Find hotels in Santa Ana, Panama City from AED 91

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Our top choices for Santa Ana hotels

Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.6 out of 10, Good, (55)
"Excelente "
Mexico
David
The price is AED 82
AED 91 total
includes taxes & fees
3 Jan - 4 January 2026
Hostal La Cigarra

Casco View Apartments

Casco View Apartments
3.5 star property
Santa Ana
9.2 out of 10, Wonderful, (55)
"We live this property and stay here whenever we are in town."
United States
chris
Casco View Apartments

Hotel República

Hotel República
2.0 star property
Santa Ana
6.6 out of 10, (182)
"Fantastic customer service"
United States
OLGA
Hotel República

ART CASCO The Hotel

ART CASCO The Hotel
2.0 star property
Santa Ana
6.0 out of 10, (11)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
United States
Eldris
ART CASCO The Hotel

La Manzana by Wynwood House

La Manzana by Wynwood House
3.0 star property
Santa Ana
7.2 out of 10, Good, (15)
"Great hotel. Very close to Casco viejo"
United States
LUCILA
The price is AED 279
AED 408 total
includes taxes & fees
29 Dec - 30 Dec
La Manzana by Wynwood House

Room-sofa Bed Stay Rooftop Pool & Gym, A

Room-sofa Bed Stay Rooftop Pool & Gym, A
2.0 star property
Santa Ana
2.0 out of 10, (1)
"You pay for a space in the apartment, it’s not the whole apartment be careful. The owner or whoever manages doesn’t give care about you as costumers they just want the money"
United States
Cristian Camilo Betancur
The price is AED 541
AED 595 total
includes taxes & fees
14 Jan - 15 January 2026
Room-sofa Bed Stay Rooftop Pool & Gym, A

Ramada Panama Centro Via Argentina

Ramada Panama Centro Via Argentina
3.0 star property
El Cangrejo, 3.8 km from Santa Ana
7.4 out of 10, Good, (270)
"Hotel staff and rooms were good , great location "
United States
Cornelly
The price is AED 312
AED 343 total
includes taxes & fees
25 Dec - 26 Dec
Ramada Panama Centro Via Argentina

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG
4.0 star property
21.1 km from Santa Ana
8.4 out of 10, Very Good, (2330)
"Beautiful lobby, friendly staff, clean room"
Canada
Kwai
The price is AED 404
AED 444 total
includes taxes & fees
31 Dec - 1 January 2026
Crowne Plaza Panama Airport by IHG

ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport
2.5 star property
20.5 km from Santa Ana
9.0 out of 10, Wonderful, (39)
"It was a cool unique antique place that had modern touches. The staff was very friendly and helpful. Will definitely stay again. "
United States
Clarissa
The price is AED 441
AED 572 total
includes taxes & fees
5 Jan - 6 January 2026
ORHO HOTEL BOUTIQUE PANAMA Airport

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino
4.0 star property
19.8 km from Santa Ana
8.6 out of 10, Excellent, (1845)
"Better than expected: Location, transportation to and from airport, pool area tropical and comfortable. "
United States
Marty
The price is AED 459
AED 505 total
includes taxes & fees
25 Dec - 26 Dec
Riande Aeropuerto Hotel & Casino

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
4.0 star property
14.6 km from Santa Ana
8.8 out of 10, Excellent, (1005)
"The hotel is conveniently close to the airport and shopping centres. "
United States
Samantha
The price is AED 403
AED 443 total
includes taxes & fees
8 Jan - 9 January 2026
Courtyard by Marriott Panama Metromall

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz, 12.7 km from Santa Ana
9.6 out of 10, Exceptional, (643)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is AED 851
AED 936 total
includes taxes & fees
4 Jan - 5 January 2026
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Arcadia Condo Suites

Arcadia Condo Suites
2.5 star property
Costa del Este, 10.2 km from Santa Ana
9.4 out of 10, Exceptional, (167)
"Everything was great, helpful staff, great room , clean, excellent service!"
United States
Gregory Walter
The price is AED 272
AED 469 total
includes taxes & fees
3 Jan - 4 January 2026
Arcadia Condo Suites

The Westin Panama

The Westin Panama
4.0 star property
Costa del Este, 9.4 km from Santa Ana
9.0 out of 10, Wonderful, (310)
"Great hotel and services"
United States
Pedro
The price is AED 786
AED 865 total
includes taxes & fees
10 Jan - 11 January 2026
The Westin Panama

