An aerial view of a coastal landscape with a dam, farmland, and dense forests.

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Check availability on Santee Family Hotels

Tonight
19 Sep - 20 Sep
Tomorrow
20 Sep - 21 Sep
Next weekend
25 Sep - 27 Sep
In two weeks
2 Oct - 4 Oct

Our top choices for Santee family-friendly hotels

Exterior
Standard Room, 2 Queen Beds, Non Smoking, Jetted Tub | Desk, laptop workspace, iron/ironing board, WiFi (surcharge)
Standard Room, 1 King Bed, Non Smoking, Refrigerator & Microwave | Bathroom | Free toiletries, hair dryer, towels, soap
Free daily continental breakfast

1. Best Western Plus Santee Inn

Best Western Plus Santee Inn
Santee
  • Family vacation paradise with an outdoor pool, fitness center, and quiet, pet-friendly atmosphere for your whole family.
AED 421
AED 468 total
includes taxes & fees
27 Sep - 28 Sep
Best Western Plus Santee Inn
Seasonal outdoor pool
Lobby
Suite, 1 Queen Bed with Sofa bed, Non Smoking (Non Smoking/Interior Hall) | Frette Italian sheets, premium bedding, pillowtop beds, blackout drapes
Suite, 1 Queen Bed with Sofa bed, Non Smoking (Non Smoking/Interior Hall) | Frette Italian sheets, premium bedding, pillowtop beds, blackout drapes

2. Comfort Inn & Suites Santee

Comfort Inn & Suites Santee
Santee
  • Family-friendly escape at Santee with seasonal outdoor pool, free breakfast, and steps from the state park.
AED 376
AED 417 total
includes taxes & fees
18 Oct - 19 Oct
Comfort Inn & Suites Santee
In-room safe, iron/ironing board, WiFi (free), alarm clocks
Business center
Free daily continental breakfast
Exterior

3. Travelodge by Wyndham Santee

Travelodge by Wyndham Santee
Santee
AED 235
AED 261 total
includes taxes & fees
20 Sep - 21 Sep
Travelodge by Wyndham Santee
Desk, iron/ironing board, WiFi (free), alarm clocks
Exterior
Desk, iron/ironing board, WiFi (free), alarm clocks
Desk, iron/ironing board, WiFi (free), alarm clocks

4. Econo Lodge Santee

Econo Lodge Santee
Santee
AED 235
AED 261 total
includes taxes & fees
19 Oct - 20 Oct
Econo Lodge Santee
Free daily continental breakfast
Combined shower/tub, hair dryer, towels
Front of property
Lobby

5. Peach Tree Inn

Peach Tree Inn
St. George
AED 237
AED 256 total
includes taxes & fees
1 Oct - 2 Oct
Peach Tree Inn
Lobby lounge
Exterior
Free daily continental breakfast
WiFi (free), alarm clocks, bed sheets

6. Red Roof Inn Orangeburg

Red Roof Inn Orangeburg
Orangeburg
AED 215
AED 238 total
includes taxes & fees
27 Sep - 28 Sep
Red Roof Inn Orangeburg
Property grounds
Exterior
Dining
Dining

7. Country living lake style near Santee

Country living lake style near Santee
Summerton
AED 349
AED 791 total
includes taxes & fees
20 Sep - 21 Sep
Country living lake style near Santee
Exterior
Exterior
Exterior
Property amenity

8. Holiday Inn Express & Suites Orangeburg by IHG

Holiday Inn Express & Suites Orangeburg by IHG
Orangeburg
  • Family-friendly retreat with scenic poolside play, planetarium exploration, and delicious breakfast buffet served daily.
AED 404
AED 448 total
includes taxes & fees
27 Sep - 28 Sep
Holiday Inn Express & Suites Orangeburg by IHG
Property grounds
Interior
Coffee/tea maker, fridge, microwave, oven
Interior

9. Pet friendly country cottage with large fenced-in yard & horses on property

Pet friendly country cottage with large fenced-in yard & horses on property
Holly Hill
AED 413
AED 760 total
includes taxes & fees
21 Sep - 22 Sep
Pet friendly country cottage with large fenced-in yard & horses on property
Interior
Interior
Shower, towels, soap, shampoo
Interior

10. Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301

Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
Bowman
AED 281
AED 597 total
includes taxes & fees
20 Sep - 21 Sep
Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
View all properties

Choose what matters most at family-friendly hotels in Santee

Breakfast included
Pool
All-inclusive
4 stars
5 stars

Top Santee Hotel Reviews

Baymont by Wyndham Santee

Baymont by Wyndham Santee

8/10 Good
"Served it's purpose. It was clean just old"
Raul 1-night trip
Posted 2 days ago
Baymont by Wyndham Santee
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

10/10 Excellent
"Great location, room and staff."
Herbert 1-night trip
Posted 4 days ago
Hampton Inn Santee-I-95
SureStay Hotel by Best Western Manning

SureStay Hotel by Best Western Manning

10/10 Excellent
"Clean and update property."
Howard 1-night trip
Posted 4 days ago
SureStay Hotel by Best Western Manning
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

10/10 Excellent
"Room was very clean and large. Staff were very friendly and enjoyed the breakfast."
Rita 1-night trip
Posted 5 days ago
Holiday Inn Santee by IHG
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

10/10 Excellent
"Great service"
Kunjan 1-night trip
Posted 7 days ago
Travelodge by Wyndham Santee
Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95

8/10 Good
"The price rate was great"
Stevenson 3-night trip
Posted 1 month ago
Ramada by Wyndham Santee I-95

Frequently asked questions

What's Santee like for family-friendly vacations?
The welcoming destination of Santee is a great choice if you've been thinking about a vacation with the kids. The excursions, lake views, and golfing are just a few things that make this an attractive vacation spot for families. Arrange a flight into Columbia Metropolitan Airport (CAE), which is located 49 mi (78.8 km) from the city center.
What's the best place to stay for families in Santee?
Fairfield Inn & Suites by Marriott Santee is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Comfort Inn & Suites Santee is another choice for your stay with the kids.
When's the best time to book a family-friendly vacation in Santee?
The hottest months are usually July and August with an average temp of 79°F, while the coldest months are January and February with an average of 52°F. Average annual precipitation for Santee is 55 inches.
What's there to see and do with your family in Santee?
While you and the family are vacationing in Santee, you might want to check out some of the attractions here such as Orangeburg County Library Mentor Branch, Lake Marion, and Congaree National Park. Make sure you have lots of time for activities like Santee National Wildlife Refuge and Taw Caw Creek.