Find Family Hotels in Perryville, MO

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Check availability on Perryville Family Hotels

Our top choices for Perryville family-friendly hotels

Exterior
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
2.5 star property
Perryville
9.2 out of 10, Wonderful, (540)
"Clean room and pleasant staff"
United States
David
The price is AED 320
AED 366 total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Express & Suites Perryville by IHG
Free buffet breakfast
Holiday Inn Express Hotel & Suites Sparta by IHG

Holiday Inn Express Hotel & Suites Sparta by IHG

Holiday Inn Express Hotel & Suites Sparta by IHG
2.5 star property
Sparta
9.2 out of 10, Wonderful, (370)
"Spotless"
United States
JAMES
The price is AED 367
AED 408 total
includes taxes & fees
28 Dec - 29 Dec
Holiday Inn Express Hotel & Suites Sparta by IHG
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
8.8 out of 10, Excellent, (668)
"Great place "
United States
GUY
The price is AED 309
AED 334 total
includes taxes & fees
7 Jan - 8 January 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Outdoor dining
Beautiful location in the secluded woods

Beautiful location in the secluded woods

Beautiful location in the secluded woods
Pomona
10.0 out of 10, Exceptional, (61)
"It was very nice and clean. We really enjoyed staying there. We would love to rent this place again. "
United States
susan B.
The price is AED 309
AED 600 total
includes taxes & fees
16 Dec - 17 Dec
Beautiful location in the secluded woods
Lobby
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
2.5 star property
Jackson
8.2 out of 10, Very Good, (739)
"Dirty "
United States
Jon
The price is AED 293
AED 317 total
includes taxes & fees
28 Dec - 29 Dec
Comfort Suites Jackson-Cape Girardeau
Children's area
Newly remodeled house minutes away from downtown, golf courses + BIG back yard

Newly remodeled house minutes away from downtown, golf courses + BIG back yard

Newly remodeled house minutes away from downtown, golf courses + BIG back yard
2.0 star property
Farmington
9.8 out of 10, Exceptional, (20)
"very nice house and good location . had so many things to enjoy"
United States
Peter V.
The price is AED 316
AED 723 total
includes taxes & fees
16 Dec - 17 Dec
Newly remodeled house minutes away from downtown, golf courses + BIG back yard
Free daily self-serve breakfast
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
2.5 star property
Murphysboro
9.4 out of 10, Exceptional, (512)
"great property, great breakfast, friendly and knowledgable staff."
United States
Ronald
The price is AED 408
AED 452 total
includes taxes & fees
5 Jan - 6 January 2026
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Perryville Hotel Reviews

Holiday Inn Express Hotel & Suites Sparta by IHG

Holiday Inn Express Hotel & Suites Sparta by IHG

10/10 Excellent
"Spotless"
JAMES 2-night trip
Posted 4 days ago
Holiday Inn Express Hotel & Suites Sparta by IHG

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Frequently asked questions

What's Perryville like for family-friendly vacations?
If you've been thinking about a vacation with your kids, Perryville is a good choice. The excursions, parks, and swimming spots are just some of the things that make this a good place for family vacations. Fly into Cape Girardeau, MO (CGI-Cape Girardeau Municipal), which is located 38.3 mi (61.7 km) from the city center.
When's the best time to book a family-friendly vacation in Perryville?
The hottest months are usually July and August with an average temp of 75°F, while the coldest months are January and February with an average of 39°F. Average annual precipitation for Perryville is 48 inches.
What's there to see and do with your family in Perryville?
While you and the family are vacationing in Perryville, you might want to check out some of the attractions here such as Popeye Museum, Mark Twain National Forest, and Mississippi River. Make sure you have lots of time for activities like Saint Marys Lake and Feltz Street Park.