A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

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Check prices for these dates

In two weeks
24 Jul - 26 Jul
In two months
4 Sep - 6 Sep
In three months
2 Oct - 4 Oct
In four months
30 Oct - 1 Nov

Our top choices for Defiance apartments

Exterior

2nd Street -Deck Suite (back entrance)

2nd Street -Deck Suite (back entrance)
Washington
10.0 out of 10, Exceptional, (6 reviews)
"Great comfortable mini apartment style."
United States
Ozzy
The price is AED 365
AED 726 total
includes taxes & fees
19 Jul - 20 Jul
2nd Street -Deck Suite (back entrance)
1 bedroom, free WiFi

1 Queen Bed | Non-Smoking, Kitchen

1 Queen Bed | Non-Smoking, Kitchen
Westport
10.0 out of 10, Exceptional, (39 reviews)
"I really enjoy it here!"
United States
Anonymous traveler
The price is AED 316
AED 366 total
includes taxes & fees
16 Jul - 17 Jul
1 Queen Bed | Non-Smoking, Kitchen
A heated pool

Great for Business Travelers! Pool + Gym

Great for Business Travelers! Pool + Gym
O'Fallon
The price is AED 500
AED 663 total
includes taxes & fees
19 Jul - 20 Jul
Great for Business Travelers! Pool + Gym
TV

Back Door Guest Suite, Zia My Retreat

Back Door Guest Suite, Zia My Retreat
New Haven
10.0 out of 10, Exceptional, (6 reviews)
"Very comfortable, spacious, great location for canoe trip. "
United States
Carolyn B.
The price is AED 496
AED 846 total
includes taxes & fees
9 Jul - 10 Jul
Back Door Guest Suite, Zia My Retreat
Property grounds

Chic 1- Queen Bed, Non Smoking-Near Airport, Kitchen, Twin Bed

Chic 1- Queen Bed, Non Smoking-Near Airport, Kitchen, Twin Bed
St. Louis
9.0 out of 10, Wonderful, (12 reviews)
"This was absolutely perfect and reasonable pricing I surely will be back "
United States
David G.
The price is AED 305
AED 402 total
includes taxes & fees
8 Aug - 9 Aug
Chic 1- Queen Bed, Non Smoking-Near Airport, Kitchen, Twin Bed
Interior

2 Bdr Upstairs Apt Walking Distance to Main St

2 Bdr Upstairs Apt Walking Distance to Main St
Saint Charles
8.0 out of 10, Very Good, (5 reviews)
"The best price-value ratio. Quiet neighborhood, close to the city center."
United States
Tamas P.
The price is AED 405
AED 1,069 total
includes taxes & fees
12 Jul - 13 Jul
2 Bdr Upstairs Apt Walking Distance to Main St
Property grounds

The Driftwood Den | Boho-Inspired 2-Bedroom

The Driftwood Den | Boho-Inspired 2-Bedroom
St. Charles Historic District
10.0 out of 10, Exceptional, (3 reviews)
"Loved our stay here. Clean, comfortable, convenient. Couldn’t have been easier, in all aspects. Already plan to stay there again!!!"
United States
Kourtney S.
The price is AED 456
AED 1,160 total
includes taxes & fees
12 Jul - 13 Jul
The Driftwood Den | Boho-Inspired 2-Bedroom
TV

Main Street Apartment

Main Street Apartment
St. Charles Historic District
9.6 out of 10, Exceptional, (39 reviews)
"Great location for shopping and a lot of restaurants nearby. Beds were very comfortable. "
United States
Brooke I.
The price is AED 595
AED 1,653 total
includes taxes & fees
14 Jul - 15 Jul
Main Street Apartment
TV

6th street 101 - Walk to Main St

6th street 101 - Walk to Main St
St. Charles Historic District
10.0 out of 10, Exceptional, (2 reviews)
"Excellent"
United States
Scott N.
The price is AED 364
AED 1,055 total
includes taxes & fees
15 Jul - 16 Jul
6th street 101 - Walk to Main St
Interior

The Historic Bricks on Main

The Historic Bricks on Main
St. Charles Historic District
9.0 out of 10, Wonderful, (18 reviews)
"Great place, very fun. I’d stay again for sure. "
United States
Michael C.
The price is AED 389
AED 848 total
includes taxes & fees
14 Jul - 15 Jul
The Historic Bricks on Main
TV

1st Capitol Mansion - Suite 401

1st Capitol Mansion - Suite 401
St. Charles Historic District
7.4 out of 10, Good, (9 reviews)
"Nice property and a great location to all the shops and restaurants that St. Charles has to offer. The place was clean and nicely updated. Will definitely stay here again!"
United States
Emily L.
The price is AED 364
AED 910 total
includes taxes & fees
9 Jul - 10 Jul
1st Capitol Mansion - Suite 401
Interior

Amazing Renovated Historic Loft on Main Street

Amazing Renovated Historic Loft on Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (65 reviews)
"Lovely accommodations, very clean, well equipped, great location. "
United States
Emily B.
The price is AED 511
AED 1,000 total
includes taxes & fees
6 Aug - 7 Aug
Amazing Renovated Historic Loft on Main Street
TV

Walk to Main St | Pet-Friendly Apt

Walk to Main St | Pet-Friendly Apt
St. Charles Historic District
8.6 out of 10, Excellent, (16 reviews)
"Property was as advertised. Perfect for my needs, clean, quiet and convenient. Loved Historic St. Charles. Would recommend anytime! Thank you! "
United States
Brian B.
The price is AED 496
AED 1,200 total
includes taxes & fees
14 Jul - 15 Jul
Walk to Main St | Pet-Friendly Apt
Fridge, microwave, oven, stovetop

