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25 Sep - 26 Sep
Tomorrow
26 Sep - 27 Sep
This weekend
25 Sep - 27 Sep
Next weekend
2 Oct - 4 Oct

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Our top choices for Cairo hotels

1. Quality Inn Cairo I-57

Quality Inn Cairo I-57
Cairo
United States
Santiago
AED 260
AED 289 total
includes taxes & fees
2 Oct - 3 Oct
Quality Inn Cairo I-57

2. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
Charleston
United States
William
AED 219
AED 243 total
includes taxes & fees
27 Sep - 28 Sep
Super 8 by Wyndham Charleston/Sikeston East MO

3. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
Charleston
United States
Jay
AED 244
AED 271 total
includes taxes & fees
28 Sep - 29 Sep
The Riverstone Hotel Charleston-Sikeston

4. Eagle Inn Charleston

Eagle Inn Charleston
Charleston
United States
Jackson
AED 242
AED 269 total
includes taxes & fees
6 Oct - 7 Oct
Eagle Inn Charleston

5. La Center Motel

La Center Motel
La Center
United States
Carrie
AED 179
AED 211 total
includes taxes & fees
26 Sep - 27 Sep
La Center Motel

6. Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
Cunningham
AED 547
AED 1,067 total
includes taxes & fees
28 Sep - 29 Sep
Quiet Country Stay: Modern Home Near Paducah
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Stay near popular Cairo attractions

Fort Defiance State Park

7.4/10 (15 reviews)
Where the mighty Mississippi and Ohio rivers converge, Fort Defiance Park offers a rare view of this natural phenomenon. Explore the historic grounds where Lewis and Clark once trained the Corps of Discovery in 1803.
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Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artifacts from this once-thriving river port town.

See all hotels in Cairo
A steel bridge with a sunset in the background.

Top Cairo Hotel Reviews

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

10/10 Excellent
"perfect"
Sandra D. 5-night trip
Posted 6 hours ago
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

10/10 Excellent
"Súper affordable pricing, and the property was clean and comfortable! Complimentary breakfast was a plus!"
Brianna 1-night trip
Posted 4 days ago
Super 8 by Wyndham Charleston/Sikeston East MO
Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake

10/10 Excellent
"Super communication! . Accommodating. Nice people"
JASEN 2-night trip
Posted 9 days ago
Cozy cabins on beautiful Horseshoe Lake
The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

8/10 Good
"Overall it was excellant, other then the toilet running constantly... Pool could have been cleaner, considering the heat-wave they were having............."
Mark E 13-night trip
Posted 12 days ago
The Riverstone Hotel Charleston-Sikeston
Wandering the wineries or hitting the hills? We got you! Come stay!

Wandering the wineries or hitting the hills? We got you! Come stay!

10/10 Excellent
"This is the 2nd time staying here and location is perfect for exploring Cache River. Brent and Wendy are amazing hosts and excellent at communicating. Already booked in November to come back for a week of relaxing with friends and doing some hunting. I highly recommend staying here if you want something clean, good communication and great location."
David P. 3-night trip
Posted 2 weeks ago
Wandering the wineries or hitting the hills? We got you! Come stay!
Quality Inn Cairo I-57

Quality Inn Cairo I-57

8/10 Good
"Good service,nice stuff and no complaints"
Santiago 1-night trip
Posted 2 weeks ago
Quality Inn Cairo I-57
Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah

10/10 Excellent
"My bridal party and I stayed here for the days leading up to the wedding, we thought the place was so cute and cozy! You can tell the host takes pride in what they do and wants to make sure their guests are taken care of. The girls appreciated the gas station that’s not even a minute away for their morning snacks and refreshments."
Stephanie H. 3-night trip
Posted 2 weeks ago
Quiet Country Stay: Modern Home Near Paducah
Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre

10/10 Excellent
"This place is magnificent if you want somewhere to get away and enjoy the peace and quiet of the country. One of the very few places I have found that isn't just surrounded by other rentals. This is one of those from back in the day before resorts started tricking you with 30 identical cabins all in a circle. Suzzie was the perfect host. Amazing views,peace and serenity just 15 or so miles from everything you may need during a stay. This is one of the few places I've reserved that I will try to stay again,if in the area. One thing there that I've never seen in person,a 2 hole outhouse. You could hold your sweeties hand while pooping,back in the day!"
kelly f. 2-night trip
Posted 1 month ago
Charming cottage overlooking Lake Acre
Upscale & Quiet Paducah Retreat on 15 Acres!

