In the heart of Jeffersonville, Deaconess Guesthouse combines historical charm with modern luxury. Enjoy stunning riverfront views from the front porch and balcony or unwind in the hot tub under starry skies. This spacious retreat boasts indoor gaming zones, a unique dome, fully-equipped kitchens, SMART ROKU TVs in every living room and bedroom.
Reviews
1010 out of 10
Exceptional
Entire home
8 bedrooms6 bathroomsSleeps 24539 sq m
Popular amenities
Hot Tub
Dryer
Kitchen
Fireplace
Washer
Barbecue grill
Add dates for prices
About this property
Entire place
You'll have the entire home to yourself and will only share it with other guests in your party.
*** Deaconess Guesthouse – Historic Luxury on the Ohio River, Minutes from Louisville & Jeffersonville ***
★ Where History Meets Timeless Luxury Step into the elegance of the Deaconess Guesthouse, a fully reimagined 1800s landmark that once served as Jeffersonville’s first public hospital. Expertly restored by Charming Vacation Homes, this iconic estate seamlessly combines historic charm with boutique-style comforts. With panoramic Ohio River views and a location just minutes from downtown Louisville, the Bourbon Trail and Jeffersonville’s lively riverfront district, it offers a truly unparalleled setting for your next gathering.
★ Crafted for Groups & Celebrations With 8 bedrooms and 6 bathrooms spread across four private units, the estate comfortably welcomes up to 24 guests. Whether hosting a family reunion, corporate retreat, wedding party or milestone celebration, the home’s layout offers the perfect blend of shared spaces and private retreats. Every detail—from the expansive living areas to the refined finishes and curated décor—is designed to create an atmosphere of warmth, connection and lasting memories.
★ Signature Features & Amenities 1. Private Hot Tub & Fire Pit – Unwind beneath the stars in your own riverfront oasis 2. Wraparound Porches & Balconies – Start mornings with sunrise views end with evening cocktails 3. Stargazing Dome – A one-of-a-kind retreat, perfect for both kids and adults 4. Ample On-Site Parking – Convenient for large groups, events and VIP transportation (concierge recommendations)
★ A Location Unlike Any Other - Walk to Downtown Jeffersonville – Explore boutique shops, local dining, and riverfront entertainment - Just 2.5 Miles to Downtown Louisville – Experience bourbon distilleries, Churchill Downs, world-class museums and live events - Adventure at Your Doorstep – Enjoy kayaking, biking trails, riverfront concerts and seasonal festivals nearby
★ Your Exclusive Riverfront Escape From tranquil mornings on the porch to evenings around the fire pit, the Deaconess Guesthouse offers a stay that is both indulgent and inspiring. Its rich history, scenic riverfront setting and luxury amenities make it an extraordinary destination for guests who expect more than just a place to stay.
Book your stay today and create memories in one of Jeffersonville’s most historic and luxurious riverfront estates.
★ CONVENIENT LOCATION The house is centrally located and is within a 10-15 minute Uber/Lyft drive to most locations:
- Big Four Walking Bridge (Connecting KY and IN) - 0.4 miles (2 mins) - Downtown Louisville/ 4th Street Live - 2.4 miles (6 mins) - KFC Yum Center - 2.3 miles (7 mins) - Churchill Downs (DERBY) - 7.7 miles (15 mins) - Waterfront Park - 3.4 miles (9 mins) - Papa Johns Stadium (Cardinal Stadium) - 6.4 miles (11 mins) - Kentucky Fairgrounds - 6.5 miles (10 min) - University of Louisville - 6.5 miles (12 mins) - Louisville Airport - 8.6 miles (10 mins) - Kentucky Exposition Center - 6.7 miles (11 mins) - Kentucky Kingdom - 7.4 miles (13 mins) - Highland Festival Grounds - 8.5 miles (12 mins) - Louisville Mega Cavern - 10.2 miles (19 mins) - UPS Worldport - 11.2 miles (20 mins) - Ford LAP Plant - 10.9 miles (16 mins) - Waverly Hills Sanatorium - 17 miles (30 mins) - Valhalla Golf Club - 19 miles (27 mins)
