O Brien, FL Vacation Homes from AED 590

O Brien Vacation Homes
Florida
United States of America
Expedia.ae

A calm river with clear water, surrounded by dense trees and rocky banks.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

In two weeks

In two months

In three months

In four months

Our top choices for O Brien vacation homes

A wooden deck overlooking a calm lake with two glasses of red wine.

A cozy log cabin room with a wooden dining table, a television, and a bed with camouflage bedding.

A wooden log wall, a refrigerator, and a wooden stool in a kitchen.

A compact kitchen with wooden cabinets, a microwave, a sink, and a refrigerator. There are three wooden stools at the kitchen island.

1. MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

O'Brien

9.4 out of 10, Exceptional, (60 reviews)

9.4/10

Exceptional

(60 reviews)

"A great get away for Labor Day weekend to do a little jet skiing with friends on the river and visiting all the local springs!"

Heather H.

MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

A bedroom with a bed, bedside lamps, a headboard, a window with curtains, and a wall sign.

2. Cozy Lake House, Hot Tub & Close to FL Springs

Cozy Lake House, Hot Tub & Close to FL Springs

Branford

10.0 out of 10, Exceptional, (1 review)

10/10

Exceptional

(1 review)

"Juan was so welcoming. The house was clean and had everything we needed for a fun family getaway - and then some! Would love to stay here again. "

Ashley L.

Cozy Lake House, Hot Tub & Close to FL Springs

A modern kitchen with wooden cabinets, a central island with stools, a stove, and a dining area with chairs.

Sleek design meets ultimate comfort. With clean lines, soothing green accents, and plenty of natural light, this bedroom offers a sophisticated space to unwind after a day of adventures.

A dining table set with white bowls, napkins, and wine glasses, with a vase of flowers in the center.

A modern living room with a grey sofa, a coffee table, and a TV. There is a kitchen area with wooden cabinets and a dining space with patterned chairs.

3. The Riverhead | Springs • Pavilion • Grill

The Riverhead | Springs • Pavilion • Grill

Fort White

9.4 out of 10, Exceptional, (17 reviews)

9.4/10

Exceptional

(17 reviews)

"Very close to springs and other attractions. Property was clean and very inviting on the inside. The beds were comfortable and the decor was very homey. Ample coffee and tea was provided and the kitchen was very equipped for cooking. Overall a really great way to enjoy the nearby springs. "

Nicole

The price is AED 364

AED 364

AED 996 total

includes taxes & fees

22 Oct - 23 Oct

The Riverhead | Springs • Pavilion • Grill

A wooden deck with two benches and a table, surrounded by a wooden fence and trees.

A compact kitchen with wooden cabinets, a microwave, a coffee maker, a sink, and a refrigerator.

A bathroom with a toilet, sink, and a framed picture on the wall.

A wooden bench and table on a wooden deck with a green railing, a beige wall, and a door in the background.

4. SpringHouse at Convict Springs

SpringHouse at Convict Springs

Mayo

10.0 out of 10, Exceptional, (1 review)

10/10

Exceptional

(1 review)

SpringHouse at Convict Springs

A living room with a sofa, armchair, and a television on a wooden cabinet.

Three Rivers Crystal Cabin with Private Spring Access - Photo of Cabin’s Primary Room

Three Rivers Crystal Cabin with Private Spring Access - Photo of Parking

A dining area with a large table, four striped chairs, a chandelier, a stone fireplace, and a wall with motivational signs.

5. Nature Cabin Itchetucknee Springs Private Access

Nature Cabin Itchetucknee Springs Private Access

Columbia County

10.0 out of 10, Exceptional, (1 review)

10/10

Exceptional

(1 review)

"Charming place to stay and enjoy the local rivers!"

Shawn

The price is AED 408

AED 408

AED 889 total

includes taxes & fees

1 Nov - 2 Nov

Nature Cabin Itchetucknee Springs Private Access

A living room with a television on a wooden stand, a wicker chair, a dark sofa, and a door to another room.

