenzo Cathedral showing a garden

Top Santa Cruz Hotel Reviews

More cheap stays in Santa Cruz

Hotels in Santa Cruz with star-rating

Find out more about Santa Cruz

Top reasons to visit Santa Cruz

  • Cultural Blend: Santa Cruz showcases a vibrant mix of cultural experiences, including iconic landmarks like the cathedral and lively neighborhoods.
  • Outdoor Activities: Enjoy a variety of outdoor adventures that allow you to soak up the local atmosphere and natural beauty.
  • Diverse Accommodations: The city offers a wide range of hotels and motels, catering to every traveler's needs.
  • Dynamic Nightlife: Experience the vibrant nightlife with live music and entertainment options across the city.
  • Family-Friendly Attractions: Santa Cruz is perfect for families, offering numerous activities and attractions for all ages.

Find great hotels in Santa Cruz

Explore a diverse range of hotel accommodations in Santa Cruz, Bolivia, catering to every type of traveler. Whether you're seeking a business-friendly hotel, a family-oriented stay, or a relaxing spa-themed getaway, Santa Cruz offers a variety of options. With numerous hotels to choose from, you can easily find the ideal spot for your vacation. Check out reviews and discover the best hotels that suit your needs in this vibrant city.

  • Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel: Experience urban luxury at Los Tajibos, where business travel meets relaxation. This 3.5-star hotel is situated in the vibrant heart of Santa Cruz, making it ideal for those looking to immerse themselves in city life. Guests can unwind at the full-service spa, which offers a variety of treatments including facials and massages. The accessible pool invites you to relax after a day of exploring. With its sophisticated ambiance and comprehensive amenities, this hotel caters to both business travelers and those seeking a rejuvenating getaway.
  • Hotel G: Hotel G is the perfect choice for pet lovers seeking a welcoming atmosphere. This 3.5-star hotel allows pets, ensuring that your furry companions can join in on the adventure. Located in Santa Cruz, the hotel features a pet-friendly policy that includes waived fees for service animals and accommodations for dogs and cats. The charming environment and thoughtful amenities create a cozy stay for you and your pets, making it an excellent option for travelers who cherish the company of their four-legged friends.
  • Marriott Santa Cruz de la Sierra Hotel: Indulge in luxury at the Marriott Santa Cruz de la Sierra, a 5-star hotel designed with families and business travelers in mind. Nestled in Santa Cruz, this hotel offers a fantastic range of amenities, including a full-service spa and accessible pool. Families will appreciate the complimentary cribs and child-friendly services available. With its elegant design and focus on relaxation, guests can enjoy both leisure and productivity, making this hotel a premium choice for an unforgettable stay in Bolivia.

Where to stay in and around Santa Cruz

Santa Cruz, Bolivia, offers a vibrant blend of culture and excitement for travelers. Explore the lively city center, where you can discover exciting venues and enjoy the dynamic nightlife. Nearby, the charming neighborhoods provide a warm atmosphere and friendly locals. Don’t miss a trip to San Francisco for a taste of the region's unique character. Whether you're on a family vacation or a cultural adventure, Santa Cruz promises an unforgettable experience.

  • La Guardia: Located approximately 20.9km from Santa Cruz, La Guardia offers a charming escape from the city's hustle and bustle. This city is particularly appealing for families and outdoor enthusiasts, with its beautiful resorts and inviting atmosphere. Visit the nearby botanical garden to enjoy a peaceful stroll among diverse plant species. La Guardia is a great spot for a day trip, especially during the peak visitor months of September and December to January, when outdoor activities thrive and the weather is ideal.
  • Warnes: Situated about 30.6km from Santa Cruz, Warnes is a vibrant city perfect for families seeking a mix of outdoor and urban experiences. The city features modern shopping centers and malls, making it a great destination for those looking to indulge in some retail therapy. Nature lovers will also appreciate the proximity to botanical gardens, providing a lovely backdrop for relaxation. Warnes sees a peak in visitor numbers during September and December to January, making it an exciting time to explore the local attractions and partake in city-themed activities.
  • Colinas del Urubo: Nestled within the Santa Cruz area, Colinas del Urubo is a tranquil village that invites visitors to enjoy its serene surroundings. Known for its outdoor offerings, this village is ideal for families looking to unwind and engage with nature. With resorts available for a comfortable stay, you can easily access the enchanting botanical garden nearby. Visitor numbers tend to increase during March and September to October, making it a lovely time to explore the scenic beauty and experience the local culture.

Things to do in Santa Cruz

Santa Cruz offers a vibrant blend of family-friendly and cultural activities, making it an ideal vacation spot. You can explore a variety of restaurants, enjoy live music, and experience the lively shopping scene in shopping centers and malls. Don't miss the opportunity to engage in outdoor activities and soak up the local atmosphere while enjoying the city’s theater and entertainment options. Santa Cruz promises a memorable experience for every traveler.

Shopping

In Santa Cruz, you can explore Ventura Mall, which offers a vibrant atmosphere with entertainment and shopping. For a more local experience, visit La Recova Artisan Walk for unique souvenirs. If you're up for a drive, check out Patio Design LifeStyle Center for a mix of shopping and family-friendly vibes.