PROPERTY HIGHLIGHTS ★ Exclusive Riverfront Retreat near downtown Louisville/Jeffersonville: Experience a rare architectural masterpiece where historic elegance meets modern sophistication—perfectly situated just minutes from Louisville/Jeffersonville, New Albany and Clarksville. ★ Prime Ohio Riverfront Setting: Wake up to sweeping river views and step outside to enjoy Jeffersonville’s vibrant downtown dining, boutique shopping, lively festivals, and entertainment—all just a short stroll away. ★ Historic Charm, Modern Luxury: This meticulously restored landmark offers refined interiors, elegant finishes and one-of-a-kind details that create an atmosphere of timeless comfort. ★ Scenic Views & Inviting Spaces: Savor your morning coffee or evening cocktails from covered porches and private balconies overlooking the river’s sparkling waters. ★ Designed for Comfort & Connection: With 8 beautifully appointed bedrooms and 6 designer bathrooms, the home provides light-filled, spacious interiors perfect for relaxation, entertaining and memory-making. ★ Chef-Inspired Living: Four gourmet kitchens, each with premium appliances and upscale touches, set the stage for unforgettable meals and gatherings. ★ Family & Pet Friendly: From cozy nooks and kid-friendly areas to accommodations for pets, every member of your group will feel right at home. ★ Private Outdoor Oasis: Unwind in the hot tub, gather around the fire pit, lounge under the Hyperdome or gazebo, grill outdoors and enjoy lawn games beneath the stars. ★ Entertainment for Every Occasion: Smart Roku TVs in every bedroom, indoor/outdoor games and inviting lounge spaces ensure fun and relaxation in every season. ★ Perfect for Groups & Celebrations: Ideal for reunions, retreats and extended stays—complete with 4 washer/dryer sets, parking for 8 and flexible gathering areas designed to bring people together. ★ Your Riverfront Escape Awaits: Discover the ultimate blend of history, luxury and location—an unforgettable getaway right on the banks of the Ohio River.
★ TOP 2025 UPCOMING EVENTS -Kentucky Bourbon Festival 2025: Sep 5-7th, 2025 -Bourbon & Beyond: Sept 11-14th, 2025 -Louder than Life: Sept 18-21st, 2025 -Jack O’ Lantern Spectacular: Oct 2025 -Halloween Weekends Louisville South KOA Holiday: Oct 2025
★ OTHER 2025 UPCOMING EVENTS (Including TRADE SHOWS) -Equipment Expo: Oct 21th to 24th, 2025 -North American International Livestock Exposition: Nov 6th to 20th, 2025
NOTE: 1) Must be 25 or older to book. 2) Please review house rules before booking. Rental Agreement & Security Hold: Guests must e-sign our rental agreement and Must submit a $500 off-platform security hold that will be collected upon signing rental agreement but it will not be placed until 2 days prior to arrival and released 7 days after departure, if no damages are reported. Please note we are API Connected to a hotel-style software called OwnerRez to safely and securely take off-platform security deposits. 3) *** STRICT CANCELLATION for DERBY/ Bourbon & Beyond *** 4) Visitors are not permitted unless you make a special request to the host and receive approval. 5) We have exterior surveillance with voice and recording capabilities of the parking area and front door. They are in place for security of guests and the home. We do NOT have interior cameras nor camera in the backyard. 6) The Dome is not recommended for use during hot summer months. We suggest enjoying the other amenities during warmer months for optimal comfort. 7) We cannot accommodate early check-ins or late check-outs for same-day turnarounds. 8) For days without same-day turnarounds, we offer early check-ins and late check-outs at the following rates: $100 for up to 2 hours, $250 for 2 to 4 hours, and a full day's rate for more than 4 hours. 9) Please note that for cancellations of bookings made on platforms other than Airbnb, a Stripe card processing fee of 3% will be deducted from the total refund.
PLEASE REVIEW THE HOUSE RULES BEFORE BOOKING. THANK YOU !!
