A calm river reflecting trees and a wooden bridge.

Search Hotels in Lafayette County

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
2 Oct - 4 Oct
Next weekend
9 Oct - 11 Oct

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Lafayette County hotels

An aerial view of a campground with RVs, a swimming pool, and tennis courts.

1. Suwannee River Rendezvous

Suwannee River Rendezvous
2.5 star property
Mayo
8.6 out of 10, Excellent, (33 reviews)
"This is a lovely place to visit"
United States
Beth
The price is AED 331
AED 443 total
includes taxes & fees
29 Sep - 30 Sep
Suwannee River Rendezvous
BBQ/picnic area

2. Cindys Motel

Cindys Motel
2.5 star property
Mayo
8.8 out of 10, Excellent, (137 reviews)
"wonderful, quiet, a hide a way for a fun stay"
United States
Diane
The price is AED 309
AED 334 total
includes taxes & fees
29 Oct - 30 Oct
Cindys Motel
A compact kitchen with wooden cabinets, a microwave, and a sink.

3. Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,

Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,
Mayo
9.6 out of 10, Exceptional, (19 reviews)
"Fantastic property very quiet with very friendly animals."
United States
Hevrard
The price is AED 173
AED 357 total
includes taxes & fees
29 Sep - 30 Sep
Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,
Outdoor dining

4. Friendlys River Retreat private Rustic Camping Cabin sleeps 4+with tent camping

Friendlys River Retreat private Rustic Camping Cabin sleeps 4+with tent camping
Mayo
9.4 out of 10, Exceptional, (17 reviews)
"Fantastic stay and amazing property owner. They were accommodating and helpful. Very glad I choose to stay here. I needed it to complete a job for a client and wasn’t expecting such a cool place to unwind after a hard days work. Two big thumbs up!"
United States
Blake
The price is AED 191
AED 356 total
includes taxes & fees
29 Sep - 30 Sep
Friendlys River Retreat private Rustic Camping Cabin sleeps 4+with tent camping
Outdoor dining

5. Rustic River Cabin 2-bedroom cabin in Branford near Santa Fe River

Rustic River Cabin 2-bedroom cabin in Branford near Santa Fe River
Branford
10.0 out of 10, Exceptional, (12 reviews)
"Hosts are awesome, and there's enough amenities to keep any family busy for as long as they'd like. "
United States
James S.
The price is AED 311
AED 719 total
includes taxes & fees
29 Sep - 30 Sep
Rustic River Cabin 2-bedroom cabin in Branford near Santa Fe River
A compact RV interior with a kitchenette, a bed, and a seating area.

6. RV with 1full bed 2twin beds and AC WiFi smart TV bathroom outdoor shower house

RV with 1full bed 2twin beds and AC WiFi smart TV bathroom outdoor shower house
Mayo
9.6 out of 10, Exceptional, (7 reviews)
"Love this little slice of heaven!"
United States
Crystal
The price is AED 202
AED 290 total
includes taxes & fees
12 Oct - 13 Oct
RV with 1full bed 2twin beds and AC WiFi smart TV bathroom outdoor shower house
Property grounds

7. Ichetucknee Springs/Ginnie Springs/Santa Fe River at the Hideaway Cottage

Ichetucknee Springs/Ginnie Springs/Santa Fe River at the Hideaway Cottage
Branford
10.0 out of 10, Exceptional, (126 reviews)
"Loved our visit. The owners were accommodating and informative about the area. As Florida residents, this will be a regular visit."
United States
Rick F.
Ichetucknee Springs/Ginnie Springs/Santa Fe River at the Hideaway Cottage
A kitchen with wooden cabinets, a stainless steel sink, and a window overlooking a forest.

8. Private 12 acre Ranch sleeps up to 8 on The Santa Fe River.

Private 12 acre Ranch sleeps up to 8 on The Santa Fe River.
high springs
9.8 out of 10, Exceptional, (96 reviews)
"Good hosts !"
United States
nick f.
Private 12 acre Ranch sleeps up to 8 on The Santa Fe River.
Property grounds

9. Butterfly Crossing peaceful getaway on the historic Suwannee. Fish, Boat, Relax

Butterfly Crossing peaceful getaway on the historic Suwannee. Fish, Boat, Relax
Branford
9.8 out of 10, Exceptional, (20 reviews)
"This is our 3rd year staying and it is always a great experience. The property is well maintained and the view and dock are great. "
United States
Stephanie M.
Butterfly Crossing peaceful getaway on the historic Suwannee. Fish, Boat, Relax
Property grounds

10. Cozy Log Cabin Retreat on the Santa Fe River – Nature, Kayaking & Relaxation!

Cozy Log Cabin Retreat on the Santa Fe River – Nature, Kayaking & Relaxation!
Branford
10.0 out of 10, Exceptional, (30 reviews)
"Great hosts!"
United States
nick f.
Cozy Log Cabin Retreat on the Santa Fe River – Nature, Kayaking & Relaxation!
A gated entrance to a wooded area with a metal gate and a wooden fence.

