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Vacation Homes in Southeast Missouri

Our top choices for Southeast Missouri vacation homes

The Sutton House 2 blocks from Main Street & Courthouse Square

10.0 out of 10, Exceptional, (37)
"Wonderful hospitality! Very clean. Elephant Rock State Park and Johnson’s Shut ins are close and amazing. "
The price is AED 639
AED 812 total
includes taxes & fees
1 Oct - 2 Oct
The Sutton House 2 blocks from Main Street & Courthouse Square

Serenity South -- Gardens, River-Views, and Refreshing Space

10.0 out of 10, Exceptional, (140)
"Three generations found rest,beauty,& joy at Serenity South. Thoughtful touches,beautiful gardens and Cape charm made this more than a stay-it became a treasured memory. We were so appreciative of the details, the fresh flowers, homemade cookies, the coffeemaker upstairs and the books and games. The beds were all comfortable. We enjoyed this historical home and our stay. "
Serenity South -- Gardens, River-Views, and Refreshing Space

Clifford's Country Cottage

2.5 star property
9.8 out of 10, Exceptional, (20)
"Great place to stayLove the interiorPerfect set up for what we needed"
The price is AED 459
AED 560 total
includes taxes & fees
7 Sep - 8 Sep
Clifford's Country Cottage

Doves Nest Guest House<br> Tranquil & Relaxing

10.0 out of 10, Exceptional, (44)
"Outstanding! I highly recommend to everyone! So well decorated with every amenity! Great location and easy walk to restaurants and activities and shopping! Great hosts!"
The price is AED 436
AED 785 total
includes taxes & fees
8 Sep - 9 Sep
Doves Nest Guest House<br> Tranquil & Relaxing

Camp Stonebass-Lake House-Hottub

10.0 out of 10, Exceptional, (3)
"We really enjoyed our time at the house."
Camp Stonebass-Lake House-Hottub

Your home away from home in downtown, historic Farmington!

10.0 out of 10, Exceptional, (31)
"Great place to rest a recoup for weekend activities "
The price is AED 426
AED 775 total
includes taxes & fees
8 Sep - 9 Sep
Your home away from home in downtown, historic Farmington!

Get Away Acres 1/2 mile off highway 60 extra sanitized

10.0 out of 10, Exceptional, (92)
"Quiet place to get away for the weekend. "
Get Away Acres 1/2 mile off highway 60 extra sanitized

Pool, Lake & Patio: Sweeping De Soto Estate

10.0 out of 10, Exceptional, (2)
"Amazing home and property for a large group. I brought my team in from all over the country to host my annual engineering team get together. This was absolutely perfect in every way and very affordable. Will be back next year for sure "
Pool, Lake & Patio: Sweeping De Soto Estate

Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff

8.4 out of 10, Very Good, (5)
"Enjoyed our stay at Andy’s place! It had everything we needed. Beds were super comfy and the water pressure in the showers was great. Nice, safe location. Easy to get to/from places. Place has a garage which we used one evening during a rain storm but otherwise felt completely safe leaving our vehicle on driveway overnight. We didn’t get a chance to use the nice deck area with bbq grill but this is definitely a great feature of the property. The large tv in the living room was a hit with my...
The price is AED 364
AED 929 total
includes taxes & fees
5 Sep - 6 Sep
Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff

Charming 2-bedroom house with AC, WiFi in serene Van Buren

2.0 star property
8.8 out of 10, Excellent, (11)
"The place was cozy. Everything worked. The amenities were plenty. We decided to take a day trip, never been to the area and we couldn’t have picked a more perfect place to stay, especially during the busy months you get to avoid the more touristy spots and stay in a very comfortable secluded space."
Charming 2-bedroom house with AC, WiFi in serene Van Buren

2 Bedroom Home less than 2 miles to Jacks Fork River

9.8 out of 10, Exceptional, (25)
"Check in was easy and the house was clean!"
2 Bedroom Home less than 2 miles to Jacks Fork River

Newly remodeled house minutes away from downtown, golf courses + BIG back yard

2.0 star property
9.8 out of 10, Exceptional, (18)
"This property worked well for our needs. Very convenient location to gas, food and golf course. "
The price is AED 353
AED 747 total
includes taxes & fees
18 Sep - 19 Sep
Newly remodeled house minutes away from downtown, golf courses + BIG back yard

Special Offer for Weekly & Monthly Stays in August & September at "Brickyard"

10.0 out of 10, Exceptional, (21)
"Lovely home perfect for our weekend celebrating our daughter’s graduation. Chip was an excellent host, even found us champagne flutes! Beds were comfortable, house was clean and nicely decorated. "
Special Offer for Weekly & Monthly Stays in August & September at "Brickyard"

Triple H Properties

8.6 out of 10, Excellent, (27)
"Lori’s place was a nice spot for a two night stay"
Triple H Properties

Guests enjoy their own one bedroom apartment in the Ozarks

10.0 out of 10, Exceptional, (70)
"Relaxing cute little apt with everything you need. "
Guests enjoy their own one bedroom apartment in the Ozarks

In-law Suite

9.8 out of 10, Exceptional, (13)
"Well taken care of, nice amenities, comfortable."
The price is AED 294
AED 768 total
includes taxes & fees
7 Sep - 8 Sep
In-law Suite

Elegant 3BR in the Heart of Historic Ste Genevieve

10.0 out of 10, Exceptional, (7)
"My friends and I enjoyed staying at the house. The interior of the house was a wonderful mix of keeping the integrity of the old brick house and adding modern aesthetics. The amenities listed were all current and working. I would definitely stay at the house again. "
Elegant 3BR in the Heart of Historic Ste Genevieve

Beautiful 3-bedrm , 3.5 ba Log/Stone in Eminence MO. Will sleep up to 16 guests.

9.8 out of 10, Exceptional, (6)
Beautiful 3-bedrm , 3.5 ba Log/Stone in Eminence MO. Will sleep up to 16 guests.

Unbeatable convenience in amazing Eminence!

10.0 out of 10, Exceptional, (17)
"Great time. Clean place. Easy access to town and river. Penty of amenities (cooking utensils, bathroom supplies, games and movies) Beds were comfortable and plenty of linens. Quiet inside from outdoor noise."
Unbeatable convenience in amazing Eminence!

The Cabin on Current River with Private Gravel Bar!!

8.8 out of 10, Excellent, (27)
"Beautiful area, secluded. We enjoyed staying at this property and access to the river was as expected."
The Cabin on Current River with Private Gravel Bar!!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southeast Missouri Hotel Reviews