A sunset over a city skyline reflected in a calm lake, with industrial buildings and trees in the foreground.

Find Business Hotels in Rochester, MN

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Rochester Business Hotels

Tonight
18 Oct - 19 Oct
Tomorrow
19 Oct - 20 Oct
Next weekend
23 Oct - 25 Oct
In two weeks
30 Oct - 1 Nov

Our top choices for Rochester business-friendly hotels

A modern indoor patio with a fire feature, seating, and large windows.
A modern interior with a seating area, a bookshelf, and a window with a view of trees.
A reception area with a curved reception desk, wooden shelving, and a green moss wall with the text "I ♥ EVEN".
A modern hotel lobby with a large glass wall, a green wall mural, and a seating area with sofas and chairs.

1. EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG
Kutzky Park
United States
James
AED 419
AED 532 total
includes taxes & fees
23 Oct - 24 Oct
EVEN Hotel Rochester - Mayo Clinic Area by IHG
An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.
A garden with a water feature, rocks, and yellow umbrellas.
A restaurant interior with wooden tables, chairs, and a stone wall.
A modern living room with a dark wall, a decorative light fixture, and a patterned wall art piece.

2. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Historic Southwest
United States
Christine
AED 419
AED 483 total
includes taxes & fees
23 Oct - 24 Oct
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
A spacious outdoor dining area with modern furniture and large windows offering views of the city.
A modern hotel room with a large bed, a sofa, a small table, a desk, and a wardrobe.
A reception desk with a modern design, featuring a wooden panel and a wall adorned with framed botanical artwork.
A modern interior with a wooden ceiling, a large black shelving unit, and a refrigerator stocked with beverages.

3. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
Downtown Rochester
United States
Hernan
AED 393
AED 452 total
includes taxes & fees
24 Oct - 25 Oct
Hotel Indigo Rochester – Mayo Clinic Area by IHG
An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.
A modern bar area with seating and a counter.
A modern dining area with round tables and chairs, a large painting on the wall, and a flat-screen TV mounted above a geometric-patterned wall.
A modern Hyatt House hotel with a prominent 'Hyatt House' sign, multiple floors, and a parking garage.

4. Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area
Downtown Rochester
United States
Elsie
AED 437
AED 503 total
includes taxes & fees
30 Oct - 31 Oct
Hyatt House Rochester/Mayo Clinic Area
An outdoor patio area with a concrete floor, wooden fence, and string lights.
Property amenity
A Fairfield Inn & Suites hotel with a modern design, featuring a prominent entrance and a parking area.
A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

5. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys
Kutzky Park
United States
Jon
AED 443
AED 510 total
includes taxes & fees
6 Nov - 7 Nov
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys
A Holiday Inn Express building with a covered entrance, outdoor seating area, and a well-lit facade.
A hotel dining area with multiple tables and chairs, a coffee station, and a seating area with sofas.
A reception desk with a wooden finish, a blue wall with the Holiday Inn Express logo, and a welcome sign for members.
A hotel room with two beds, a desk, a chair, a television, and a kitchenette.

6. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG
Kutzky Park
United States
Janet
AED 371
AED 427 total
includes taxes & fees
23 Oct - 24 Oct
Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG
A restaurant with wooden tables and bar stools, a bar area with a counter, and multiple televisions mounted on the walls.
A hotel room with two beds, a desk, a chair, and a mirror.
A bar with wooden stools and a neon sign.
A modern kitchen with wooden cabinets, a microwave, an oven, and a dishwasher.

7. AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic
Rochester
United States
blake
AED 268
AED 309 total
includes taxes & fees
25 Oct - 26 Oct
AmericInn by Wyndham Rochester Near Mayo Clinic
A rooftop terrace with outdoor seating and a city skyline in the background.
A spacious lobby with modern furniture, a staircase, and large windows.
A hotel room with a large bed, a desk, a chair, a small table, and a TV.
A modern hotel entrance with a glass facade, a covered entrance area, and a visible 'Hilton' sign.

8. Hilton Rochester Mayo Clinic Area

Hilton Rochester Mayo Clinic Area
Downtown Rochester
United States
Raymond
AED 715
AED 823 total
includes taxes & fees
31 Oct - 1 Nov
Hilton Rochester Mayo Clinic Area
A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.
A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.
A compact laundry area with a washing machine, dryer, and a water fountain.
A reception area with a wooden reception desk, a red doormat, and framed awards on the wall.

9. Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area
Rochester
United States
Ashley
AED 242
AED 279 total
includes taxes & fees
8 Nov - 9 Nov
Econo Lodge Mayo Clinic Area
An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.
A modern hotel room with a bed, desk, and kitchenette.
An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.
A modern lounge area with a sofa, chairs, and tables.

10. Home2 Suites by Hilton Rochester Mayo Clinic Area

Home2 Suites by Hilton Rochester Mayo Clinic Area
Rochester
United States
howard
AED 434
AED 500 total
includes taxes & fees
12 Nov - 13 Nov
Home2 Suites by Hilton Rochester Mayo Clinic Area
View all properties

Top Rochester Hotel Reviews

AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

10/10 Excellent
"We needed a place to stay for one night, with our dog, and it was a great place to land. It was comfortable, plenty of towels and other amenities. It was so helpful to have a good-sized refrigerator as we are traveling across the country and we always bring food."
Jacki 1-night trip
Posted less than an hour ago
AmericInn by Wyndham Rochester Near Mayo Clinic
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

10/10 Excellent
"Has been updated a bit since our last stay. Has been clean and newer items in the room. Staff always helpful. Breakfast dinning has been upgraded too! nice to see the change in the stations. Excellent to take the subway to Mayo apts. Caribou coffee downstairs, Jimmy John's, Chinese in the hotel restaurant. Have stayed here 15+ times in the past 2 years. Would recommend."
Sandy 2-night trip
Posted 1 hour ago
Kahler Inn and Suites - Mayo Clinic Area
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

10/10 Excellent
"My husband and I got a room for a little get away. The hotel was very clean. And the man at the front desk was very nice and helpful. Was nice that breakfast was included. Just a standard hotel breakfast. Parking was right on the side of the hotel. There was a fee. But very low fee. Being right across the street from saint Mary’s hospital I understand. We had a suite. The room was super clean. The bed was so comfy! Some great restaurants just walking distance away. All and all the e had a very nice night away and would definitely book at this hotel in the future."
Amy 1-night trip
Posted 3 hours ago
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
Kahler Grand Hotel

Kahler Grand Hotel

10/10 Excellent
"Very close to the clinic, great place to rest!"
Christina 5-night trip
Posted 1 day ago
Kahler Grand Hotel
Quality Inn near Medical Center

Quality Inn near Medical Center

8/10 Good
"Property seemed to be in the middle of an upgrade"
Shannon 2-night trip
Posted 4 days ago
Quality Inn near Medical Center