Upscale & Quiet Paducah Retreat on 15 Acres!

10/10 Excellent
"Pretty place. Clean. Nicely set back in the woods."
Luanne S. 2-night trip
Posted 2 months ago
Upscale & Quiet Paducah Retreat on 15 Acres!

More cheap stays in Cairo

La Center Motel

La Center Motel

474 W Kentucky Dr La Center KY
AED 179
AED 211 total
26 Sep - 27 Sep
includes taxes & fees
7.6/10 Good! (22 reviews)
La Center Motel
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO
AED 219
AED 243 total
27 Sep - 28 Sep
includes taxes & fees
6.8/10 (669 reviews)
Super 8 by Wyndham Charleston/Sikeston East MO
The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

102 Drake St Charleston MO
AED 244
AED 271 total
28 Sep - 29 Sep
includes taxes & fees
The Riverstone Hotel Charleston-Sikeston
Quality Inn Cairo I-57

Quality Inn Cairo I-57

13201 Kessler Road Cairo IL
AED 260
AED 289 total
2 Oct - 3 Oct
includes taxes & fees
6.4/10 (295 reviews)
Quality Inn Cairo I-57
Eagle Inn Charleston

Eagle Inn Charleston

2811 East Marshall Street Charleston MO
AED 283
AED 314 total
26 Sep - 27 Sep
includes taxes & fees
6.6/10 (107 reviews)
Eagle Inn Charleston

Find out more about Cairo

Top reasons to visit Cairo

  • Outdoor Adventures: Cairo offers a variety of outdoor activities including scenic riverboat tours, golf courses, and national parks, perfect for nature enthusiasts.
  • Charming Scenery: The picturesque landscapes and charming town provide a romantic backdrop for a getaway or family excursion.
  • Rich History: Explore historic sites that reflect the unique heritage of Cairo and its surroundings.
  • Cultural Insights: Immerse yourself in local culture through vibrant neighborhoods and community events.
  • Diverse Accommodations: Choose from family-friendly and pet-friendly lodging options to suit every traveler's needs.

Find great hotels in and around Cairo

Discover a variety of lodging options in Cairo, Illinois, perfect for every type of traveler. From family-friendly hotels to pet-friendly accommodations, you'll find the ideal place to unwind after a day of exploration. Whether you're here for business or leisure, Cairo offers an array of choices to suit your needs, complemented by excellent amenities and services. Explore the best hotels and read reviews to ensure a memorable stay in this charming destination.

  • Super 8 by Wyndham Charleston/Sikeston East MO: Nestled 16.1km away from Cairo, Super 8 by Wyndham Charleston/Sikeston East MO is a charming motel ideal for families and pet lovers seeking a comfortable getaway. The hotel features family-friendly amenities, including complimentary cribs for infants. Guests can enjoy a relaxed atmosphere with the added benefit of pet accommodations, allowing certain pets on-site. With its inviting environment and focus on family, this motel ensures a pleasant stay for all.
  • Quality Inn Charleston - Sikeston: Located 19.3km from Cairo, Quality Inn Charleston - Sikeston is a perfect choice for business travelers and pet owners alike. This hotel emphasizes convenience and comfort, with amenities designed to cater to the needs of professionals on the go. Pets are permitted with restrictions, making it easy to travel with furry companions. The hotel's welcoming atmosphere and strategic location provide guests with easy access to local business hubs while ensuring a cozy retreat after a busy day.
  • Quality Inn Cairo I-57: Situated within Cairo, Quality Inn Cairo I-57 offers a delightful blend of family-friendly accommodations and pet-friendly policies. With amenities such as free cribs and first aid kits for children, families can feel at home during their stay. The hotel welcomes pets, with specific guidelines to ensure a comfortable experience. With its central location and focus on both family and pet needs, this hotel is an excellent choice for those visiting Cairo.

Where to stay near Cairo

Cairo, Illinois, offers a unique blend of outdoor adventures and charming scenery, perfect for romantic getaways and family-friendly excursions. Explore local shops and enjoy the warm weather while immersing yourself in the area's rich history. Nearby cities and neighborhoods provide a vibrant atmosphere filled with cultural insights, making it an ideal destination for travelers seeking both relaxation and exploration. Don't miss the chance to experience the diverse vibes of this captivating region.

