A beach with palm trees, people relaxing on chairs, and colorful kayaks.

Find Business Hotels in Florida Keys

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Florida Keys Business Hotels

Tonight
18 Oct - 19 Oct
Tomorrow
19 Oct - 20 Oct
Next weekend
23 Oct - 25 Oct
In two weeks
30 Oct - 1 Nov

Our top choices for Florida Keys business-friendly hotels

A pool area with lounge chairs and umbrellas, surrounded by palm trees and a view of the ocean.
A hotel room with a large bed, a TV mounted on a wooden cabinet, and a balcony with a view of palm trees.
A bar area with a thatched roof, wooden chairs, and a poolside view.
A hotel room with a balcony, a bed, a desk, and two chairs.

1. Hampton Inn Key West FL

Hampton Inn Key West FL
Key West
Canada
Erika
AED 621
AED 698 total
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn Key West FL
A pool area with lounge chairs and umbrellas, surrounded by palm trees.
An outdoor patio area with tables and chairs, a bar area with a counter and bar stools, and a TV mounted on the wall.
A wooden outdoor dining table set with glassware, candles, and lanterns, surrounded by lush greenery.
A hotel room with a large bed, a wooden nightstand, a desk, a chair, and a window with curtains.

2. Fairfield by Marriott Inn & Suites Key West at The Keys Collection

Fairfield by Marriott Inn & Suites Key West at The Keys Collection
New Town
United States
Brian
AED 459
AED 620 total
includes taxes & fees
25 Oct - 26 Oct
Fairfield by Marriott Inn & Suites Key West at The Keys Collection
Pool
A modern cafe with a wooden counter, seating area, and shelves stocked with beverages.
A spacious living area with a sofa, chairs, a coffee table, and a foosball table. Large windows offer a view of the outdoor area.
A hotel room with a bed, a sofa, a round table with a book, a window with a view, and a radiator.

3. Blue Flamingo Resort Key West

Blue Flamingo Resort Key West
New Town
United States
Esteban
AED 459
AED 724 total
includes taxes & fees
25 Oct - 26 Oct
Blue Flamingo Resort Key West
A swimming pool with water splashing, surrounded by palm trees and a building in the background.
The entrance to Silver Palms Inn with a reception desk, a seating area, and a glass door.
A hotel with a pool, bicycles, and lush greenery.
The exterior of the Silver Palms Inn with a two-story structure, a green awning over the entrance, and a palm tree to the right.

4. Silver Palms Inn & Historic Homes

Silver Palms Inn & Historic Homes
Old Town Key West
United States
sam
AED 327
AED 616 total
includes taxes & fees
25 Oct - 26 Oct
Silver Palms Inn & Historic Homes
A beach with palm trees and lounge chairs.
A swimming pool with clear blue water, surrounded by a white deck and a black metal fence.
A balcony with two blue lounge chairs, a wooden ceiling, and a view of the ocean and palm trees.
A hotel room with a large bed, a ceiling fan, a nightstand with a lamp, and a view of the beach through the window.

5. Chesapeake Beach Resort

Chesapeake Beach Resort
Matecumbe
United States
Dianne
AED 521
AED 793 total
includes taxes & fees
20 Oct - 21 Oct
Chesapeake Beach Resort
An aerial view of a resort with two swimming pools surrounded by palm trees and sun loungers.
A bar area with a wooden counter, bar stools, and potted plants.
A beachside patio with wooden furniture, a thatched roof, and a view of the ocean.
A wooden pier leading to a beach with palm trees and a row of beach huts.

6. Islander Resort

Islander Resort
Matecumbe
United States
Clara
AED 717
AED 1,075 total
includes taxes & fees
15 Nov - 16 Nov
Islander Resort
A beach with palm trees, lounge chairs, and a clear view of the ocean.
A resort with a thatched-roof structure, palm trees, and lounge chairs on a sandy beach.
A tropical garden with palm trees, various colorful plants, and a seating area with chairs.
A hotel room with a kitchenette, two beds, a desk, a television, and a ceiling fan.

