Photo by Eddie Melendez

Search Vacation Homes in Santa Isabel

Start date: Check-in selected.
To Date
End date: Check-out

    Change your mind

    Book hotels with free cancellation

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
31 Oct - 2 Nov
In two weeks
7 Nov - 9 Nov
In one month
21 Nov - 23 Nov
In two months
19 Dec - 21 Dec

Vacation Homes in Santa Isabel

Property grounds
Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep
Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep
8.8 out of 10, Excellent, (44)
"It was amazing to be in the center of the culture. Friendly neighbors! Food amazing! Beach’s all around I would definitely stay there again!!!"
United States
Claudine N.
The price is AED 735
AED 1,337 total
includes taxes & fees
26 Oct - 27 Oct
Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep
Pool
Seaside Serenity – Oceanfront Villa with Infinity Pool & Garden Sanctuary
Seaside Serenity – Oceanfront Villa with Infinity Pool & Garden Sanctuary
10.0 out of 10, Exceptional, (1)
"Such an amazing place. Views are spectacular. The outside family area was our favorite part. The pool was perfect too. My family and I were very comfortable here. Definitely look forward to coming back!"
United States
Selena R.
The price is AED 953
AED 2,219 total
includes taxes & fees
31 Oct - 1 Nov
Seaside Serenity – Oceanfront Villa with Infinity Pool & Garden Sanctuary
Pool
Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL
Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL
10.0 out of 10, Exceptional, (1)
"Our stay at Mimi’s VRBO was unforgettable, and we’re already planning our return! After searching for the ideal family rental, we chose Mimi’s listing and it was a game-changer. Her warmth and quick responses made everything seamless. When our flight was delayed, Mimi arranged a car to get us to the property and coordinated a rental car delivery the next morning.The house is a gem in a safe, friendly neighborhood, steps from Walmart and close to dining options. Packed with kid-friendly amenities...
United States
Henry S.
The price is AED 926
AED 1,813 total
includes taxes & fees
26 Oct - 27 Oct
Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL
1 bedroom, iron/ironing board, WiFi, bed sheets
Coming and enjoy panoramic views to mountains and sea in Santa Isabel
Coming and enjoy panoramic views to mountains and sea in Santa Isabel
The price is AED 661
AED 1,240 total
includes taxes & fees
27 Oct - 28 Oct
Coming and enjoy panoramic views to mountains and sea in Santa Isabel
Pool
Cozy studio with private Pool and Bar modern amentities perfect for relaxation.
Cozy studio with private Pool and Bar modern amentities perfect for relaxation.
10.0 out of 10, Exceptional, (3)
"We have a wonderful time! The pool and bar were perfect!"
United States
Anna D.
The price is AED 413
AED 934 total
includes taxes & fees
25 Oct - 26 Oct
Cozy studio with private Pool and Bar modern amentities perfect for relaxation.
Fridge, microwave, coffee/tea maker, toaster
Trinitarias Guest's House's pool/bar/karaoke/wifi
Trinitarias Guest's House's pool/bar/karaoke/wifi
10.0 out of 10, Exceptional, (2)
"Hecmar’s property was awesome!!! Near to restaurants, beaches etc..We felt comfortable at her home . I will definitely be back.."
United States
jackie r.
The price is AED 367
AED 624 total
includes taxes & fees
26 Oct - 27 Oct
Trinitarias Guest's House's pool/bar/karaoke/wifi
Terrace/patio
Oasis Salinas
Oasis Salinas
7.8 out of 10, Good, (13)
"Excellent place to stay near everything in town "
United States
Mayra
The price is AED 349
AED 506 total
includes taxes & fees
26 Oct - 27 Oct
Oasis Salinas
Terrace/patio
HW Tiny Home Cidra
HW Tiny Home Cidra
10.0 out of 10, Exceptional, (2)
"Beautiful area, great AC, clean hot tub, lovely acces to lake with paddleboat!"
United States
Elizabeth C.
The price is AED 420
AED 680 total
includes taxes & fees
26 Oct - 27 Oct
HW Tiny Home Cidra
Outdoor dining
A cozy place to stay walking distance from the beach and Restaurants.
