Monroe County Vacation Homes
Missouri
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Vacation Homes in Monroe County

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Our top choices for Monroe County vacation homes

A covered outdoor deck with a table and chairs, a railing, and a view of a green landscape.

A gravel driveway leading to a white pickup truck parked on the side.

A room with two beds, a window with a view, and wall art.

A kitchen with wooden cabinets, a white refrigerator, a stove, a ceiling fan, and a dining table with chairs.

1. 3 Bedroom 2 Bath Cabin nestled in the woods minutes from Mark Twain Lake.

3 Bedroom 2 Bath Cabin nestled in the woods minutes from Mark Twain Lake.

Stoutsville

10.0 out of 10, Exceptional, (100 reviews)

10/10

Exceptional

(100 reviews)

"Everything was great and it was a peaceful place to stay"

Curtis L.

3 Bedroom 2 Bath Cabin nestled in the woods minutes from Mark Twain Lake.

A porch with a wicker chair, a rocking chair, and a table with a vase of flowers.

A living room with a sofa, armchairs, a coffee table, and a rug. There is a door, a water dispenser, and wall decorations.

A compact kitchen with a dining area, featuring light green cabinets, a black stove, and a white refrigerator.

A bedroom with a bed, a ceiling fan, a nightstand, and a lamp.

2. Charming 2-bedroom house at Mark Twain Lake

Charming 2-bedroom house at Mark Twain Lake

Stoutsville

10.0 out of 10, Exceptional, (45 reviews)

10/10

Exceptional

(45 reviews)

"Very clean and nice spot for a fishing vacation"

Melissa H.

Charming 2-bedroom house at Mark Twain Lake

A living room with a fireplace, two armchairs, a sofa, a coffee table, and a chandelier.

A room with a wooden ceiling, a dining table with chairs, a desk with a chair, and large windows with blinds.

A two-story house with a front porch, a garage, and a well-maintained lawn.

A dining room with a wooden table, four chairs, a chandelier, and a view of the outdoors through large windows.

3. Beautiful historic home in downtown Centralia, just 20 minutes from Columbia, MO

Beautiful historic home in downtown Centralia, just 20 minutes from Columbia, MO

Centralia

10.0 out of 10, Exceptional, (54 reviews)

10/10

Exceptional

(54 reviews)

"Great place to stay. "

braden l.

Beautiful historic home in downtown Centralia, just 20 minutes from Columbia, MO

A living room with a dark brown coffee table, a vase with yellow flowers, and a colorful woven placemat.

A dining area with a table set for two, a vase with sunflowers, and a television in the background.

A dining area with a long table, chairs, and a vase of sunflowers. There is a kitchen in the background with cabinets and a refrigerator.

A covered porch with a bench, a star decoration, and a view of the lawn.

4. Holder House at Beautiful Mark Twain Lake.

Holder House at Beautiful Mark Twain Lake.

Stoutsville

10.0 out of 10, Exceptional, (71 reviews)

10/10

Exceptional

(71 reviews)

"Beautiful home. Loved everything about it. Close to the lake and plenty of room for everything we brought. Loved it."

Rodney

Holder House at Beautiful Mark Twain Lake.

A lodge with a stone exterior, large windows, and a green roof.

A covered outdoor area with a stone bench and a fire pit, overlooking a body of water and trees.

A dessert shop with a glass display case filled with various ice cream flavors and a sign that reads "HOW CAN YOU TOP IT?".

A bedroom with a bed, two bedside tables with lamps, a ceiling fan, and a window with blinds.

5. Mark Twain lake getaway at Blue Lagoon!

Mark Twain lake getaway at Blue Lagoon!

Monroe City

10.0 out of 10, Exceptional, (52 reviews)

10/10

Exceptional

(52 reviews)

"Place was great for our fishing tournament."

Richard P.

Mark Twain lake getaway at Blue Lagoon!

A wooden spa area with a hot tub, wooden steps, and large windows.

A spacious kitchen with wooden cabinets, stainless steel appliances, and granite countertops.

A spacious indoor area with a wooden floor, a hot tub, and a large window providing a view of trees.

A dining area with a marble table, wooden chairs, a chandelier, and a view through a window with curtains.

