A large eye sculpture in a park surrounded by trees.

Search Vacation Homes in Northeast Missouri

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
11 Sep - 13 Sep
In two months
23 Oct - 25 Oct
In three months
20 Nov - 22 Nov
In four months
18 Dec - 20 Dec

Our top choices for Northeast Missouri vacation homes

Smart TV, books

1. Unwind on Vine

Unwind on Vine
Macon
9.6 out of 10, Exceptional, (36 reviews)
"We have stayed twice at Unwind on the Vine and have enjoyed our stays. The owners are very attentive to any needs we have had during our stays."
United States
Nancy E.
The price is AED 512
AED 631 total
includes taxes & fees
29 Aug - 30 Aug
Unwind on Vine
Coffee/tea maker, fridge, microwave, oven

2. Spacious & Modern 2BR Home with Attached Garage

Spacious & Modern 2BR Home with Attached Garage
Quincy
10.0 out of 10, Exceptional, (50 reviews)
"Nicely decorated and very comfortable."
United States
Marsha
The price is AED 298
AED 699 total
includes taxes & fees
30 Aug - 31 Aug
Spacious & Modern 2BR Home with Attached Garage
Coffee/tea maker, fridge, microwave, oven

3. Aunt Lele's Cozy Cottage

Aunt Lele's Cozy Cottage
Quincy
9.8 out of 10, Exceptional, (46 reviews)
"Perfect place for our family of 5 to enjoy a weekend visiting my wife’s family."
United States
Matt B.
The price is AED 367
AED 720 total
includes taxes & fees
30 Aug - 31 Aug
Aunt Lele's Cozy Cottage
Dining

4. Vibey home a few blocks from downtown Hannibal

Vibey home a few blocks from downtown Hannibal
Hannibal
9.8 out of 10, Exceptional, (15 reviews)
"Very Nice house!!! Enjoyed my stay there."
United States
Shaun P.
The price is AED 312
AED 1,038 total
includes taxes & fees
30 Aug - 31 Aug
Vibey home a few blocks from downtown Hannibal
Interior

5. Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi

Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi
Hannibal
9.8 out of 10, Exceptional, (62 reviews)
"This place was amazing!"
United States
Nancy S.
The price is AED 404
AED 683 total
includes taxes & fees
8 Sep - 9 Sep
Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi
Dining

6. Peaceful, Country Cottage with Open Floor Plan

Peaceful, Country Cottage with Open Floor Plan
Quincy
9.8 out of 10, Exceptional, (221 reviews)
"Only there for a one night stay, but very beautiful and comfortable!"
United States
Vicki W.
The price is AED 477
AED 915 total
includes taxes & fees
1 Sep - 2 Sep
Peaceful, Country Cottage with Open Floor Plan
Interior

7. The John Sydney House - Family and Pet Friendly Historic Home Downtown

The John Sydney House - Family and Pet Friendly Historic Home Downtown
Hannibal
9.8 out of 10, Exceptional, (22 reviews)
"Rooms were clean and the decor was very well done! We loved our stay here and the hosts were responsive to all our needs."
United States
Brian H.
The price is AED 618
AED 932 total
includes taxes & fees
31 Aug - 1 Sep
The John Sydney House - Family and Pet Friendly Historic Home Downtown
Exterior

8. Our 80-Acre Farm, Lake, Nature Trail, Bonfires, Starry Nights 2 Miles Grafton

Our 80-Acre Farm, Lake, Nature Trail, Bonfires, Starry Nights 2 Miles Grafton
Grafton
10.0 out of 10, Exceptional, (148 reviews)
"My wife and I stayed there for a few days for her birthday. It was so peaceful there. The host keeps the place very clean and includes many additional thoughtful items. The trail is a nice touch and worth exploring. It was super hot during our stay and the A/C kept us nice and cool."
United States
Alex
The price is AED 582
AED 1,104 total
includes taxes & fees
30 Aug - 31 Aug
Our 80-Acre Farm, Lake, Nature Trail, Bonfires, Starry Nights 2 Miles Grafton
Coffee/tea maker, fridge, microwave, oven

9. Settle into Soulard! 6 beds 2 full baths!

Settle into Soulard! 6 beds 2 full baths!
Soulard
8.6 out of 10, Excellent, (18 reviews)
"Clean, convenient and satisfied our needs for this stay. "
United States
Michael L.
The price is AED 202
AED 1,039 total
includes taxes & fees
30 Aug - 31 Aug
Settle into Soulard! 6 beds 2 full baths!
Property grounds

10. Cozy little house blocks from the Park & Fair Grounds.

Cozy little house blocks from the Park & Fair Grounds.
Washington
10.0 out of 10, Exceptional, (74 reviews)
"This was the second stay and it is always great. Hostess is an amazing communicator. We will stay again!"
United States
Jeanie S.
The price is AED 446
AED 936 total
includes taxes & fees
30 Aug - 31 Aug
Cozy little house blocks from the Park & Fair Grounds.
Living area

