Santa Cruz Vacations

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Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center

Historical Center

7 out of top 10 points of interest in this area
4.5/5(600 area reviews)

Casa de la Memoria Cultural Center and Calle Sierpes are a few top attractions in Historical Center. Hop around the city on the metro at Plaza Nueva Tram Stop or Archivo de Indias Tram Stop and check out the area's fantastic nightlife, stunning cathedral, and popular shops.

Find hotels in Historical Center

Santa Cruz Hotel Deals

Hotel Fernando III

Hotel Fernando III

4 out of 5
San Jose 21 Seville Seville
Fully refundableReserve now, pay when you stay
The price is AED 1,078 per night from Mar 7 to Mar 8
AED 1,078
AED 1,186 total
7 Mar - 8 Mar
includes taxes & fees
9.6/10 Exceptional! (1,524 reviews)
Clean and good room, great location!!!

Reviewed on 1 February 2026

Hotel Fernando III
Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center

4 out of 5
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
The price is AED 452 per night from Feb 10 to Feb 11
AED 452
AED 497 total
10 Feb - 11 Feb
includes taxes & fees
9.2/10 Wonderful! (1,003 reviews)
The history of the building, beautiful surroundings.

Reviewed on 6 February 2026

Las Casas de la Judería, Sevilla Historic City Center
Hotel Rey Alfonso X

Hotel Rey Alfonso X

4 out of 5
Calle Ximenez De Enciso, 35 Seville Seville
The price is AED 838 per night from Feb 24 to Feb 25
AED 838
AED 922 total
24 Feb - 25 Feb
includes taxes & fees
9.4/10 Exceptional! (1,134 reviews)
Good

Reviewed on 7 February 2026

Hotel Rey Alfonso X
See all 437 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Santa Cruz

La Giralda which includes a castle and heritage architecture

Giralda Tower

4.5/5(496 reviews)

You can find out about the history of Seville with a stop at Giralda Tower. Check out the stunning cathedral and lively bars in this culturally rich area.

Giralda Tower
San Telmo Palace which includes heritage architecture

San Telmo Palace

After visiting San Telmo Palace, make a plan to see the other sights and activities in Paseo de Las Delicias. Visit the stunning cathedral and shops in this romantic area.

San Telmo Palace
Cabildo Catedral showing heritage elements and heritage architecture

Cabildo Catedral

Find out about the history of Seville when you take a trip to Cabildo Catedral. Visit the stunning cathedral and shops in this culturally rich area.

Cabildo Catedral