6. Spacious Home w/ Pond ~ 13 Mi to Columbia!

Spacious Home w/ Pond ~ 13 Mi to Columbia!

Hallsville

8.0 out of 10, Very good, (15 reviews)

8.0/10

Very good

(15 reviews)

"Great place for a staff of baseball coaches to stay at. AC had issues first night we were there and they jumped on it quick to get it back up and running"

Will D.

Spacious Home w/ Pond ~ 13 Mi to Columbia!

A covered porch with a wooden bench, a hanging plant, and a table with chairs.

A bedroom with a bed, dresser, ceiling fan, and a window with decorative shutters.

A house with a covered porch, a lawn, and a flag.

A spacious living room with a ceiling fan, a dining area in the background, and a staircase with a wooden railing.

7. Tastefully restored historic home in quaint town, 20 minute drive to Columbia MO

Tastefully restored historic home in quaint town, 20 minute drive to Columbia MO

Centralia

10.0 out of 10, Exceptional, (168 reviews)

10/10

Exceptional

(168 reviews)

"Fantastic property and host! We’ve stayed here many times."

Laura P.

Tastefully restored historic home in quaint town, 20 minute drive to Columbia MO

A spacious living area with a leather sofa, a dining table, and a kitchen with wooden cabinets and modern appliances.

A wooden deck with a swimming pool, surrounded by lush greenery and trees.

A kitchen with wooden cabinets, stainless steel appliances, and a corrugated metal ceiling.

A hot tub in a wooden cabin with large windows and a ceiling fan.

8. 'Grace Place' Clark House on Farm: Shared Hot Tub!

'Grace Place' Clark House on Farm: Shared Hot Tub!

Clark

10.0 out of 10, Exceptional, (33 reviews)

10/10

Exceptional

(33 reviews)

"Loved staying on the farm and loved meeting all the doggies. Kim was fantastic and made sure we had everything we needed. She even had fresh eggs in the fridge from her chickens."

Cherie T.

'Grace Place' Clark House on Farm: Shared Hot Tub!

A spacious living area with a large wooden dining table, comfortable seating, and a staircase leading to an upper level.

A modern kitchen with grey cabinets, a wooden countertop, stainless steel appliances, and a sign above the cabinets reading "OUR HAPPY PLACE".

An outdoor seating area with two blue chairs and a table, surrounded by trees and open grassy field.

A bedroom with a bed, a ceiling fan, a window, a door, and a small bedside table.

9. Totally Renovated Home on 5 Acres - Just 4 Miles From Mark Twain Lake

Totally Renovated Home on 5 Acres - Just 4 Miles From Mark Twain Lake

Monroe City

10.0 out of 10, Exceptional, (9 reviews)

10/10

Exceptional

(9 reviews)

"The property was perfect for sitting and relaxing at the end of the day, and the owners were very helpful and communicative. :-)"

Beth B.

Totally Renovated Home on 5 Acres - Just 4 Miles From Mark Twain Lake

A covered porch with wicker chairs, a blue door, and a large umbrella.

A dining area with a wooden table, chairs, and a ceiling light fixture.

A single-story house with a grey roof and white trim, a chimney, and a small front yard with a tree and shrubs.

A kitchen with white cabinets, a granite countertop, and a wooden floor.

10. Cozy 3 bed, 2 bath home close to historic downtown Hannibal

Cozy 3 bed, 2 bath home close to historic downtown Hannibal

Hannibal

10.0 out of 10, Exceptional, (70 reviews)

10/10

Exceptional

(70 reviews)

"Enjoyed our stay, it was very convenient location to get to everything. Thank you!"

Margaret L.

Cozy 3 bed, 2 bath home close to historic downtown Hannibal

A living room with a brown sofa, a wooden coffee table, a television on a stand, and a bookshelf.

A bedroom with a bed, pillows, a dark wooden door, and a window with curtains.

A dining room with a round table and six chairs, a patterned rug, and a view of a dining area through an open doorway.

A kitchen with wooden cabinets, a white refrigerator, a stove, and a sink.