A bedroom with a bed, a ceiling fan, a nightstand, a lamp, and a wall decoration.

A picnic table and a mailbox in a wooded area with a small building in the background.

A compact kitchen with wooden cabinets, a white refrigerator, a stove, and a sink.

6. O'LE LADYBUG COTTAGE

O'LE LADYBUG COTTAGE

Lake City

9.6 out of 10, Exceptional, (57 reviews)

9.6/10

Exceptional

(57 reviews)

"Everything was great will stay again if I’m ever in the area"

regina

The price is AED 357

AED 357

AED 771 total

includes taxes & fees

22 Oct - 23 Oct

O'LE LADYBUG COTTAGE

A kitchen with a black induction cooktop, hanging utensils, and a small shelf with kitchen items.

A green door with a white window, a 'HOME' sign, and a red brick wall.

A bookshelf with books and a container of Jenga blocks.

A living room with a sectional sofa, ottoman, and a kitchen in the background.

7. Your Cozy Farmhouse Inspired Retreat. Just 5 minutes to I-75. Pets Welcomed.

Your Cozy Farmhouse Inspired Retreat. Just 5 minutes to I-75. Pets Welcomed.

Lake City

9.2 out of 10, Wonderful, (7 reviews)

9.2/10

Wonderful

(7 reviews)

"Amenities were surprisingly good, glad to have coffee available "

Cindy M.

The price is AED 367

AED 367

AED 652 total

includes taxes & fees

25 Oct - 26 Oct

Your Cozy Farmhouse Inspired Retreat. Just 5 minutes to I-75. Pets Welcomed.

A covered outdoor seating area with a round wooden table, white wicker chairs, and a black grill.

A kitchen with wooden cabinets, a central island, a stove, and a microwave.

A bedroom with a bed, a ceiling fan, a window with curtains, a painting, a bathroom door, a small table with a lamp, and a blue chair.

A living room with a fireplace, a ceiling fan, a television, and a sofa.

8. < 1 Mi From Suwannee River, Hideaway w/ Lanai

< 1 Mi From Suwannee River, Hideaway w/ Lanai

Old Town

The price is AED 404

AED 404

AED 1,372 total

includes taxes & fees

22 Oct - 23 Oct

< 1 Mi From Suwannee River, Hideaway w/ Lanai

A kitchen area with a wicker basket containing folded towels, a bottle of dish soap, and a sponge.

A modern kitchen with white cabinets, a stainless steel dishwasher, a sink with a faucet, and a countertop with a basket and jars.

A porch with two white rocking chairs, a blue mat, and a door with a sign above it.

A living room with a grey sofa, wooden chairs, a dining table with chairs, a chandelier, and large windows with blinds.

9. Nature + Music + Town - Cozy Farmhouse Retreat

Nature + Music + Town - Cozy Farmhouse Retreat

Live Oak

10.0 out of 10, Exceptional, (22 reviews)

10/10

Exceptional

(22 reviews)

"It feels just like staying with family "

Starr T.

The price is AED 520

AED 520

AED 1,097 total

includes taxes & fees

2 Nov - 3 Nov

Nature + Music + Town - Cozy Farmhouse Retreat

Screened-In Lanai | Dining Table | Bar Area | Private Pool (Not Heated)

A two-story building with a covered porch and a staircase leading to the upper level.

Property Interior | Single-Story Home | Free WiFi | Central A/C & Heating

10. Suwannee River Retreat: Pet Friendly, Private Dock

Suwannee River Retreat: Pet Friendly, Private Dock

Branford

9.8 out of 10, Exceptional, (9 reviews)

9.8/10

Exceptional

(9 reviews)

"A nice little getaway for a couple of days - great change of pace.While we didn’t bring children, I could see this an ideal place to bring kids and/or a large family to have plenty of space. Our dog (passed after we booked it) would have loved the ability to roam around in a gated area.Owner was very attentive. A tree fell on the wood bridge to the river right before we arrived and she had it fixed within the hour."

Matt W.