Property amenities
Pool/Spa
Hot tub
Internet
Available in the house: Free WiFi
Parking and transportation
Car recommended
Parking on site
Kitchen
Coffee/tea maker
Cookware, dishware, and utensils
Dishwasher
Ice maker
Kitchen island
Microwave
Oven
Refrigerator
Spices
Stovetop
Toaster
Dining
Dining table
Bedrooms
8 bedrooms
Bedsheets provided
Sofa bed
Bathroom
6 bathrooms
Bathtub or shower
Hair dryer
Shower
Towels provided
Living spaces
Dining table
Fireplace
Living room
Entertainment
Books
Games
Smart TV
Outdoor areas
Balcony
Barbecue grill
Fenced yard
Firepit
Garden
Laundry
Laundry facilities
Washing machine
Work spaces
Desk
Desk chair
Comfort
Air conditioning
Heating
Pets
Pet friendly
Suitability/Accessibility
If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
Area rugs in public areas
Handrails in hallways
Handrails in stairways
Hardwood flooring in public areas
Smooth flooring in public areas
Thin carpet in public areas
Tile flooring in public areas
Well-lit path to entrance
Smoking not allowed
Services and conveniences
Iron/ironing board
Location highlights
In the city center
Near a hospital
Near a zoo
Near the marina
On a river
On the waterfront
Things to do
Arcade/game room
Water park
Casino nearby
Fishing nearby
Golfing nearby
Kayaking nearby
Motor boating nearby
Theme park nearby
Winery tours nearby
Safety features
Carbon monoxide detector (host has indicated there is a carbon monoxide detector on the property)
Smoke detector (host has indicated there is a smoke detector on the property)
First aid kit
Fire extinguisher
Deadbolt lock
General
At least 80% lighting from LEDs
Garden
Recycling
Unit size: 5,800 square feet
Water-efficient showers
Water-efficient toilets
Policies
Check-in
Check-in time starts at 4:00 PM
Contactless check-in available
Minimum check-in age: 25
Check-out
Check-out before 10:00 AM
Special check-in instructions
You will receive an email from the host with check-in and check-out instructions
Rules
Must sign rental agreement upon booking which will be sent via email
A $500 security hold will be placed 2 days prior to arrival and released 7 days after departure, if no damages are reported
Must follow all house rules listed in the end of the description and also on the rental agreement.
Pets
Pets allowed
Service animals are welcome, and are exempt from fees
Note from host: Up to 2 pets 50lbs max.
Children and extra beds
Children are welcome
Events
No events allowed
Smoking
Smoking is not permitted
Important information
You need to know
Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
Onsite parties or group events are strictly prohibited
Host has indicated there is a carbon monoxide detector on the property
Host has indicated there is a smoke detector on the property
Safety features at this property include a fire extinguisher, a first aid kit, and a deadbolt lock
This property is managed through our partner, Vrbo. You will receive an email from Vrbo with a link to a Vrbo account, where you can change or cancel your reservation
We should mention
A car is recommended for transportation to and from this property
Property is also known as
orp5b65a95x
About the neighborhood
Jeffersonville, IN
What's nearby
KFC Yum Center - 3 min drive - 3.1 km
Whiskey Row - 3 min drive - 3.1 km
Louisville Waterfront Park - 4 min drive - 3.4 km
Kentucky International Convention Center - 4 min drive - 3.8 km
Louisville Slugger Museum - 4 min drive - 4.5 km
Getting around
Louisville, KY (LOU-Bowman Field) - 16 min drive
Restaurants
Pearl Street Taphouse - 12 min walk
Parlour - 10 min walk
Cluckers - 5 min walk
KingFish - 15 min walk
Fresco Tea Bar - 9 min walk
Frequently asked questions
Is 6000SF~Sleeps24~Louisville~Views~LawnOasis~HotTub~Dome~Firepit~Pet~Lux Amenities pet-friendly?
Yes, pets are allowed at this property.
What time is check-in at 6000SF~Sleeps24~Louisville~Views~LawnOasis~HotTub~Dome~Firepit~Pet~Lux Amenities?
Check-in begins at 4:00 PM.
What time is check-out at 6000SF~Sleeps24~Louisville~Views~LawnOasis~HotTub~Dome~Firepit~Pet~Lux Amenities?
Check-out is at 10:00 AM.
Where is 6000SF~Sleeps24~Louisville~Views~LawnOasis~HotTub~Dome~Firepit~Pet~Lux Amenities located?
This family-friendly Jeffersonville vacation home is located on the waterfront, within a 10-minute walk of Falls of the Ohio Interpretive State Park, Ohio River, and Big Four Bridge. KFC Yum Center is 2.2 mi (3.6 km) away.
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