A calm river with clear water, surrounded by dense trees and rocky banks.

Search Vacation Homes in O Brien

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
In two months
In three months
In four months

Our top choices for O Brien vacation homes

1. MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY
O'Brien
9.4 out of 10, Exceptional, (60 reviews)
"A great get away for Labor Day weekend to do a little jet skiing with friends on the river and visiting all the local springs!"
United States
Heather H.
The price is AED 547
AED 1,293 total
includes taxes & fees
8 Nov - 9 Nov
MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

2. Cozy House, Hot Tub & Close to FL Springs

Cozy House, Hot Tub & Close to FL Springs
Branford
10.0 out of 10, Exceptional, (1 review)
"Juan was so welcoming. The house was clean and had everything we needed for a fun family getaway - and then some! Would love to stay here again. "
United States
Ashley L.
Cozy House, Hot Tub & Close to FL Springs

3. SpringHouse at Convict Springs

SpringHouse at Convict Springs
Mayo
10.0 out of 10, Exceptional, (1 review)
SpringHouse at Convict Springs

4. O'LE LADYBUG COTTAGE

O'LE LADYBUG COTTAGE
Lake City
9.6 out of 10, Exceptional, (58 reviews)
"Everything was great will stay again if I’m ever in the area"
United States
regina
The price is AED 357
AED 735 total
includes taxes & fees
11 Nov - 12 Nov
O'LE LADYBUG COTTAGE

5. Three Rivers Retreat

Three Rivers Retreat
Fort White
The price is AED 473
AED 1,080 total
includes taxes & fees
19 Nov - 20 Nov
Three Rivers Retreat

6. Nature Cabin Itchetucknee Springs Private Access ~ Nature Lovers Only

Nature Cabin Itchetucknee Springs Private Access ~ Nature Lovers Only
Fort White
Nature Cabin Itchetucknee Springs Private Access ~ Nature Lovers Only

7. < 1 Mi From Suwannee River, Hideaway w/ Lanai

< 1 Mi From Suwannee River, Hideaway w/ Lanai
Old Town
The price is AED 404
AED 1,372 total
includes taxes & fees
7 Nov - 8 Nov
< 1 Mi From Suwannee River, Hideaway w/ Lanai

8. Nature + Music + Town - Cozy Farmhouse Retreat

Nature + Music + Town - Cozy Farmhouse Retreat
Live Oak
10.0 out of 10, Exceptional, (22 reviews)
"It feels just like staying with family "
United States
Starr T.
The price is AED 520
AED 1,046 total
includes taxes & fees
9 Nov - 10 Nov
Nature + Music + Town - Cozy Farmhouse Retreat

9. Suwannee River Retreat: Pet Friendly, Private Dock

Suwannee River Retreat: Pet Friendly, Private Dock
Branford
9.8 out of 10, Exceptional, (9 reviews)
"A nice little getaway for a couple of days - great change of pace.While we didn’t bring children, I could see this an ideal place to bring kids and/or a large family to have plenty of space. Our dog (passed after we booked it) would have loved the ability to roam around in a gated area.Owner was very attentive. A tree fell on the wood bridge to the river right before we arrived and she had it fixed within the hour."
United States
Matt W.
The price is AED 966
AED 2,136 total
includes taxes & fees
9 Nov - 10 Nov
Suwannee River Retreat: Pet Friendly, Private Dock

10. 3-bed 2 bath River house on the Santa fe. 6 miles from Ginnie Springs

3-bed 2 bath River house on the Santa fe. 6 miles from Ginnie Springs
Fort White
10.0 out of 10, Exceptional, (6 reviews)
"We loved our stay !"
United States
Melissa R.
The price is AED 624
AED 1,261 total
includes taxes & fees
6 Dec - 7 Dec
3-bed 2 bath River house on the Santa fe. 6 miles from Ginnie Springs

11. Your Cozy Farmhouse Inspired Retreat. Just 5 minutes to I-75. Pets Welcomed.

Your Cozy Farmhouse Inspired Retreat. Just 5 minutes to I-75. Pets Welcomed.
Lake City
9.2 out of 10, Wonderful, (7 reviews)
"Amenities were surprisingly good, glad to have coffee available "
United States
Cindy M.
The price is AED 442
AED 710 total
includes taxes & fees
6 Dec - 7 Dec
Your Cozy Farmhouse Inspired Retreat. Just 5 minutes to I-75. Pets Welcomed.

