The Best Business Hotels in Florida Keys from AED 472 in 2026 | Expedia

A beach with palm trees, people relaxing on chairs, and colorful kayaks.

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Check availability on Florida Keys Business Hotels

Tonight

16 Oct - 17 Oct

Tomorrow

17 Oct - 18 Oct

This weekend

16 Oct - 18 Oct

Next weekend

23 Oct - 25 Oct

Our top choices for Florida Keys business-friendly hotels

A pool area with lounge chairs and umbrellas, surrounded by palm trees and a view of the ocean.

A bar area with a thatched roof, wooden chairs, and a poolside view.

A modern kitchen with a marble island, wooden cabinets, and pendant lighting.

A hotel room with a balcony, a bed, a desk, and two chairs.

1. Hampton Inn Key West FL

Key West

Canada

Erika

AED 621

AED 698 total

includes taxes & fees

25 Oct - 26 Oct

A bar area with a long counter, bar stools, and a view of the water.

A waterfront property with a large building, a smaller structure with a thatched roof, and several boats docked.

A balcony with a view of the ocean, a round table, and two chairs.

A balcony with a view of a body of water, a pool, and outdoor seating.

2. Fairfield Inn & Suites by Marriott Marathon Florida Keys

Marathon

United States

Andrew

AED 493

AED 554 total

includes taxes & fees

25 Oct - 26 Oct

A swimming pool with water splashing, surrounded by palm trees and a building in the background.

A hotel with a pool, bicycles, and lush greenery.

A two-story yellow house with a porch, white railings, and green shutters.

The entrance to Silver Palms Inn with a reception desk, a seating area, and a glass door.

3. Silver Palms Inn & Historic Homes

Old Town Key West

United States

sam

AED 327

AED 616 total

includes taxes & fees

25 Oct - 26 Oct

Pool

A modern cafe with a wooden counter, seating area, and shelves stocked with beverages.

A couple holding hands in a tropical setting with palm trees and greenery.

A hotel room with a bed, a sofa, a round table with a book, a window with a view, and a radiator.

4. Blue Flamingo Resort Key West

New Town

United States

Esteban

AED 459

AED 724 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with a bed, a view of the beach, a hammock, and beach chairs.

A beachfront restaurant with outdoor seating, a seafood sign, and a market sign.

A marina with boats docked, a beach resort building, and palm trees.

A beachfront hotel with multiple colorful buildings, a pool area, and a boat dock.

5. Ibis Bay Beach Resort

Northside Resort

United States

Andre

AED 500

AED 681 total

includes taxes & fees

18 Oct - 19 Oct

A beach with palm trees and lounge chairs.

A balcony with two blue lounge chairs, a wooden ceiling, and a view of the ocean and palm trees.

A waterfront hotel with multiple floors, palm trees, and a calm reflective pool.

A hotel room with a large bed, a ceiling fan, a nightstand with a lamp, and a view of the beach through the window.

6. Chesapeake Beach Resort

Matecumbe

United States

Phelicia

AED 521

AED 793 total

includes taxes & fees

20 Oct - 21 Oct

A white building with a covered patio area, surrounded by palm trees and a view of the ocean.

A spacious living area with a flat-screen TV, a wooden coffee table, a sofa with colorful cushions, and a blue chair.

Beach chairs and a blue umbrella on a sandy shore with a calm body of water and a palm tree in the background.

A dining area with a table and chairs, a ceiling fan, a television, and a window with a view of the outdoors.

7. Parmer's Resort

Summerland Key

United States

Mireya

AED 539

AED 726 total

includes taxes & fees

3 Nov - 4 Nov

An aerial view of a resort with two swimming pools surrounded by palm trees and sun loungers.

A paved pathway leading to a beach with palm trees and a view of the ocean.

A beachside patio with wooden furniture, a thatched roof, and a view of the ocean.

A bar area with a wooden counter, bar stools, and potted plants.

8. Islander Resort

Matecumbe

United States

Steven

AED 717

AED 1,075 total

includes taxes & fees

15 Nov - 16 Nov

View all properties

Top Florida Keys Hotel Reviews

Bayside Inn Key Largo

Bayside Inn Key Largo

10/10 Excellent

"Really nice restaurant next to it , you get 10% discount when you stay at hotel."

Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton

10/10 Excellent

"Staff was very attentive and provided great service! Checked out at 11:00am and were allowed to stay until late afternoon. They had showers and towels we could use next to the Dry Rocks bar and grill to clean up before needing to drive back to Miami for the evening."

Cheeca Lodge & Spa

Cheeca Lodge & Spa

10/10 Excellent

"Loved the property, staff and rooms"

Islander Resort

Islander Resort

10/10 Excellent

"Very nice experience and cosy hotel in the Keys, super recommended!"

Reefhouse Resort & Marina

Reefhouse Resort & Marina

10/10 Excellent

"The room was clean and the property was beautiful."

Waterside Suites & Marina

Waterside Suites & Marina

10/10 Excellent

"Esther was really helpful. Very nice and professional. Room was spotless!! Balcony with a beautiful view."

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

10/10 Excellent

"As soon as we"

Sunset Cove Beach Resort

Sunset Cove Beach Resort

10/10 Excellent

"Everything was wonderful, clean room, nice and cool. Beach area had floats and paddle boards for guest use. Enjoyed a short walk to a great restaurant."