The Best Hotels Closest to Sikeston Depot Museum in Sikeston for 2026

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Our top choices for Sikeston Depot Museum hotels

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

1. Fairfield Inn & Suites by Marriott Sikeston

2.4 km from Sikeston Depot Museum

Allen

AED 371

AED 422 total

includes taxes & fees

18 Oct - 19 Oct

An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.

A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.

2. TownePlace Suites by Marriott Sikeston

2.3 km from Sikeston Depot Museum

Rubin

AED 372

AED 423 total

includes taxes & fees

18 Oct - 19 Oct

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

3. Hampton Inn Sikeston

2.3 km from Sikeston Depot Museum

Lori

AED 387

AED 440 total

includes taxes & fees

18 Oct - 19 Oct

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A buffet with various food items, including omelets and baked goods, served in metal containers.

A kitchenette with a coffee machine, a kettle, and storage shelves.

A Holiday Inn Express & Suites building with a covered entrance, multiple windows, and a parking lot.

4. Holiday Inn Express & Suites Sikeston Southwest by IHG

2.1 km from Sikeston Depot Museum

Melissa

AED 356

AED 405 total

includes taxes & fees

8 Nov - 9 Nov

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.

5. Drury Inn & Suites Sikeston, MO

5.1 km from Sikeston Depot Museum

Tim

AED 345

AED 397 total

includes taxes & fees

18 Oct - 19 Oct

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.

A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.

6. Best Western Plus Sikeston I-55

5.4 km from Sikeston Depot Museum

Shelley

AED 311

AED 355 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A living room with a sofa, two chairs, a coffee table, a television, and a window with blinds.

A reception area with a sign for 'Travel Inn and Suites' and a counter with a computer and a phone.

A Travel Inn and Suites with a brick facade, a flat roof, and a welcoming entrance.

7. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

5 km from Sikeston Depot Museum

Craig

AED 225

AED 256 total

includes taxes & fees

22 Oct - 23 Oct

A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.

A hot tub area with a tiled floor, a wooden deck surrounding the tub, and a view of the sky through large windows.

A hotel lobby with a reception desk, seating area, and large windows offering a view of the outdoors.

A living room with two sofas, a coffee table, a TV, and a cabinet.

8. Comfort Inn & Suites Sikeston I-55

4.9 km from Sikeston Depot Museum

Kathryn

AED 306

AED 348 total

includes taxes & fees

1 Nov - 2 Nov

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.

A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

9. Days Inn and Suites by Wyndham Sikeston

5.4 km from Sikeston Depot Museum

David

AED 244

AED 278 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

A hotel room with a flat-screen TV, a microwave, a coffee maker, a dining table, and two sofas.

A hotel room with two beds, a sofa, a coffee table, and artwork on the walls.

A motel with a covered entrance, multiple rooms, and a parking lot.

10. Super 8 by Wyndham Sikeston/Miner Area

4.7 km from Sikeston Depot Museum

Marcia

AED 210

AED 239 total

includes taxes & fees

18 Oct - 19 Oct

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

A reception area with a sofa, a small table, a trash bin, a microwave, and a book display.

A reception area with a counter, a coffee machine, and seating.

A motel with a blue awning and a green 7-Eleven. It has a covered parking area and a two-story structure with a balcony.

11. Country Yard Inn and Suite

5.5 km from Sikeston Depot Museum

William

AED 197

AED 235 total

includes taxes & fees

13 Oct - 14 Oct

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Compare popular hotels close to Sikeston Depot Museum

Property	Property class	Guest rating
Fairfield Inn & Suites by Marriott Sikeston	9.4 Exceptional 117 reviews	View
TownePlace Suites by Marriott Sikeston	9.4 Exceptional 26 reviews	View
Hampton Inn Sikeston	9.0 Wonderful 636 reviews	View
Holiday Inn Express & Suites Sikeston Southwest by IHG	8.8 Excellent 517 reviews	View
Drury Inn & Suites Sikeston, MO	9.6 Exceptional 1,008 reviews	View

Top Sikeston Depot Museum Hotel Reviews

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Awesome place will be staying in more of them"

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good

"Easy parking, our bathroom sink was leaning forward and we had to place our soap in the sink so it didn't slide on the floor."

Holiday Inn Express & Suites Sikeston Southwest by IHG

10/10 Excellent

"Clean, comfortable room. Nice staff and good breakfast choices."