11. Beautiful, wooded campsite in Branford, FL perfect for outdoor adventures

Beautiful, wooded campsite in Branford, FL perfect for outdoor adventures
Branford
Beautiful, wooded campsite in Branford, FL perfect for outdoor adventures
Exterior

12. Suwannee River Retreat with Private Dock, Free Kayaks, and Fire pit

Suwannee River Retreat with Private Dock, Free Kayaks, and Fire pit
Mayo
10.0 out of 10, Exceptional, (85 reviews)
"Could use some cleaning but it was perfect"
United States
Olivia
Suwannee River Retreat with Private Dock, Free Kayaks, and Fire pit
A two-story building with a porch and a sign that reads "Mable's."

13. Wonderful Vacation Home For Making Memories

Wonderful Vacation Home For Making Memories
Branford
9.8 out of 10, Exceptional, (181 reviews)
"One of the most peaceful places we have ever stayed. Our entire family enjoyed our visit. The house is beautiful and the location is perfect. If you need a home to get away from your busy life - this is where you should go!"
United States
Joella S.
Wonderful Vacation Home For Making Memories
Outdoor dining

14. Santa Fe River Basecamp — 15 Acres Near 10 Springs

Santa Fe River Basecamp — 15 Acres Near 10 Springs
Branford
10.0 out of 10, Exceptional, (2 reviews)
"Don made our stay easy and enjoyable from start to finish. We did have an issue with the oven not working, but things happen, and Don stayed on top of it to make sure everything was taken care of.One of our favorite parts of the trip was relaxing on the deck while watching a dozen or more deer come out to feed. It made for a peaceful and memorable experience.The location is perfect for anyone bringing a boat. The Highway 129 boat ramp is only about a mile away, making it incredibly convenient to...
United States
Kevin D.
Santa Fe River Basecamp — 15 Acres Near 10 Springs
Beach

15. Riverbend Retreat / Suwannee Riverfront/ Kayaks & Hot Tub

Riverbend Retreat / Suwannee Riverfront/ Kayaks & Hot Tub
Branford
10.0 out of 10, Exceptional, (4 reviews)
"Great place, enjoyed our stay!"
United States
Mary W.
Riverbend Retreat / Suwannee Riverfront/ Kayaks & Hot Tub
A wooden deck with a table and chairs, large windows, and a ceiling light.

16. The Chalet On the Suwannee River

The Chalet On the Suwannee River
Mayo
10.0 out of 10, Exceptional, (1 review)
"We were in the area to check out some local spring and loved the accessibility of this VRBO’s location. This property was amazing and super fun. Can’t wait to go back."
United States
Mandy B.
The price is AED 826
AED 958 total
includes taxes & fees
29 Sep - 30 Sep
The Chalet On the Suwannee River
A large, multi-story house with a covered porch and a wooden deck.

17. Serene, Luxurious Riverside Home w/ Dock!

Serene, Luxurious Riverside Home w/ Dock!
Branford
8.8 out of 10, Excellent, (14 reviews)
"We had a great time fishing, kayaking, and swimming in the springs!"
United States
Erin A.
Serene, Luxurious Riverside Home w/ Dock!
A wooden staircase leading to a riverbank with a view of the water and surrounding trees.

18. The Best memories are made on the Suwannee River

The Best memories are made on the Suwannee River
Mayo
9.8 out of 10, Exceptional, (58 reviews)
"Was there for a family reunion and was great for what we needed."
United States
Anonymous traveler
The price is AED 397
AED 891 total
includes taxes & fees
1 Oct - 2 Oct
The Best memories are made on the Suwannee River
A wooden deck with a metal railing overlooking a pathway through a park.

19. Suwannee Riverfront Home: Grill, Near Springs

Suwannee Riverfront Home: Grill, Near Springs
Branford
9.0 out of 10, Wonderful, (17 reviews)
"Awesome stay! Right on the river and still close to boat ramp and town of Branford. Mr Clyde was very nice and made sure to make us feel very welcome! Hoping to stay again soon "
United States
Holly C.
Suwannee Riverfront Home: Grill, Near Springs
A covered porch with wooden flooring, a ceiling fan, a table with a covered chair, a sofa with cushions, and large windows offering a view of the forest.

20. Riverfront home in Branford on the Sante Fe and access to the Ichetucknee!

Riverfront home in Branford on the Sante Fe and access to the Ichetucknee!
Branford
10.0 out of 10, Exceptional, (12 reviews)
"A great place to stay!!"
United States
Lauren W.
Riverfront home in Branford on the Sante Fe and access to the Ichetucknee!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Lafayette County Hotel Reviews

Lots of open and private space for the family and pets

Lots of open and private space for the family and pets

10/10 Excellent
"I see why others mention the neighborhood, but although there are some properties that are questionable we felt safe and the neighborhood was quiet. If you plan to cook during your stay, there are not many options for cooking pans/utensils. So bring casserole dishes, a frying pan if you prefer “non Teflon” type. There aren’t items like tin foil, plastic wrap or zip locks either. These are not complaints however, just informative for the next person. It would be nice if there were TVs in each room but we made it work. No fans in the rooms either, again just a note. Overall it was spacious and the outdoor area was nice and somewhat secluded and private. The place was clean and beds were comfortable."
Connie P. 2-night trip
Posted 21 hours ago
Lots of open and private space for the family and pets

Explore a world of travel with Expedia