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Check prices for these dates

This weekend
13 Nov - 15 Nov
Next weekend
20 Nov - 22 Nov

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Our top choices for Main Street Fort Pierce hotels

A hotel lobby with a seating area, a reception desk, and a TV mounted on the wall.

1. Hampton Inn & Suites Ft. Pierce

Hampton Inn & Suites Ft. Pierce
2.5 star property
7.9 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (1,001 reviews)
"Rooms & common areas were clean & breakfast was good with a wide variety to choose from. Would stay here again."
United States
Ashton
The price is AED 340
AED 381 total
includes taxes & fees
29 Nov - 30 Nov
Hampton Inn & Suites Ft. Pierce
An outdoor patio with tables and chairs, surrounded by palm trees and other greenery.

2. Fairfield Inn & Suites by Marriott Fort Pierce

Fairfield Inn & Suites by Marriott Fort Pierce
3.0 star property
7.7 km from Main Street Fort Pierce
8.8 out of 10, Excellent, (1,004 reviews)
"Even though the property is undergoing renovation, it was very clean and the staff are so nice."
United States
Don
The price is AED 340
AED 381 total
includes taxes & fees
19 Nov - 20 Nov
Fairfield Inn & Suites by Marriott Fort Pierce
A beach with two chairs, a palm tree, and a pier in the background.

3. Hutchinson Island Hotel

Hutchinson Island Hotel
2.5 star property
3.1 km from Main Street Fort Pierce
8.2 out of 10, Very good, (1,368 reviews)
"Great place to stay"
United States
Calvin
The price is AED 403
AED 522 total
includes taxes & fees
22 Nov - 23 Nov
Hutchinson Island Hotel
An outdoor seating area with fire feature, stone walls, and a view into the building.

4. Home2 Suites by Hilton Ft. Pierce I-95

Home2 Suites by Hilton Ft. Pierce I-95
3.0 star property
7.8 km from Main Street Fort Pierce
9.4 out of 10, Exceptional, (280 reviews)
"Wet nice"
United States
Cheryl
The price is AED 465
AED 521 total
includes taxes & fees
28 Nov - 29 Nov
Home2 Suites by Hilton Ft. Pierce I-95
A buffet with various food items, including omelets and other dishes, served in metal containers with glass lids.

5. Holiday Inn Express Hotel & Suites Fort Pierce West by IHG

Holiday Inn Express Hotel & Suites Fort Pierce West by IHG
2.5 star property
8.3 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (913 reviews)
"Clean rooms and bathrooms, breakfast and ample parking. The staff was very helpful as well"
United States
Dorisbell
The price is AED 386
AED 432 total
includes taxes & fees
6 Dec - 7 Dec
Holiday Inn Express Hotel & Suites Fort Pierce West by IHG
A spacious living area with a grey sofa, a blue sofa, and a wooden accent wall with a flat-screen TV.

6. La Quinta Inn & Suites by Wyndham Ft. Pierce

La Quinta Inn & Suites by Wyndham Ft. Pierce
3.0 star property
7.9 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,001 reviews)
"Great property and service but they allow dogs to stay in the hotel and getting awaken by barking dogs is a no go"
United States
Willie
The price is AED 323
AED 362 total
includes taxes & fees
19 Nov - 20 Nov
La Quinta Inn & Suites by Wyndham Ft. Pierce
A hotel room with two beds, a desk, a TV, and a balcony with a view of the ocean.

7. Days Inn & Suites by Wyndham Fort Pierce Midtown

Days Inn & Suites by Wyndham Fort Pierce Midtown
2.0 star property
4.5 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (21 reviews)
"Very clean and convenient."
United States
Gary
The price is AED 259
AED 290 total
includes taxes & fees
15 Nov - 16 Nov
Days Inn & Suites by Wyndham Fort Pierce Midtown
A hotel entrance with a welcome sign, a black mat, and two potted plants.

8. At Home Inn

At Home Inn
2.5 star property
8.2 km from Main Street Fort Pierce
8.2 out of 10, Very good, (1,395 reviews)
"Everything was great!"
United States
John
The price is AED 207
AED 232 total
includes taxes & fees
12 Dec - 13 Dec
At Home Inn
A hotel room with two beds, a television, a ceiling fan, and a view of the beach.

9. Royal Inn Beach Hotel Hutchinson Island

Royal Inn Beach Hotel Hutchinson Island
2.5 star property
3.8 km from Main Street Fort Pierce
7.2 out of 10, Good, (1,003 reviews)
"Property and staff were great. Convenient place to stay if visiting Fort Pierce. I would definitely book again."
United States
Malia
The price is AED 393
AED 499 total
includes taxes & fees
7 Dec - 8 Dec
Royal Inn Beach Hotel Hutchinson Island
A hotel room with two large beds, a bedside table with a lamp, and a view of the outside through a large window.