11. Unwind on Vine

Unwind on Vine

Macon

9.6 out of 10, Exceptional, (38 reviews)

9.6/10

Exceptional

(38 reviews)

"Awesome place! Clean, spacious, and quiet. Highly recommend for short or long stays."

Josh C.

The price is AED 545

AED 545

AED 896 total

includes taxes & fees

26 Oct - 27 Oct

Unwind on Vine

A bathroom with a toilet, a shower curtain, a sink, a mirror, and a wall-mounted shelf with a plant and decorative items.

A directional sign with various destinations and distances.

A bunk bed with a ceiling fan, a plush unicorn toy, and a motivational poster.

A kitchen with a central island, stainless steel appliances, and green cabinetry.

12. Secluded Retreat: Updated Modern Home Near Mark Twain Lake

Secluded Retreat: Updated Modern Home Near Mark Twain Lake

Stoutsville

10.0 out of 10, Exceptional, (3 reviews)

10/10

Exceptional

(3 reviews)

"Beautiful, secluded retreat. Met high school friends of 45 years, large kitchen was the heart of the home."

Kelly H.

Secluded Retreat: Updated Modern Home Near Mark Twain Lake

A covered porch with two rocking chairs and a view of a forest.

A kitchen with wooden cabinets, a white refrigerator, and a tiled floor.

A living room with a sofa, two armchairs, a coffee table, and a fireplace.

A traditional living room with a sofa, armchairs, a coffee table, a dining table with chairs, a piano, and a chandelier.

13. Charming Paris Home w/ Porch: Hunt + Unwind!

Charming Paris Home w/ Porch: Hunt + Unwind!

Paris

8.0 out of 10, Very good, (4 reviews)

8.0/10

Very good

(4 reviews)

"Comfy beds. Safe neighborhood. Nice porch overlooking backyard (although we didn't use it). Host communicated well with us and in a timely manner. Too many plug ins (air fresheners). It was overwhelming. Over cleanliness was ok, but not excellent. "

Kathy S.

Charming Paris Home w/ Porch: Hunt + Unwind!

A neatly made bed with a headboard, two bedside tables with lamps, and a painting of a sunset over a lake on the wall.

A modern kitchen with wooden cabinets, a central island with stools, a black refrigerator, and pendant lighting.

A dock with a covered seating area and a boat.

A deck with wicker furniture and a view of a lake.

14. Relax fish/play: Pvt 25-acre clear Blue Lake w/ home that sleeps 10 comfortably.

Relax fish/play: Pvt 25-acre clear Blue Lake w/ home that sleeps 10 comfortably.

Mexico

10.0 out of 10, Exceptional, (15 reviews)

10/10

Exceptional

(15 reviews)

"Beautiful, peaceful, and perfect for a family getaway. Even handicap accessible for our disabled veterans. This was our second time staying and will absolutely be going back."

Joy K.

Relax fish/play: Pvt 25-acre clear Blue Lake w/ home that sleeps 10 comfortably.

A wooden deck with a fire pit and seating area overlooking a lake.

A cozy living room with a fireplace, a Christmas tree, and a large window offering a view of the outdoors.

A cozy living room with a fireplace, comfortable seating, a TV, and large windows with a view of nature.

A modern kitchen with a central island, black cabinets, and a herringbone-patterned countertop.

15. Peaceful Lakeside Getaway with Private Dock surrounded with Serene Wilderness

Peaceful Lakeside Getaway with Private Dock surrounded with Serene Wilderness

Cairo

10.0 out of 10, Exceptional, (30 reviews)

10/10

Exceptional

(30 reviews)

"Wonderful location that is very private and peaceful. The house is decorated very well and they have complimentary breakfast. Perfect for a weekend getaway. "

Brandon R.

Peaceful Lakeside Getaway with Private Dock surrounded with Serene Wilderness

A modern kitchen with wooden cabinets, stainless steel appliances, and a large island with bar stools.

A garage with a large black door, a wooden beam ceiling, and a concrete floor.

A modern kitchen with white paneling, a stainless steel refrigerator, and a bar area with stools.

16. Shouse Near Mark Twain Lake!

Shouse Near Mark Twain Lake!