Sheraton Grand Panama

Sheraton Grand Panama
4.0 star property
San Francisco, 5.7 km from Santa Ana
8.6 out of 10, Excellent, (994)
"Was amazing food was delicious and stay was great "
United States
Amanda
The price is AED 493
AED 542 total
includes taxes & fees
9 Jan - 10 January 2026
Sheraton Grand Panama

Aloft Panama

Aloft Panama
3.5 star property
San Francisco, 5.7 km from Santa Ana
8.8 out of 10, Excellent, (896)
"Great staff..warm and welcoming...enjoyed our stay!"
United States
Alystra Marissa Arjoon
The price is AED 436
AED 480 total
includes taxes & fees
2 Jan - 3 January 2026
Aloft Panama

JW Marriott Panama

JW Marriott Panama
5.0 star property
Punta Pacifica, 4.3 km from Santa Ana
9.0 out of 10, Wonderful, (1003)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
The price is AED 1,172
AED 1,289 total
includes taxes & fees
3 Jan - 4 January 2026
JW Marriott Panama

Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica
4.0 star property
San Francisco, 5.1 km from Santa Ana
9.6 out of 10, Exceptional, (1123)
"The hotel is in a great location in Panama. Great amenities excellent breakfast."
United States
Maria
The price is AED 360
AED 396 total
includes taxes & fees
10 Jan - 11 January 2026
Ramada Plaza by Wyndham Panama Punta Pacifica

Residence Inn by Marriott Panama City

Residence Inn by Marriott Panama City
4.0 star property
Punta Paitilla, 4 km from Santa Ana
9.0 out of 10, Wonderful, (541)
"It's location is close to everything. "
United States
Sharon
The price is AED 590
AED 649 total
includes taxes & fees
10 Jan - 11 January 2026
Residence Inn by Marriott Panama City

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
Punta Paitilla, 3.4 km from Santa Ana
9.4 out of 10, Exceptional, (2140)
"Great location of the hotel with a lovely breakfast and friendly staff"
United States
fouad
The price is AED 396
AED 436 total
includes taxes & fees
16 Jan - 17 January 2026
Plaza Paitilla Inn Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.

Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Crown Casino. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Punta Paitilla

Travelers come to Punta Paitilla for its abundant dining options, and you can see top attractions like Avenida Balboa and Multicentro Panama while you're in town.

Top Santa Ana Hotel Reviews

Find out more about Santa Ana

Top reasons to visit Santa Ana

  • Vibrant Nightlife: Experience the lively bar scene in Santa Ana, perfect for those looking to enjoy Panama City's nightlife.
  • Cultural Attractions: Visit historical sites such as Santa Ana Casco Viejo and local museums to immerse yourself in Panama's rich heritage.
  • Stunning Views: Enjoy picturesque hilltop views that provide a breathtaking backdrop for your vacation.
  • Family-Friendly Activities: Explore various attractions and parks that cater to visitors of all ages.
  • Diverse Accommodations: Choose from a range of hotels and apartments that meet different needs and preferences.

Find great hotels near Santa Ana

Santa Ana offers a diverse selection of accommodations, including hotels and apartments, perfect for every traveler. Whether you seek a pet-friendly stay, a business-friendly environment, or a relaxed vacation experience, you'll find suitable options. With popular choices like Hotel El Panama and various city-themed hotels, Santa Ana is an ideal base for exploring Panama City while enjoying modern amenities and a welcoming atmosphere.

  • Central Hotel Panama Casco Viejo: Experience romance and luxury at the Central Hotel Panama Casco Viejo, a 4-star gem located a mere 805m from Santa Ana. This hotel is an ideal choice for couples seeking a romantic getaway, featuring enticing romance packages and exquisite food and beverage services, including 24-hour room service and champagne service. Guests can indulge in rejuvenating spa treatments, with amenities like facial treatments and a full-service spa available. The hotel’s central location makes it a perfect base for exploring the vibrant city while enjoying a serene retreat.
  • American Trade Hotel: The American Trade Hotel, a stylish 4.5-star property located 644m from Santa Ana, caters to business travelers and pet owners alike. This city-themed hotel provides a blend of comfort and convenience, allowing some pets on-site with waived fees for service animals. Guests can enjoy modern amenities and a prime location in the heart of the city, making it easy to conduct business or explore nearby attractions. With its elegant design and thoughtful services, the American Trade Hotel is perfect for those combining work and leisure.
  • Innfiniti Hotel & Suites: Offering a welcoming atmosphere, the Innfiniti Hotel & Suites is a 3.5-star accommodation located 1.4km from Santa Ana. This city-themed hotel is tailored for business travelers, providing essential amenities and a convenient location in the bustling city center. With comfortable rooms and a focus on guest satisfaction, Innfiniti is an excellent choice for those looking to balance work and relaxation during their stay in Panama City.