10. Comfort Suites Fort Pierce I-95

Comfort Suites Fort Pierce I-95
2.5 star property
7.7 km from Main Street Fort Pierce
7.8 out of 10, Good, (984 reviews)
"Clean rooms, friendly staff"
United States
Marina
The price is AED 297
AED 332 total
includes taxes & fees
6 Dec - 7 Dec
Comfort Suites Fort Pierce I-95
A modern living room with a sofa, a glass coffee table with a bowl, and a textured wall.

11. Hampton Inn & Suites Vero Beach Downtown

Hampton Inn & Suites Vero Beach Downtown
2.5 star property
22.1 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (1,001 reviews)
"Room was basic hotel room .Nothing special but was clean and large"
United States
steven
The price is AED 449
AED 503 total
includes taxes & fees
6 Dec - 7 Dec
Hampton Inn & Suites Vero Beach Downtown
A hotel with a modern facade, a welcoming entrance, and a flagpole.

12. Hampton Inn & Suites Port St. Lucie, West

Hampton Inn & Suites Port St. Lucie, West
2.5 star property
17.4 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (1,011 reviews)
"Was very good cleaning, my staying was really nice and relaxing"
United States
Neiva
The price is AED 356
AED 399 total
includes taxes & fees
6 Dec - 7 Dec
Hampton Inn & Suites Port St. Lucie, West
An outdoor seating area with wicker furniture, a fire pit, and palm trees.

13. Staybridge Suites Vero Beach by IHG

Staybridge Suites Vero Beach by IHG
3.0 star property
24.1 km from Main Street Fort Pierce
9.6 out of 10, Exceptional, (729 reviews)
"Perfect stay"
United States
Michelle
The price is AED 455
AED 510 total
includes taxes & fees
29 Nov - 30 Nov
Staybridge Suites Vero Beach by IHG
A hotel lobby with a reception desk, a chandelier, a clock, and a sofa.

14. Sleep Inn Fort Pierce I-95

Sleep Inn Fort Pierce I-95
2.5 star property
7.9 km from Main Street Fort Pierce
7.6 out of 10, Good, (928 reviews)
"it was a good stay"
United States
JOHN
The price is AED 276
AED 310 total
includes taxes & fees
29 Nov - 30 Nov
Sleep Inn Fort Pierce I-95
A clear blue swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a gazebo.

15. Best Western Port St. Lucie

Best Western Port St. Lucie
2.5 star property
14 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,002 reviews)
"Great stay"
United States
Patrisha
The price is AED 331
AED 370 total
includes taxes & fees
29 Nov - 30 Nov
Best Western Port St. Lucie
A multi-story hotel with a modern design, featuring a prominent sign for 'Springhill Suites Marriott'.

16. SpringHill Suites Port St. Lucie

SpringHill Suites Port St. Lucie
3.0 star property
17.2 km from Main Street Fort Pierce
8.8 out of 10, Excellent, (1,001 reviews)
"Loved our stay, great staff."
United States
Amy
The price is AED 372
AED 416 total
includes taxes & fees
17 Nov - 18 Nov
SpringHill Suites Port St. Lucie
A hotel lobby with a reception desk, seating area, and a hallway leading to other rooms.

17. Days Inn & Suites by Wyndham Fort Pierce I-95

Days Inn & Suites by Wyndham Fort Pierce I-95
2.5 star property
7.8 km from Main Street Fort Pierce
7.4 out of 10, Good, (1,000 reviews)
"The staff was excellent"
United States
Carlton
The price is AED 217
AED 243 total
includes taxes & fees
29 Nov - 30 Nov
Days Inn & Suites by Wyndham Fort Pierce I-95
A hotel lobby with a reception desk, seating area, and a large window offering a view of the outdoors.

18. Red Roof Inn Ft Pierce

Red Roof Inn Ft Pierce
2.0 star property
4.6 km from Main Street Fort Pierce
7.2 out of 10, Good, (819 reviews)
"Great place to stay as a family the day staff was wonderful when my hubby went to ask for an extra towel he was only given a had towel then had a fall in the shower due to no grip in the tub/shower but the room was up to par for the price pool was even still open"
United States
Sam
The price is AED 279
AED 313 total
includes taxes & fees
15 Nov - 16 Nov
Red Roof Inn Ft Pierce
A Holiday Inn Express hotel with a covered entrance, palm trees, and a landscaped garden.

