Find Family Hotels in Santee, SC

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Santee Family Hotels

Next weekend
5 Jun - 7 Jun
In two weeks
12 Jun - 14 Jun

Our top choices for Santee family-friendly hotels

Property amenity

Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee
3.0 star property
Santee
9.8 out of 10, Exceptional, (1,001 reviews)
  • cleanliness
    A family escape that offers vibrant pool days, premium entertainment, and free breakfast just minutes from Santee State Park.
The price is AED 493
AED 547 total
includes taxes & fees
14 Jun - 15 Jun
Fairfield Inn & Suites by Marriott Santee
Exterior

Best Western Plus Santee Inn

Best Western Plus Santee Inn
2.5 star property
Santee
8.8 out of 10, Excellent, (1,001 reviews)
  • cleanliness
    Family vacation paradise with an outdoor pool, fitness center, and quiet, pet-friendly atmosphere for your whole family.
The price is AED 428
AED 475 total
includes taxes & fees
21 Jun - 22 Jun
Best Western Plus Santee Inn
Seasonal outdoor pool

Comfort Inn & Suites Santee

Comfort Inn & Suites Santee
2.5 star property
Santee
8.0 out of 10, Very Good, (1,004 reviews)
  • cleanliness
    Family-friendly escape at Santee with seasonal outdoor pool, free breakfast, and steps from the state park.
The price is AED 356
AED 395 total
includes taxes & fees
21 Jun - 22 Jun
Comfort Inn & Suites Santee
In-room safe, iron/ironing board, free WiFi, bed sheets

Travelodge by Wyndham Santee

Travelodge by Wyndham Santee
2.0 star property
Santee
7.2 out of 10, Good, (732 reviews)
The price is AED 231
AED 257 total
includes taxes & fees
2 Jun - 3 Jun
Travelodge by Wyndham Santee
Interior

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Santee
10.0 out of 10, Exceptional, (43 reviews)
The price is AED 525
AED 1,399 total
includes taxes & fees
8 Jun - 9 Jun
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Desk, iron/ironing board, free WiFi, bed sheets

Econo Lodge Santee

Econo Lodge Santee
2.0 star property
Santee
6.4 out of 10, (314 reviews)
The price is AED 279
AED 310 total
includes taxes & fees
14 Jun - 15 Jun
Econo Lodge Santee
Free daily continental breakfast

Peach Tree Inn

Peach Tree Inn
2.5 star property
St. George
7.2 out of 10, Good, (214 reviews)
The price is AED 219
AED 236 total
includes taxes & fees
1 Jun - 2 Jun
Peach Tree Inn
Free WiFi

Suburban Studios Orangeburg

Suburban Studios Orangeburg
2.0 star property
Orangeburg
6.6 out of 10, (20 reviews)
The price is AED 236
AED 262 total
includes taxes & fees
29 Jun - 30 Jun
Suburban Studios Orangeburg
Lobby

Quality Inn Manning I-95

Quality Inn Manning I-95
2.5 star property
Manning
6.8 out of 10, (531 reviews)
  • cleanliness
    Spacious family rooms with premium TV and movie options make for perfect entertainment during your Manning stay.
The price is AED 312
AED 347 total
includes taxes & fees
15 Jun - 16 Jun
Quality Inn Manning I-95
Room, 1 King Bed, Non Smoking | Premium bedding, desk, laptop workspace, iron/ironing board

Days Inn by Wyndham St George

Days Inn by Wyndham St George
2.5 star property
St. George
7.4 out of 10, Good, (1,002 reviews)
The price is AED 367
AED 408 total
includes taxes & fees
31 May - 1 Jun
Days Inn by Wyndham St George
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Choose what matters most at family-friendly hotels in Santee

Breakfast included
Pool

Top Santee Hotel Reviews

Baymont by Wyndham Santee

Baymont by Wyndham Santee

6/10 Okay
"Room was clean but smelled musky. Refrigerator had mold in it. The lady at the desk that checked us in last night was great!!!"
Wendy 1-night trip
Posted 2 hours ago
Baymont by Wyndham Santee

Explore a world of travel with Expedia

Frequently asked questions

What's Santee like for family-friendly vacations?
The welcoming destination of Santee is a great choice if you've been thinking about a vacation with the kids. The excursions, lake views, and golfing are just a few things that make this an attractive vacation spot for families. Arrange a flight into Columbia Metropolitan Airport (CAE), which is located 49 mi (78.8 km) from the city center.
What's the best place to stay for families in Santee?
Fairfield Inn & Suites by Marriott Santee is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Comfort Inn & Suites Santee is another choice for your stay with the kids.
When's the best time to book a family-friendly vacation in Santee?
The hottest months are usually July and August with an average temp of 79°F, while the coldest months are January and February with an average of 52°F. Average annual precipitation for Santee is 55 inches.
What's there to see and do with your family in Santee?
While you and the family are vacationing in Santee, you might want to check out some of the attractions here such as Orangeburg County Library Mentor Branch, Lake Marion, and Taw Caw Creek. Make sure you have lots of time for activities like Congaree National Park and Santee National Wildlife Refuge.