Find hotels near Sioux Empire Medical Museum, Sioux Falls from AED 209

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
15 Dec - 16 Dec
Tomorrow
16 Dec - 17 Dec
This weekend
19 Dec - 21 Dec
Next weekend
26 Dec - 28 Dec

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Sioux Empire Medical Museum hotels

Terrace/patio
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center
3.0 star property
University Heights, 0.2 km from Sioux Empire Medical Museum
9.4 out of 10, Exceptional, (585)
"This is a great hotel - centrally located and very clean and quiet. Will definitely be staying there again. "
United States
Tracey
The price is AED 379
AED 423 total
includes taxes & fees
22 Dec - 23 Dec
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center
Interior detail
Hotel On Phillips

Hotel On Phillips

Hotel On Phillips
2.5 star property
Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum
9.6 out of 10, Exceptional, (1297)
"Great staff and location!"
United States
Gerald
Hotel On Phillips
Exterior detail
Clubhouse Hotel Suites Sioux Falls

Clubhouse Hotel Suites Sioux Falls

Clubhouse Hotel Suites Sioux Falls
3.0 star property
Mall District, 2.8 km from Sioux Empire Medical Museum
9.4 out of 10, Exceptional, (1003)
"Absolutely beautiful places to stay with family excellent service staff great food service great hospitality great "
United States
Rosario
Clubhouse Hotel Suites Sioux Falls
Meeting facility
Canopy By Hilton Sioux Falls Downtown

Canopy By Hilton Sioux Falls Downtown

Canopy By Hilton Sioux Falls Downtown
4.0 star property
Downtown Sioux Falls, 2.5 km from Sioux Empire Medical Museum
9.4 out of 10, Exceptional, (156)
"Room was very clean, great overall stay."
United States
Destiny
The price is AED 479
AED 547 total
includes taxes & fees
1 Jan - 2 January 2026
Canopy By Hilton Sioux Falls Downtown
Meeting facility
Hilton Garden Inn Sioux Falls Downtown

Hilton Garden Inn Sioux Falls Downtown

Hilton Garden Inn Sioux Falls Downtown
3.0 star property
Downtown Sioux Falls, 2.1 km from Sioux Empire Medical Museum
9.0 out of 10, Wonderful, (883)
"Friendly front desk staff, clean room, great location, safe "
United States
Hannah
The price is AED 373
AED 431 total
includes taxes & fees
21 Dec - 22 Dec
Hilton Garden Inn Sioux Falls Downtown
Exterior
Hampton Inn Sioux Falls

Hampton Inn Sioux Falls

Hampton Inn Sioux Falls
2.5 star property
Mall District, 3.1 km from Sioux Empire Medical Museum
9.2 out of 10, Wonderful, (1000)
"Great location and a friendly staff "
United States
Dan
The price is AED 358
AED 400 total
includes taxes & fees
26 Dec - 27 Dec
Hampton Inn Sioux Falls
Porch
Historic Victorian Inn

Historic Victorian Inn

Historic Victorian Inn
3.0 star property
Cathedral, 1.5 km from Sioux Empire Medical Museum
8.8 out of 10, Excellent, (56)
"It was a great place to stay and super interesting."
United States
Kathy
The price is AED 398
AED 497 total
includes taxes & fees
18 Dec - 19 Dec
Historic Victorian Inn
Exterior
Holiday Inn Sioux Falls-City Centre by IHG

Holiday Inn Sioux Falls-City Centre by IHG

Holiday Inn Sioux Falls-City Centre by IHG
3.0 star property
Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum
8.6 out of 10, Excellent, (1002)
"Always a great stay. "
United States
Shawn
The price is AED 334
AED 374 total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Sioux Falls-City Centre by IHG
Exterior
Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG
2.5 star property
Mall District, 3.1 km from Sioux Empire Medical Museum
8.8 out of 10, Excellent, (1001)
"Breakfast good, staff very accommodating and friendly. "
United States
Geraldine
The price is AED 470
AED 523 total
includes taxes & fees
4 Jan - 5 January 2026
Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG
Exterior
Country Inn & Suites by Radisson, Sioux Falls, SD

Country Inn & Suites by Radisson, Sioux Falls, SD

Country Inn & Suites by Radisson, Sioux Falls, SD
3.0 star property
Downtown Sioux Falls, 2 km from Sioux Empire Medical Museum
8.4 out of 10, Very Good, (1154)
"It was a great place to stay!"
United States
Trinity
The price is AED 371
AED 415 total
includes taxes & fees
5 Jan - 6 January 2026
Country Inn & Suites by Radisson, Sioux Falls, SD
Lobby
Sheraton Sioux Falls Hotel & Convention Center

Sheraton Sioux Falls Hotel & Convention Center

Sheraton Sioux Falls Hotel & Convention Center
4.0 star property
Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum
8.6 out of 10, Excellent, (1001)
"Great hotel. Staff was excellent "
United States
Kristina
The price is AED 356
AED 398 total
includes taxes & fees
4 Jan - 5 January 2026
Sheraton Sioux Falls Hotel & Convention Center
Suite 2 Queens, Recliner, Pullout Sofa | Free WiFi, bed sheets
The Center Inn

The Center Inn

The Center Inn
2.5 star property
All Saints, 2.4 km from Sioux Empire Medical Museum
8.4 out of 10, Very Good, (701)
"Clean room and friendly staff."
United States
Betty
The Center Inn
Basic Studio, 1 King Bed | Desk, free WiFi, wheelchair access
Valley Inn