A cozy place to stay walking distance from the beach and Restaurants.
9.8 out of 10, Exceptional, (21)
"The description of the house is accurate and the cleanliness of the rental was perfect. The neighborhood was amazing with restaurants and access to the water within walking distance. "
United States
Melanie D.
The price is AED 294
AED 584 total
includes taxes & fees
27 Oct - 28 Oct
A cozy place to stay walking distance from the beach and Restaurants.
Property grounds
Cozy cabin with hot water jacuzzi and AC in the mountains of Guayama.
Cozy cabin with hot water jacuzzi and AC in the mountains of Guayama.
10.0 out of 10, Exceptional, (2)
"Property was so beautiful didn’t have any complains. Everything you need in one spot you’d never want to leave."
United States
Jonathan
The price is AED 477
AED 749 total
includes taxes & fees
26 Oct - 27 Oct
Cozy cabin with hot water jacuzzi and AC in the mountains of Guayama.
Dining
Anime Escape with Private Jacuzzi & Themed Rooms
Anime Escape with Private Jacuzzi & Themed Rooms
10.0 out of 10, Exceptional, (1)
"Our host was very accommodating. We enjoyed all of the games the house had to offer. The home was beautiful and private. We would stay again!"
United States
Katherine T.
The price is AED 353
AED 968 total
includes taxes & fees
28 Oct - 29 Oct
Anime Escape with Private Jacuzzi & Themed Rooms
Property grounds
Grandpa's lake house lake private access mountain view museum 1950's experience
Grandpa's lake house lake private access mountain view museum 1950's experience
9.4 out of 10, Exceptional, (6)
"We had a great peaceful visit!"
United States
Kelly N.
The price is AED 239
AED 408 total
includes taxes & fees
28 Oct - 29 Oct
Grandpa's lake house lake private access mountain view museum 1950's experience
Beach
Spacious Retreat with Private Jacuzzi and Tropical Patio
Spacious Retreat with Private Jacuzzi and Tropical Patio
10.0 out of 10, Exceptional, (1)
"This property was convenient, super clean and had everything that we needed! "
United States
Heather L.
The price is AED 404
AED 772 total
includes taxes & fees
28 Oct - 29 Oct
Spacious Retreat with Private Jacuzzi and Tropical Patio
Interior
3-bedroom house in Coamo with AC on bedroom 1
3-bedroom house in Coamo with AC on bedroom 1
6.0 out of 10, (2)
"The house was nice ,comfortable and community was quiet and safe. we will be back..."
United States
Kenny R.
The price is AED 180
AED 443 total
includes taxes & fees
29 Oct - 30 Oct
3-bedroom house in Coamo with AC on bedroom 1
Beach
Expansive Paradise with Private Jacuzzi and Tropical Patio
Expansive Paradise with Private Jacuzzi and Tropical Patio
The price is AED 606
AED 1,290 total
includes taxes & fees
17 Nov - 18 Nov
Expansive Paradise with Private Jacuzzi and Tropical Patio
Beach
Big House with 7 Private Apts, 10 Rooms & 17 beds
Big House with 7 Private Apts, 10 Rooms & 17 beds
10.0 out of 10, Exceptional, (1)
"The apartments were ideal for a large group of older adults. There were plenty of comfortable beds and the kitchen was good to work out of for group meals. Armando was very responsive when we had some minor issues. The location was great. The solar hot water was sometimes luke warm, but our volunteers were hot from working on repairing homes, so it wasn't a big problem. The two porches off Units 3 and 4 were a nice gathering place for a large group."
United States
Richard G.
The price is AED 2,296
AED 5,453 total
includes taxes & fees
4 Nov - 5 Nov
Big House with 7 Private Apts, 10 Rooms & 17 beds
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Santa Isabel Hotel Reviews

Aloft Ponce Hotel & Casino

Aloft Ponce Hotel & Casino

10/10 Excellent
"The rooms are wonderful. The whole hotel is awesome the staff are really great and friendly. The only thing is that they need to give people access to the AC cause the rooms were brick. But that’s my mom’s feedback. I have no complaints I will definitely be back and I will definitely recommend"
Quetcy 1-night trip
Posted 2 days ago
Aloft Ponce Hotel & Casino