12. Hillside Abode in the Heart of Historic White Springs and the Suwannee River

Hillside Abode in the Heart of Historic White Springs and the Suwannee River
White Springs
10.0 out of 10, Exceptional, (37 reviews)
"Well worth the cost place was clean organized and a nice little safe haven during our trip "
United States
Cory P.
The price is AED 496
AED 941 total
includes taxes & fees
6 Dec - 7 Dec
Hillside Abode in the Heart of Historic White Springs and the Suwannee River

13. The Best memories are made on the Suwannee River

The Best memories are made on the Suwannee River
Mayo
9.8 out of 10, Exceptional, (59 reviews)
"Was there for a family reunion and was great for what we needed."
United States
Anonymous traveler
The price is AED 397
AED 876 total
includes taxes & fees
10 Nov - 11 Nov
The Best memories are made on the Suwannee River

14. Beautiful 2 story house overlooking the water. Has arcade & Close to the springs

Beautiful 2 story house overlooking the water. Has arcade & Close to the springs
Live Oak
10.0 out of 10, Exceptional, (85 reviews)
"Peaceful, clean, and well-kept property. We had a lovely stay and especially enjoyed the massage chair! The host communicated everything upfront and welcomed our dogs, which was great. The fenced in backyard was perfect to let them run off-leash without any worries. Would definitely stay here again!"
United States
Madelynn H.
The price is AED 493
AED 874 total
includes taxes & fees
8 Nov - 9 Nov
Beautiful 2 story house overlooking the water. Has arcade & Close to the springs

15. Cottage Charm Retreat: Porch, Near Downtown

Cottage Charm Retreat: Porch, Near Downtown
Live Oak
The price is AED 569
AED 1,557 total
includes taxes & fees
1 Dec - 2 Dec
Cottage Charm Retreat: Porch, Near Downtown

16. Downtown three bedroom house with game room and outside lounge area.

Downtown three bedroom house with game room and outside lounge area.
Lake City
9.6 out of 10, Exceptional, (5 reviews)
"Great place"
United States
Angie L.
Downtown three bedroom house with game room and outside lounge area.

17. Three Rivers Retreat

Three Rivers Retreat
Lake City
The price is AED 546
AED 1,173 total
includes taxes & fees
8 Nov - 9 Nov
Three Rivers Retreat

18. Beautiful memories are made on the Suwannee River in Mayo Fl

Beautiful memories are made on the Suwannee River in Mayo Fl
Mayo
Beautiful memories are made on the Suwannee River in Mayo Fl

19. Cozy 1-bedroom house in delightful High Springs

Cozy 1-bedroom house in delightful High Springs
High Springs
10.0 out of 10, Exceptional, (14 reviews)
"Close to everything, super clean, great hosts."
United States
Sabrina D.
The price is AED 331
AED 581 total
includes taxes & fees
8 Nov - 9 Nov
Cozy 1-bedroom house in delightful High Springs

20. Modern 5BR Live Oak Haven – Minutes from Suwannee Music Park & Springs!

Modern 5BR Live Oak Haven – Minutes from Suwannee Music Park & Springs!
Live Oak
10.0 out of 10, Exceptional, (1 review)
"We were in town for a baseball state tournament. This was a fantastic place to stay for multiple families. This house has been newly updated and is beautiful in the inside. It was a very short distance to the Sportsplex. The host is very responsive and helpful. I highly recommend this house to all those families coming into Live Oak!"
United States
Tara W.
The price is AED 1,087
AED 2,379 total
includes taxes & fees
9 Nov - 10 Nov
Modern 5BR Live Oak Haven – Minutes from Suwannee Music Park & Springs!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top O Brien Hotel Reviews