7. Hampton Inn Key Largo Manatee Bay

Hampton Inn Key Largo Manatee Bay
Key Largo
United States
Mee
AED 479
AED 539 total
includes taxes & fees
27 Oct - 28 Oct
Hampton Inn Key Largo Manatee Bay
A hotel room with a bed, a view of the beach, a hammock, and beach chairs.
A marina with boats docked, a beach resort building, and palm trees.
A pool area with blue lounge chairs, a hot tub, and a covered seating area.
A beachfront hotel with multiple colorful buildings, a pool area, and a boat dock.

8. Ibis Bay Beach Resort

Ibis Bay Beach Resort
Northside Resort
United States
Andre
AED 500
AED 681 total
includes taxes & fees
20 Oct - 21 Oct
Ibis Bay Beach Resort
A balcony with a view of a pool area, palm trees, and outdoor seating.
A large conference room with round tables, chairs, and a central carpeted area.
An outdoor patio area with tables and chairs, umbrellas, and palm trees.
A sign for Doubletree by Hilton Grand Key Resort surrounded by lush greenery and palm trees.

9. DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West
Key West
United States
Nancy
AED 438
AED 617 total
includes taxes & fees
29 Oct - 30 Oct
DoubleTree Resort by Hilton Grand Key - Key West
A hotel with a covered entrance, multiple balconies, and palm trees.
A waterfront hotel with multiple balconies, a dock, and boats.
A covered balcony with white Adirondack chairs and a small table with flowers, overlooking a turquoise sea and distant shoreline.
A room with a stone wall, a wooden bench, a cactus, and a framed painting.

10. Opal Key Resort & Marina, Key West

Opal Key Resort & Marina, Key West
Old Town Key West
United States
Susan
AED 951
AED 1,215 total
includes taxes & fees
25 Oct - 26 Oct
Opal Key Resort & Marina, Key West
View all properties

Top Florida Keys Hotel Reviews

Amara Cay Resort

Amara Cay Resort

10/10 Excellent
"Pool side bar On the ocean Very clean and friendly"
Ronald 2-night trip
Posted 1 hour ago
Amara Cay Resort
Bayside Inn Key Largo

Bayside Inn Key Largo

10/10 Excellent
"The room was very clean and comfortable. Best shower ever! Nice shampoo, conditioner, and body lotion. Great fluffy towels, and ice cold air conditioning… What more could you want? Great location next to snooks restaurant/bar. Refreshing little pool next to a beach if you wanna sit in the sand. Cute chickens, roosters, and iguanas roaming around. Walking distance to Burger King, Starbucks, sandal, factory, Walgreens… Just a great hotel and a great location!"
Susan 7-night trip
Posted 16 hours ago
Bayside Inn Key Largo
Islander Resort

Islander Resort

10/10 Excellent
"Great resort for families with children"
Bryan 4-night trip
Posted 17 hours ago
Islander Resort
Hawks Cay Resort

Hawks Cay Resort

10/10 Excellent
"We thoroughly enjoyed our stay at Hawks Cay Resort. The staff were very friendly and always available. When we had to cut our stay short by a day to alter our route home due to Hurricane Isiais, it was not an issue at all. We visited The Cafe on several occasions for coffee, breakfast, and sandwiches. Everything was delicious. But our favorite meal on property was at Angler & Ale. Our meals were phenomenal and the staff was fabulous. Our room overlooked the adult pool and gave us a great view of the sunrise. I would highly recommend staying at Hawks Cay if you are looking for a centrally located resort in the Keys!"
James 5-night trip
Posted 20 hours ago
Hawks Cay Resort
Reefhouse Resort & Marina

Reefhouse Resort & Marina

8/10 Good
"Room are a little dated but overall nice. Pool and beach area were well maintained. We got couples massages and those were great. Pricing for them was reasonable. We would come back again!"
Austin 3-night trip
Posted 1 day ago
Reefhouse Resort & Marina
Waterside Suites & Marina

Waterside Suites & Marina

10/10 Excellent
"Esther was really helpful. Very nice and professional. Room was spotless!! Balcony with a beautiful view."
Manuel 1-night trip
Posted 4 days ago
Waterside Suites & Marina
Sunset Cove Beach Resort

Sunset Cove Beach Resort

10/10 Excellent
"Everything was wonderful, clean room, nice and cool. Beach area had floats and paddle boards for guest use. Enjoyed a short walk to a great restaurant."
Tracy 1-night trip
Posted 6 days ago
Sunset Cove Beach Resort