Find Family Hotels in Charleston, MO

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Charleston Family Hotels

Tonight
2 Nov - 3 Nov
Tomorrow
3 Nov - 4 Nov
Next weekend
7 Nov - 9 Nov
In two weeks
14 Nov - 16 Nov

Top Charleston Family Hotels

Desk, laptop workspace, blackout drapes, iron/ironing board
Quality Inn Charleston - Sikeston
Quality Inn Charleston - Sikeston
2.5 star property
6.8 out of 10, (406)
"I consistently choose to stay there due to positive past encounters."
United States
IMTIAZ
The price is AED 241
AED 268 total
includes taxes & fees
9 Nov - 10 Nov
Quality Inn Charleston - Sikeston
Front of property - evening/night
Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
6.6 out of 10, (602)
"Tracey Allen checked me in. She was great!"
United States
Timothy
The price is AED 203
AED 225 total
includes taxes & fees
4 Nov - 5 Nov
Super 8 by Wyndham Charleston/Sikeston East MO
Lobby
Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau West
2.5 star property
9.0 out of 10, Wonderful, (1004)
"Everything was clean and looked newly renovated. Staff was friendly. Parking was convenient and the area seemed safe. "
United States
Lisa
The price is AED 257
AED 290 total
includes taxes & fees
3 Nov - 4 Nov
Pear Tree Inn Cape Girardeau West
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
9.6 out of 10, Exceptional, (1001)
"Great place"
United States
Eric
The price is AED 345
AED 389 total
includes taxes & fees
14 Nov - 15 Nov
Drury Plaza Hotel Cape Girardeau Conference Center
Property amenity
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
3.0 star property
9.4 out of 10, Exceptional, (1001)
"Great staff. "
United States
Troy
The price is AED 345
AED 397 total
includes taxes & fees
9 Nov - 10 Nov
Drury Inn & Suites Sikeston, MO
Lobby
Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
9.4 out of 10, Exceptional, (133)
"Excellent hotel…"
United States
Danny
The price is AED 323
AED 365 total
includes taxes & fees
30 Nov - 1 Dec
Fairfield Inn & Suites by Marriott Cape Girardeau
Lobby
Quality Inn Cairo I-57
Quality Inn Cairo I-57
2.5 star property
6.6 out of 10, (271)
"We had a quiet and convenient one night stay. "
United States
Cindy
The price is AED 246
AED 273 total
includes taxes & fees
14 Nov - 15 Nov
Quality Inn Cairo I-57
Lobby
Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 star property
9.4 out of 10, Exceptional, (1002)
"Everything was up to par. Enjoyed our stay. "
United States
Greg
The price is AED 283
AED 325 total
includes taxes & fees
9 Nov - 10 Nov
Pear Tree Inn Sikeston
Property amenity
Candlewood Suites Cape Girardeau by IHG
Candlewood Suites Cape Girardeau by IHG
2.5 star property
8.0 out of 10, Very Good, (864)
"Great staff and convenient location "
United States
Greg
The price is AED 283
AED 339 total
includes taxes & fees
16 Nov - 17 Nov
Candlewood Suites Cape Girardeau by IHG
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
9.0 out of 10, Wonderful, (1004)
"Always enjoy our stay. Staff is very friendly, especially at breakfast! "
United States
Paul
The price is AED 257
AED 290 total
includes taxes & fees
6 Nov - 7 Nov
Pear Tree Inn Cape Girardeau Near the Medical Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Charleston Hotel Reviews

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

10/10 Excellent
"The room was spacious, clean and comfortable and the staff were helpful and friendly! This is a great place to stay!"
Dean 1-night trip
Posted 22 hours ago
Hampton Inn Cape Girardeau I 55 East

Explore a world of travel with Expedia

Frequently asked questions

What's Charleston like for family-friendly vacations?
The destination of Charleston is a good option if you've been considering a getaway with the kids. The entertainment, theaters, and restaurants are just a few things that make this an attractive family vacation spot. Arrange a flight into Cairo, IL (CIR-Cairo Regional), which is located 11.8 mi (19 km) from the city center.
When's the best time to book a family-friendly vacation in Charleston?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Charleston is 59 inches.
What's there to see and do with your family in Charleston?
While you and the family are vacationing in Charleston, you might want to check out some of the attractions here such as Front Street Studio & Art Gallery, Mississippi River, and Ohio River. Make sure you have lots of time for activities like Shawnee National Forest and Ohio River Valley.