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Vacation Homes in Scott County

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Our top choices for Scott County vacation homes

Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space
Cape Girardeau
10.0 out of 10, Exceptional, (159 reviews)
"Nice location to river front and downtown. Very lovely place."
United States
Marcie R.
The price is AED 551
AED 906 total
includes taxes & fees
24 Jul - 25 Jul
Serenity South -- Gardens, River-Views, and Refreshing Space

“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau

“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau
Cape Girardeau
10.0 out of 10, Exceptional, (41 reviews)
"Beautiful home. "
United States
Anna M.
“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy
Dexter
7.8 out of 10, Good, (33 reviews)
"Stayed many times. Nice and comfortable "
United States
Susan R.
The price is AED 393
AED 782 total
includes taxes & fees
13 Jul - 14 Jul
Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

Wandering the wineries or hitting the hills? We got you! Come stay!

Wandering the wineries or hitting the hills? We got you! Come stay!
Tamms
10.0 out of 10, Exceptional, (30 reviews)
"Great communication and perfect location for what we were looking for."
United States
David P.
Wandering the wineries or hitting the hills? We got you! Come stay!

Magical Victorian near hiking / wine trail

Magical Victorian near hiking / wine trail
Anna
9.8 out of 10, Exceptional, (14 reviews)
"Adorable house and great host! Will definitely be back!"
United States
Ellen W.
The price is AED 652
AED 1,280 total
includes taxes & fees
8 Jul - 9 Jul
Magical Victorian near hiking / wine trail

Charming 2-bedroom with AC, WiFi in lovely Jonesboro

Charming 2-bedroom with AC, WiFi in lovely Jonesboro
Jonesboro
10.0 out of 10, Exceptional, (9 reviews)
"It was a beautiful building and just what my sister in law needed to stay at after a local event. "
United States
Heather C.
The price is AED 426
AED 950 total
includes taxes & fees
14 Jul - 15 Jul
Charming 2-bedroom with AC, WiFi in lovely Jonesboro

3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau

3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau
Cape Girardeau
9.8 out of 10, Exceptional, (23 reviews)
"We really enjoyed our stay here. It was in a great location and was a very cute house. The beds were also comfortable."
United States
Jamie G.
3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.6 out of 10, Exceptional, (9 reviews)
"Nice place, great times"
United States
Jace W.
The price is AED 1,240
AED 2,038 total
includes taxes & fees
14 Jul - 15 Jul
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

Charming 3-bedroom house in delightful Advance with AC, WiFi

Charming 3-bedroom house in delightful Advance with AC, WiFi
Advance
10.0 out of 10, Exceptional, (11 reviews)
"Very nice and cute house with plenty of room and amenities. Would definitely stay here again!"
United States
Dakota D.
Charming 3-bedroom house in delightful Advance with AC, WiFi

Charming 2-bedroom house in delightful Jackson with AC, WiFi

Charming 2-bedroom house in delightful Jackson with AC, WiFi
Jackson
10.0 out of 10, Exceptional, (6 reviews)
"Nice Get Away Place."
United States
Jim B.
Charming 2-bedroom house in delightful Jackson with AC, WiFi

Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very Good, (57 reviews)
"Great cute place. "
United States
Jeremy W.
The price is AED 298
AED 397 total
includes taxes & fees
3 Jul - 4 Jul
Little Blue Cottage on Spanish

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (41 reviews)
"Will definitely book again! Great location, comfortable stay."
United States
Pynktoria !.
The price is AED 658
AED 1,165 total
includes taxes & fees
14 Jul - 15 Jul
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi
Cape Girardeau
10.0 out of 10, Exceptional, (12 reviews)
"A large and comfortable house with cool historical details and just about everything you need to have a great, easy, smooth-running vacation. Great location for downtown exploring."
United States
Virginia C.
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

“Kozy on Kingsway” is a charming 4-bedroom house in Cape -The City of Roses

“Kozy on Kingsway” is a charming 4-bedroom house in Cape -The City of Roses
Cape Girardeau
9.8 out of 10, Exceptional, (6 reviews)
“Kozy on Kingsway” is a charming 4-bedroom house in Cape -The City of Roses

Quaint, Beautiful Home next to SEMO and Hospital

Quaint, Beautiful Home next to SEMO and Hospital
Cape Girardeau
9.8 out of 10, Exceptional, (50 reviews)
"Enjoyed our stay! Great place for a great price."
United States
Nikolas S.
Quaint, Beautiful Home next to SEMO and Hospital

Large Home next to Southeast Hospital - 2 King Beds - Fast Wifi

Large Home next to Southeast Hospital - 2 King Beds - Fast Wifi
Cape Girardeau
10.0 out of 10, Exceptional, (4 reviews)
"The property was nice, spacious, and easy access to everything! We enjoyed our stay!"
United States
Abby T.
Large Home next to Southeast Hospital - 2 King Beds - Fast Wifi

Luxury 4BR w/ King Bed | Fast Wi-Fi | Private Yard

Luxury 4BR w/ King Bed | Fast Wi-Fi | Private Yard
Jackson
10.0 out of 10, Exceptional, (3 reviews)
"The house was absolutely perfect. Very accommodating, Had everything we needed and more. Would definitely recommend and would rent again!!"
United States
Lori N.
Luxury 4BR w/ King Bed | Fast Wi-Fi | Private Yard

Urban 2-bedroom Escape in Downtown Cape Girardeau

Urban 2-bedroom Escape in Downtown Cape Girardeau
Cape Girardeau
10.0 out of 10, Exceptional, (10 reviews)
"Great location and a cozy stay for a weekend trip. Highly recommend. "
United States
Connor c.
Urban 2-bedroom Escape in Downtown Cape Girardeau

Country Setting & Views - Garage Parking - Fast Wifi

Country Setting & Views - Garage Parking - Fast Wifi
Jackson
8.0 out of 10, Very Good, (1 review)
"Very nice property in a very nice location. Overall a nice place to stay. Pros: 1) House by itself on a large piece of land 2) Very quiet and peaceful 3)House is large with plenty of room 4) Nicely remodeled with very nice furnishings 5) The one bed we slept on was very comfortable 6) Amazing view of the sun coming up over the hill in the mornings Cons: 1) Although newly remodeled, it's still a very old house and the old house smell is crazy strong. I mean VERY strong 2) The smart thermostat...
United States
Alex M.
Country Setting & Views - Garage Parking - Fast Wifi

Coastal Comfort at The Salty Nest: Pet-Friendly with King Bed & Fast WiFi!

Coastal Comfort at The Salty Nest: Pet-Friendly with King Bed & Fast WiFi!
Jackson
10.0 out of 10, Exceptional, (4 reviews)
"It was a great stay . Charming and quiet ."
United States
Bobbie M.
Coastal Comfort at The Salty Nest: Pet-Friendly with King Bed & Fast WiFi!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Scott County Hotel Reviews