South Central Houston Vacations

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Where to stay in South Central Houston

Find the best South Central Houston areas and neighborhoods for the activities you enjoy most. Learn more about South Central Houston
Discovery Green which includes a city, central business district and a high rise building

Downtown Houston

3 out of top 10 points of interest in this area
4.5/5(2,300 area reviews)

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

Find hotels in Downtown Houston

South Central Houston Hotel Deals

Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical Center
4.5 out of 5
6633 Travis St, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AED 382 per night from Jun 8 to Jun 9
AED 382
AED 451 total
8 Jun - 9 Jun
includes taxes & fees
8.2/10 Very Good! (1,367 reviews)
"If your on vacation this is perfect spot, everything you wanna do is walking distance..and if your going other places transportation is easy to get...what I didn't like is that to park it cost 20 dollars a day,don't believe it tells you that I think it says parking available..my thought is parking ..."

Reviewed on 4 June 2025

Hilton Houston Plaza/Medical Center
Hotel Zaza Houston Museum District
Hotel Zaza Houston Museum District
4.5 out of 5
5701 Main Street, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AED 750 per night from Jun 8 to Jun 9
AED 750
AED 1,027 total
8 Jun - 9 Jun
includes taxes & fees
8.8/10 Excellent! (1,677 reviews)
"Great"

Reviewed on 3 June 2025

Hotel Zaza Houston Museum District
The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum District
4 out of 5
1709 DRYDEN ROAD, Houston, TX
Fully refundableReserve now, pay when you stay
The price is AED 531 per night from Jun 7 to Jun 8
AED 531
AED 661 total
7 Jun - 8 Jun
includes taxes & fees
9/10 Wonderful! (1,001 reviews)
"Clean and quiet."

Reviewed on 5 June 2025

The Westin Houston Medical Center/Museum District
See all 1,130 properties in South Central Houston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in South Central Houston

Rice University

Rice University

4.5/5(356 reviews)

Enjoy the collegiate vibe around Rice University, a top university in Houston. Experience the area's acclaimed art scene and great live music.

Rice University
Houston Zoo

Houston Zoo

4.5/5(998 reviews)

Why not visit the native and exotic animals who call Houston Zoo home during your trip to Houston? Experience the area's fascinating museums and lively festivals.

Houston Zoo
University of Houston

University of Houston

4/5(392 reviews)

Enjoy the collegiate vibe around University of Houston, a top university in Houston. Experience the acclaimed theater scene and lively festivals in this vibrant area.

University of Houston