Monroe City

10.0 out of 10, Exceptional, (13 reviews)

10/10

Exceptional

(13 reviews)

"This was our second stay, and it was just as great as the first time! Plenty of room to play, huge TVs for family movie night, and a well equipped kitchen for serving meals. Thank you! "

Christina H.

The price is AED 845

AED 845

AED 1,202 total

includes taxes & fees

25 Oct - 26 Oct

Shouse Near Mark Twain Lake!

A modern kitchen with white cabinets, stainless steel appliances, a granite countertop island, and wooden stools.

A spacious living room with a fireplace, leather sofas, a dining table, and a ceiling fan.

A dining area with a round wooden table and chairs, a chandelier, and a wall-mounted deer head.

A building with a covered porch, a barbecue grill, and construction materials.

17. Mark Twain lake getaway.

Mark Twain lake getaway.

Santa Fe

9.8 out of 10, Exceptional, (33 reviews)

9.8/10

Exceptional

(33 reviews)

"Great place!!!"

tom r.

Mark Twain lake getaway.

A stone water feature with a waterfall, surrounded by a variety of rocks and pebbles.

A two-story house with a porch, a number '409' above the door, and a 'Nightingale Rental' sign.

A dining area with a wooden chair, a yellow bowl with fruits, and a clear glass bowl on a wooden table.

18. A real charmer built in 1915 , pet friendly , located next to Mark Twain lake.

A real charmer built in 1915 , pet friendly , located next to Mark Twain lake.

Perry

10.0 out of 10, Exceptional, (27 reviews)

10/10

Exceptional

(27 reviews)

"Host was very accommodating to family plans changing! Nice decor, great house for the price. Would stay again!"

Daniel C.

A real charmer built in 1915 , pet friendly , located next to Mark Twain lake.

A large, two-story building with a prominent chimney, surrounded by lush greenery.

A kitchen counter with a coffee machine, jars of coffee beans, and a sign that reads "Coffee and Tea Makes the Perfect Blend."

A gazebo with a fire pit and seating, surrounded by a wooden fence, under a night sky with a visible moon.

A bedroom with a bed, two bedside tables, a nightstand, a lamp, a picture frame, and a window with curtains.

19. “Peaceful Retreat” @ MTL

“Peaceful Retreat” @ MTL

Monroe City

10.0 out of 10, Exceptional, (115 reviews)

10/10

Exceptional

(115 reviews)

"Awesome place and the host was excellent!!"

Larry B.

“Peaceful Retreat” @ MTL

A covered outdoor area with steps leading up to it, featuring a railing and a bench.

A modern kitchen with a granite countertop, stainless steel sink, and a black stove.

A modern two-story house with a covered porch and a wooden deck.

A cozy living room with a sofa, a wooden coffee table, and a dining table with chairs. There are multiple windows with blinds, a kitchen area with a sink and cabinets, and a balcony with a railing.

20. Blue Heron Hut - At the Lodges of Long Branch

Blue Heron Hut - At the Lodges of Long Branch

Bevier Township

10.0 out of 10, Exceptional, (3 reviews)

10/10

Exceptional

(3 reviews)

"Very clean and a lovely place to stay."

Jean F.

The price is AED 606

AED 606

AED 1,012 total

includes taxes & fees

22 Oct - 23 Oct

Blue Heron Hut - At the Lodges of Long Branch

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Top Monroe County Hotel Reviews

Comfort Inn & Suites - Hannibal

8/10 Good

"The property is in a great location for either visitors to Hannibal or travelers on U.S. 61. The front desk staff were very courteous and efficient. The breakfast was plentiful and tasty. There was ample parking. The property could use some refreshing. Carpeting was a bit worn. Plumbing in room 309 needed work on that the toilet needs to be reseated and the tub was very slow to drain. Room was clean and the beds were comfortable."

James 1-night trip

Posted 1 day ago

Comfort Inn & Suites - Hannibal

Quality Inn & Suites Hannibal West

8/10 Good

"Room was very comfortable, staff was friendly. Breakfast was great. Very clean. Nice area. The restaurant Fiddlesticks is about 300 feet from the hotel."

Timothy 4-night trip

Posted 1 day ago

Quality Inn & Suites Hannibal West