Peaceful secluded cabin located near Horseshoe Lake

8/10 Good

"I booked this cabin for a getaway for two adults and two dogs who don't like other dogs, and it was the perfect location for that. There are no other cabins within sight or within earshot, the road that runs by the cabin is quiet, and there's a park that's similarly very quiet about a 5-minute drive away. Check in was smooth and the cabin is very cute. The facilities, especially the shower, are pretty basic, but everything worked. The cabin is small, but comfortable for two people. There's AC and heating, so the temperature was comfortable.My notes are less a critique of the cabin, and more things to know: The water smells like rotten eggs, to the point where the entire bathroom stank after a shower. My dogs happily drank the tap water, so it seems safe - the area is marshy, so I suspect that explains the smell. If you're sensitive to smells, this might be a challenge. This is woods in the southern Midwest, so mosquitoes were out in force, and my dogs were covered in sticky pricklies the second they left the (nicely!) mowed area of the cabin - again, nothing to do with the cabin, just the reality of the area, and it meant we didn't spend a ton of time outside near the cabin. I might be interested in revisiting during a colder time of year when bugs and plants are dormant. I recommend bringing your own dry firewood because it's humid so any wood at the site might not burn very easily."

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

8/10 Good

"Host is great. I've stayed here many times."

TownePlace Suites by Marriott Sikeston

10/10 Excellent

"My overall experience was amazing from the time I checked in until I left. The staff were super pleasant and incredible. My room was clean and spacious. I never been in an extended stay room before. I definitely will be booking a suite like this one again."

Eagle Inn Charleston

10/10 Excellent

"Great"

Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

10/10 Excellent

"The host was very quick to respond and so great to work with for on our stay. "

Other attractions near Sikeston Depot Museum

Central Park

7.2/10 (56 reviews)

Explore the great outdoors at Central Park, a lovely green space in Sikeston. While in this family-friendly area, you can savor the top-notch restaurants.

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City of Miner Convention Center

Learn about the events happening at City of Miner Convention Center during your trip to Miner. While in this relaxing area, you can savor the top-notch restaurants.

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Front Street Studio & Art Gallery

8.6/10 (15 reviews)

You can spend time browsing the exhibits at Front Street Studio & Art Gallery during your travels in Blodgett. While in this relaxing area, you can savor the top-notch restaurants.

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Hunter-Dawson State Historic Site

7.6/10 (13 reviews)

You can browse the exhibits at Hunter-Dawson State Historic Site, a museum with a story of its own, during your travels to New Madrid. Amble around the area's parks or experience its museums.

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River Ridge Winery

8.4/10 (15 reviews)

You can enjoy a tasting or tour at River Ridge Winery during your travels to New Madrid. Amble around the area's parks or experience its museums.

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New Madrid Historical Museum

8.2/10 (36 reviews)

You can study the exhibits at New Madrid Historical Museum, a museum with a storied past, during your travels to New Madrid. Amble around the area's parks or experience its museums.

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Dexter Welcome Center Depot and Museum

7.6/10 (12 reviews)

You can study the exhibits at Dexter Welcome Center Depot and Museum, a museum with a story of its own, during your trip to Dexter. While in this family-friendly area, you can enjoy the restaurants.

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The Heritage House

8.4/10 (7 reviews)

Learn about the local history of Dexter when you take a trip to The Heritage House. While in this family-friendly area, you can enjoy the restaurants.

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Frequently asked questions

What's the area like around Sikeston Depot Museum?

Sikeston Depot Museum is located in a welcoming area of Sikeston known for its array of dining options. If you're looking for a convenient place to stay, check out the 5 hotels and other accommodations you'll find within a mile.

What's the best hotel to stay near Sikeston Depot Museum?

Drury Inn & Suites Sikeston, MO is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an outdoor pool. It's located 3.2 mi (5.1 km) from Sikeston Depot Museum. Other good choices within 5 miles include Hampton Inn Sikeston and Days Inn and Suites by Wyndham Sikeston.

How many hotels should I expect to find close to Sikeston Depot Museum?

Expedia has 5 hotels and other accommodations within a mile from Sikeston Depot Museum.

If I need to cancel the hotel reservation for my stay near Sikeston Depot Museum, will I receive a refund?

Yes! The majority of hotel room reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of booking. Put your dates in and click on "Search", then use the filter option "fully refundable" to get the best deals near Sikeston Depot Museum.

Where can I learn more about changing or cancelling my trip in the area near Sikeston Depot Museum?

To find more details about picking new dates or cancelling your stay near Sikeston Depot Museum, head over to our customer service page.

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Our top choices for Sikeston Depot Museum hotels

1. Fairfield Inn & Suites by Marriott Sikeston