The price is AED 966

AED 966

AED 2,231 total

includes taxes & fees

2 Nov - 3 Nov

Suwannee River Retreat: Pet Friendly, Private Dock

A wooden house with a porch and stairs, surrounded by trees.

A spacious living room with a dark wood floor, a leather sofa, a wicker coffee table, and a brown armchair.

A modern kitchen with wooden cabinets, a refrigerator, a coffee maker, and a dining area with wooden chairs and a glass table.

An outdoor seating area with a fire feature, wooden deck, and string lights.

11. Hillside Abode in the Heart of Historic White Springs and the Suwannee River

Hillside Abode in the Heart of Historic White Springs and the Suwannee River

White Springs

10.0 out of 10, Exceptional, (36 reviews)

10/10

Exceptional

(36 reviews)

"Well worth the cost place was clean organized and a nice little safe haven during our trip "

Cory P.

The price is AED 496

AED 496

AED 1,000 total

includes taxes & fees

28 Oct - 29 Oct

Hillside Abode in the Heart of Historic White Springs and the Suwannee River

A two-story house with a porch, surrounded by trees and a body of water.

A wooden bed with a quilt, two bedside tables, and lamps.

A staircase with wooden steps and a handrail, leading to a landing with a white wall and a window with blinds.

A two-story house with a porch and outdoor seating area.

12. Beautiful 2 story house overlooking the water. Has arcade & Close to the springs

Beautiful 2 story house overlooking the water. Has arcade & Close to the springs

Live Oak

10.0 out of 10, Exceptional, (85 reviews)

10/10

Exceptional

(85 reviews)

"Perfect home base for my daughter’s wedding weekend! Owner was responding e and accommodating for my questions and needs!"

Lisa P.

Beautiful 2 story house overlooking the water. Has arcade & Close to the springs

A small cabin with a porch, two windows, and a door.

A modern home interior with a wooden floor, a flat-screen TV mounted on the wall, a dining table, and a kitchen area with white cabinets and a window.

A kitchen with white cabinets, a stainless steel refrigerator, a dining table with chairs, and a clock on the wall.

A bedroom with a bed, a dresser, a mirror, and a painting on the wall.

13. 3-bed 2 bath River house on the Santa fe. 6 miles from Ginnie Springs

3-bed 2 bath River house on the Santa fe. 6 miles from Ginnie Springs

Fort White

10.0 out of 10, Exceptional, (5 reviews)

10/10

Exceptional

(5 reviews)

"We loved our stay !"

Melissa R.

The price is AED 551

AED 551

AED 1,259 total

includes taxes & fees

2 Nov - 3 Nov

3-bed 2 bath River house on the Santa fe. 6 miles from Ginnie Springs

A wooden staircase leading to a riverbank with a view of the water and surrounding trees.

A spacious hallway with wooden flooring, a bench with floral cushions, a door with a window, and a cabinet with glass doors.

A spacious living room with a wooden staircase, a bookshelf, and a coffee table.

A wooden deck leading to a lake with a bench and a lifebuoy.

14. The Best memories are made on the Suwannee River

The Best memories are made on the Suwannee River

Mayo

9.8 out of 10, Exceptional, (59 reviews)

9.8/10

Exceptional

(59 reviews)

"Was there for a family reunion and was great for what we needed."

Anonymous traveler

The price is AED 496

AED 496

AED 1,034 total

includes taxes & fees

19 Nov - 20 Nov

The Best memories are made on the Suwannee River

A spacious living area with a high ceiling, wooden flooring, a dining table with chairs, a sofa, a bookshelf, and a staircase.

A bedroom with a single bed, a small table, and a window with curtains.

A two-story building with a covered porch and a staircase leading to an upper level.

A sunlit room with a tiled floor, a table with chairs, and a window with a view of trees.

15. Beautiful memories are made on the Suwannee River in Mayo Fl

Beautiful memories are made on the Suwannee River in Mayo Fl

Mayo

The price is AED 496

AED 496

AED 1,019 total

includes taxes & fees

27 Oct - 28 Oct

Beautiful memories are made on the Suwannee River in Mayo Fl

An outdoor patio with wicker furniture, a grill, and a ceiling fan.