Where to stay near Santa Ana

Santa Ana, a vibrant neighborhood in Panama City, offers a unique blend of family-friendly attractions and business opportunities. Visitors can enjoy the welcoming atmosphere and explore nearby areas that showcase the rich culture of Panama. From local markets to luxurious accommodations, Santa Ana caters to all types of travelers seeking relaxation or adventure. Immerse yourself in the charm of this lively neighborhood while discovering the diverse experiences that Panama City has to offer.

  • Panama City: The vibrant heart of Panama, Panama City boasts a unique blend of modern skyscrapers and historic neighborhoods. Santa Ana is situated within its bustling limits, making it a convenient base for your adventures. Travelers flock here year-round, with peak visits in January, July, and September, drawn by its family-friendly atmosphere and urban experiences. Don't miss the chance to explore shopping centers and malls, while local attractions like beaches, parks, and lively streets offer a perfect backdrop for relaxation and exploration.
  • Casco Viejo: Just 644m from Santa Ana, Casco Viejo is a historic neighborhood filled with charming cobblestone streets and colonial architecture. This area is particularly popular in January and the spring months, catering to families and outdoor enthusiasts alike. Visitors can indulge in shopping at local markets and enjoy the vibrant atmosphere of cafes and restaurants. With close proximity to beautiful parks and stunning beachfront views, Casco Viejo is a must-visit for those looking to soak in the culture and history of Panama City.
  • San Felipe: Also located 644m from Santa Ana, San Felipe is known for its rich history and cultural landmarks. This neighborhood attracts families and outdoor lovers, especially during peak seasons in February, March, and December. Explore local resorts and shopping areas, and take a leisurely stroll through picturesque parks or along the beach. With historic sites nearby, San Felipe offers a delightful mix of recreation and education, making it an enriching stop on your Panama journey.

Things to do near Santa Ana

Santa Ana offers a vibrant mix of family-friendly and business-themed activities perfect for any traveler. Explore nearby shopping malls and centers, or indulge in the local bar crawl to experience Panama City's lively nightlife. Whether you're looking to shop or enjoy entertainment, Santa Ana provides a variety of options to make your vacation enjoyable and memorable.

Shopping

For a great shopping experience in Santa Ana, visit Albrook Shopping Mall, just 1.6km away, offering a mix of entertainment and family vibes. Avenida Central, only 483m away, features a lively atmosphere, while Uruguay Street, 3.2km away, is perfect for exploring local shops.

Recreation

In Santa Ana, you can visit Maracana Stadium for an energetic atmosphere, perfect for sports enthusiasts. Estadio Rommel Fernandez and Estadio Nacional Rod Carew offer vibrant sports experiences, making them excellent spots to enjoy local games and immerse yourself in Panama's sports culture.

Adventure

Explore the Honeycreeper Ridge Trail, a stunning hiking trail 43.5km from Santa Ana, offering breathtaking scenery and a chance to connect with nature. For an adrenaline rush, visit Gatun Eco Adventures, a thrilling zipline ropes course located 48.3km away, perfect for adventure seekers.

Nightlife

In Santa Ana, the vibrant nightlife features venues like the National Theater, Anita Villalaz Theater, and Amador Theater, all within 1.6km's reach. Each offers a unique blend of romance, culture, and entertainment, making for an enchanting evening in Panama City.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Santa Ana

To save money on your trip to Santa Ana, consider visiting between September and November, when prices are lower. Book your stay on a Tuesday for the best rates, as Saturdays tend to be the most expensive. Use Expedia’s search tool to filter options by budget and location, and arrange results from lowest to highest price. Additionally, combining hotel reservations with flights and activities through an Expedia package deal can lead to significant savings. Don't forget to look for expedia coupons to maximize your budget.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Santa Ana are September to November, where the prices are slightly lower. This is in comparison to January and March to April, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Santa Ana is Tuesday. The most expensive day to stay around Santa Ana is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia’s search tool to refine your preferences, such as your budget, desired location, and the type of hotel you’re looking for. To find the best prices and deals, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel reservations in Santa Ana with your flights and activities through an Expedia package deal.

