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Check prices for these dates

In two weeks
30 Jan - 1 Feb
In two months
13 Mar - 15 Mar
In three months
10 Apr - 12 Apr
In four months
8 May - 10 May

Our top choices for Defiance apartments

Exterior
Sunny SparkingClean King bed Apt- CreveCoeurPark

Apartment in Maryland Heights

Sunny SparkingClean King bed Apt- CreveCoeurPark
9.8 out of 10, Exceptional, (12 reviews)
"Good Stay"
United States
Lanai
The price is AED 400
AED 863 total
includes taxes & fees
14 Jan - 15 Jan
Sunny SparkingClean King bed Apt- CreveCoeurPark
TV
6th street 101 - Walk to Main St

Apartment in St. Charles Historic District

6th street 101 - Walk to Main St
10.0 out of 10, Exceptional, (1 review)
The price is AED 301
AED 966 total
includes taxes & fees
14 Jan - 15 Jan
6th street 101 - Walk to Main St
TV, fireplace
2-bedroom apartment in awesome West County with AC, Fitness Room and Laundry

Apartment in St. Louis

2-bedroom apartment in awesome West County with AC, Fitness Room and Laundry
The price is AED 279
AED 444 total
includes taxes & fees
25 Jan - 26 Jan
2-bedroom apartment in awesome West County with AC, Fitness Room and Laundry
Exterior
2nd Street -Deck Suite (back entrance)

Apartment in Washington

2nd Street -Deck Suite (back entrance)
2.0 star property
10.0 out of 10, Exceptional, (2 reviews)
"Easy check in/check out, super nice host! Very clean space. "
United States
Emily L.
The price is AED 365
AED 707 total
includes taxes & fees
25 Jan - 26 Jan
2nd Street -Deck Suite (back entrance)
Interior
Amazing Renovated Historic Loft on Main Street

Apartment in St. Charles Historic District

Amazing Renovated Historic Loft on Main Street
10.0 out of 10, Exceptional, (58 reviews)
"Great place and location. Owners were easy to work with."
United States
Cory M.
The price is AED 437
AED 927 total
includes taxes & fees
14 Jan - 15 Jan
Amazing Renovated Historic Loft on Main Street
Fridge, microwave, oven, stovetop
The Hidden Gem - 2BR Basement Apartment on 7 Acres

Apartment in Moscow Mills

The Hidden Gem - 2BR Basement Apartment on 7 Acres
10.0 out of 10, Exceptional, (12 reviews)
"Great place, nice neighborhood. "
United States
Julie L.
The Hidden Gem - 2BR Basement Apartment on 7 Acres
Fridge, microwave, oven, stovetop
Main Street Living! 2 Bedroom Unit right On Main!

Apartment in St. Charles Historic District

Main Street Living! 2 Bedroom Unit right On Main!
9.6 out of 10, Exceptional, (34 reviews)
"Great Stay and great location! "
United States
Angela
The price is AED 444
AED 1,256 total
includes taxes & fees
14 Jan - 15 Jan
Main Street Living! 2 Bedroom Unit right On Main!
Interior
The Historic Bricks on Main

Apartment in St. Charles Historic District

The Historic Bricks on Main
9.0 out of 10, Wonderful, (14 reviews)
"Had a wonderful stay. Host was very responsive. Great stay in the middle of everything- so we could walk out and shop or grab a bite to eat. "
United States
Alison C.
The price is AED 298
AED 724 total
includes taxes & fees
14 Jan - 15 Jan
The Historic Bricks on Main
Smart TV
Prime Loft of Main Street

Apartment in St. Charles Historic District

Prime Loft of Main Street
9.8 out of 10, Exceptional, (104 reviews)
"The loft was very nice, very clean, well appointed, and in a perfect location. I highly recommend this property!"
United States
Mary ann S.
The price is AED 400
AED 867 total
includes taxes & fees
18 Jan - 19 Jan
Prime Loft of Main Street
Living area
The Cul-de-Sac Retreat

Apartment in Saint Charles

The Cul-de-Sac Retreat
8.4 out of 10, Very Good, (9 reviews)
"Great house, great location - close to the St. Charles convention center"
United States
Joe H.
The price is AED 588
AED 1,120 total
includes taxes & fees
14 Jan - 15 Jan
The Cul-de-Sac Retreat
TV
Spacious 2-Bedroom Near Main St by StayLage

Apartment in St. Charles Historic District

Spacious 2-Bedroom Near Main St by StayLage
8.8 out of 10, Excellent, (13 reviews)
"Great space! Very comfortable! "
United States
Mary H.
Spacious 2-Bedroom Near Main St by StayLage
1 bedroom, WiFi, bed sheets
Duplex Hideaway in St. Charles, MO

Apartment in St. Charles Historic District

Duplex Hideaway in St. Charles, MO
10.0 out of 10, Exceptional, (5 reviews)
"I will stay here again. It was a great location for my visit. Lots of room and amenities. Highly recommend this location if you are visiting the St Louis area. Barely a mile to get to Hwy 70, so easy access to St Louis, St Peter's, Wentzville etc. Maybe two blocks from Historic St Charles and Ameristar Casino."
United States
Karen M.
The price is AED 313
AED 804 total
includes taxes & fees
19 Jan - 20 Jan
Duplex Hideaway in St. Charles, MO
TV
Back Door Guest Suite, Zia My Retreat