  • Mound City: Located 9.7km from Cairo, Mound City offers a delightful escape into nature with its beautiful outdoor settings and scenic views. This city is perfect for adventure seekers, boasting activities like golf and access to recreational areas. Visitors can explore nearby landmarks such as national parks, forests, and lakes, making it an ideal spot for those looking to immerse themselves in the great outdoors. The best times to visit are in March, July, and October when the weather is pleasant and the surroundings are picturesque.
  • Charleston: Situated 17.7km from Cairo, Charleston is a city that enchants with its mix of outdoor adventures and scenic beauty. The city attracts travelers looking for recreational activities, educational experiences, and shopping opportunities. Highlights include visits to national state parks and historic sites, allowing you to delve into local history while enjoying the lush landscapes. Peak visitor months are April and June to July, when Charleston buzzes with activity and vibrant community events.
  • Villa Ridge: Also located 17.7km from Cairo, Villa Ridge is another gem for nature enthusiasts, offering outdoor adventures and stunning scenery. This city features recreational areas and golf courses, making it an excellent choice for those who enjoy sports and relaxation in a serene environment. Local attractions include national parks, forests, and lakes, perfect for hiking, picnicking, and wildlife watching. The summer months from June to August see the highest number of visitors, providing great opportunities to enjoy the warm weather and scenic landscapes.

Things to do near Cairo

Cairo, Illinois offers a delightful mix of outdoor activities and scenic views, perfect for a romantic getaway or weekend retreat. Visitors can enjoy recreational areas, golf courses, and riverboat tours while exploring the town's unique charm. For those looking to camp or partake in indoor activities, Cairo has something for everyone. Embrace the local culture and the beautiful surroundings as you unwind in this picturesque destination.

Shopping

In Cairo, visit the local shops along Washington Avenue for unique gifts and souvenirs. If you're up for a drive, head to the West Park Mall in Cape Girardeau, about 32.2km away, featuring a variety of stores, dining options, and entertainment for a full day of shopping.

Recreation

eDen Spa & Salon offers a rejuvenating body treatment experience, located 45.1km from Cairo. This serene retreat provides wellness and relaxation vibes, allowing you to unwind with luxurious services designed to refresh your body and mind amidst a tranquil atmosphere.

Adventure

At Cape Splash Family Aquatic Center, enjoy thrilling water slides and a relaxing lazy river, perfect for families seeking fun and adventure. For a scenic hike, head to Limekin Springs Trail Trailhead, where you can immerse yourself in nature and explore beautiful landscapes.

Nightlife

Cairo, Illinois, offers a laid-back nightlife experience with spots like The Hangout, where you can enjoy live music and friendly vibes. For a cozy evening, visit The Coffee House for a relaxed atmosphere and artisanal drinks, perfect for unwinding after a day of exploration.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Cairo

To save money on your trip to Cairo, Illinois, consider visiting between November and January, when accommodation prices are lower. Tuesdays are the cheapest days to stay, while Saturdays are pricier. Use Expedia’s search tool to find great hotel deals, and filter results by price to uncover budget-friendly options. Additionally, consider bundling your hotel, flights, and activities into an Expedia package for further savings. For local exploration, take advantage of free activities and efficient public transport to keep costs down while enjoying your visit.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Cairo are November to January, where the prices are slightly lower. This is in comparison to April to May and August, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Cairo is Tuesday. The most expensive day to stay in Cairo is Saturday.
  • Find cheap hotels on Expedia: Leverage Expedia’s search tool to refine your choices based on your budget, preferred location, and the type of hotel you desire. To find the best prices and deals, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel reservation in Cairo with your flights and activities through an Expedia package deal.

Find the best attractions in and around Cairo

Cairo, Illinois, offers a delightful escape for outdoor lovers and those seeking romantic scenery. Popular attractions include national parks, nature reserves, and event venues that cater to culture and adventure. Whether you're interested in exploring the stunning landscapes or engaging in local events, Cairo has something for everyone. Don't miss the chance to visit the historic sites and enjoy the beautiful surroundings during your vacation.