Recreation

Experience the lively atmosphere at Ramon Tahuichi Aguilera Stadium, where you can engage in various sports activities and soak up the vibrant energy of the local community. Enjoy the thrill of live sports events or participate in recreational activities that foster wellness and camaraderie.

Adventure

Explore the wild beauty of Amboró National Park, where diverse ecosystems await, offering thrilling hiking trails and breathtaking views. For adrenaline seekers, the Arenal River provides exciting rafting experiences amidst stunning landscapes, perfect for those looking to embrace nature's challenges in Santa Cruz.

Nightlife

Experience the nightlife in Santa Cruz by catching a film at Cine Center, which offers a cozy atmosphere perfect for families and couples. For a cultural touch, visit Casa Municipal de Cultura Raúl Otero Reiche, where you can enjoy engaging performances that celebrate local art and romance.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Santa Cruz

To save money on your trip to Santa Cruz, consider visiting during the cheaper months of January, June, or August, and aim to book your stay on a Saturday for the best rates. Use Expedia’s search tool to filter for budget-friendly hotels, including eco-certified options, and combine bookings for flights and activities to unlock additional savings. Public transport is affordable, and exploring the city on foot allows you to enjoy free activities while minimizing expenses. Always compare room rates and look for flexible booking options to secure the best deals.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Santa Cruz are January, June and August, where the prices are slightly lower. This is in comparison to February, September and December, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Santa Cruz is Saturday. The most expensive day to stay in Santa Cruz is Tuesday.
  • Find cheap hotels on Expedia: Expedia’s search tool enables you to specify your budget, desired location, and additional preferences. You can easily sort the results to display the lowest prices first, helping you find the most affordable hotels right away. Additionally, you have the option to filter your search by hotel type; for instance, selecting the Eco-certified filter will showcase sustainable and environmentally-friendly hotels that you can book.
  • Consider bundling your trip: You can save money by combining your Santa Cruz hotel reservation with your flights and activities when you book an Expedia package.

Find the best attractions in Santa Cruz

Santa Cruz, Bolivia, offers a vibrant mix of city-themed and family-friendly attractions, perfect for cultural vacations. Visitors can explore iconic sites like the cathedral, piazza, and various landmarks. The area is rich in cultural experiences and outdoor activities, making it ideal for families. Additionally, you can find accommodations in local motels and enjoy the nearby beach, ensuring a well-rounded visit to this lively city.

  • Plaza 24 de Septiembre: This vibrant square is the heart of Santa Cruz, surrounded by lively cafes and shops. Experience the rich culture and local traditions as you soak in the energetic atmosphere, often filled with street performances and festivities.
  • San Lorenzo Cathedral: An architectural gem in the city, this stunning cathedral showcases beautiful artwork and intricate details. Step inside to admire its peaceful ambiance and cultural significance, making it a perfect spot for reflection and appreciation of Bolivian heritage.
  • Lomas de Arena Regional Park: Escape to this unique natural reserve, characterized by rolling sand dunes and sunny weather. Ideal for outdoor activities like hiking and sandboarding, it offers a refreshing contrast to the urban environment of Santa Cruz.

Best time to go to Santa Cruz

The best time to visit Santa Cruz is dependent on what kind of holiday you are seeking. October is its hottest month on average. At this time, visitor numbers are slightly low and weather is mostly sunny with light rain. June is its coolest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January78.3°F (25.7°C)Light RainMostly SunnySlightly HighSlightly Low
February77.0°F (25.0°C)Light RainMostly CloudyAverageSlightly High
March76.5°F (24.7°C)Light RainMostly SunnyAverageAverage
April74.5°F (23.6°C)Light RainMostly SunnyAverageAverage
May70.2°F (21.2°C)Light RainMostly SunnySlightly LowAverage
June67.8°F (19.9°C)Light RainMostly SunnyAverageSlightly Low
July68.5°F (20.3°C)No RainMostly SunnySlightly HighAverage
August72.9°F (22.7°C)No RainSunnyAverageSlightly Low
September77.9°F (25.5°C)Light RainSunnySlightly HighSlightly High
October79.5°F (26.4°C)Light RainMostly SunnySlightly LowAverage
November79.3°F (26.3°C)Light RainMostly SunnyAverageAverage
December78.4°F (25.8°C)Light RainMostly SunnySlightly LowSlightly High

The nearest major airports for your trip to Santa Cruz

Traveling to Santa Cruz, Bolivia is convenient with its main airport, Viru Viru International Airport (VVI), located 16.1km from the city. Nearby, you'll find excellent accommodations such as the 5-star Marriott Santa Cruz de la Sierra, situated 14.5km away, and the Radisson Hotel Santa Cruz, also 14.5km from the airport. Another option is the Novotel Santa Cruz De La Sierra, located 17.7km from VVI. These hotels provide easy access to the airport, ensuring a smooth transition for travelers. Enjoy your stay in Santa Cruz with comfortable lodging and straightforward transportation options to the airport.

