A large white dome building with a red brick base, surrounded by green trees and a clear blue sky.

Search Vacation Homes in Central Missouri

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
23 Oct - 25 Oct
In two months
4 Dec - 6 Dec
In three months
1 Jan - 3 Jan
In four months
29 Jan - 31 Jan

Our top choices for Central Missouri vacation homes

A modern living room with a dining area, a flat-screen TV mounted on the wall, and a door leading to another room.

1. Jefferson City Bungalow: Hot Tub & Patio!

Jefferson City Bungalow: Hot Tub & Patio!
Jefferson City
9.0 out of 10, Wonderful, (9 reviews)
"Clean and perfect location. Hot tub and message chair were great! "
United States
Heather I.
The price is AED 309
AED 1,027 total
includes taxes & fees
5 Nov - 6 Nov
Jefferson City Bungalow: Hot Tub & Patio!
A staircase with wooden steps and white walls, leading to a room with a green wall and a door labeled "Guest Room."

2. The Big House, Historic 4-Bedroom Home With Custom Art And Dedicated Workspace

The Big House, Historic 4-Bedroom Home With Custom Art And Dedicated Workspace
Jefferson City
9.8 out of 10, Exceptional, (47 reviews)
"A phenomenal stay. Great atmosphere; a truly unique experience with the artwork as well as tongue-in-cheek names for the spaces. By far our favorite spot during our week-long travels across Missouri. Great location. An amazing house - a historic home in every sense of the word; and the best value of any place we stayed. Coupled with exceptional places to eat or have a drink within walking distance, and even more within a 2-mile drive, staying at the Big House made Jefferson City our...
United States
pat
The price is AED 691
AED 1,107 total
includes taxes & fees
13 Oct - 14 Oct
The Big House, Historic 4-Bedroom Home With Custom Art And Dedicated Workspace
A modern living room with a sectional sofa, a round coffee table, and a flat-screen TV.

3. Historic 4-bedroom pet friendly rental close to downtown.

Historic 4-bedroom pet friendly rental close to downtown.
Jefferson City
9.8 out of 10, Exceptional, (13 reviews)
"We loved staying here! Would definitely book again. "
United States
Hannah E.
The price is AED 735
AED 1,660 total
includes taxes & fees
12 Oct - 13 Oct
Historic 4-bedroom pet friendly rental close to downtown.
A covered patio with string lights, wicker furniture, and a ceiling fan.

4. Tranquil 3-bedroom house with AC in Holts Summit

Tranquil 3-bedroom house with AC in Holts Summit
Holts Summit
10.0 out of 10, Exceptional, (5 reviews)
"Great property in a convenient location"
United States
Camren B.
The price is AED 559
AED 829 total
includes taxes & fees
12 Oct - 13 Oct
Tranquil 3-bedroom house with AC in Holts Summit
A modern kitchen with dark cabinets, stainless steel appliances, and a wooden dining table.

5. 3-bedroom Ranch Duplex in charming Columbia with WiFi, 6 miles to Mizzou Arena

3-bedroom Ranch Duplex in charming Columbia with WiFi, 6 miles to Mizzou Arena
Columbia
9.6 out of 10, Exceptional, (15 reviews)
"Great place to stay! "
United States
Stacy B.
The price is AED 489
AED 1,272 total
includes taxes & fees
12 Oct - 13 Oct
3-bedroom Ranch Duplex in charming Columbia with WiFi, 6 miles to Mizzou Arena
A spacious living area with a sofa, a patterned ottoman, and a fireplace.

6. Whispering Woods Hideaway ~ Large Home ~ 85 in TV

Whispering Woods Hideaway ~ Large Home ~ 85 in TV
Columbia
10.0 out of 10, Exceptional, (5 reviews)
"Clean house. Very responsive"
United States
Gary B.
The price is AED 536
AED 1,750 total
includes taxes & fees
12 Oct - 13 Oct
Whispering Woods Hideaway ~ Large Home ~ 85 in TV
A wooden bench with a large mirror, a white vase with flowers, a small wooden sculpture, and a globe.