  • Fort Defiance State Park: Immerse yourself in history at Fort Defiance State Park, where you can explore the remnants of a historic fort with cultural significance. Enjoy scenic views of the confluence of the Ohio and Mississippi Rivers while walking through its serene trails.
  • Ballard Wildlife Management Area: Located 8.0km from Cairo, this wildlife preserve offers a budget-friendly adventure. Experience its rich history and diverse ecosystems, perfect for birdwatching and hiking amid tranquil natural surroundings.
  • Columbus-Belmont State Park: Situated 27.4km away, this national park is a haven for outdoor enthusiasts. Enjoy breathtaking scenery, hiking trails, and opportunities for adventure, including fishing and camping along the scenic riverbanks.

Best time to go to Cairo

The best time to visit Cairo is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are moderately low and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January35.2°F (1.8°C)Light RainMostly SunnyModerately LowSlightly Low
February38.5°F (3.6°C)Light RainMostly SunnyModerately LowAverage
March48.7°F (9.3°C)Light RainMostly SunnyModerately HighAverage
April57.7°F (14.3°C)Light RainMostly SunnyModerately HighSlightly High
May67.5°F (19.7°C)Light RainMostly SunnyAverageSlightly High
June76.5°F (24.7°C)Light RainMostly SunnyAverageAverage
July79.0°F (26.1°C)Light RainMostly SunnyAverageAverage
August77.2°F (25.1°C)Light RainMostly SunnyModerately HighSlightly High
September71.6°F (22.0°C)Light RainMostly SunnyAverageAverage
October60.1°F (15.6°C)Light RainMostly SunnyAverageAverage
November47.8°F (8.8°C)Light RainMostly SunnyModerately LowSlightly Low
December40.6°F (4.8°C)Light RainMostly SunnyAverageSlightly Low

The nearest major airports for your trip to Cairo

Traveling to Cairo, Illinois, offers convenient access through several nearby airports. Paducah, KY (PAH-Barkley Regional) is located 37.0km away, with hotel options like The Respite Bed and Breakfast, 14.5km from the airport, and Harrah's Metropolis Hotel & Casino, just 9.7km away. Marion, IL (MWA-Williamson County Regional) is 83.7km from Cairo, featuring accommodations such as Drury Inn & Suites Marion, 3.2km from the airport. Cape Girardeau, MO (CGI-Cape Girardeau Municipal) is 29.7km away, with options like Drury Plaza Hotel Cape Girardeau Conference Center, 9.7km from the airport. Each airport provides various transportation services for a smooth travel experience.

Frequently asked questions

Where is the best place for a stay in Cairo?
Based on our traveler data, Quality Inn Cairo I-57 is one of the top choices for your stay. This hotel offers free breakfast and free parking. Other good choices for your trip to the area are Super 8 by Wyndham Charleston/Sikeston East MO and The Riverstone Hotel Charleston-Sikeston. See all available top hotels, or vacation rentals in Cairo.
What are some of the best vacation rentals in Cairo?
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286: This vacation home rental near Cairo is located in a rural location and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. See all vacation rentals in Cairo.
If I need to cancel my hotel reservation in Cairo, will I receive a refund?
Yes! Most hotel room reservations are refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cairo.
Where can I learn more about changing or cancelling my trip to Cairo?
For more information about updating your trip to Cairo or cancelling it, head over to our customer service page.
Where is the best hotel to stay close to Fort Defiance?
Quality Inn Cairo I-57 is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. It's located 4.9 mi (7.8 km) from Fort Defiance. Other good options around the area include Victorian Splendor in So. Illinois: wallmanor.com and Eagle Inn Charleston.
What's the best hotel for staying near Barkley Regional Airport (PAH)?
Drury Inn & Suites Paducah is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and an indoor pool. It's located 4.7 mi (7.6 km) from Barkley Regional Airport. Other choices close to the airport include La Quinta Inn & Suites by Wyndham Paducah and Baymont by Wyndham Paducah.
What is staying in Cairo like?
Visitors can enjoy all that Cairo has to offer including the restaurants, entertainment choices, and riverfront. This city also attracts tourists with its small-town vibe. There are 29 hotels and other accommodations in the surrounding area. Find out more about Cairo.
What should I see while I'm in Cairo?
The picturesque setting of Mississippi River and Ohio River Valley exemplify the area's natural beauty. Additionally, you might want to add Fort Defiance State Park to your itinerary. Check out what more to see and do in Expedia's Cairo guide.
What's the seasonal weather like in Cairo?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Cairo is 61 inches.