East Cape Girardeau Vacation Rentals

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Check prices for these dates

In two weeks
27 Nov - 29 Nov
In two months
8 Jan - 10 Jan
In three months
5 Feb - 7 Feb
In four months
5 Mar - 7 Mar

Our top choices for East Cape Girardeau vacation rentals

A living room with a TV, a fireplace, a sofa, and wall art.

1. Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very good, (59 reviews)
"Great cute place. "
United States
Jeremy W.
The price is AED 298
AED 368 total
includes taxes & fees
14 Nov - 15 Nov
Little Blue Cottage on Spanish
A cozy room with a wooden table and chairs, a large window, and a door with a sign.

2. Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake
Olive Branch
9.8 out of 10, Exceptional, (44 reviews)
"Super communication! . Accommodating. Nice people"
United States
JASEN
The price is AED 413
AED 485 total
includes taxes & fees
15 Nov - 16 Nov
Cozy cabins on beautiful Horseshoe Lake
A kitchen with grey cabinets, a stainless steel dishwasher, a microwave, and an oven.

3. Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals

Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals
Cape Girardeau
The price is AED 390
AED 676 total
includes taxes & fees
7 Dec - 8 Dec
Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals
A small, single-story building with a wooden exterior and large windows.

4. The Rested Duck Mallard Room

The Rested Duck Mallard Room
Olive Branch
9.4 out of 10, Exceptional, (32 reviews)
"This is an excellent place to stay. With a nice lake right across the street. If i. In the are i will stay again for sure"
United States
mike b.
The price is AED 413
AED 485 total
includes taxes & fees
15 Nov - 16 Nov
The Rested Duck Mallard Room
A bedroom with a bed, a bottle of J. Roget champagne, two glasses, and a plate with snacks.

5. The Cottage, Rusted Route Farms

The Cottage, Rusted Route Farms
Jackson
10.0 out of 10, Exceptional, (3 reviews)
"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"
United States
Renee C.
The price is AED 459
AED 694 total
includes taxes & fees
15 Nov - 16 Nov
The Cottage, Rusted Route Farms
Exterior

6. Purple Tiny House with Fire pit & Nature

Purple Tiny House with Fire pit & Nature
Cape Girardeau
10.0 out of 10, Exceptional, (1 review)
"First time staying in the purple house, second time staying at the property. 10/10 recommend"
United States
Shawn A.
The price is AED 507
AED 723 total
includes taxes & fees
15 Nov - 16 Nov
Purple Tiny House with Fire pit & Nature
An outdoor seating area with Adirondack chairs and a wooden pergola, surrounded by trees and string lights.

7. Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly

Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
Cape Girardeau
10.0 out of 10, Exceptional, (3 reviews)
"The house was very clean and Will kept and the whole property was well maintained. It was very comfortable and nicely decorated. The host was very responsive and helpful! Would definitely stay again and recommend."
United States
Sara C.
The price is AED 570
AED 794 total
includes taxes & fees
14 Nov - 15 Nov
Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
A row of colorful houses with a clear sky and trees in the background.

8. Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly

Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly
Cape Girardeau
10.0 out of 10, Exceptional, (1 review)
"Very cute, especially because it's pet friendly! Currently building additional structures on site but appears almost complete and still a beautiful setting and property."
United States
Elizabeth K.
The price is AED 612
AED 850 total
includes taxes & fees
15 Nov - 16 Nov
Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly
An outdoor seating area with Adirondack chairs and a wooden pergola, surrounded by trees and string lights.

9. The Little Château | Woodland Escape

The Little Château | Woodland Escape
Cape Girardeau
The price is AED 570
AED 801 total
includes taxes & fees
14 Nov - 15 Nov
The Little Château | Woodland Escape
A two-story house with a front porch, a small garden, and a white picket fence.

10. 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (46 reviews)
"Will definitely book again! Great location, comfortable stay."
United States
Pynktoria !.
The price is AED 658
AED 1,110 total
includes taxes & fees
15 Nov - 16 Nov
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
A modern living room with a wooden ceiling, a stone fireplace, a TV mounted on the wall, and a bar area with stools.

11. The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse
Cape Girardeau
10.0 out of 10, Exceptional, (42 reviews)
"The hosts were excellent."
United States
Jason L.
The price is AED 915
AED 1,361 total
includes taxes & fees
7 Dec - 8 Dec
The Twisted Sassafras Treehouse
Exterior

12. The Little Cape Lofted Cottage | Creek & Nature

The Little Cape Lofted Cottage | Creek & Nature
Cape Girardeau
9.0 out of 10, Wonderful, (2 reviews)
"It was very clean and had a good feel. It was well stocked. I appreciated the cute little ice tray in the freezer that was full. I also appreciated 4 waters in the fridge. The bed on the loft upstairs was atrocious. You can feel the springs through the mattress. The downstairs bed was good. The pillows were fantastic! I’m a pillow snob. We needed a quick place to land for a church function so I can’t say much about the outside amenities as we weren’t there much. But it was a beautifully tucked...
United States
Trisha S.
The price is AED 591
AED 824 total
includes taxes & fees
14 Nov - 15 Nov
The Little Cape Lofted Cottage | Creek & Nature
A log cabin interior with a stone fireplace, leather sofa, and a mounted deer head.