7. Cozy Home on the edge of Rolla!

Cozy Home on the edge of Rolla!
Rolla
9.6 out of 10, Exceptional, (23 reviews)
"Stay was exactly as described, no issues whatsoever. It’s perfectly located for quick access to everything. Would definitely stay again if we make another trip to the area!"
United States
Jesse C.
The price is AED 257
AED 607 total
includes taxes & fees
12 Oct - 13 Oct
Cozy Home on the edge of Rolla!
A modern kitchen with white cabinets, a stainless steel dishwasher, and a dark wooden countertop.

8. Stylish 2Bdrm Bungalow | Walkable + Well Equipped

Stylish 2Bdrm Bungalow | Walkable + Well Equipped
Rolla
10.0 out of 10, Exceptional, (34 reviews)
"Everything we needed to be comfortable was there. Clean and beautifully decorated."
United States
Valerie
The price is AED 182
AED 825 total
includes taxes & fees
14 Oct - 15 Oct
Stylish 2Bdrm Bungalow | Walkable + Well Equipped
A bedroom with a bed, bedside table, bench, and a window with curtains.

9. Simply Sweet 3 Bedroom Home - near MS&T & Fort Leonard Wood

Simply Sweet 3 Bedroom Home - near MS&T & Fort Leonard Wood
Rolla
9.4 out of 10, Exceptional, (49 reviews)
"Great stay!!"
United States
Liz H.
The price is AED 312
AED 819 total
includes taxes & fees
18 Oct - 19 Oct
Simply Sweet 3 Bedroom Home - near MS&T & Fort Leonard Wood
A white entertainment center with a flat-screen TV, decorative items, and a remote control.

10. 10min from MIZZOU/Univ Hospital/downtown! Family sized, CLEAN! Short term avail!

10min from MIZZOU/Univ Hospital/downtown! Family sized, CLEAN! Short term avail!
Columbia
9.8 out of 10, Exceptional, (50 reviews)
"Very comfortable and friendly host!"
United States
Troy V.
The price is AED 426
AED 743 total
includes taxes & fees
13 Oct - 14 Oct
10min from MIZZOU/Univ Hospital/downtown! Family sized, CLEAN! Short term avail!
A kitchen with white cabinets, a microwave, a refrigerator, and a wooden dining table.

11. Cozy 2-bedroom house in Cuba, MO.

Cozy 2-bedroom house in Cuba, MO.
Cuba
9.8 out of 10, Exceptional, (7 reviews)
"Nice spot by Route 66"
United States
Ann W.
The price is AED 309
AED 452 total
includes taxes & fees
13 Oct - 14 Oct
Cozy 2-bedroom house in Cuba, MO.
A modern living room with a grey sofa set, a coffee table, and a fireplace. There are large windows providing natural light and a view of greenery outside.

12. Newly Built Home w/ Fresh Design!

Newly Built Home w/ Fresh Design!
Columbia
9.8 out of 10, Exceptional, (26 reviews)
"Great place and great house!"
United States
Dan R.
The price is AED 698
AED 1,279 total
includes taxes & fees
13 Oct - 14 Oct
Newly Built Home w/ Fresh Design!
A kitchen with a wooden floor, white cabinets, a black refrigerator, and a wooden bench.

13. Home Away From Home

Home Away From Home
Warrensburg
10.0 out of 10, Exceptional, (48 reviews)
"Place was excellent!!"
United States
Garrett
The price is AED 417
AED 737 total
includes taxes & fees
12 Oct - 13 Oct
Home Away From Home
A dining table set with plates, glasses, and a decorative centerpiece.

