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Check prices for these dates

In two weeks
17 Oct - 19 Oct
In one month
31 Oct - 2 Nov
In two months
28 Nov - 30 Nov
In three months
26 Dec - 28 Dec

Apartments in Defiance

Amazing Renovated Historic Loft on Main Street
Fridge, microwave, oven, stovetop

Amazing Renovated Historic Loft on Main Street

10.0 out of 10, Exceptional, (55)
"Perfect location. Spacious and clean!"
The price is AED 360
AED 814 total
includes taxes & fees
7 Oct - 8 Oct
Amazing Renovated Historic Loft on Main Street
Sunny SparkingClean King bed Apt- CreveCoeurPark
Smart TV, books, music library, computer monitors

Sunny SparkingClean King bed Apt- CreveCoeurPark

9.8 out of 10, Exceptional, (12)
"Good Stay"
The price is AED 386
AED 856 total
includes taxes & fees
6 Oct - 7 Oct
Sunny SparkingClean King bed Apt- CreveCoeurPark
Wentzville King Bed Walk to Downtown!
Fridge, microwave, oven, stovetop

Wentzville King Bed Walk to Downtown!

2.0 star property
The price is AED 460
AED 1,270 total
includes taxes & fees
7 Oct - 8 Oct
Wentzville King Bed Walk to Downtown!
The Hidden Gem - 2BR Basement Apartment on 7 Acres
Fridge, microwave, oven, stovetop

The Hidden Gem - 2BR Basement Apartment on 7 Acres

10.0 out of 10, Exceptional, (12)
"Great place, nice neighborhood. "
The price is AED 404
AED 922 total
includes taxes & fees
9 Oct - 10 Oct
The Hidden Gem - 2BR Basement Apartment on 7 Acres
Studio on Historic Main by StayLage
1 bedroom, iron/ironing board, WiFi, bed sheets

Studio on Historic Main by StayLage

9.2 out of 10, Wonderful, (31)
"From the welcome email with clear concise directions on how to enter with door codes to a dwelling that had everything I needed with a very comfortable bed, it was a great stay and I wanted for nothing."
The price is AED 337
AED 770 total
includes taxes & fees
7 Oct - 8 Oct
Studio on Historic Main by StayLage
Back Door Guest Suite, Zia My Retreat
TV

Back Door Guest Suite, Zia My Retreat

10.0 out of 10, Exceptional, (5)
"Beautiful relaxing place in adorable neighborhood! Quite the find!"
The price is AED 496
AED 824 total
includes taxes & fees
6 Oct - 7 Oct
Back Door Guest Suite, Zia My Retreat
1st Capitol Mansion - Suite 401
Private kitchen

1st Capitol Mansion - Suite 401

8.4 out of 10, Very Good, (7)
"Nice property and a great location to all the shops and restaurants that St. Charles has to offer. The place was clean and nicely updated. Will definitely stay here again!"
The price is AED 364
AED 914 total
includes taxes & fees
2 Nov - 3 Nov
1st Capitol Mansion - Suite 401
Private Basement Retreat w/ HOT TUB by StayLage
TV

Private Basement Retreat w/ HOT TUB by StayLage

9.0 out of 10, Wonderful, (7)
"My husband could not say enough about his stay. We not only recommend this place but will stay there again. Great communication and a beautiful space!"
The price is AED 317
AED 853 total
includes taxes & fees
7 Oct - 8 Oct
Private Basement Retreat w/ HOT TUB by StayLage
PinkeVilla- Girls Dream Decor
Terrace/patio

PinkeVilla- Girls Dream Decor

2.0 star property
The price is AED 918
AED 1,954 total
includes taxes & fees
6 Oct - 7 Oct
PinkeVilla- Girls Dream Decor
Western-Themed 2-Bedroom Hideout for Outlaws 204-2
Fridge, microwave, oven, stovetop

Western-Themed 2-Bedroom Hideout for Outlaws 204-2

9.2 out of 10, Wonderful, (9)
"This place was a gem! Cozy, spotless, and stylish, with thoughtful touches. Perfect location, comfy beds, and a vibe that made us feel right at home. Can’t wait to return!"
The price is AED 327
AED 1,026 total
includes taxes & fees
9 Oct - 10 Oct
Western-Themed 2-Bedroom Hideout for Outlaws 204-2
6th street 101 - Walk to Main St
Fridge, microwave, oven, stovetop

6th street 101 - Walk to Main St

The price is AED 327
AED 1,010 total
includes taxes & fees
6 Oct - 7 Oct
6th street 101 - Walk to Main St
The Historic Bricks on Main
TV

The Historic Bricks on Main

9.0 out of 10, Wonderful, (12)
"Love how close it is to everything. Very clean. Would stay there again. "
The Historic Bricks on Main
The Lofts of North Main Street
Dining