A compact kitchen with white cabinetry, a countertop, a coffee maker, a toaster, and a trash bin.

A compact kitchen with a white countertop, a coffee maker, a toaster, and shelves with kitchenware.

A modern bedroom with a bed, a TV, a small table, and a chair.

16. Cozy 1-bedroom house in delightful High Springs

Cozy 1-bedroom house in delightful High Springs

High Springs

10.0 out of 10, Exceptional, (13 reviews)

10/10

Exceptional

(13 reviews)

"Close to everything, super clean, great hosts."

Sabrina D.

The price is AED 312

AED 312

AED 590 total

includes taxes & fees

22 Oct - 23 Oct

Cozy 1-bedroom house in delightful High Springs

A modern kitchen with grey cabinets, a black refrigerator, stainless steel appliances, and a window with blinds.

A bedroom with two beds, a television, and large windows with blinds.

A conference room with a wooden table, six chairs, a chandelier, a fire extinguisher, and a door.

A single-story house with a metal roof, a front porch, and a small attached garage.

17. Downtown three bedroom house with game room and outside lounge area.

Downtown three bedroom house with game room and outside lounge area.

Lake City

9.6 out of 10, Exceptional, (5 reviews)

9.6/10

Exceptional

(5 reviews)

"Great place"

Angie L.

The price is AED 502

AED 502

AED 1,336 total

includes taxes & fees

2 Nov - 3 Nov

Downtown three bedroom house with game room and outside lounge area.

A house with a porch and a garden with yellow flowers.

A dining area with a wooden table and four chairs, a stone fireplace, and motivational wall art.

A bedroom with a bed, a TV, an air conditioner, and a window with curtains.

A modern kitchen with granite countertops, stainless steel appliances, and a variety of storage cabinets.

18. Nature Cabin Itchetucknee Springs Private Access ~ Nature Lovers Only

Nature Cabin Itchetucknee Springs Private Access ~ Nature Lovers Only

Fort White

The price is AED 393

AED 393

AED 1,011 total

includes taxes & fees

22 Oct - 23 Oct

Nature Cabin Itchetucknee Springs Private Access ~ Nature Lovers Only

A covered outdoor dining area with a table and chairs, large windows, and a view of greenery.

A rustic cabin with a wooden deck and a staircase leading to a porch.

A spacious living room with a floral sofa, a round coffee table, and a ceiling fan.

A small, compact bathroom with a shower curtain, a toilet, and a wooden floor.

19. A-frame on the Suwannee River Rendezvous

A-frame on the Suwannee River Rendezvous

Mayo

6.0 out of 10, (1 review)

6.0/10

(1 review)

"Overnight night enroute"

Doug M.

The price is AED 863

AED 863

AED 997 total

includes taxes & fees

21 Nov - 22 Nov

A-frame on the Suwannee River Rendezvous

A living room with two black leather sofas, a glass coffee table, a patterned rug, and a painting on the wall.

A doorway with three windows, a white door, and a tiled floor.

A kitchen with white cabinets, a stainless steel refrigerator, a microwave, and a stove.

A wooden staircase with white paneling on the walls and a handrail on the left.

20. Modern 5BR Live Oak Haven – Minutes from Suwannee Music Park & Springs!

Modern 5BR Live Oak Haven – Minutes from Suwannee Music Park & Springs!

Live Oak

10.0 out of 10, Exceptional, (1 review)

10/10

Exceptional

(1 review)

"We were in town for a baseball state tournament. This was a fantastic place to stay for multiple families. This house has been newly updated and is beautiful in the inside. It was a very short distance to the Sportsplex. The host is very responsive and helpful. I highly recommend this house to all those families coming into Live Oak!"

Tara W.

The price is AED 1,102

AED 1,102

AED 2,512 total

includes taxes & fees

17 Nov - 18 Nov

Modern 5BR Live Oak Haven – Minutes from Suwannee Music Park & Springs!