Find the best attractions near Santa Ana

Santa Ana offers a delightful mix of family-friendly, city-themed, and business vacation options. Visitors can explore fascinating attractions like hilltop views, history museums, and cathedrals. Key points of interest include Santa Ana Casco Viejo, Plaza Santa Ana, Panama City Beach, Santa Ana Square, and Playa Bonita. These sites provide a rich cultural experience, stunning scenery, and a taste of local history, ensuring a memorable visit for travelers.

  • Metropolitan Cathedral of Panama: An architectural marvel, this cathedral features stunning colonial design and intricate details. Visitors can immerse themselves in the rich history and vibrant cultural atmosphere that surrounds this sacred space.
  • Interoceanic Canal Museum: Delve into the fascinating history of the Panama Canal at this engaging museum. With interactive exhibits and informative displays, you'll gain insights into the canal's significance and impact on global trade and travel.
  • Ancon Hill: Offering breathtaking panoramic views of Panama City and the canal, Ancon Hill is perfect for outdoor enthusiasts. Enjoy a scenic hike or leisurely stroll amidst lush greenery and diverse wildlife, making it a peaceful retreat from urban life.

Best time to go to Santa Ana

The best time to visit Santa Ana can depend on the weather and when visitor numbers rise and fall. The hottest average temperature around Santa Ana falls in April, when visitor numbers are average and weather is mostly sunny with light rain. The coolest average temperature around Santa Ana falls in November, visitor numbers are average and weather is mostly cloudy with frequent rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January78.8°F (26.0°C)No RainMostly SunnyAverageSlightly High
February79.2°F (26.2°C)No RainMostly SunnySlightly HighAverage
March79.7°F (26.5°C)No RainMostly SunnySlightly HighSlightly High
April80.4°F (26.9°C)Light RainMostly SunnyAverageSlightly High
May80.2°F (26.8°C)Frequent RainMostly CloudySlightly LowAverage
June79.9°F (26.6°C)Frequent RainMostly CloudySlightly LowAverage
July79.3°F (26.3°C)Frequent RainMostly CloudyAverageAverage
August79.2°F (26.2°C)Frequent RainMostly CloudyAverageAverage
September79.3°F (26.3°C)Frequent RainMostly CloudySlightly LowSlightly Low
October78.6°F (25.9°C)Frequent RainMostly CloudyAverageSlightly Low
November78.3°F (25.7°C)Frequent RainMostly CloudyAverageSlightly Low
December78.6°F (25.9°C)Light RainMostly CloudySlightly HighAverage

The nearest major airports for your trip to Santa Ana

Traveling to Santa Ana, Panama is convenient with access to major airports. Panama City (PTY-Tocumen Intl.) is located 20.9km away, with nearby hotels like The Santa Maria, a Luxury Collection Hotel, 8.0km from the airport, and JW Marriott Panama, 16.1km away. Alternatively, Panama City (PAC-Marcos A. Gelabert Intl.) is only 3.2km from Santa Ana, featuring excellent accommodations such as Waldorf Astoria Panama and Sofitel Legend Casco Viejo, both within 3.2km of the airport. For a more remote option, Rio Hato (RIH-Scarlett Martinez Intl.) is 91.7km away, with resorts like The Buenaventura Golf & Beach Resort offering transport services to the airport.

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Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighborhood that travelers like for its seafood restaurants, shopping, and parks. Are you looking for Santa Ana travel tips? Be sure to check out Cinta Costera and Avenida Balboa while you're in the neighborhood.
Where is the best hotel for a stay in Santa Ana?
Based on our traveler data, Casco View Apartments is one of the top choices for your stay in Santa Ana. This condo is a short 8-minute walk from Avenida Balboa, and it offers an outdoor pool and in-room kitchens.
How many hotels can I expect to find in Santa Ana?
Expedia has 111 hotels and other accommodations in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! Most hotel room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Add dates, click "Search", then use the "fully refundable" filter to get top deals in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about picking new dates or cancelling your trip to Santa Ana, head over to our customer service page.
What is there to do in this Panama City neighborhood?
If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighborhood. Albrook Shopping Mall, Amador Theater, and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.