The Best Business Hotels in Muscatine, IA from AED 230 in 2026

A river with docks, a bridge, and buildings in the background.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check availability on Muscatine Business Hotels

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for Muscatine business-friendly hotels

A modern lobby with a stone accent wall, comfortable seating, a reception desk, and a flat-screen TV.

A gym with treadmills, weight machines, and a mirrored wall.

An indoor swimming pool with a 'NO DIVING' sign, lounge chairs, and a pool area use sign.

A hotel room with two beds, a desk, a chair, and a television.

1. Best Western Muscatine / Pearl City Hotel

Muscatine

Daniel

AED 314

AED 352 total

includes taxes & fees

21 Oct - 22 Oct

A modern living room with a large painting, a sofa, two armchairs, a coffee table, and a view of a lake through large windows.

A spacious banquet hall with round tables, chairs, and a large view of the outdoors.

A spacious room with large windows, a stage, and a table with a cake.

A modern living room with a fireplace, large windows, and contemporary furniture.

2. The Merrill Hotel, Muscatine, a Tribute Portfolio Hotel

Muscatine

Brianna

AED 602

AED 675 total

includes taxes & fees

13 Nov - 14 Nov

A hotel dining area with wooden furniture, a stone accent wall, and a view of the outdoors.

A gym with treadmills, elliptical machines, and free weights.

A hotel pantry with shelves stocked with snacks and beverages.

A hotel reception area with two computer workstations, a desk with a printer, and two office chairs.

3. Hampton Inn Muscatine

Muscatine

CARRIE

AED 357

AED 400 total

includes taxes & fees

8 Nov - 9 Nov

A large indoor swimming pool with a wooden ceiling and large windows.

A hotel room with two beds, a desk, a TV, and a large window.

A reception area with a wooden reception desk, a stone pillar, and a staircase leading to an upper level.

A modern kitchen with dark blue cabinets, wooden tables, and chairs. There is a chalkboard with 'Good Morning' written on it, and a clock on the wall.

4. AmericInn by Wyndham Muscatine

Muscatine

Larry

AED 328

AED 367 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with three beds, a desk, and a television.

A restaurant with wooden flooring, red upholstered chairs, and a kitchen area with various appliances.

A hotel lobby with a sofa, chairs, a TV, a dining area, and a clock on the wall.

A reception area with a wooden counter, a reception desk, a digital kiosk, and a patterned rug.

5. Comfort Inn Muscatine near Hwy 61

Muscatine

John

AED 265

AED 297 total

includes taxes & fees

13 Nov - 14 Nov

A hotel room with two beds, a desk, a TV, a large window with curtains, and artwork on the walls.

A room with a brown leather sofa, a wooden coffee table with candles, a desk with a computer, and two windows with red curtains.

A hotel with a prominent 'Sofitel' sign, a brick facade, and a parking lot.

A breakfast area with a counter, coffee machines, and seating.

6. Super 8 by Wyndham Muscatine

Muscatine

Richard

AED 234

AED 262 total

includes taxes & fees

25 Oct - 26 Oct

A staircase with a metal railing, a display of books, and a door with an exit sign.

A building entrance with a brick facade, a large window, and a door with 'Welcome' signage.

A hotel room with two beds, a desk, a chair, a dresser, and a window with curtains.

A reception area with a stone counter, a red sofa, and a signboard.

7. The Sage Hotel

Muscatine

Luis

AED 198

AED 222 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with two beds, a desk with a TV, a desk lamp, a vanity with a sink, and a large mirror.

A multi-story hotel with a flat roof, a parking lot, and a covered entrance.

A hotel lobby with a patterned carpet, blue armchairs, a sofa, and a coffee table.

A reception desk with a sign reading "Comfort Inn" and a reception area with a wooden counter and a patterned rug.

8. Comfort Inn Walcott near Davenport

Walcott

Jose

AED 364

AED 408 total

includes taxes & fees

8 Nov - 9 Nov

View all properties

Top Muscatine Hotel Reviews

Isle Casino Hotel Bettendorf - A Caesars Rewards Destination

10/10 Excellent

"Great service all around .The seats where not comfortable in the convention center"

Wyndham Moline on John Deere Commons

10/10 Excellent

"The lobby was decked out in Halloween decorations and it was such a fun vibe. The room was clean and spacious. There was a large living area with its own TV. I liked that there was a door separating the bedroom so there was privacy. We were there to see our sons cross country meet and there were numerous teams staying at the hotel. The staff who handled breakfast was amazing. She kept everything fresh and clean even though it was super busy."

Comfort Inn & Suites Davenport - Quad Cities

10/10 Excellent

"Hotel was in excellent shape! We were surprised we had a suite instead of a regular king room!!! Hotel was surprisingly quiet even with the close proximity to all the truck plazas. Breakfast was typical but well stocked and kept very clean!"

Stoney Creek Hotel Quad Cities - Moline

10/10 Excellent

"Always a great place to stay! Great location!"

Sleep Inn & Suites Davenport - Quad Cities

10/10 Excellent

"Just a overnight stay. Room was clean and we were happy. Good price, and great location."

Best Western Muscatine / Pearl City Hotel

8/10 Good

"Staff was very nice and helpful and accommodating and the overall motel was clean and easy to get around."

Hampton Inn Muscatine

10/10 Excellent

"Hotel.staff was friendly. Renovations were being done while we were there but didnt interfere with our stay at all. Breakfast was good. Room was clean, bed was comfortable."

Room 1

Change your mind

Treat yourself

Be picky

Check availability on Muscatine Business Hotels

Our top choices for Muscatine business-friendly hotels

1. Best Western Muscatine / Pearl City Hotel