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Compare 1,521 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Pet-friendly Central Cottage: 2 Miles to Clemson!
3.0 star property
Pet-friendly Central Cottage: 2 Miles to Clemson!
Best Western Plus Clemson Hotel & Conference Center
2.5 star property
8.2 out of 10, Very Good, (888)
"Property was very reasonable priced, nice rooms and clean, would recommend."
The price is AED 356
AED 395 total
includes taxes & fees
1 Oct - 2 Oct
Best Western Plus Clemson Hotel & Conference Center
Inn @ Clemson
2.5 star property
8.2 out of 10, Very Good, (1004)
"It is very close to Clemson. A small hotel so there are not a ton of people staying. The breakfast is good. "
The price is AED 312
AED 347 total
includes taxes & fees
24 Sep - 25 Sep
Inn @ Clemson
Days Inn by Wyndham Anderson
2.0 star property
7.2 out of 10, Good, (838)
"Love it"
The price is AED 203
AED 225 total
includes taxes & fees
26 Sep - 27 Sep
Days Inn by Wyndham Anderson
Comfort Inn & Suites Clemson - University Area
2.5 star property
8.2 out of 10, Very Good, (1006)
"Room was clean and comfortable. The maid service was very good - friendly and responsive. Breakfast was good."
The price is AED 320
AED 356 total
includes taxes & fees
7 Oct - 8 Oct
Comfort Inn & Suites Clemson - University Area
Lakeside Lodge Clemson
2.5 star property
9.0 out of 10, Wonderful, (713)
"It was a wonderful visit "
The price is AED 400
AED 494 total
includes taxes & fees
24 Sep - 25 Sep
Lakeside Lodge Clemson
Microtel Inn & Suites by Wyndham Anderson/Clemson
2.0 star property
8.2 out of 10, Very Good, (1004)
"It was great meeting people and staff was very helpful and friendly "
The price is AED 262
AED 291 total
includes taxes & fees
26 Sep - 27 Sep
Microtel Inn & Suites by Wyndham Anderson/Clemson
Holiday Inn Express & Suites Clemson, an IHG Hotel
2.5 star property
9.0 out of 10, Wonderful, (815)
"I had an enjoyable stay. The hotel is clean and my room was comfortable. "
The price is AED 406
AED 451 total
includes taxes & fees
30 Sep - 1 Oct
Holiday Inn Express & Suites Clemson, an IHG Hotel
Quality Inn Clemson near University
2.5 star property
7.0 out of 10, Good, (775)
"Everything was great"
The price is AED 191
AED 212 total
includes taxes & fees
7 Oct - 8 Oct
Quality Inn Clemson near University
The Shepherd Hotel Downtown Clemson
4.0 star property
9.8 out of 10, Exceptional, (387)
"Best hotel in Clemson. Perfectly located downtown. Nicely decorated hotel and rooms. Very comfortable beds. The roof top is a great place to hang out. "
The price is AED 657
AED 730 total
includes taxes & fees
30 Sep - 1 Oct
The Shepherd Hotel Downtown Clemson
Days Inn by Wyndham Seneca / Clemson Area
2.0 star property
6.8 out of 10, (632)
"It was nice to get away"
The price is AED 256
AED 282 total
includes taxes & fees
29 Sep - 30 Sep
Days Inn by Wyndham Seneca / Clemson Area
Horizon Inn & Suites
2.0 star property
5.8 out of 10, (89)
"Close to everything.tv didnt work.they fix it the next day"
The price is AED 185
AED 217 total
includes taxes & fees
29 Sep - 30 Sep
Horizon Inn & Suites
Hilton Garden Inn Anderson
3.0 star property
8.8 out of 10, Excellent, (546)
"Need EV charger"
The price is AED 403
AED 447 total
includes taxes & fees
29 Sep - 30 Sep
Hilton Garden Inn Anderson
Fairfield Inn & Suites Seneca Clemson Univ Area
2.5 star property
9.4 out of 10, Exceptional, (116)
"This is a wonderful clean hotel. Great for game day or visit to Clemson University. My favorite in the area!"
The price is AED 474
AED 521 total
includes taxes & fees
24 Sep - 25 Sep
Fairfield Inn & Suites Seneca Clemson Univ Area
Comfort Suites Anderson-Clemson
2.5 star property
8.4 out of 10, Very Good, (923)
"Easy access to Clemson and Anderson. Nice hotel and comfortable accommodations."
The price is AED 350
AED 388 total
includes taxes & fees
17 Oct - 18 Oct
Comfort Suites Anderson-Clemson
Tru by Hilton Seneca Clemson
2.5 star property
9.2 out of 10, Wonderful, (623)
"Very convenient location as I was working at Clemson for a couple of days. About a 6 minute drive to campus. Plenty of food options in the area and the workout facility was great. "
The price is AED 393
AED 433 total
includes taxes & fees
24 Sep - 25 Sep
Tru by Hilton Seneca Clemson
The Abernathy of Clemson
4.0 star property
9.6 out of 10, Exceptional, (443)
"Great find in Clemson! Close to campus and walkable to many shops and restaurants. Free on-site parking. Friendly staff: front desk, bartender and housekeeper were all wonderful. Rooms are spacious, clean and functional. Would highly recommend and stay here again! "
The price is AED 584
AED 648 total
includes taxes & fees
24 Sep - 25 Sep
The Abernathy of Clemson
Quality Inn Seneca US-123
2.5 star property
7.8 out of 10, Good, (531)
"Great room at a great price"
The price is AED 262
AED 323 total
includes taxes & fees
13 Oct - 14 Oct
Quality Inn Seneca US-123
Hampton Inn Clemson-University Area
2.5 star property
8.8 out of 10, Excellent, (552)
"Great location!"
The price is AED 403
AED 447 total
includes taxes & fees
1 Oct - 2 Oct
Hampton Inn Clemson-University Area
Days Inn by Wyndham Clemson
3.5 star property
7.2 out of 10, Good, (116)
"Bathroom needs updating. Water was cold at times. Only towels were refilled. Nothing else. But it was clean and staff was excellent. "
The price is AED 293
AED 325 total
includes taxes & fees
29 Sep - 30 Sep
Days Inn by Wyndham Clemson
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Frequently asked questions

