An aerial view of a coastal landscape with a dam, farmland, and dense forests.

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Check prices for these dates

Next weekend
23 Oct - 25 Oct
In two weeks
30 Oct - 1 Nov
In one month
13 Nov - 15 Nov
In two months
11 Dec - 13 Dec
No exact matches found, but these alternatives could be just right

Recommended hotels in Santee

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

1. Hampton Inn Santee-I-95

Hampton Inn Santee-I-95
2.5 star property
Santee
9.6 out of 10, Exceptional, (1,000 reviews)
"Nice place to stay"
United States
sandra
The price is AED 433
AED 480 total
includes taxes & fees
2 Nov - 3 Nov
Hampton Inn Santee-I-95
A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

2. Tru By Hilton Santee

Tru By Hilton Santee
2.5 star property
Santee
9.2 out of 10, Wonderful, (987 reviews)
"Great place to stay!"
United States
Connor
The price is AED 372
AED 412 total
includes taxes & fees
1 Nov - 2 Nov
Tru By Hilton Santee
A patio area with wicker furniture, a stone fire pit, and outdoor seating.

3. Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee
3.0 star property
Santee
9.8 out of 10, Exceptional, (1,002 reviews)
"Property was clean and the breakfast was delicious would stay there again."
United States
Melissa
The price is AED 509
AED 565 total
includes taxes & fees
20 Oct - 21 Oct
Fairfield Inn & Suites by Marriott Santee
A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

4. Baymont by Wyndham Santee

Baymont by Wyndham Santee
2.5 star property
Santee
8.0 out of 10, Very good, (1,490 reviews)
"Good hotel for an overnight stay. Staff was very friendly & helpful."
United States
Cindy
The price is AED 294
AED 326 total
includes taxes & fees
15 Oct - 16 Oct
Baymont by Wyndham Santee
A water park with a pool, slides, and umbrellas.

5. Holiday Inn Santee by IHG

Holiday Inn Santee by IHG
3.0 star property
Santee
8.2 out of 10, Very good, (1,000 reviews)
"property was good, staff was excellent"
United States
roderick
The price is AED 349
AED 387 total
includes taxes & fees
18 Oct - 19 Oct
Holiday Inn Santee by IHG
A hotel entrance with a sign reading "Best Western PLISS."

6. Best Western Plus Santee Inn

Best Western Plus Santee Inn
2.5 star property
Santee
8.8 out of 10, Excellent, (1,003 reviews)
"Nice location and very convenient parking, Breakfast was very good."
United States
Johnny
The price is AED 512
AED 568 total
includes taxes & fees
20 Oct - 21 Oct
Best Western Plus Santee Inn
A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

7. Comfort Inn & Suites Santee

Comfort Inn & Suites Santee
2.5 star property
Santee
8.0 out of 10, Very good, (1,002 reviews)
"Was a good place to stay"
United States
santa
The price is AED 380
AED 422 total
includes taxes & fees
8 Nov - 9 Nov
Comfort Inn & Suites Santee
A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

8. Travelodge by Wyndham Santee

Travelodge by Wyndham Santee
2.0 star property
Santee
7.2 out of 10, Good, (781 reviews)
The price is AED 239
AED 265 total
includes taxes & fees
15 Oct - 16 Oct
Travelodge by Wyndham Santee
A dining area with multiple tables and chairs, a ceiling fan, and large windows.

9. Super 8 by Wyndham Santee/I-95

Super 8 by Wyndham Santee/I-95
2.0 star property
Santee
6.8 out of 10, (476 reviews)
"An older fecility but certainly well maintained. Loved Mr. Patel!"
United States
William
The price is AED 234
AED 260 total
includes taxes & fees
20 Oct - 21 Oct
Super 8 by Wyndham Santee/I-95
A two-story building with a flat roof and a central entrance.

10. Red Roof Inn Santee

Red Roof Inn Santee
2.0 star property
Santee
6.6 out of 10, (665 reviews)
"Clean rooms and staff was great"
United States
Tiffany
The price is AED 231
AED 257 total
includes taxes & fees
18 Oct - 19 Oct
Red Roof Inn Santee
A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

11. Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95
2.5 star property
Santee
5.8 out of 10, (599 reviews)
"would never stay there again"
United States
Doug
The price is AED 200
AED 240 total
includes taxes & fees
3 Nov - 4 Nov
Quality Inn & Suites Santee I-95
A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

12. Econo Lodge Santee

Econo Lodge Santee
2.0 star property
Santee
6.4 out of 10, (317 reviews)
"Pretty nice and clean with a comfortable bed at a great rate."
United States
Arthur
The price is AED 250
AED 277 total
includes taxes & fees
3 Nov - 4 Nov
Econo Lodge Santee
A spacious living room with a large sofa, two coffee tables, and a potted plant.

13. Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Santee
10.0 out of 10, Exceptional, (46 reviews)
"Comfortable home with fenced in yard for dogs is a plus. The house had everything needed for a stay. Furniture was comfy. House is an hour drive from congaree NP. Many opportunities nearby to connect with nature."
United States
Jessica C.
The price is AED 382
AED 1,227 total
includes taxes & fees
21 Oct - 22 Oct
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
A modern kitchen with white cabinets, stainless steel appliances, a black countertop, and a tiled floor.

14. Lake Marion Condo, Boat Slip Included, Pet Friendly

Lake Marion Condo, Boat Slip Included, Pet Friendly
Santee
10.0 out of 10, Exceptional, (1 review)
"My husband, son and I booked a relatively last-minute weekend trip. Gabriel was great, and fast about answering my questions. The unit was easy to find and gain entry to. It is very clean, quiet, and accessible to the water; a very short walk to the on-prem docks and the covered porch is very nice. We had an enjoyable stay and liked the area."
United States
Katie A.
The price is AED 643
AED 1,207 total
includes taxes & fees
17 Oct - 18 Oct
Lake Marion Condo, Boat Slip Included, Pet Friendly
A covered patio with outdoor furniture, a view of a lake, and a sunset.

15. LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
Santee
9.0 out of 10, Wonderful, (8 reviews)
"We had a wonderful stay. Couldn't have asked for better location. It was beautiful, close to everything and perfect for our family."
United States
Michelle H.
The price is AED 768
AED 1,888 total
includes taxes & fees
18 Oct - 19 Oct
LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
A wicker outdoor seating area with cushioned chairs and a matching ottoman on a porch.

16. Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
Santee
10.0 out of 10, Exceptional, (16 reviews)
"Annual golf trip with old friends. Perfect accommodations & location. Hope to stay again"
United States
Greg M.
The price is AED 845
AED 1,875 total
includes taxes & fees
21 Oct - 22 Oct
Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
Lobby

17. Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95
2.0 star property
Santee
6.4 out of 10, (595 reviews)
"The price rate was great"
United States
Stevenson
The price is AED 291
AED 323 total
includes taxes & fees
18 Oct - 19 Oct
Ramada by Wyndham Santee I-95
A bedroom with a bed, bedside tables, a mirror, a door, and a wall-mounted telephone.

18. Ashburn Inn Manning I 95

Ashburn Inn Manning I 95
2.5 star property
Manning
The price is AED 228
AED 253 total
includes taxes & fees
15 Oct - 16 Oct
Ashburn Inn Manning I 95
A covered outdoor seating area with a view of a dock and boats, wooden furniture, and string lights.

19. Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.

Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.
Summerton
8.8 out of 10, Excellent, (37 reviews)
"Great place to stay on the lake! "
United States
Troy S.
The price is AED 323
AED 644 total
includes taxes & fees
11 Nov - 12 Nov
Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.
A reception desk with a flat-screen TV, a Dell computer, and a door.

20. Red Roof Inn Orangeburg

Red Roof Inn Orangeburg
2.0 star property
Orangeburg
5.8 out of 10, (745 reviews)
"Nice place to stay at an affordable price during our trip to Disney it was our halfway point"
United States
phyllis
The price is AED 208
AED 231 total
includes taxes & fees
20 Oct - 21 Oct
Red Roof Inn Orangeburg
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santee Hotel Reviews

SureStay Hotel by Best Western Manning

SureStay Hotel by Best Western Manning

10/10 Excellent
"I like everything. And when I went to get coffee the lady cleaning in there was so nice."
Latonya 1-night trip
Posted 2 days ago
SureStay Hotel by Best Western Manning

Frequently asked questions

What can I expect from a resort vacation in Santee?
You deserve a vacation, and a resort is the perfect place to treat yourself to the services and amenities you need for a relaxing trip to Santee. One of the comfortable resorts in the surrounding area might be just what you're searching for, whether you want a luxurious suite, shopping possibilities, or nightly entertainment options.
What's a favorite resort in Santee?
Here's our top-rated Santee resort: Waterfront Condo on Lake Marion - Golf resort. Features a fitness center.
How many resorts will I find in Santee?
Choose among Expedia's 5 resort hotels in Santee where you'll find onsite spas, beautiful rooms, and more.
What can I do in Santee?
Travelers enjoy the golfing and other activities in Santee, and also have good things to say about the dining options here. If you brought your golf clubs, you can hit the links at Santee Cooper Country Club or Santee National Golf Club. Additional attractions in the area include Santee State Park and Lake Marion.
What's the seasonal weather like in Santee?
The hottest months are usually July and August with an average temp of 79°F, while the coldest months are January and February with an average of 52°F. Average annual precipitation for Santee is 55 inches.
What's the best way to get to and around Santee?
Fly into Columbia Metropolitan Airport (CAE), which is located 49 mi (78.8 km) from the heart of the city. If you'd like to venture out around the area, you may want to rent a car for your trip.