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Check prices for these dates

This weekend
11 Sep - 13 Sep
Next weekend
18 Sep - 20 Sep

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Our top choices for South Central Houston hotels

Lobby lounge

1. InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
South Central Houston
9.4 out of 10, Exceptional, (1,010 reviews)
"Great bar staff and food"
United States
Eric
The price is AED 676
AED 864 total
includes taxes & fees
13 Sep - 14 Sep
InterContinental Houston by IHG
Outdoor pool, free cabanas, pool umbrellas

2. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,202 reviews)
"Great place to stay"
United States
Kevin
The price is AED 503
AED 626 total
includes taxes & fees
27 Sep - 28 Sep
The Westin Houston Medical Center/Museum District
Dinner served

3. Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1,004 reviews)
"I enjoyed my stay!"
United States
Valencia
The price is AED 625
AED 850 total
includes taxes & fees
11 Sep - 12 Sep
Houston Marriott Medical Center/Museum District
Terrace/patio

4. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
South Central Houston
8.4 out of 10, Very Good, (2,143 reviews)
"Our stay was great"
United States
Cindy
The price is AED 397
AED 468 total
includes taxes & fees
13 Sep - 14 Sep
Hilton Houston Plaza/Medical Center
Premium bedding, pillowtop beds, minibar, in-room safe

5. Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (1,007 reviews)
"Nice hotel"
United States
Deul
The price is AED 923
AED 1,225 total
includes taxes & fees
9 Sep - 10 Sep
Hotel Zaza Houston Museum District
Laptop workspace, blackout drapes, soundproofing

6. Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
South Central Houston
9.2 out of 10, Wonderful, (236 reviews)
"Second time stay here. Lovely place"
United States
Jaelon
The price is AED 339
AED 396 total
includes taxes & fees
9 Sep - 10 Sep
Downtowner Inns - Houston Downtown
Exterior detail

7. Sentral Forme Houston

Sentral Forme Houston
4.5 star property
South Central Houston
9.0 out of 10, Wonderful, (81 reviews)
"Very convenient and great staff. I love this place."
United States
Aaron
The price is AED 496
AED 688 total
includes taxes & fees
13 Sep - 14 Sep
Sentral Forme Houston
Breakfast, lunch and dinner served

8. DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
South Central Houston
8.4 out of 10, Very Good, (666 reviews)
"Love the place, the staff are very friendly. Very accesible and close to the museum and the zoo"
United States
Maria
The price is AED 479
AED 560 total
includes taxes & fees
13 Sep - 14 Sep
DoubleTree by Hilton Houston Medical Center Hotel & Suites
Exterior

9. La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (596 reviews)
"I loved this property and the people who owned it are awesome!! Delicious breakfast, great location..clean and stylish rooms. Great amenitie!!!. Highly recommended!!"
United States
Charles
The price is AED 651
AED 762 total
includes taxes & fees
13 Sep - 14 Sep
La Maison in Midtown an urban B&B
Reception

10. Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown
2.0 star property
South Central Houston
8.0 out of 10, Very Good, (1,002 reviews)
"This was my 4th stay at this property.. clean, comfortable, and great location.."
United States
Susanne
The price is AED 320
AED 374 total
includes taxes & fees
9 Sep - 10 Sep
Americas Best Value Inn Medical Center Downtown
Outdoor pool

11. Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (218 reviews)
"Beautiful place and wonderful management. Would definitely stay again! "
United States
Shelly
The price is AED 646
AED 811 total
includes taxes & fees
10 Sep - 11 Sep
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
Lobby

12. Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
South Central Houston
6.0 out of 10, (1,013 reviews)
"Amazing stay love this place"
United States
Edna
The price is AED 248
AED 291 total
includes taxes & fees
13 Sep - 14 Sep
Extended Stay America Suites Houston Med Ctr Braeswood Bl
Iron/ironing board (on request), bed sheets

13. Scott Inn Suites - Downtown Houston

Scott Inn Suites - Downtown Houston
2.0 star property
South Central Houston
8.4 out of 10, Very Good, (47 reviews)
"Nice staff, good clean room and close to public transportation"
United States
Sergio
The price is AED 222
AED 278 total
includes taxes & fees
15 Sep - 16 Sep
Scott Inn Suites - Downtown Houston
Lobby

14. Hilton University of Houston

Hilton University of Houston
3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (974 reviews)
"Pretty amazing stay"
United States
DELISA
The price is AED 569
AED 666 total
includes taxes & fees
14 Sep - 15 Sep
Hilton University of Houston
House | Private kitchen | Fridge, stovetop, toaster

15. The Oasis Checkmate HTX Rooftop

The Oasis Checkmate HTX Rooftop
3.0 star property
South Central Houston
10.0 out of 10, Exceptional, (3 reviews)
"Great house and location was perfect for the World Cup."
United States
Gabriella
The price is AED 634
AED 2,110 total
includes taxes & fees
9 Sep - 10 Sep
The Oasis Checkmate HTX Rooftop
Standard Room, 1 King Bed | 1 bedroom, premium bedding, blackout drapes, WiFi (free)