Where is the best place for a stay in Seneca?

Tru by Hilton Seneca Clemson is ranked highly by Expedia customers. This hotel is a short 5-minute walk from Lake Hartwell, and it offers free breakfast and free parking. Traveler reviews also recommend Lakeside Lodge Clemson and Hampton Inn & Suites Seneca-Clemson Area as top choices for your visit. See all available top hotels, or vacation rentals in Seneca.

What's the top vacation rental in Seneca?

JULY WEEK OPEN!!Waterfront Home w/ Covered Dock, 2 Decks, & Pet Friendly: Visitors give good reviews to this Seneca vacation home rental, which is located on a lake and has a fireplace, a balcony, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a garden and an arcade game room. Our travelers also rate 5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub! as a favorite home for rent in Seneca. See all vacation rentals in Seneca.

If I need to cancel my hotel reservation in Seneca, will I receive a refund?

Yes, the majority of hotel reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Seneca.

Where can I learn more about changing or cancelling my trip to Seneca?

To find more details about updating your trip to Seneca or cancelling it, click here.

What's the best place to stay for a family vacation to Seneca?

Fairfield Inn & Suites Seneca Clemson Univ Area is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Attractions in the area like Ultimate Action Sports are also fun for the whole family. Find more child-friendly accommodations in Seneca.

What's the best LGBTQ-friendly place to stay in Seneca?

Tru by Hilton Seneca Clemson is a top LGBTQ-friendly hotel, and features free breakfast and free WiFi. Hampton Inn & Suites Seneca-Clemson Area is another good choice for your stay.

What's the best pet-friendly accommodation in Seneca?

Lakeside Lodge Clemson is a top hotel for people traveling with their pets, and offers a restaurant and a seasonal outdoor pool for its human guests. Other good choices to stay with your pet include Tru by Hilton Seneca Clemson and Days Inn by Wyndham Seneca / Clemson Area. See more pet-friendly hotel accommodations in Seneca.

What are some hotels with pools in Seneca?

Hampton Inn & Suites Seneca-Clemson Area is a top hotel with a seasonal outdoor pool, free buffet breakfast, and free WiFi. View all hotels with pools in Seneca.

What is the best accommodation for staying close to Greenville-Spartanburg International Airport (GSP)?

Wyndham Garden Greenville Airport is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and a restaurant. It's located 3.8 mi (6.1 km) from Greenville-Spartanburg Intl. Airport. Other good options near the airport include Best Western Greenville Airport Inn and Extended Stay America - Greenville - Airport.

What is staying in Seneca like?

Visitors to Seneca are sure to enjoy the sporting events, lakeside setting, and university setting. Welcoming and scenic, this city also attracts tourists with its coffeehouses. In Seneca, there are 266 hotels and other accommodations to choose from. Find out more about Seneca.

What should I do while I'm visiting Seneca?

Natural beauty is on display at Lake Keowee, Lake Hartwell, and Keowee Reservoir. Exploring the waterfront is a great activity, and Keowee Key Golf Course is one place to visit. The university setting is a highlight and Clemson University is worth a campus tour. Check out what more to see and do in Expedia's Seneca guide.

What's the weather like in Seneca?

The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 46°F. Average annual precipitation for Seneca is 62 inches.