Valley Inn

Valley Inn
2.5 star property
University Heights, 0.2 km from Sioux Empire Medical Museum
7.6 out of 10, Good, (1001)
"Room was clean, staff was friendly, very convenient location "
United States
Theresa
Valley Inn
3 indoor pools, open 9:00 AM to 10:00 PM, sun loungers
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
3.0 star property
Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum
7.8 out of 10, Good, (1461)
"staff was friendly "
United States
Rob
The price is AED 220
AED 248 total
includes taxes & fees
18 Dec - 19 Dec
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
50-inch flat-screen TV with cable channels, fireplace, Netflix
Historic Twin Tudors Inn

Historic Twin Tudors Inn

Historic Twin Tudors Inn
3.0 star property
1.4 km from Sioux Empire Medical Museum
8.8 out of 10, Excellent, (3)
"Lovely place! Wish we could have stayed longer. Steve was attentive and helpful. "
United States
Anonymous traveler
The price is AED 988
AED 1,121 total
includes taxes & fees
16 Dec - 17 Dec
Historic Twin Tudors Inn
Pool
Ramada by Wyndham Sioux Falls Arpt & Suites

Ramada by Wyndham Sioux Falls Arpt & Suites

Ramada by Wyndham Sioux Falls Arpt & Suites
2.0 star property
Northwest Sioux Falls, 3 km from Sioux Empire Medical Museum
7.0 out of 10, Good, (51)
"Great "
United States
Jorge
Ramada by Wyndham Sioux Falls Arpt & Suites
Exterior
WoodSpring Suites Sioux Falls

WoodSpring Suites Sioux Falls

WoodSpring Suites Sioux Falls
2.5 star property
2.8 km from Sioux Empire Medical Museum
5.2 out of 10, (60)
"The price was good, the cleanliness was better than other cheap hotels I've stayed in. My primary complaint was the slow internet speeds. There was also damage that had not been repaired from prior guests."
United States
Trent
The price is AED 253
AED 285 total
includes taxes & fees
16 Dec - 17 Dec
WoodSpring Suites Sioux Falls
Double Room, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes
Highpoint Hotel

Highpoint Hotel

Highpoint Hotel
3.0 star property
University Heights, 0.2 km from Sioux Empire Medical Museum
The price is AED 618
AED 685 total
includes taxes & fees
21 Dec - 22 Dec
Highpoint Hotel
Lobby
Ramada by Wyndham Sioux Falls

Ramada by Wyndham Sioux Falls

Ramada by Wyndham Sioux Falls
2.0 star property
2.6 km from Sioux Empire Medical Museum
5.6 out of 10, (1001)
"Good room for the price."
United States
Michael
The price is AED 184
AED 209 total
includes taxes & fees
23 Dec - 24 Dec
Ramada by Wyndham Sioux Falls
Exterior
Staybridge Suites Sioux Falls Southwest by IHG

Staybridge Suites Sioux Falls Southwest by IHG

Staybridge Suites Sioux Falls Southwest by IHG
3.0 star property
South Sioux Falls, 5.2 km from Sioux Empire Medical Museum
9.6 out of 10, Exceptional, (456)
"Staff was great, all very friendly. Room was very clean, and we had a great nights sleep. "
United States
Eric
The price is AED 331
AED 370 total
includes taxes & fees
1 Jan - 2 January 2026
Staybridge Suites Sioux Falls Southwest by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Sioux Empire Medical Museum Hotel Reviews

Canopy By Hilton Sioux Falls Downtown

Canopy By Hilton Sioux Falls Downtown

10/10 Excellent
"Everything and everyone was wonderful. "
Brian 2-night trip
Posted 18 hours ago
Canopy By Hilton Sioux Falls Downtown

Hotels near other Sioux Empire Medical Museum attractions

Great Plains Zoo

4.3/5 (74 reviews)
Why not visit the native and exotic animals who live at Great Plains Zoo during your travels in Sioux Falls? Attend a sporting event or discover the area's beautiful waterfalls.
See properties

University of Sioux Falls

4.1/5 (170 reviews)
Take a campus tour or just explore the area of University of Sioux Falls, during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.
See properties

Frequently asked questions

What's the area like around Sioux Empire Medical Museum?
Sioux Empire Medical Museum is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, check out the 106 hotels and other accommodations you'll find within a mile.
What's the best place to stay close to Sioux Empire Medical Museum?
Adjacent to Sioux Empire Medical Museum, Home2 Suites By Hilton Sioux Falls/Sanford Medical Center is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. Another good choice is Valley Inn, located just 0.1 mi (0.2 km) away.
How many hotels will I be able to find close to Sioux Empire Medical Museum?
Expedia has 106 hotels and other accommodations within a mile from Sioux Empire Medical Museum.
If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund?
Yes, most hotel room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to review the best options available near Sioux Empire Medical Museum.
Where can I learn more about changing or cancelling my trip in the area near Sioux Empire Medical Museum?
For more details about changing or cancelling your stay near Sioux Empire Medical Museum, go to https://www.expedia.com/service/.
What can I see and do near Sioux Empire Medical Museum?
Washington Pavilion of Arts and Science, Center for Western Studies, and Old Courthouse Museum feature a variety of fascinating exhibits to see while you're in town. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. You can wander around Falls Park, Sherman Park, or Fawick Park if you want a dose of fresh air.

Explore a world of travel with Expedia