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Check prices for these dates

In two weeks
5 Dec - 7 Dec
In two months
16 Jan - 18 Jan
In three months
13 Feb - 15 Feb
In four months
13 Mar - 15 Mar

Apartments in Defiance

Fridge, microwave, oven, stovetop
Western-Themed 2-Bedroom Hideout for Outlaws 204-2

Western-Themed 2-Bedroom Hideout for Outlaws 204-2

St. Charles Historic District
9.0 out of 10, Wonderful, (10)
"Property is very clean, the location is awesome and convenient to historic St. Charles. Plenty of shopping, restaurants and bars within walking distance. The property is perfect for a get away and relax in!!!"
United States
Stephen H.
Western-Themed 2-Bedroom Hideout for Outlaws 204-2
TV
The Historic Bricks on Main

The Historic Bricks on Main

St. Charles Historic District
9.0 out of 10, Wonderful, (13)
"Had a wonderful stay. Host was very responsive. Great stay in the middle of everything- so we could walk out and shop or grab a bite to eat. "
United States
Alison C.
The Historic Bricks on Main
Fridge, microwave, oven, stovetop
The Hidden Gem - 2BR Basement Apartment on 7 Acres

The Hidden Gem - 2BR Basement Apartment on 7 Acres

Moscow Mills
10.0 out of 10, Exceptional, (12)
"Great place, nice neighborhood. "
United States
Julie L.
The price is AED 404
AED 911 total
includes taxes & fees
20 Nov - 21 Nov
The Hidden Gem - 2BR Basement Apartment on 7 Acres
Smart TV, books, music library, computer monitors
Sunny SparkingClean King bed Apt- CreveCoeurPark

Sunny SparkingClean King bed Apt- CreveCoeurPark

Maryland Heights
9.8 out of 10, Exceptional, (12)
"Good Stay"
United States
Lanai
The price is AED 400
AED 863 total
includes taxes & fees
15 Dec - 16 Dec
Sunny SparkingClean King bed Apt- CreveCoeurPark
Fridge, microwave, oven, stovetop
Main Street Living! 2 Bedroom Unit right On Main!

Main Street Living! 2 Bedroom Unit right On Main!

St. Charles Historic District
9.6 out of 10, Exceptional, (33)
"Old House charm with modern convenience! The host responded to questions quickly, the property was kept, the location was perfect for exploring St. Charles. We would definitely stay here again! "
United States
Lauren R.
Main Street Living! 2 Bedroom Unit right On Main!
Fridge, microwave, oven, stovetop
Duplex Hideaway in St. Charles, MO

Duplex Hideaway in St. Charles, MO

St. Charles Historic District
10.0 out of 10, Exceptional, (5)
"Good location, comfortable bed, new interior, well equipped. Very clean and organized!"
United States
Steve D.
The price is AED 456
AED 998 total
includes taxes & fees
20 Nov - 21 Nov
Duplex Hideaway in St. Charles, MO
TV
Back Door Guest Suite, Zia My Retreat

Back Door Guest Suite, Zia My Retreat

New Haven
10.0 out of 10, Exceptional, (6)
"We loved staying at the Zia! It was adorable, quaint, comfortable and accommodating. Laura was a pleasure to work with and was extremely helpful. We definitely recommend!"
United States
Jess M.
The price is AED 496
AED 827 total
includes taxes & fees
20 Nov - 21 Nov
Back Door Guest Suite, Zia My Retreat
Fridge, microwave, oven, stovetop
6th street 101 - Walk to Main St

6th street 101 - Walk to Main St

St. Charles Historic District
The price is AED 327
AED 999 total
includes taxes & fees
23 Nov - 24 Nov
6th street 101 - Walk to Main St
Smart TV
Prime Loft of Main Street

Prime Loft of Main Street

St. Charles Historic District
9.8 out of 10, Exceptional, (99)
"The loft was very nice, very clean, well appointed, and in a perfect location. I highly recommend this property!"
United States
Mary ann S.
The price is AED 393
AED 870 total
includes taxes & fees
20 Nov - 21 Nov
Prime Loft of Main Street
A heated pool
Great for Business Travelers! Pool + Gym

Great for Business Travelers! Pool + Gym

O'Fallon
The price is AED 507
AED 675 total
includes taxes & fees
5 Dec - 6 Dec
Great for Business Travelers! Pool + Gym
Fridge, microwave, oven, stovetop
Amazing Renovated Historic Loft on Main Street

Amazing Renovated Historic Loft on Main Street

St. Charles Historic District
10.0 out of 10, Exceptional, (56)
"Great place and location. Owners were easy to work with."
United States
Cory M.
The price is AED 511
AED 1,022 total
includes taxes & fees
14 Dec - 15 Dec
Amazing Renovated Historic Loft on Main Street
Dining
The Lofts of North Main Street

The Lofts of North Main Street

St. Charles Historic District
9.6 out of 10, Exceptional, (149)
"Perfect location!"
United States
Tim K.
The price is AED 511
AED 1,022 total
includes taxes & fees
23 Nov - 24 Nov
The Lofts of North Main Street
Terrace/patio
Great for Business Travelers! Studio Suite Near Edward Jones! Shared Pool + Free Breakfast!

Great for Business Travelers! Studio Suite Near Edward Jones! Shared Pool + Free Breakfast!