The Lofts of North Main Street

9.6 out of 10, Exceptional, (147)
"Perfect location!"
The price is AED 360
AED 814 total
includes taxes & fees
7 Oct - 8 Oct
The Lofts of North Main Street
Duplex Hideaway in St. Charles, MO
Fridge, microwave, oven, stovetop

Duplex Hideaway in St. Charles, MO

10.0 out of 10, Exceptional, (4)
"Good location, comfortable bed, new interior, well equipped. Very clean and organized!"
The price is AED 456
AED 1,013 total
includes taxes & fees
8 Oct - 9 Oct
Duplex Hideaway in St. Charles, MO
Prime Loft of Main Street
Smart TV

Prime Loft of Main Street

9.8 out of 10, Exceptional, (99)
"This is a great property located in wiyhin walking distance to shops restaurants and interesting things to see"
The price is AED 360
AED 814 total
includes taxes & fees
6 Oct - 7 Oct
Prime Loft of Main Street
Charming Duplex on Main
Fridge, microwave, stovetop, toaster

Charming Duplex on Main

10.0 out of 10, Exceptional, (15)
"We had an AMAZING time here and you can't beat the close walking distance to main st!! Absolutely loved our stay. "
The price is AED 456
AED 998 total
includes taxes & fees
2 Nov - 3 Nov
Charming Duplex on Main
AK`s STL Pearl Grey House - Game Room
Fridge, microwave, oven, stovetop

AK`s STL Pearl Grey House - Game Room

9.0 out of 10, Wonderful, (7)
"Quiet neighborhood, comfortable house, well-stocked kitchen. We would stay here again."
The price is AED 808
AED 1,763 total
includes taxes & fees
6 Oct - 7 Oct
AK`s STL Pearl Grey House - Game Room
New lisiting Sale! 3King Bed
Fridge, microwave, oven, stovetop

New lisiting Sale! 3King Bed

The price is AED 1,010
AED 1,994 total
includes taxes & fees
6 Oct - 7 Oct
New lisiting Sale! 3King Bed
Main Street Living! 2 Bedroom Unit right On Main!
Fridge, microwave, oven, stovetop

Main Street Living! 2 Bedroom Unit right On Main!

10.0 out of 10, Exceptional, (31)
"Old House charm with modern convenience! The host responded to questions quickly, the property was kept, the location was perfect for exploring St. Charles. We would definitely stay here again! "
Main Street Living! 2 Bedroom Unit right On Main!
FALL SALE,Cozy 2BR Chalet, W/ Hot Tub on 1.2 Private Acres!
Exterior

FALL SALE,Cozy 2BR Chalet, W/ Hot Tub on 1.2 Private Acres!

6.0 out of 10, (1)
"The house was clean and cute but smaller than we expected. The 2nd bedroom was very small and while it technically could sleep two, with the bottom mattress pulled out, it just wasn't the best experience. The master bedroom was spacious and bed was comfortable."
The price is AED 771
AED 1,854 total
includes taxes & fees
9 Oct - 10 Oct
FALL SALE,Cozy 2BR Chalet, W/ Hot Tub on 1.2 Private Acres!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66

10/10 Excellent
"Continues to be our stop, friendly staff, clean room, quiet area."
Dennis 1-night trip
Posted 17 hours ago
Wingate by Wyndham St. Louis/Fenton Route 66

Frequently asked questions

What's it like to stay at an apartment in Defiance?
You'll find 10 apartments to choose from in Defiance for your stay.
Why choose an apartment versus a traditional hotel?
Often more spacious than a traditional hotel room, an apartment includes a kitchen for convenient home-cooked meals. Apartments are ideal for families who want the conveniences of home, and also for couples who want something in a quieter part of town.
What's a favorite apartment for a stay in Defiance?
Here's a top apartment in the area: 'the Ruebling House' Historic Defiance Apartment!: Situated in Defiance, 0.1 mi/0.2 km from the heart of Defiance.
How many apartments will I be able to find in Defiance?
Expedia has 10 apartments to book in Defiance.
What can I expect from the weather during my trip to Defiance?
Weather is only one factor, but it can really affect your travel plans, especially if you're planning an extended stay in Defiance. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.
What are the must-see places to visit in Defiance?
August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. While here, Yellow Farmhouse Winery and Chandler Hill Vineyards are other places worth a visit.
What's the best way to get to and around Defiance?
Knowing a bit about the transportation options can save you time when you get to your destination. Fly into St. Louis, MO (SUS-Spirit of St. Louis), which is located 7.5 mi (12 km) from the heart of the city. You can also search for flights into St. Louis Lambert Intl. Airport (STL), which is 23.5 mi (37.8 km) away. If you'd like to explore around the area, you may want a rental car for your journey.

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