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

View all properties

Find vacation rentals that suit your style

Apartments

search for apartments

Cabins

search for cabins

Private vacation homes

search for private vacation homes

Cottages

search for cottages

Condos

search for condos

Chalets

search for chalets

Save an average of 15% on thousands of hotels when you're signed in

Top O Brien Hotel Reviews

Quality Inn & Suites Live Oak I-10 Exit 283

8/10 Good

"Room was clean the TV didn't work would turn on but couldn't watch anything"

Brittany 1-night trip

Posted 8 hours ago

Quality Inn & Suites Live Oak I-10 Exit 283

Fairfield Inn & Suites Lake City

10/10 Excellent

"Great place! Very clean. Awesome breakfast."

Kevin 1-night trip

Posted 11 hours ago

Fairfield Inn & Suites Lake City

Best Western Plus Lake City

10/10 Excellent

"Very clean, comfortable bed and good breakfast. Also enjoyed Kerug coffee pots in room."

Ronald 1-night trip

Posted 11 hours ago

Best Western Plus Lake City

Baymont by Wyndham Lake City I-75

10/10 Excellent

"Loved the staff very quiet"

Sierra 1-night trip

Posted 18 hours ago

Baymont by Wyndham Lake City I-75

Comfort Suites Lake City

10/10 Excellent

"n/a"

Johnmichael 1-night trip

Posted 2 days ago

Comfort Suites Lake City

Quality Inn Lake City

8/10 Good

"The room was comfortable and clean. Staff nice, and you could tell the manager/owner paid attention to things. Breakfast was nice. Personally, I do not care for the hanging communal soap, shower stuff. It may be easier for staff but communal shared items are a no for me. They also could use another trash receptacle by the entrance. I would stay there again, the location is great,"

Geraldine 1-night trip

Posted 2 days ago

Quality Inn Lake City

Days Inn by Wyndham Lake City I-10

10/10 Excellent

"Booked on line....very nice room and very nice people!"

Cynthia 1-night trip

Posted 2 days ago

Days Inn by Wyndham Lake City I-10

Courtyard By Marriott Lake City

8/10 Good

"Quiet."

Aurel 1-night trip

Posted 2 days ago

Courtyard By Marriott Lake City

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

10/10 Excellent

"Clean room, super friendly and helpful staff, and great breakfast. Will stay again when back in the area!"

Megan 2-night trip

Posted 2 days ago

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Search Vacation Homes in O Brien

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for O Brien vacation homes

1. MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

2. Cozy Lake House, Hot Tub & Close to FL Springs

3. The Riverhead | Springs • Pavilion • Grill

4. SpringHouse at Convict Springs

5. Nature Cabin Itchetucknee Springs Private Access

6. O'LE LADYBUG COTTAGE

7. Your Cozy Farmhouse Inspired Retreat. Just 5 minutes to I-75. Pets Welcomed.

8. < 1 Mi From Suwannee River, Hideaway w/ Lanai

9. Nature + Music + Town - Cozy Farmhouse Retreat

10. Suwannee River Retreat: Pet Friendly, Private Dock

11. Hillside Abode in the Heart of Historic White Springs and the Suwannee River

12. Beautiful 2 story house overlooking the water. Has arcade & Close to the springs

13. 3-bed 2 bath River house on the Santa fe. 6 miles from Ginnie Springs

14. The Best memories are made on the Suwannee River

15. Beautiful memories are made on the Suwannee River in Mayo Fl

16. Cozy 1-bedroom house in delightful High Springs

17. Downtown three bedroom house with game room and outside lounge area.

18. Nature Cabin Itchetucknee Springs Private Access ~ Nature Lovers Only

19. A-frame on the Suwannee River Rendezvous

20. Modern 5BR Live Oak Haven – Minutes from Suwannee Music Park & Springs!

Find vacation rentals that suit your style

Top O Brien Hotel Reviews

Quality Inn & Suites Live Oak I-10 Exit 283