19. Holiday Inn Express & Suites Port St. Lucie West by IHG

Holiday Inn Express & Suites Port St. Lucie West by IHG
2.5 star property
17.1 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,000 reviews)
"Great stay"
United States
AEON
The price is AED 466
AED 522 total
includes taxes & fees
22 Nov - 23 Nov
Holiday Inn Express & Suites Port St. Lucie West by IHG
An outdoor patio area with a fire pit, red and black wicker furniture, and string lights.

20. Residence Inn by Marriott Port St. Lucie

Residence Inn by Marriott Port St. Lucie
3.0 star property
17.8 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (1,001 reviews)
"The staff was friendly, breakfast was hot and lots of great options and our room was a king studio - very spacious!"
United States
Vicki
The price is AED 433
AED 485 total
includes taxes & fees
29 Nov - 30 Nov
Residence Inn by Marriott Port St. Lucie
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Main Street Fort Pierce

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A buffet with various food items, including omelets and other dishes, served in metal containers with glass lids.
Holiday Inn Express Hotel & Suites Fort Pierce West by IHG
2.5 star property
9.0
Wonderful
913 reviews
View
An outdoor patio with tables and chairs, surrounded by palm trees and other greenery.
Fairfield Inn & Suites by Marriott Fort Pierce
3.0 star property
8.8
Excellent
1,004 reviews
View
A hotel lobby with a seating area, a reception desk, and a TV mounted on the wall.
Hampton Inn & Suites Ft. Pierce
2.5 star property
9.2
Wonderful
1,001 reviews
View
An outdoor seating area with fire feature, stone walls, and a view into the building.
Home2 Suites by Hilton Ft. Pierce I-95
3.0 star property
9.4
Exceptional
280 reviews
View
A spacious living area with a grey sofa, a blue sofa, and a wooden accent wall with a flat-screen TV.
La Quinta Inn & Suites by Wyndham Ft. Pierce
3.0 star property
8.6
Excellent
1,001 reviews
View

Where to stay in Main Street Fort Pierce

Find the best Main Street Fort Pierce areas and neighborhoods for the activities you enjoy most.
A coastal area with a narrow waterway, a beach, and residential buildings.

Lakewood Park

While Lakewood Park isn't home to many top sights, McKee Botanical Garden and Avalon State Park are some notable places to visit nearby.

Spanish Lakes Country Club Village

While there might not be top attractions in Spanish Lakes Country Club Village, you can explore the larger area and discover places like Harbor Branch Ocean Discovery Center and McKee Botanical Garden.

A calm lake reflecting trees and a clear sky.

Spanish Lakes Fairways

While Spanish Lakes Fairways might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Lakewood Park Regional Park / Pool and Indrio Road Park / Schoolhouse.

A coastal city with a bay, mangrove islands, and a clear blue sky.

Meadowood

If you're looking for some top things to see and do in Meadowood and surrounding area, you can visit Endless Summer Vineyard & Winery and Al's Family Farms.

A mosaic sign with 'Mainstreet Fort Pierce' written on it.

Panther Woods

If you're looking for some top things to see and do in Panther Woods and surrounding area, you can visit Endless Summer Vineyard & Winery and Al's Family Farms.

Top Main Street Fort Pierce Hotel Reviews

voco Sandpiper All-Inclusive Resort by IHG

voco Sandpiper All-Inclusive Resort by IHG

10/10 Excellent
"Great place."
Alejandro 4-night trip
Posted 11 hours ago
voco Sandpiper All-Inclusive Resort by IHG

Frequently asked questions

What is Main Street Fort Pierce like?
Main Street Fort Pierce is a neighborhood that travelers like for its waterfront, art, and shopping. Be sure to check out Sunrise Theater and Fort Pierce Farmer's Market as part of your Main Street Fort Pierce travel plans.
How many hotels can I expect to find in Main Street Fort Pierce?
Book one of Expedia's 7 hotels and other accommodations in Main Street Fort Pierce and start exploring everything Fort Pierce has to offer.
If I need to cancel my hotel reservation in Main Street Fort Pierce, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then use the filter option "fully refundable" to review the top deals on offer in Main Street Fort Pierce.
Where can I learn more about changing or cancelling my trip to Main Street Fort Pierce?
For additional details about changing or cancelling your trip to Main Street Fort Pierce, head over to our customer service page.
What is there to do in this Fort Pierce neighborhood?
Sights like Sunrise Theater and Official Highwaymen Art Gallery can be part of your cultural tour of Main Street Fort Pierce. Fort Pierce Farmer's Market and Fort Pierce City Marina are also a couple of places to visit in the neighborhood. A few places to visit in the area around Main Street Fort Pierce include Manatee Education and Observation Center, House of Seven Gables, and A.E. Backus Museum. Marina at Fort Pierce and Causeway Cove are also worth a visit when you're out sightseeing in Fort Pierce.