Vacation Homes in Scott County
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Our top choices for Scott County vacation homes
1. “Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau
“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape GirardeauCape Girardeau
10.0 out of 10, Exceptional, (44 reviews)
"Spectacular place and great host! Highly recommend!"
Eric P.
2. Serenity South -- Gardens, River-Views, and Refreshing Space
Serenity South -- Gardens, River-Views, and Refreshing SpaceCape Girardeau
10.0 out of 10, Exceptional, (159 reviews)
"Nice place. I’d stay there again. "
John H.
3. 3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau
3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape GirardeauCape Girardeau
9.8 out of 10, Exceptional, (29 reviews)
"We had a great stay. Great location as well "
Tracy H.
4. Quaint, Beautiful Home next to SEMO and Hospital
Quaint, Beautiful Home next to SEMO and HospitalCape Girardeau
9.8 out of 10, Exceptional, (51 reviews)
"Would stay here again!"
Michelle C.
5. Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy
Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & CozyDexter
8.0 out of 10, Very Good, (36 reviews)
"Stayed many times. Nice and comfortable "
Susan R.
The price is AED 393
AED 796 total
includes taxes & fees
30 Aug - 31 Aug
6. The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO
The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MODexter
The price is AED 452
AED 563 total
includes taxes & fees
6 Sep - 7 Sep
7. Little Blue Cottage on Spanish
Little Blue Cottage on SpanishCape Girardeau
8.4 out of 10, Very Good, (57 reviews)
"Great cute place. "
Jeremy W.
The price is AED 298
AED 397 total
includes taxes & fees
31 Aug - 1 Sep
8. Stunning 2 bedroom in town, close to Shawnee National Forest
Stunning 2 bedroom in town, close to Shawnee National ForestJonesboro
10.0 out of 10, Exceptional, (12 reviews)
"Cool renovated property that keeps that old fashioned charm. Spacious living with all the amenities you need for a vacation stay."
Dylan
The price is AED 505
AED 1,057 total
includes taxes & fees
28 Aug - 29 Aug
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Scott County Hotel Reviews
Super 8 by Wyndham Sikeston/Miner Area
10/10 Excellent
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