13. Gorgeous 1856 Log Cabin, Completely Renovated

Gorgeous 1856 Log Cabin, Completely Renovated
Jackson
10.0 out of 10, Exceptional, (6 reviews)
"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."
United States
Chandler G.
The price is AED 735
AED 1,098 total
includes taxes & fees
15 Nov - 16 Nov
Gorgeous 1856 Log Cabin, Completely Renovated
A loft-style room with a wooden interior, a sofa, a table with a pumpkin decoration, and a staircase leading to an upper level.

14. Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake
Miller City
9.8 out of 10, Exceptional, (40 reviews)
"great getaway. tucked away in the woods. beautiful scenery"
United States
Crystal R.
The price is AED 514
AED 763 total
includes taxes & fees
15 Nov - 16 Nov
Peaceful secluded cabin located near Horseshoe Lake
A kitchen with wooden cabinets, a black refrigerator, a microwave, a stove, and a ceiling fan. There are three stools at the island.

15. Relax in the country at Countryside Villas! - Villa A

Relax in the country at Countryside Villas! - Villa A
Jackson
10.0 out of 10, Exceptional, (39 reviews)
"Great place to stay, felt like home away from home. "
United States
Brittany
The price is AED 551
AED 630 total
includes taxes & fees
15 Nov - 16 Nov
Relax in the country at Countryside Villas! - Villa A
A compact kitchen with wooden cabinets and a dining area with a table and chairs.

16. Villa B offers peace and quiet with beautiful views of the countryside.

Villa B offers peace and quiet with beautiful views of the countryside.
Jackson
9.8 out of 10, Exceptional, (16 reviews)
"We were only there for 1 night for a business trip but it was perfect for our stay. Very clean and comfortable and the host was onsite to welcome us. She even gave us a tip on the best place nearby for dinner that we will be going to any time we can in the future. I would gladly stay here again for future trips."
United States
Terry H.
The price is AED 551
AED 630 total
includes taxes & fees
14 Nov - 15 Nov
Villa B offers peace and quiet with beautiful views of the countryside.
A modern kitchen with a large island, white cabinetry, and a brick accent wall.

17. Beautifully Renovated Farmhouse in Jackson, MO

Beautifully Renovated Farmhouse in Jackson, MO
Jackson
9.4 out of 10, Exceptional, (3 reviews)
" great stay,property landscape nicely manicured, quiet and relaxing inside and outside of the the dwelling."
United States
Sandy S.
The price is AED 735
AED 1,047 total
includes taxes & fees
16 Nov - 17 Nov
Beautifully Renovated Farmhouse in Jackson, MO
A serene outdoor area with a pond, surrounded by trees and a grassy lawn. There are two wooden benches facing the water.

18. Charming cabin overlooking Lake Acre

Charming cabin overlooking Lake Acre
Dongola
10.0 out of 10, Exceptional, (107 reviews)
"The cottage was clean, spacious, had 2 bathrooms (which is uncommon for small cabins). It was very well stocked with kitchen items, and the bath towels were awesome, the bed was very nice. It was peaceful and beautiful. The hostess, Suzie was easy to contact and helpful when we had a question upon checking ìn. I would recommend this place and would stay again if we are in the area!"
United States
Teresa
The price is AED 551
AED 946 total
includes taxes & fees
1 Dec - 2 Dec
Charming cabin overlooking Lake Acre
A house with a backyard swimming pool, outdoor furniture, and a barbecue area.

19. 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.8 out of 10, Exceptional, (11 reviews)
"Nice place, great times"
United States
Jace W.
The price is AED 1,319
AED 2,034 total
includes taxes & fees
15 Nov - 16 Nov
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
A wooden cabinet with a microwave, coffee maker, and plates.

20. Cozy and Updated Farmhouse with King Suite

Cozy and Updated Farmhouse with King Suite
Anna
10.0 out of 10, Exceptional, (30 reviews)
"Comfortable bed which is what we needed. We weren’t there long but is was everything we needed."
United States
Kathy H.
The price is AED 377
AED 602 total
includes taxes & fees
24 Nov - 25 Nov
Cozy and Updated Farmhouse with King Suite
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top East Cape Girardeau Hotel Reviews

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau

10/10 Excellent

Nice and clean room. Very spacious for our stay. Enjoyed it very much.
United States
Kristin
Reviewed November 9, 2026
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Frequently Asked Questions

Are there vacation rentals in East Cape Girardeau?

Yes, there are vacation rentals near well known sights in East Cape Girardeau, or you can select a more secluded option if you'd like a relaxing place to stay.

What are some of the best vacation home rentals that East Cape Girardeau has to offer?

3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau: This vacation home rental near East Cape Girardeau is equipped with a barbecue grill, air-conditioning, and laundry facilities to help you feel comfortable during your stay. Kitchen amenities include a dishwasher, a fridge, and a stovetop.

What’s there to see and do in East Cape Girardeau?

Explore the area and family-friendly sights such as Cape Splash Family Aquatic Center, or get out into nature at a spot like Fort D Historic Site. Century Casino & Hotel Cape Girardeau and Southeast Missouri State University are a couple of places you'll find in the larger area.

What’s a vacation rental in East Cape Girardeau like?

A vacation rental is a private property you can book for a couple of days or more in East Cape Girardeau. Vacation rentals offer extras like WiFi and washers and dryers so you'll have everything you need. If you're concerned about a clean environment, a vacation rental can provide a sense of privacy away from shared hotel elevators and busy front desks while still allowing you the excitement and enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great option for a small group gathering.