16. Southmore Boulevard Motel

Southmore Boulevard Motel
2.0 star property
South Central Houston
5.6 out of 10, (244 reviews)
"I was pleasantly surprised by how well kept the room was and the staff was very friendly"
United States
Brian
The price is AED 202
AED 236 total
includes taxes & fees
9 Oct - 10 Oct
Southmore Boulevard Motel
Reception

17. Golden Motel Near Houston Medical Center

Golden Motel Near Houston Medical Center
2.5 star property
South Central Houston
2.0 out of 10, (4 reviews)
"Room smelt like cigarettes burnt wholes in the wall and bed sheet all 6 walls had stains toilet seat look like someone stood on it "
United States
Jacari
The price is AED 239
AED 294 total
includes taxes & fees
1 Oct - 2 Oct
Golden Motel Near Houston Medical Center
Interior

18. Wanderstay Houston Hostel

Wanderstay Houston Hostel
2.0 star property
South Central Houston
8.2 out of 10, Very Good, (213 reviews)
"Excellent stay experience"
United States
Binkeung
The price is AED 190
AED 222 total
includes taxes & fees
9 Sep - 10 Sep
Wanderstay Houston Hostel
House | 3 bedrooms

19. Modern 3BR Near UH Downtown Toyota Center NRG

Modern 3BR Near UH Downtown Toyota Center NRG
2.0 star property
South Central Houston
The price is AED 385
AED 3,173 total
includes taxes & fees
9 Sep - 10 Sep
Modern 3BR Near UH Downtown Toyota Center NRG
House | 4 bedrooms, desk, high-speed internet

20. The Green Haus Luxxe Cabana Rooftop Retreat

The Green Haus Luxxe Cabana Rooftop Retreat
2.0 star property
South Central Houston
10.0 out of 10, Exceptional, (1 review)
The price is AED 843
AED 2,355 total
includes taxes & fees
5 Oct - 6 Oct
The Green Haus Luxxe Cabana Rooftop Retreat
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in South Central Houston

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
Exterior
La Maison in Midtown an urban B&B
3.5 star property
9.8
Exceptional
596 reviews
View
Outdoor pool
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
9.6
Exceptional
218 reviews
View
Laptop workspace, blackout drapes, soundproofing
Downtowner Inns - Houston Downtown
2.0 star property
9.2
Wonderful
236 reviews
View
Lobby lounge
InterContinental Houston by IHG
4.0 star property
9.4
Exceptional
1,010 reviews
View
Premium bedding, pillowtop beds, minibar, in-room safe
Hotel Zaza Houston Museum District
4.5 star property
9.2
Wonderful
1,007 reviews
View

Where to stay in South Central Houston

Find the best South Central Houston areas and neighborhoods for the activities you enjoy most.
A cityscape with modern skyscrapers and a park with trees and people.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

A large, modern shopping mall with a glass ceiling and multiple levels.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Gerald D. Hines Waterwall Park.

A cityscape with tall buildings, including a prominent one with 'Texas Children's Hospital' on it, under a partly cloudy sky.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

An art gallery with a minimalist design, featuring a central bench and large abstract paintings on the walls.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Rothko Chapel while you're exploring the area.

A modern cityscape with a tram and tall buildings.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

Top South Central Houston Hotel Reviews

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

10/10 Excellent
"We couldn’t have chosen a better place to stay. We needed a room near Methodist Hospital due to a family member having a medical procedure. The convenience of walking to and from was perfect. The check in process was easy. The stay was great check out was the same. We truly appreciate the front desk staff for having great customer service. Thank you for a great stay."
Karicia 2-night trip
Posted 8 hours ago
The Westin Houston Medical Center/Museum District

Frequently asked questions

What's it like in South Central Houston?
Travelers are sure to enjoy a stay in Houston's South Central Houston neighborhood. Be sure to check out TDECU Stadium and Children's Museum of Houston as part of your South Central Houston travel plans.
What's the best accommodation in South Central Houston?
Based on our traveler data, Hotel Zaza Houston Museum District is one of the top choices for your stay in South Central Houston. This hotel is a short 6-minute walk from Rice University, and it offers a full-service spa and a restaurant. Other good options for your stay in the area include Hilton Houston Plaza/Medical Center and The Westin Houston Medical Center/Museum District.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1270 hotels and other accommodations in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to review the best options available in South Central Houston.
Where can I learn more about changing or cancelling my trip to South Central Houston?
To access more information about changing or cancelling your trip to South Central Houston, go to https://www.expedia.com/service/.
What is there to do around this Houston neighborhood?
Spend some time exploring the great outdoors at Hermann Park, Twilight Epiphany Skyspace, and Cullen Sculpture Garden. TDECU Stadium and Children's Museum of Houston are some other stops to visit in the neighborhood. Daikin Park and Toyota Center are some favorite places to visit in the area around South Central Houston. Shape Community Center and Project Row Houses are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station, or Ensemble/HCC Station. If you want to venture out of town, M. D. Anderson Station is the closest train station. You can also catch a ride at Kinder Station.