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Find 4 Star Hotels in De Soto, MO
Compare De Soto 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Old Caledonian Bed and Breakfast
Old Caledonian Bed and Breakfast
9.8 out of 10, Exceptional, (30)
Frequently asked questions
De Soto Hotels by Star Rating
Stay near popular De Soto attractions
- Mississippi River
- Meramec State Park
- Bonne Terre Mine
- Meramec River
- St. Joe State Park
- Hawn State Park
- Pickle Springs Natural Area
- Washington State Park
- St. Francois State Park
- Crown Pointe Golf Club
- Big River
- Missouri Mines State Historic Site
- Weingarten Vineyard
- Mastodon State Historic Site
- Fort de Chartes
- Villa Antonio Winery
- Illinois Caverns State Natural Area
- Robertsville State Park
More Accommodation Types in De Soto
Explore more hotels
- WoodSpring Suites St. Louis Arnold
- La Quinta Inn & Suites by Wyndham Festus - St. Louis South
- Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an IHG Hotel
- Quality Inn Farmington
- Holiday Inn Express & Suites Farmington, an IHG Hotel
- Super 8 by Wyndham Bonne Terre
- Super 8 by Wyndham Potosi
- Quality Inn Festus
- Crown Pointe Lodge, BW Signature Collection
- Hampton Inn Farmington
- Relax and enjoy the privacy
- Hagood farms and trails
- Couples Retreat with hot tub (cabin2)
- Stewart Acres..."Big City Close, w/ Big Country Charm"
- ❤️ THE MAGIC TIPI RETREAT
- Cozy Three bedroom home in Central Farmington
- Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE
- Serenity Log Inn -Log out and Log Inn to Serenity
- Oakdale Primitive cabin (1)@Spring Lake Ranch
- Lake Haven - Updated Mid Century Cabin Only 35 Mins from St. Louis