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Check prices for these dates

Tonight
29 Sep - 30 Sep
Tomorrow
30 Sep - 1 Oct
This weekend
2 Oct - 4 Oct
Next weekend
9 Oct - 11 Oct

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Our top choices for Matthews hotels

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.
A kitchenette with a coffee machine, a kettle, and storage shelves.
A breakfast buffet area with a display of cinnamon sweet rolls, a sign indicating the roll selection, and a patterned wall in the background.
A reception area with a reception desk, a large wall-mounted sign, and a potted plant.

1. Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
Sikeston
United States
Melissa
AED 342
AED 387 total
includes taxes & fees
4 Oct - 5 Oct
Holiday Inn Express & Suites Sikeston Southwest by IHG
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.
A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.
A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".
A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

2. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
Sikeston
United States
Allen
AED 371
AED 420 total
includes taxes & fees
11 Oct - 12 Oct
Fairfield Inn & Suites by Marriott Sikeston
A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.
A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.
An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.
A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

3. Hampton Inn Sikeston

Hampton Inn Sikeston
Sikeston
United States
John
AED 373
AED 423 total
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn Sikeston
Property amenity
A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.
A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.
An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

4. TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
Sikeston
United States
Stacy
AED 400
AED 453 total
includes taxes & fees
8 Oct - 9 Oct
TownePlace Suites by Marriott Sikeston
An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.
A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.
An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.
A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

5. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
Sikeston
United States
Scott
AED 345
AED 397 total
includes taxes & fees
4 Oct - 5 Oct
Drury Inn & Suites Sikeston, MO
A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.
Room
A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.
A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.

6. Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
Sikeston
United States
Shelley
AED 309
AED 352 total
includes taxes & fees
1 Oct - 2 Oct
Best Western Plus Sikeston I-55
A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.
A hotel kitchen with a long counter, various appliances, and a tiled backsplash.
A hotel room with two beds, a sofa, a coffee table, and artwork on the walls.
A hotel room with a flat-screen TV, a microwave, a coffee maker, a dining table, and two sofas.

7. Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
Sikeston
United States
William
AED 210
AED 239 total
includes taxes & fees
5 Oct - 6 Oct
Super 8 by Wyndham Sikeston/Miner Area
A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.
A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.
A living room with a sofa, two chairs, a coffee table, a television, and a window with blinds.
A Travel Inn and Suites with a brick facade, a flat roof, and a welcoming entrance.

8. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Sikeston
United States
Craig
AED 235
AED 268 total
includes taxes & fees
30 Sep - 1 Oct
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.
A spacious lobby with a central atrium, a piano, and a reception desk.
Lobby
A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

9. Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
Sikeston
United States
David
AED 244
AED 278 total
includes taxes & fees
4 Oct - 5 Oct
Days Inn and Suites by Wyndham Sikeston
A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.
A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.
A hotel lobby with a reception desk, seating area, and large windows offering a view of the outdoors.
A living room with two sofas, a coffee table, a TV, and a cabinet.

10. Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
Sikeston
United States
Starlette
AED 316
AED 360 total
includes taxes & fees
29 Oct - 30 Oct
Comfort Inn & Suites Sikeston I-55
A hotel room with two beds, a desk, a chair, a TV, and a mirror.
A reception area with a sofa, a small table, a trash bin, a microwave, and a book display.
A bathroom with a bathtub, toilet, and shower curtain.
A motel with a blue awning and a green 7-Eleven. It has a covered parking area and a two-story structure with a balcony.

11. Country Yard Inn and Suite

Country Yard Inn and Suite
Sikeston
United States
William
AED 207
AED 246 total
includes taxes & fees
30 Sep - 1 Oct
Country Yard Inn and Suite
A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.
A hotel with a central entrance, multiple parking spaces, and a well-lit facade.
A modern kitchen with a built-in microwave, a black refrigerator, and a wooden countertop.
A room with a brown leather sofa, a red chair, and a cityscape painting on the wall.

12. Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
Marston
United States
Brenda
AED 212
AED 242 total
includes taxes & fees
1 Oct - 2 Oct
Super 8 By Wyndham Marston
A building with a fountain and flower beds in front.
A hotel room with a beige sofa, two patterned armchairs, a ceiling fan, a flat-screen TV, and a window with curtains.
A reception area with a stone wall, wooden cabinets, and a sign for The Riverstone Hotel.
A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.

13. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
Charleston
United States
Kathleen
AED 244
AED 271 total
includes taxes & fees
2 Oct - 3 Oct
The Riverstone Hotel Charleston-Sikeston
A hotel room with two beds, a television, a desk, and a mirror.
A reception area with a counter, a refrigerator stocked with beverages, a no smoking sign, and a window with an American flag.
A hotel room with a bed, a desk, a television, and a seating area with a small table.
A motel with multiple rooms, a parking lot, and a sign indicating 'Travel Inn Marston.'

14. Travel Inn Marston I-55 by Hotel O

Travel Inn Marston I-55 by Hotel O
Marston
United States
Frank
AED 164
AED 197 total
includes taxes & fees
1 Oct - 2 Oct
Travel Inn Marston I-55 by Hotel O
A hotel room with a bed, a desk, a chair, a bathroom with a bathtub, and a patterned floor.
A hotel reception area with a reception desk, framed certificates, and a painting on the wall.
A kitchen with wooden cabinets, a stainless steel sink, a microwave, and a dishwasher.
A living room with a sofa, a coffee table, a clock, and a painting on the wall.

15. Econo Lodge Dexter

Econo Lodge Dexter
Dexter
United States
Herman
AED 187
AED 210 total
includes taxes & fees
28 Oct - 29 Oct
Econo Lodge Dexter
A diner with booth seating, a checkered floor, and a counter with a cash register.
A hotel room with a bed, a desk, a chair, a large mirror, a sink, and a trash bin.
A reception area with a marble counter, potted plants, a clock, and a TV on the wall.
A gym with multiple exercise machines, a clock on the wall, and a window with blinds.

16. Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter
Dexter
United States
Steven
AED 335
AED 376 total
includes taxes & fees
18 Oct - 19 Oct
Travelodge by Wyndham Dexter
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.
A reception area with a counter, a flat-screen TV, and a window with blinds.
A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.
A hotel with a covered entrance, a sign for the brand, and a parking lot with cars.

17. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
Charleston
United States
William
AED 219
AED 243 total
includes taxes & fees
30 Sep - 1 Oct
Super 8 by Wyndham Charleston/Sikeston East MO
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.
A hotel room with two beds, a nightstand, a lamp, and a window with curtains.
A kitchen with wooden cabinets, a granite countertop, a built-in microwave, and a window with a view.
A motel with a sign reading "Eagle Inn" and a parking lot with several cars.

18. Eagle Inn Charleston

Eagle Inn Charleston
Charleston
United States
Jackson
AED 242
AED 269 total
includes taxes & fees
30 Sep - 1 Oct
Eagle Inn Charleston
A modern hotel lobby with a bar area, seating, and artwork on the walls.
A swimming pool with clear blue water, surrounded by sun loungers and a lifeguard stand.
A modern hotel with a prominent sign, a covered entrance, and a well-lit exterior.
A modern kitchen with a large island, bar stools, wine bottles, and a built-in TV.

19. Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
Dexter
United States
Kendall
AED 358
AED 402 total
includes taxes & fees
11 Oct - 12 Oct
Hampton Inn By Hilton Dexter
A coffee shop with a coffee machine, espresso cups, a sink, and a trash bin.
A kitchen with a white microwave, a fruit basket, a coffee maker, and a storage container.
A hotel lobby with a reception desk, a waiting area with a sofa and armchairs, and a patterned carpet.
A hotel room with two beds, a desk with a lamp, a chair, a dresser, and a door with a handle.