Frequently asked questions

What's the best place for a stay in Santa Cruz?
Ibis Santa Cruz DE LA Sierra is a favorite with Expedia customers. This hotel offers a restaurant and free parking. Reviews from our site also recommend Chairú Eco Hotel and Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel as top options for your trip. See all available top hotels, or vacation rentals in Santa Cruz.
What's the top vacation rental that Santa Cruz has to offer?
Casa Vida: Visitors give good reviews to this Santa Cruz vacation home rental, which is located in a rural location and has an outdoor pool, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a full-sized fridge, a stovetop, and a microwave, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a private yard and a selection of games. Some other homes for rent in Santa Cruz include Cozy and independent. Downtown house JH. and Jose Luis Noya. See all vacation rentals in Santa Cruz.
If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes! Most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.
Where can I learn more about changing or cancelling my trip to Santa Cruz?
To find more details about picking new dates or cancelling your trip to Santa Cruz, head over to our customer service page.
What's the best budget-friendly accommodation in Santa Cruz?
Based on our traveler reviews, residencial francia - Hostel is a top choice for a less expensive stay. Other choices for your budget-friendly stay include Residencial Ikandire II and Nomad Hostel. View all budget hotels in Santa Cruz.
What's the best accommodation for a family trip to Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a hotel with an outdoor pool and a restaurant, and it's a top choice on Expedia for families. Other choices for your stay with the kids include Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel and Novotel Santa Cruz De La Sierra. Attractions like Santa Cruz Zoo and Play Land Amusement Park are also fun for kids of all ages. Find more child-friendly accommodations in Santa Cruz.
What is the top LGBTQ-friendly accommodation in Santa Cruz?
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia is a top LGBTQ-friendly hotel that features free breakfast and free WiFi. Swissôtel Santa Cruz De La Sierra and Radisson Hotel Santa Cruz are other good choices for your trip.
What's the best pet-friendly hotel in Santa Cruz?
Ibis Santa Cruz DE LA Sierra is a top hotel for people traveling with their pets, and offers a restaurant and free WiFi for its human guests. Other good options for you and your pet's trip include HOTEL OSHO and Hotel LP Equipetrol. See more pet-friendly hotel accommodations in Santa Cruz.
Where is the best place to stay close to Plaza 24 de Septiembre?
Adjacent to Plaza 24 de Septiembre, Nomad Hostel is one of the top choices for your stay based on our traveler data, and this property offers a restaurant and a bar. Other good options close by include Senses Centro and Cosmopolitano Hotel Boutique.
What about the best place to stay near Ventura Mall?
One of the top choices for your stay is Camino Real Hotel, located next to Ventura Mall, and this 4-star hotel offers 2 bars and a restaurant. Los Tajibos Hotel And Convention Center and Marriott Santa Cruz de la Sierra Hotel are two other good choices in the immediate area.
What's the best luxury accommodation in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Novotel Santa Cruz De La Sierra and Camino Real Hotel are other upscale choices for your vacation. Find more luxury hotels in Santa Cruz.
What are some accommodations with pools in Santa Cruz?
Sun Hotel is a top hotel with a children's pool, an outdoor pool, and free buffet breakfast. A couple of other options that offer an onsite pool include Yotau All Suites Hotel and Buganvillas Hotel Suites & Spa. View all hotels with pools in Santa Cruz.
What is the best spa hotel in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a top luxury spa hotel featuring a rooftop terrace, a fitness center, tennis courts, and a bar. Spend an afternoon at Hotel Spa where you'll find massage treatments. Other popular spa hotels in Santa Cruz include Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel and Hotel Cortez. See all spa hotels in Santa Cruz.
What's the best hotel for staying near Viru Viru International Airport (VVI)?
Sun Hotel is a popular 3.5-star hotel featuring free breakfast and a restaurant. It's located a short 1.3 mi (2.1 km) from Viru Viru Intl. Airport.
How is it to stay in Santa Cruz?
Visitors to Santa Cruz are sure to enjoy the shopping. Tourists can also enjoy the city's cafes, zoo, and cathedral. In Santa Cruz, there are 285 hotels and other accommodations to choose from. Find out more about Santa Cruz.
What should I do while I'm visiting Santa Cruz?
Cultural venues include Ethno-folkloric Museum, Cine Center, and Sacred Art Museum. Landmarks like San Lorenzo Cathedral, Plaza 24 de Septiembre, and Blacutt Square might be worth a visit. Natural beauty is on display at Guembe Biocenter, Lomas de Arena Regional Park, and Arenal Park. Check out what more to see and do in Expedia's Santa Cruz guide.
How should I get around Santa Cruz?
To see more of the larger area, ride aboard one of the trains from Santa Cruz de la Sierra Station. If you want to venture out around the area, you may want a rental car in Santa Cruz for your journey.
What's the weather like in Santa Cruz?
The hottest months are usually October and November with an average temp of 79°F, while the coldest months are June and July with an average of 70°F. Average annual precipitation for Santa Cruz is 48 inches.

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