11. Unique Tiny Home! Lakefront ~ BBQ Grill ~ Couple's Retreat

Unique Tiny Home! Lakefront ~ BBQ Grill ~ Couple's Retreat
Bourbon
10.0 out of 10, Exceptional, (4 reviews)
"Very charming lil cabin! It was perfect for a solo trip. I’d love to come back with my husband for a romantic weekend getaway."
United States
Wendy L.
The price is AED 439
AED 1,323 total
includes taxes & fees
30 Aug - 31 Aug
Unique Tiny Home! Lakefront ~ BBQ Grill ~ Couple's Retreat
Property grounds

12. Charming 1-bedroom house in nice Imperial with AC. Attn! Traveling Contractors

Charming 1-bedroom house in nice Imperial with AC. Attn! Traveling Contractors
Imperial
9.8 out of 10, Exceptional, (8 reviews)
"The host was very responsive to all communication and our stay was very nice. It was a nice place to stay. It was comfortable and met are needs very well."
United States
Denise S.
The price is AED 248
AED 399 total
includes taxes & fees
2 Sep - 3 Sep
Charming 1-bedroom house in nice Imperial with AC. Attn! Traveling Contractors
Coffee/tea maker, fridge, microwave, oven

13. Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!

Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!
The Hill
9.8 out of 10, Exceptional, (196 reviews)
"Looks exactly like the pictures. Clean, beautiful shower. Friendly staff, had no problems answering questions, had all the things you needed to relax for a few days with a couple of friends. The neighborhood is lovely & peaceful at night. Beautiful yard. So pleased I came across this cottage. Thanks guy, our stay was awesome"
United States
Crystal
The price is AED 314
AED 559 total
includes taxes & fees
31 Aug - 1 Sep
Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!
Dining

14. Centrally located in the Tower Grove East neighborhood!

Centrally located in the Tower Grove East neighborhood!
Tower Grove East
9.8 out of 10, Exceptional, (170 reviews)
"Great place!"
United States
Arthur S.
The price is AED 248
AED 563 total
includes taxes & fees
30 Aug - 31 Aug
Centrally located in the Tower Grove East neighborhood!
Coffee/tea maker, fridge, microwave, oven

15. Convenience 2 Bedroom House to Explore All of St Louis

Convenience 2 Bedroom House to Explore All of St Louis
University City
9.8 out of 10, Exceptional, (50 reviews)
"The house was immaculately clean and beds were extremely comfortable!"
United States
Anna M.
The price is AED 433
AED 977 total
includes taxes & fees
27 Sep - 28 Sep
Convenience 2 Bedroom House to Explore All of St Louis
Coffee/tea maker, fridge, microwave, oven

16. Private Entry Basement Suite • Pond & Farm View • Pet Friendly • St Peters

Private Entry Basement Suite • Pond & Farm View • Pet Friendly • St Peters
St. Peters
10.0 out of 10, Exceptional, (16 reviews)
"Great place to stay! Beautiful property! "
United States
Carrie G.
The price is AED 338
AED 1,014 total
includes taxes & fees
30 Aug - 31 Aug
Private Entry Basement Suite • Pond & Farm View • Pet Friendly • St Peters
Exterior

17. Kid and pet friendly 2 nd floor duplex

Kid and pet friendly 2 nd floor duplex
Pacific
9.0 out of 10, Wonderful, (30 reviews)
"The house was clean and comfortable. Would stay there again."
United States
Jason T.
The price is AED 570
AED 737 total
includes taxes & fees
30 Aug - 31 Aug
Kid and pet friendly 2 nd floor duplex
Coffee/tea maker, fridge, microwave, oven

18. Shouse Near Mark Twain Lake!

Shouse Near Mark Twain Lake!
Monroe City
10.0 out of 10, Exceptional, (12 reviews)
"This was our second stay, and it was just as great as the first time! Plenty of room to play, huge TVs for family movie night, and a well equipped kitchen for serving meals. Thank you! "
United States
Christina H.
The price is AED 808
AED 1,147 total
includes taxes & fees
30 Aug - 31 Aug
Shouse Near Mark Twain Lake!
Smart TV

19. 3-bedroom family friendly home on 4 acres near Hermann with WiFi, AC, deck

3-bedroom family friendly home on 4 acres near Hermann with WiFi, AC, deck
Hermann
9.6 out of 10, Exceptional, (15 reviews)
"Host was very accommodating, property perfect, I can't say enough good things about our stay."
United States
Susan R.
The price is AED 744
AED 1,358 total
includes taxes & fees
30 Aug - 31 Aug
3-bedroom family friendly home on 4 acres near Hermann with WiFi, AC, deck
Smart TV

20. Modern and comfy home five minutes from downtown

Modern and comfy home five minutes from downtown
Hannibal
10.0 out of 10, Exceptional, (21 reviews)
"House was perfect for our stay."
United States
Brent W.
The price is AED 336
AED 1,062 total
includes taxes & fees
7 Sep - 8 Sep
Modern and comfy home five minutes from downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Northeast Missouri Hotel Reviews

Live by Loews - St.Louis

Live by Loews - St.Louis

10/10 Excellent
"I loved this hotel! I didn’t want to leave! The balcony was everything! Everything was great about this hotel! Bed was like sleeping on a cloud. Yes it’s pricey, but lucky I got an upgrade and it was my birthday! I will come back."
Lashundra 3-night trip
Posted 2 hours ago
Live by Loews - St.Louis

Explore a world of travel with Expedia