Top 10 Hotels in Santa Fe, FL from AED 249 - Competitive Prices

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Go beyond your typical stay in Santa Fe

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Santa Fe hotels

A hotel with a covered entrance, stone facade, and blue lighting accents.

1. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Alachua

Austin

AED 413 total

includes taxes & fees

14 Dec - 15 Dec

A modern kitchen area with a central counter, various food stations, and a chalkboard menu.

2. Hampton Inn & Suites Alachua I-75

Alachua

Pamela

AED 467 total

includes taxes & fees

29 Nov - 30 Nov

A large, multi-story hotel with a central courtyard, palm trees, and an American flag.

3. Best Western Gateway Grand

Gainesville

Jvotric

AED 349 total

includes taxes & fees

19 Nov - 20 Nov

A modern hotel with a prominent 'La Quinta' sign, a covered entrance, and a well-maintained outdoor area with a parking lot.

4. La Quinta by Wyndham Gainesville

Gainesville

Megan

AED 402 total

includes taxes & fees

15 Nov - 16 Nov

A cozy restaurant with wooden beams, yellow walls, and a bar area with coffee machines.

5. Quality Inn Alachua - Gainesville Area

Alachua

faye

AED 299 total

includes taxes & fees

22 Nov - 23 Nov

A modern hotel room with a large bed, a flat-screen TV, a desk, and a mural of a landscape.

6. Clarion Pointe Alachua - Gainesville Area

Alachua

Debra

AED 299 total

includes taxes & fees

3 Dec - 4 Dec

An outdoor patio with wicker furniture, stone walls, and a barbecue grill.

7. TownePlace Suites by Marriott Gainesville Northwest

Gainesville

Jell

AED 433 total

includes taxes & fees

16 Nov - 17 Nov

A modern bar area with a long counter, green bar stools, and a television displaying a golf game.

8. Fairfield Inn & Suites by Marriott Gainesville I-75

Gainesville

Robert

AED 492 total

includes taxes & fees

15 Nov - 16 Nov

A modern interior with a staircase, a seating area, and a colorful abstract wall design.

9. Hyatt Place Gainesville Downtown

Downtown Gainesville

Misak

AED 428 total

includes taxes & fees

16 Nov - 17 Nov

A hotel room with a bed, bedside tables, a TV, a window with curtains, and a wall with artwork.

10. Sleep Inn & Suites University/Shands

Gainesville

Gertlenith

AED 333 total

includes taxes & fees

4 Dec - 5 Dec

A stone water feature with cascading water, surrounded by a brick wall and greenery.

11. BlueGem Motel

High Springs

Myra

AED 395 total

includes taxes & fees

16 Nov - 17 Nov

A modern living room with a fireplace, comfortable seating, a flat-screen TV, and a large window.

12. Comfort Suites Gainesville near University

Gainesville

Samantha

AED 344 total

includes taxes & fees

29 Nov - 30 Nov

A multi-story hotel with a central entrance, palm trees, and a clear sky.

13. Country Inn & Suites by Radisson, Gainesville, FL

Gainesville

Jeff

AED 365 total

includes taxes & fees

22 Nov - 23 Nov

A hotel room with a bed, a desk, a chair, a refrigerator, and a microwave.

14. Palms Garden Inn

Lake City

Ron

AED 285 total

includes taxes & fees

15 Nov - 16 Nov

An outdoor patio with stone walls, a wooden ceiling, and a built-in grill station.

15. Holiday Inn Express & Suites Gainesville I-75 by IHG

Gainesville

Meredith

AED 442 total

includes taxes & fees

13 Dec - 14 Dec

A hotel room with a bed, a sofa, a coffee table, and a small table with a lamp.

16. Best Western Waldo Inn and Suites

Waldo

Sarah

AED 348 total

includes taxes & fees

22 Nov - 23 Nov

A spacious lobby with a sectional sofa, a wooden cabinet, and a television mounted on the wall.

17. Drury Inn & Suites Gainesville

Gainesville

Michael

AED 434 total

includes taxes & fees

26 Nov - 27 Nov

An outdoor seating area with a fire feature, chairs, and tables.

18. Hotel Indigo Gainesville-Celebration Pointe by IHG

Gainesville

Lorraine

AED 422 total

includes taxes & fees

22 Nov - 23 Nov

A modern hotel with a flat roof, multiple floors, and a prominent 'aloft' sign.

19. Aloft by Marriott Gainesville University Area

Gainesville

Esteban

AED 360 total

includes taxes & fees

15 Nov - 16 Nov

A hotel lobby with a seating area, a sofa, a table, and a lamp.

20. Hampton Inn & Suites Gainesville Downtown University

Downtown Gainesville

Graziella

AED 376 total

includes taxes & fees

27 Nov - 28 Nov

View all properties

Compare top hotels in Santa Fe

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG 3.5 star property Alachua View	Hampton Inn & Suites Alachua I-75 2.5 star property Alachua View	Best Western Gateway Grand 3.0 star property Gainesville View	La Quinta by Wyndham Gainesville 3.0 star property Gainesville View	Quality Inn Alachua - Gainesville Area 2.5 star property Alachua View
9.4 Exceptional 1,002 reviews	9.4 Exceptional 572 reviews	8.6 Excellent 1,530 reviews	9.2 Wonderful 1,389 reviews	7.2 Good 1,009 reviews
The price is AED 367 AED 413 total includes taxes & fees 14 Dec - 15 Dec	The price is AED 415 AED 467 total includes taxes & fees 29 Nov - 30 Nov	The price is AED 311 AED 349 total includes taxes & fees 19 Nov - 20 Nov	The price is AED 357 AED 402 total includes taxes & fees 15 Nov - 16 Nov	The price is AED 265 AED 299 total includes taxes & fees 22 Nov - 23 Nov
Yes, Breakfast included Yes, Pool No Spa Yes, Pet friendly Yes, WiFi included Yes, Parking	No Breakfast included Yes, Pool No Spa Yes, Pet friendly No WiFi included Yes, Parking	Yes, Breakfast included Yes, Pool No Spa Yes, Pet friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included Yes, Pool No Spa Yes, Pet friendly No WiFi included Yes, Parking	Yes, Breakfast included Yes, Pool No Spa Yes, Pet friendly Yes, WiFi included Yes, Parking

