Photo by Jessica King

Find Resorts & Hotels with Spas in De Soto, MO

Start date: Check-in selected.
To Date
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on De Soto Resorts & Hotels with Spas

Next weekend
In two weeks

Top De Soto Resorts & Hotels with Spas

We don't have any properties that match your exact search
See all properties in De Soto

Recommended hotels in De Soto

Pear Tree Inn St. Louis Arnold

2.5 star property
9.2 out of 10, Wonderful, (1002)
"Clean, comfortable and pleasant stay."
The price is AED 331
AED 382 total
includes taxes & fees
13 Oct - 14 Oct
Pear Tree Inn St. Louis Arnold

Drury Inn & Suites St. Louis Arnold

3.0 star property
9.6 out of 10, Exceptional, (1000)
"The hotel staff was very helpful and friendly. The breakfast and dinner were an awesome treat."
The price is AED 411
AED 476 total
includes taxes & fees
2 Nov - 3 Nov
Drury Inn & Suites St. Louis Arnold

The Conner House B&B

3.5 star property
10.0 out of 10, Exceptional, (18)
"Connie’s house was beautiful and historically very rich. She is so sweet and kind. Breakfast was great. Would love to come back again. "
The price is AED 505
AED 561 total
includes taxes & fees
22 Oct - 23 Oct
The Conner House B&B

82 Acre Hobby Farm with Lincoln Log Cabin

10.0 out of 10, Exceptional, (39)
"We absolutely loved our stay! The property is as listed and super clean. The owner was very easy to work with, considerate and the personal touches she provided put our stay over the top."
The price is AED 551
AED 996 total
includes taxes & fees
13 Oct - 14 Oct
82 Acre Hobby Farm with Lincoln Log Cabin

Lovely 2-bedroom apartment with WIFI/PRIVATE PARKING/LAUNDRY

2.0 star property
The price is AED 511
AED 584 total
includes taxes & fees
31 Oct - 1 Nov
Lovely 2-bedroom apartment with WIFI/PRIVATE PARKING/LAUNDRY

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 star property
8.0 out of 10, Very Good, (1003)
"Great location"
The price is AED 197
AED 224 total
includes taxes & fees
26 Oct - 27 Oct
Baymont Inn and Suites by Wyndham Farmington, MO

Super 8 by Wyndham Farmington

2.0 star property
8.0 out of 10, Very Good, (590)
"Clean, friendly staff, quiet"
The price is AED 219
AED 249 total
includes taxes & fees
12 Oct - 13 Oct
Super 8 by Wyndham Farmington

Corner George Inn Bed & Breakfast

2.5 star property
9.0 out of 10, Wonderful, (153)
"Hosts were excellent, very quiet and the breakfast was wonderful"
The price is AED 435
AED 482 total
includes taxes & fees
14 Oct - 15 Oct
Corner George Inn Bed & Breakfast

Newly remodeled house minutes away from downtown, golf courses + BIG back yard

2.0 star property
9.8 out of 10, Exceptional, (18)
"This property worked well for our needs. Very convenient location to gas, food and golf course. "
The price is AED 481
AED 921 total
includes taxes & fees
3 Nov - 4 Nov
Newly remodeled house minutes away from downtown, golf courses + BIG back yard

Hampton Inn Farmington

2.5 star property
8.8 out of 10, Excellent, (504)
"Had a very nice stay!"
The price is AED 546
AED 622 total
includes taxes & fees
2 Nov - 3 Nov
Hampton Inn Farmington
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about De Soto

Find out more about De Soto

Top De Soto attractions for a relaxing vacation

In De Soto, Missouri, travelers seeking a rejuvenating escape at hotels with spas will find a blend of relaxation and adventure. Start your day at the nearby Huzzah Conservation Area, where scenic trails offer opportunities for hiking and nature photography, perfect for families looking to bond in the great outdoors. After exploring, unwind at one of the local spas that provide a variety of treatments, from massages to facials, ensuring you leave feeling refreshed. For a unique experience, visit the historic downtown area where charming boutiques and cafes invite you to explore local flavors and crafts. Don't miss the chance to enjoy a family picnic at the picturesque De Soto City Park, complete with playgrounds and serene picnic areas, making it an ideal spot for relaxation after a day of activities. For accommodations, consider staying in hotel areas that prioritize wellness amenities and attentive service, ensuring that both you and your family can indulge in pampering while enjoying the beauty and charm of De Soto.

Top De Soto Hotel Reviews

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

Looking for a spa hotel in De Soto?
Soothe the senses with some time in one of our wonderful spa hotels. Hotels with spas are a great way to break out of your routine and add a layer of luxury to your vacation.
What's there to see and do in De Soto?
Enjoy all that De Soto has to offer when you visit Sunrise Lake Beach, Washington State Park, and Big River. If you have a little extra time during your trip, you might want to make a stop at Victoria Glaces Conservation Area Trailhead and Big Lake.
What is a De Soto spa hotel?
Spa hotels in De Soto provide lodging and have a full on-site spa offering services including couples massages as well as body treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.