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Find Resorts & Hotels with Spas in Northeast Missouri, MO

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Check prices for these dates

Tonight
14 Nov - 15 Nov
Tomorrow
15 Nov - 16 Nov
Next weekend
20 Nov - 22 Nov
In two weeks
27 Nov - 29 Nov

Our top choices for Northeast Missouri hotels with a spa

A wooden interior with a hot tub, a wheelchair-accessible bench, and a window.

1. Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
2.5 star property
Hannibal
7.6 out of 10, Good, (776 reviews)
  • cleanliness
    Serene spa sanctuary awaits in the heart of Hannibal with rejuvenating hot tub, indoor pool, and hydromassage showers.
The price is AED 264
AED 315 total
includes taxes & fees
17 Nov - 18 Nov
Comfort Inn & Suites - Hannibal
A Holiday Inn hotel with a modern facade, a covered entrance, and landscaped areas with shrubs.

2. Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG
3.0 star property
Quincy
8.8 out of 10, Excellent, (700 reviews)
  • cleanliness
    Revitalizing spa treatments await at this hotel, where an indoor pool, cozy pillow menus, and attentive staff create a relaxing retreat.
The price is AED 397
AED 452 total
includes taxes & fees
13 Dec - 14 Dec
Holiday Inn Quincy East by IHG
A room with a dark wooden door, a chandelier, green plants, and a seating area with a sofa and chairs.

3. Truitt Hotel

Truitt Hotel
2.0 star property
Lafayette Square
10.0 out of 10, Exceptional, (32 reviews)
The price is AED 617
AED 749 total
includes taxes & fees
15 Nov - 16 Nov
Truitt Hotel
A spa area with a tiled floor, a glass enclosure, and a pool visible through the glass.

4. 21C Museum Hotel St Louis

21C Museum Hotel St Louis
4.5 star property
Downtown West
9.0 out of 10, Wonderful, (2,129 reviews)
  • cleanliness
    Discover spa services, a steam room, and an Olympic-sized indoor pool at this modern hotel, all designed for rejuvenating getaways.
The price is AED 528
AED 635 total
includes taxes & fees
6 Dec - 7 Dec
21C Museum Hotel St Louis
A spa area with a massage table, a hot tub, and a grill.

5. Hermann Hill

Hermann Hill
4.0 star property
Hermann
9.6 out of 10, Exceptional, (123 reviews)
  • cleanliness
    Riverside bed and breakfast with private hot tubs and spa treatments offers romantic rejuvenation.
The price is AED 810
AED 931 total
includes taxes & fees
6 Dec - 7 Dec
Hermann Hill
A modern bathroom with a glass shower enclosure, a built-in jacuzzi, and a tiled floor.

6. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
St. Charles
8.8 out of 10, Excellent, (1,090 reviews)
  • cleanliness
    Riverside wellness oasis offers full-service spa with aromatherapy and hydrotherapy for a restorative retreat.
The price is AED 585
AED 744 total
includes taxes & fees
30 Nov - 1 Dec
Ameristar Casino Resort and Spa
A modern kitchen with wooden cabinets, a central island, and framed artwork on the walls.

7. The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
5.0 star property
Clayton
9.2 out of 10, Wonderful, (589 reviews)
  • cleanliness
    Revel in a rejuvenating spa retreat with aromatherapy treatments and hot stone massages at this luxury St. Louis hotel.
The price is AED 2,016
AED 2,354 total
includes taxes & fees
27 Nov - 28 Nov
The Ritz-Carlton, St. Louis
A couple relaxing by a window overlooking a bridge and water.

8. Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1,000 reviews)
  • cleanliness
    Discover a tranquil haven with 12 treatment rooms, outdoor pool, and breathtaking views at this rejuvenating spa retreat.
The price is AED 1,377
AED 1,611 total
includes taxes & fees
15 Nov - 16 Nov
Four Seasons Hotel St Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Northeast Missouri

Pool
Breakfast included

Top Northeast Missouri Hotel Reviews

A room with a dark wooden door, a chandelier, green plants, and a seating area with a sofa and chairs.
Truitt Hotel

Truitt Hotel

Truitt Hotel
Lafayette Square

10/10 Excellent

It was a nice getaway feel
United States
Whitney
Reviewed November 10, 2026
Truitt Hotel

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