Top Santa Fe Hotel Reviews

Hampton Inn & Suites Alachua I-75

Alachua

10/10 Excellent

Jose

La Quinta by Wyndham Gainesville

Gainesville

10/10 Excellent

Alan

Best Western Gateway Grand

Gainesville

10/10 Excellent

jennifer Louise

Fairfield Inn & Suites by Marriott Gainesville I-75

Gainesville

10/10 Excellent

Marita

Drury Inn & Suites Gainesville

Gainesville

10/10 Excellent

Jennifer

A large, two-story house with a porch, multiple windows, and a chimney.

Sweetwater Branch Inn

Gainesville

10/10 Excellent

I had a mini vacation here between conferences at the University of Florida. I had a delightful room, wonderful facilities, gardens, saltwater pool, and the cat Butterscotch was a wonderful friend as I had a lovely evening in a rocker on the porch with a bit of wine and a book. I highly recommend the massage therapist option. She was wonderful and set up and collapse was not intrusive in my room.

Carol

A modern kitchen with a flat-screen TV, a microwave, and a coffee maker on a wooden cabinet. There is a window with a view of a green landscape.

Vista Verde Farm Retreat

Lake City

10/10 Excellent

Steven

Comfort Suites Gainesville near University

Gainesville

10/10 Excellent

My daughter & I stay here frequently as it’s conveniently located near the medical facility UF Health. They apparently put great effort in keeping the facility clean. A lot of fact that it’s just shy of all the hustle and bustle of Gainesville, but within minutes of the University and the Hospital, the staff has accommodated me when I’ve asked for special needs, and I will always return to this this hotel.

Elizabeth

Country Inn & Suites by Radisson, Gainesville, FL

Gainesville

10/10 Excellent

Georgette

A cabin with a cozy interior, a dining area, and a view of the forest.

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

High Springs

10/10 Excellent

Alexander

Hotel Indigo Gainesville-Celebration Pointe by IHG

Gainesville

10/10 Excellent

Katrina

Sleep Inn & Suites University/Shands

Gainesville

10/10 Excellent

Lisa

Best Western Waldo Inn and Suites

Waldo

10/10 Excellent

Parker

TownePlace Suites by Marriott Gainesville Northwest

Gainesville

10/10 Excellent

Lyla

Frequently Asked Questions

What are some of the best vacation rentals in Santa Fe?

5BR UF Family Retreat with Private Pool, Pond, Game Room – Sleeps 10: This vacation home rental outside of Santa Fe is located on a lake and has an outdoor pool, a fireplace, and a barbecue grill to put you at ease in your new surroundings. It has 5 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. It offers a patio, a garden, and a selection of games so you can immerse yourself in your vacation. See all vacation rentals in Santa Fe.

If I need to cancel my hotel reservation in Santa Fe, will I receive a refund?

Yes, most hotel bookings are fully refundable if cancelled before the hotel’s cancellation deadline, which is often 24 or 48 hours before check in. If you have a non-refundable reservation, you might still have the option to cancel and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Fe.

Where can I learn more about changing or cancelling my trip to Santa Fe?

To access more information about picking new dates or cancelling your trip to Santa Fe, go to https://www.expedia.com/service/.

Find hotels in Santa Fe, FL from AED 249

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Santa Fe

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Santa Fe hotels

1. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

2. Hampton Inn & Suites Alachua I-75

3. Best Western Gateway Grand

4. La Quinta by Wyndham Gainesville

5. Quality Inn Alachua - Gainesville Area

6. Clarion Pointe Alachua - Gainesville Area

7. TownePlace Suites by Marriott Gainesville Northwest

8. Fairfield Inn & Suites by Marriott Gainesville I-75

9. Hyatt Place Gainesville Downtown

10. Sleep Inn & Suites University/Shands

11. BlueGem Motel

12. Comfort Suites Gainesville near University

13. Country Inn & Suites by Radisson, Gainesville, FL

14. Palms Garden Inn

15. Holiday Inn Express & Suites Gainesville I-75 by IHG

16. Best Western Waldo Inn and Suites

17. Drury Inn & Suites Gainesville

18. Hotel Indigo Gainesville-Celebration Pointe by IHG

19. Aloft by Marriott Gainesville University Area

20. Hampton Inn & Suites Gainesville Downtown University

Compare top hotels in Santa Fe

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Hampton Inn & Suites Alachua I-75

Best Western Gateway Grand

La Quinta by Wyndham Gainesville

Quality Inn Alachua - Gainesville Area

Top Santa Fe Hotel Reviews

Hampton Inn & Suites Alachua I-75

10/10 Excellent

Frequently Asked Questions

What are some of the best vacation rentals in Santa Fe?

If I need to cancel my hotel reservation in Santa Fe, will I receive a refund?

Where can I learn more about changing or cancelling my trip to Santa Fe?