20. Dexter Inn

Dexter Inn
Dexter
United States
Edward
AED 253
AED 285 total
includes taxes & fees
30 Sep - 1 Oct
Dexter Inn
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Top Matthews Hotel Reviews

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

10/10 Excellent
"Everything"
James 1-night trip
Posted 3 hours ago
Holiday Inn Express & Suites Sikeston Southwest by IHG
OYO Hickory House Inn

OYO Hickory House Inn

10/10 Excellent
"Great staff! Clean rooms and convinient"
DIEGO 7-night trip
Posted 17 hours ago
OYO Hickory House Inn
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good
"NA NA NA NA NA NA NA NA NA NA NA NA NA"
Kevin 1-night trip
Posted 1 day ago
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Super 8 By Wyndham Marston

Super 8 By Wyndham Marston

8/10 Good
"Very clean and a very friendly staff! Air conditioner in room wasn’t working perfectly so it felt very humid but overall was not bad. I would stay here again!"
Brenda 1-night trip
Posted 2 days ago
Super 8 By Wyndham Marston
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Clean room and perfect stay. We have come to consistently appreciate Drury brand for a quality stay. We would definitely recommend this location for clean comfortable accommodations."
Hiram 1-night trip
Posted 6 days ago
Drury Inn & Suites Sikeston, MO
TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston

10/10 Excellent
"My overall experience was amazing from the time I checked in until I left. The staff were super pleasant and incredible. My room was clean and spacious. I never been in an extended stay room before. I definitely will be booking a suite like this one again."
Stacy 2-night trip
Posted 13 days ago
TownePlace Suites by Marriott Sikeston

More cheap stays in Matthews

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave Sikeston MO
AED 210
AED 239 total
5 Oct - 6 Oct
includes taxes & fees
Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO
AED 219
AED 243 total
30 Sep - 1 Oct
includes taxes & fees
Super 8 by Wyndham Charleston/Sikeston East MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
AED 244
AED 278 total
4 Oct - 5 Oct
includes taxes & fees
Days Inn and Suites by Wyndham Sikeston
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO
AED 309
AED 352 total
1 Oct - 2 Oct
includes taxes & fees
Best Western Plus Sikeston I-55
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

115 Hospitality Dr Sikeston MO
AED 342
AED 387 total
4 Oct - 5 Oct
includes taxes & fees
8.8/10 Excellent! (513 reviews)
Holiday Inn Express & Suites Sikeston Southwest by IHG
Hampton Inn Sikeston

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO
AED 373
AED 423 total
25 Oct - 26 Oct
includes taxes & fees
9/10 Wonderful! (624 reviews)
Hampton Inn Sikeston

Frequently asked questions

Where is the best place for a stay in Matthews?
Drury Inn & Suites Sikeston, MO, located 9.7 mi (15.5 km) from the heart of Matthews, is a top choice for your stay based on our traveler data. Two other choices for your stay in the area are Days Inn and Suites by Wyndham Sikeston and Best Western Plus Sikeston I-55. See all available top hotels, or vacation rentals in Matthews.
What are some of the best vacation rentals in Matthews?
Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy: This vacation home rental near Matthews offers a fireplace, a balcony, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You can relax into your vacation with a garden and a selection of games. See all vacation rentals in Matthews.
If I need to cancel my hotel reservation in Matthews, will I receive a refund?
Yes, the majority of hotel bookings are refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you might be able to cancel it and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Matthews.
Where can I learn more about changing or cancelling my trip to Matthews?
To access more information about changing or cancelling your trip to Matthews, click here.
What's it like to stay in Matthews?
Travelers to Matthews will find plenty to explore and enjoy. There are 42 hotels and other accommodations in the surrounding area. Find out more about Matthews.
What should I see while I'm in Matthews?
Places to visit in the wider area include Marston Community Center, Big Oak Tree State Park, and Sikeston Depot Museum. You'll also find New Madrid Historical Museum and Central Park in the area. Check out what more to see and do in Expedia's Matthews guide.
What's the weather like in Matthews?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Matthews is 60 inches.