Maryland Heights
9.6 out of 10, Exceptional, (4)
"It was an easy experience renting this place"
United States
Dominic M.
The price is AED 509
AED 664 total
includes taxes & fees
29 Nov - 30 Nov
Great for Business Travelers! Studio Suite Near Edward Jones! Shared Pool + Free Breakfast!
Fridge, microwave, oven, stovetop
AK`s STL Pearl Grey House - Game Room

AK`s STL Pearl Grey House - Game Room

Maryland Heights
9.0 out of 10, Wonderful, (7)
"My kids loved this house! It was very comfortable for my family of 7. We were able to cook dinner, play games, watch TV, and were within close proximity to all things St. Louis. We would definitely stay here again. "
United States
Tiffanny B.
The price is AED 790
AED 1,719 total
includes taxes & fees
20 Nov - 21 Nov
AK`s STL Pearl Grey House - Game Room
Fridge, microwave, stovetop, toaster
Charming Duplex on Main

Charming Duplex on Main

St. Charles Historic District
10.0 out of 10, Exceptional, (16)
"We had an AMAZING time here and you can't beat the close walking distance to main st!! Absolutely loved our stay. "
United States
Wendy K.
The price is AED 436
AED 982 total
includes taxes & fees
1 Dec - 2 Dec
Charming Duplex on Main
Fridge, microwave, oven, stovetop
Spacious 2-Bedroom Near Main St by StayLage

Spacious 2-Bedroom Near Main St by StayLage

St. Charles Historic District
8.8 out of 10, Excellent, (13)
"Great space! Very comfortable! "
United States
Mary H.
The price is AED 496
AED 1,096 total
includes taxes & fees
23 Nov - 24 Nov
Spacious 2-Bedroom Near Main St by StayLage
Smart TV
2nd Street Loft - Riverview

2nd Street Loft - Riverview

Washington
The price is AED 357
AED 709 total
includes taxes & fees
1 Dec - 2 Dec
2nd Street Loft - Riverview
1 bedroom, iron/ironing board, WiFi, bed sheets
Studio on Historic Main by StayLage

Studio on Historic Main by StayLage

St. Charles Historic District
9.0 out of 10, Wonderful, (32)
"My wife and I had a great time staying at this little place. Everything was clean and as advertised close to everything downtown within walking distance, beautiful area felt very safe. We had one small issue with the air conditioner and it was very quick to be addressed Fantastic service. We would very much stay at this unit again."
United States
Eric H.
The price is AED 357
AED 811 total
includes taxes & fees
1 Dec - 2 Dec
Studio on Historic Main by StayLage
Smart TV
The FarmHouse 3bd/2ba B&B in MO Wine Country & Katy Trail

The FarmHouse 3bd/2ba B&B in MO Wine Country & Katy Trail

Marthasville
8.6 out of 10, Excellent, (4)
"Great option for group of 5-6 riding Katy Trail "
United States
Gary G.
The price is AED 848
AED 1,490 total
includes taxes & fees
20 Nov - 21 Nov
The FarmHouse 3bd/2ba B&B in MO Wine Country & Katy Trail
Fridge, microwave, oven, stovetop
The Lilly Pad House - Doddridge

The Lilly Pad House - Doddridge

Maryland Heights
The price is AED 872
AED 1,838 total
includes taxes & fees
3 Dec - 4 Dec
The Lilly Pad House - Doddridge
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Hilton St. Louis Frontenac

Hilton St. Louis Frontenac

10/10 Excellent
"."
Elam 1-night trip
Posted 2 days ago
Hilton St. Louis Frontenac

Frequently asked questions

What's it like to stay at an apartment in Defiance?
You'll find 10 apartments to choose from in Defiance for your stay.
Why choose an apartment versus a traditional hotel?
Often more spacious than a traditional hotel room, an apartment includes a kitchen for convenient home-cooked meals. Apartments are ideal for families who want the conveniences of home, and also for couples who want something in a quieter part of town.
What's a favorite apartment for a stay in Defiance?
Here are some of the top apartments in the area: Cozy Clark Suite in Frenchtown Saint Charles: Situated in St. Charles, 19.6 mi/31.6 km from the heart of Defiance. Includes free WiFi, private balconies, and separate dining areas. Historic Main Street Heritage Retreat: Located 18.5 mi/29.7 km away in St. Charles. Private patios, sofa beds, and Smart TVs are included. Access to onsite laundry facilities is available on site. The Wild West Getaway- 204-1: Located in St. Charles, 19.1 mi/30.7 km away. Includes private patios and Smart TVs. Access to onsite laundry facilities is available on site. Prime Loft of Main Street: Located 19.2 mi/30.9 km away in St. Charles. Free WiFi, sofa beds, and Smart TVs are included. Access to onsite laundry facilities is available on site. 2-bedroom apartment in awesome West County with AC, Fitness Room and Laundry: Located in St. Louis, 17.4 mi/27.9 km from Defiance. Includes fireplaces. A fitness center and onsite laundry facilities are on site.
How many apartments will I be able to find in Defiance?
Expedia has 10 apartments to book in Defiance.
What can I expect from the weather during my trip to Defiance?
Weather is only one factor, but it can really affect your travel plans, especially if you're planning an extended stay in Defiance. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.
What are the must-see places to visit in Defiance?
Matson Hill Park Trailhead and August A. Busch Memorial Conservation Area are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. While here, Yellow Farmhouse Winery and Chandler Hill Vineyards are other places worth a visit.
What's the best way to get to and around Defiance?
Knowing a bit about the transportation options can save you time when you get to your destination. Fly into St. Louis, MO (SUS-Spirit of St. Louis), which is located 7.5 mi (12 km) from the heart of the city. You can also search for flights into St. Louis Lambert Intl. Airport (STL), which is 23.5 mi (37.8 km) away. If you'd like to explore around the area, you may want a rental car for your journey.