Photo by PhotoJoy
Luxury Hotels in Panama from AED 573
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Panama Luxury Hotels
Pick from 67 Panama Luxury Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
JW Marriott Panama
San Francisco
9.0 out of 10, Wonderful, (1007)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
Sarran
The price is AED 889
AED 978 total
includes taxes & fees
4 Jan - 5 January 2026
Bristol Panama, a Registry Collection Hotel
Bella Vista
9.4 out of 10, Exceptional, (1000)
"Love this hotel. Busy area, but hotel and restaurant make up for it."
Allen
The price is AED 706
AED 777 total
includes taxes & fees
4 Jan - 5 January 2026
Waldorf Astoria Panama
Bella Vista
9.0 out of 10, Wonderful, (1002)
"I loved everything about my stay "
Stephanie
The price is AED 660
AED 726 total
includes taxes & fees
16 Dec - 17 Dec
American Trade Hotel
Casco Viejo
9.4 out of 10, Exceptional, (601)
"Excellent service and great rooms on a beautiful and historical building"
Manuel
The price is AED 1,071
AED 1,178 total
includes taxes & fees
4 Jan - 5 January 2026
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
Bella Vista
8.8 out of 10, Excellent, (1001)
"Clean room nice location "
daniel
The price is AED 584
AED 642 total
includes taxes & fees
13 Dec - 14 Dec
Hilton Panama
Bella Vista
8.8 out of 10, Excellent, (1001)
"Great place to stay."
Salvador
The price is AED 684
AED 752 total
includes taxes & fees
2 Jan - 3 January 2026
Megapolis Hotel Panamá
San Francisco
8.4 out of 10, Very Good, (1000)
"Great stay! Very safe!"
MARVIN
The Buenaventura Golf & Beach Resort Panama, Autograph Collection
El Chiru
9.2 out of 10, Wonderful, (683)
"Great place for a short stay "
jeffrey
The price is AED 643
AED 707 total
includes taxes & fees
14 Dec - 15 Dec
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Top Panama Hotel Reviews
Novotel Panama City
10/10 Excellent
Explore a world of travel with Expedia
Top destinations for Luxury Hotels in Panama
More Hotel Options in Panama
- Hotels with WiFi in Panama
- Hotels with Free Parking in Panama
- Family Hotels in Panama
- Hotels with Bars in Panama
- Beach Hotels in Panama
- Hotels with a Pool in Panama
- Adventure Hotels in Panama
- Business Hotels in Panama
- Shopping Hotels in Panama
- Hotel with a Concierge in Panama
- Hotels with smoking rooms in Panama
- Historic Hotels in Panama
- Casinos in Panama
- Resorts & Hotels with Spas in Panama
- Pet-friendly Hotels in Panama
- Hotel Wedding Venues in Panama
- Cheap Hotels in Panama
- Romantic Hotels in Panama
- Hotels with Hot Tubs in Panama
- Golf Hotels in Panama
More Themes
- All-inclusive Hotel
- Hotels with Bars
- Beach Hotels
- Boutique Hotels
- Cheap Hotels
- Business Hotels
- Casinos
- Hotel with a Concierge
- Family Hotels
- Hotels with Free Parking
- Golf Hotels
- Historic Hotels
- Hotels with Hot Tubs
- Hotels with an Indoor Pool
- Apartment Hotel
- Hotels with a Lazy River
- Pet-friendly Hotels
- Hotels with a Pool
- Adventure Hotels
- Romantic Hotels
- Shopping Hotels
- Ski Hotels
- Hotels with smoking rooms
- Resorts & Hotels with Spas
- Green Hotels
- Waterpark Hotels
- Hotels with Waterslides
- Hotel Wedding Venues
- Hotels with WiFi
- Winery Hotels