14. Cozy House On The HILL Military Family Favorite

Cozy House On The HILL Military Family Favorite
Waynesville
10.0 out of 10, Exceptional, (66 reviews)
"We had a wonderful stay! The house was beautiful, and the location was perfect—close enough to walk to downtown and just a short drive to Ft. Leonard Wood. We had a great time exploring the area, and the host was responsive and easy to communicate with throughout our stay. We would happily stay here again!"
United States
Wylie M.
The price is AED 436
AED 777 total
includes taxes & fees
12 Oct - 13 Oct
Cozy House On The HILL Military Family Favorite
A bedroom with a sloped ceiling, a bed, a chair, a dresser, and a window.

15. Relax Enjoy Country Living-Hot Tub & Seasonal Pool

Relax Enjoy Country Living-Hot Tub & Seasonal Pool
New Franklin
10.0 out of 10, Exceptional, (11 reviews)
"We really enjoyed our stay. It is such a tranquil property and Jill was an amazing host. "
United States
Mike P.
The price is AED 711
AED 1,489 total
includes taxes & fees
12 Oct - 13 Oct
Relax Enjoy Country Living-Hot Tub & Seasonal Pool
A modern kitchen with white cabinets, a stainless steel refrigerator, and a central island.

16. Haven House New Comfortable and Clean Retreat

Haven House New Comfortable and Clean Retreat
Sedalia
10.0 out of 10, Exceptional, (39 reviews)
"Awesome place to stay in Sedalia, beautiful cosy home. Top notch host. Would definitely recommend and stay again."
Canada
James
The price is AED 584
AED 712 total
includes taxes & fees
26 Oct - 27 Oct
Haven House New Comfortable and Clean Retreat
A living room with a grey sofa, a coffee table, and a flat-screen TV. There are two potted plants and a clock on the wall.

17. Cozy 2-Bedroom House in Enchanting Rolla with AC Comfort

Cozy 2-Bedroom House in Enchanting Rolla with AC Comfort
Rolla
10.0 out of 10, Exceptional, (1 review)
"Great location with clean house."
United States
Kevin R.
The price is AED 429
AED 850 total
includes taxes & fees
13 Oct - 14 Oct
Cozy 2-Bedroom House in Enchanting Rolla with AC Comfort
A living room with a sofa, a patterned armchair, a television on a stand, and a lamp.

18. Relax Enjoy Mid-Missouri with Fenced in Back Yard

Relax Enjoy Mid-Missouri with Fenced in Back Yard
Boonville
10.0 out of 10, Exceptional, (18 reviews)
"Good location for the wedding and other family members"
United States
Deborah
The price is AED 630
AED 1,361 total
includes taxes & fees
21 Oct - 22 Oct
Relax Enjoy Mid-Missouri with Fenced in Back Yard
A living room with a fireplace, a television mounted above it, and a sofa.

19. Downtown Retreat with large privacy fenced yard. Pet Friendly!

Downtown Retreat with large privacy fenced yard. Pet Friendly!
Warrensburg
10.0 out of 10, Exceptional, (68 reviews)
"Nice place to stay in Warrensburg"
United States
Jon S.
The price is AED 417
AED 649 total
includes taxes & fees
12 Oct - 13 Oct
Downtown Retreat with large privacy fenced yard. Pet Friendly!
A living room with a sofa, armchair, coffee table, and a rug.

20. Pet-friendly 2BR with fenced yard

Pet-friendly 2BR with fenced yard
Saint James
9.8 out of 10, Exceptional, (28 reviews)
"Great stay, great accommodations, very clean place to stay. "
United States
Jake B.
The price is AED 378
AED 956 total
includes taxes & fees
21 Oct - 22 Oct
Pet-friendly 2BR with fenced yard
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Central Missouri Hotel Reviews

Stoney Creek Hotel Columbia

Stoney Creek Hotel Columbia

8/10 Good
"Location is great, we love the proximity to trails and the quiet location. If we had to complain it would be about our mattress. Not a great mattress in room 268"
Ami 2-night trip
Posted 1 hour ago
Stoney Creek Hotel Columbia

Explore a world of travel with Expedia