Apartment in New Haven

Back Door Guest Suite, Zia My Retreat
10.0 out of 10, Exceptional, (6 reviews)
"Very comfortable, spacious, great location for canoe trip. "
United States
Carolyn B.
The price is AED 496
AED 824 total
includes taxes & fees
14 Jan - 15 Jan
Back Door Guest Suite, Zia My Retreat
Interior
The Lofts of North Main Street

Apartment in St. Charles Historic District

The Lofts of North Main Street
9.6 out of 10, Exceptional, (157 reviews)
"Perfect location!"
United States
Tim K.
The price is AED 400
AED 878 total
includes taxes & fees
25 Jan - 26 Jan
The Lofts of North Main Street
Dining
Great for Business Travelers! Studio Suite Near Edward Jones! Shared Pool + Free Breakfast!

Apartment in Maryland Heights

Great for Business Travelers! Studio Suite Near Edward Jones! Shared Pool + Free Breakfast!
9.6 out of 10, Exceptional, (4 reviews)
"It was an easy experience renting this place"
United States
Dominic M.
The price is AED 509
AED 664 total
includes taxes & fees
16 Jan - 17 Jan
Great for Business Travelers! Studio Suite Near Edward Jones! Shared Pool + Free Breakfast!
Fridge, microwave, stovetop, toaster
Charming Duplex on Main

Apartment in St. Charles Historic District

Charming Duplex on Main
10.0 out of 10, Exceptional, (16 reviews)
"We had an AMAZING time here and you can't beat the close walking distance to main st!! Absolutely loved our stay. "
United States
Wendy K.
The price is AED 325
AED 829 total
includes taxes & fees
25 Jan - 26 Jan
Charming Duplex on Main
Exterior
Studio on Historic Main by StayLage

Apartment in St. Charles Historic District

Studio on Historic Main by StayLage
9.0 out of 10, Wonderful, (33 reviews)
"Nice property.. Clean. "
United States
Belinda J.
The price is AED 270
AED 692 total
includes taxes & fees
25 Jan - 26 Jan
Studio on Historic Main by StayLage
A heated pool
Great for Business Travelers! Pool + Gym

Apartment in O'Fallon

Great for Business Travelers! Pool + Gym
The price is AED 473
AED 634 total
includes taxes & fees
25 Jan - 26 Jan
Great for Business Travelers! Pool + Gym
Interior
AK`s STL Pearl Grey House - Game Room

Apartment in Maryland Heights

AK`s STL Pearl Grey House - Game Room
9.0 out of 10, Wonderful, (8 reviews)
"My kids loved this house! It was very comfortable for my family of 7. We were able to cook dinner, play games, watch TV, and were within close proximity to all things St. Louis. We would definitely stay here again. "
United States
Tiffanny B.
The price is AED 785
AED 1,714 total
includes taxes & fees
14 Jan - 15 Jan
AK`s STL Pearl Grey House - Game Room
Smart TV
The FarmHouse 3bd/2ba B&B in MO Wine Country & Katy Trail

Apartment in Marthasville

The FarmHouse 3bd/2ba B&B in MO Wine Country & Katy Trail
8.6 out of 10, Excellent, (4 reviews)
"Great option for group of 5-6 riding Katy Trail "
United States
Gary G.
The price is AED 848
AED 1,490 total
includes taxes & fees
14 Jan - 15 Jan
The FarmHouse 3bd/2ba B&B in MO Wine Country & Katy Trail
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis

10/10 Excellent
"Very nice and friendly staff"
Pamela 5-night trip
Posted 1 day ago
Drury Inn & Suites Southwest St. Louis

Frequently asked questions

What's it like to stay at an apartment in Defiance?
You'll find 10 apartments to choose from in Defiance for your stay.
Why choose an apartment versus a traditional hotel?
Often more spacious than a traditional hotel room, an apartment includes a kitchen for convenient home-cooked meals. Apartments are ideal for families who want the conveniences of home, and also for couples who want something in a quieter part of town.
What's a favorite apartment for a stay in Defiance?
Here's a top apartment in the area: 'the Ruebling House': Bright, Modern, & Renovated!: Situated in Defiance, 0.1 mi/0.2 km from the heart of Defiance.
How many apartments will I be able to find in Defiance?
Expedia has 10 apartments to book in Defiance.
What can I expect from the weather during my trip to Defiance?
Weather is only one factor, but it can really affect your travel plans, especially if you're planning an extended stay in Defiance. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.
What are the must-see places to visit in Defiance?
Matson Hill Park Trailhead and August A. Busch Memorial Conservation Area are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. While here, Yellow Farmhouse Winery and Chandler Hill Vineyards are other places worth a visit.
What's the best way to get to and around Defiance?
Knowing a bit about the transportation options can save you time when you get to your destination. Fly into St. Louis, MO (SUS-Spirit of St. Louis), which is located 7.5 mi (12 km) from the heart of the city. You can also search for flights into St. Louis Lambert Intl. Airport (STL), which is 23.5 mi (37.8 km) away. If you'd like to explore around the area, you may want a rental car for your journey.