Historic Main St. Customs House Upstairs Apartment

Historic Main St. Customs House Upstairs Apartment
St. Charles Historic District
9.6 out of 10, Exceptional, (38 reviews)
"Lovely place to stay!"
United States
Margaret A.
The price is AED 595
AED 1,467 total
includes taxes & fees
19 Jul - 20 Jul
Historic Main St. Customs House Upstairs Apartment
Exterior

Stay on Main Historic Studio

Stay on Main Historic Studio
St. Charles Historic District
9.0 out of 10, Wonderful, (34 reviews)
"From the welcome email with clear concise directions on how to enter with door codes to a dwelling that had everything I needed with a very comfortable bed, it was a great stay and I wanted for nothing."
United States
Jacob G.
The price is AED 397
AED 846 total
includes taxes & fees
2 Aug - 3 Aug
Stay on Main Historic Studio
Interior

Family Home: Game Room & Huge Yard, Airport

Family Home: Game Room & Huge Yard, Airport
Maryland Heights
10.0 out of 10, Exceptional, (1 review)
"Very nice"
United States
Steven S.
The price is AED 735
AED 1,660 total
includes taxes & fees
12 Jul - 13 Jul
Family Home: Game Room & Huge Yard, Airport
Fridge, microwave, stovetop, toaster

Charming Duplex on Main

Charming Duplex on Main
St. Charles Historic District
10.0 out of 10, Exceptional, (21 reviews)
"We had an AMAZING time here and you can't beat the close walking distance to main st!! Absolutely loved our stay. "
United States
Wendy K.
The price is AED 456
AED 1,013 total
includes taxes & fees
21 Jul - 22 Jul
Charming Duplex on Main
Smart TV

Prime Loft of Main Street

Prime Loft of Main Street
St. Charles Historic District
9.8 out of 10, Exceptional, (112 reviews)
"Really liked the location, lots to do within walking distance. Very good check in process - easy to follow.Well maintained place."
United States
William H.
The price is AED 511
AED 1,029 total
includes taxes & fees
13 Jul - 14 Jul
Prime Loft of Main Street
1 bedroom, WiFi, bed sheets

Duplex Hideaway in St. Charles, MO

Duplex Hideaway in St. Charles, MO
St. Charles Historic District
9.8 out of 10, Exceptional, (6 reviews)
"I will stay here again. It was a great location for my visit. Lots of room and amenities. Highly recommend this location if you are visiting the St Louis area. Barely a mile to get to Hwy 70, so easy access to St Louis, St Peter's, Wentzville etc. Maybe two blocks from Historic St Charles and Ameristar Casino."
United States
Karen M.
The price is AED 456
AED 1,009 total
includes taxes & fees
19 Jul - 20 Jul
Duplex Hideaway in St. Charles, MO
Interior

Historic Main St Apt | Private Garage

Historic Main St Apt | Private Garage
St. Charles Historic District
9.2 out of 10, Wonderful, (18 reviews)
"The location is excellent. The appartment is nice, spacious, comfortable, and practical. The parking spot is a big plus. Everything was perfect with our stay. Would stay again and highly recommedn."
United States
Bettina I.
The price is AED 595
AED 1,256 total
includes taxes & fees
20 Jul - 21 Jul
Historic Main St Apt | Private Garage
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters

10/10 Excellent
"Always a great stay at this Drury. The food is great and the pool isn’t bad either."
Jessica 1-night trip
Posted 1 hour ago
Drury Inn & Suites St. Louis St. Peters

Frequently asked questions

What's it like to stay at an apartment in Defiance?
You'll find 10 apartments to choose from in Defiance for your stay.
Why choose an apartment versus a traditional hotel?
Often more spacious than a traditional hotel room, an apartment includes a kitchen for convenient home-cooked meals. Apartments are ideal for families who want the conveniences of home, and also for couples who want something in a quieter part of town.
What's a favorite apartment for a stay in Defiance?
Here are some of the top apartments in the area: Chic 1- Queen Bed, Non Smoking-Near Airport, Kitchen, Twin Bed: Situated in Overland, 20.7 mi/33.2 km from the heart of Defiance. Includes free WiFi, private balconies, and Smart TVs. 1 Queen Bed | Non-Smoking, Kitchen: Located 18.7 mi/30.1 km away in Maryland Heights. Free WiFi and Smart TVs are included. 2 Queen Beds | Non-Smoking, Kitchen: It's situated in Maryland Heights, 18.7 mi/30.1 km away. Includes free WiFi and Smart TVs. The Lofts of North Main Street: Located 19.2 mi/30.8 km away in St. Charles. Free WiFi, sofa beds, and Smart TVs are included. Access to onsite laundry facilities is available on site. 1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed: It's located in Maryland Heights, 18.7 mi/30.1 km from Defiance. Includes free WiFi and Smart TVs.
How many apartments will I be able to find in Defiance?
Expedia has 10 apartments to book in Defiance.
What can I expect from the weather during my trip to Defiance?
Weather is only one factor, but it can really affect your travel plans, especially if you're planning an extended stay in Defiance. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.
What are the must-see places to visit in Defiance?
August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. While here, Chandler Hill Vineyards and Sugar Creek Winery are other places worth a visit.
What's the best way to get to and around Defiance?
Knowing a bit about the transportation options can save you time when you get to your destination. Fly into St. Louis, MO (SUS-Spirit of St. Louis), which is located 7.5 mi (12 km) from the heart of the city. You can also search for flights into St. Louis Lambert Intl. Airport (STL), which is 23.5 mi (37.8 km) away. If you'd like to explore around the area, you may want a rental car for your journey.