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Search Vacation Homes in Southeast Missouri

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Check prices for these dates

Next weekend
19 Dec - 21 Dec
In two weeks
26 Dec - 28 Dec
In one month
9 Jan - 11 Jan
In two months
6 Feb - 8 Feb

Vacation Homes in Southeast Missouri

House | Living area
Tiny Houses of French Village

Vacation Home in French Village

2.5 star property
10.0 out of 10, Exceptional, (3)
"Charming property with a space for everything and everything in its place. Would not hesitate to recommend or stay again."
United States
Norma
Tiny Houses of French Village
Exterior
The Morning Glory - Country Cottage

Vacation Home in Piggott

10.0 out of 10, Exceptional, (2)
"Great stay. Home was just as advertised. Great communication with owner. Will visit again. "
United States
Scott C.
The price is AED 558
AED 998 total
includes taxes & fees
22 Dec - 23 Dec
The Morning Glory - Country Cottage
Smart TV
In-law Suite

Vacation Home in Leadwood

9.8 out of 10, Exceptional, (14)
"Well taken care of, nice amenities, comfortable."
United States
Daniel K.
The price is AED 261
AED 746 total
includes taxes & fees
21 Dec - 22 Dec
In-law Suite
2 bedrooms, iron/ironing board, free WiFi, bed sheets
Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff

Vacation Home in Poplar Bluff

8.6 out of 10, Excellent, (8)
"The house was very clean and nicely decorated. The huge TV in the living room was a plus and the mattress was very comfortable. We would stay again!"
United States
Brian
The price is AED 367
AED 933 total
includes taxes & fees
27 Dec - 28 Dec
Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff
Fridge, microwave, oven, stovetop
Clifford's Country Cottage

Vacation Home in Bonne Terre

2.5 star property
10.0 out of 10, Exceptional, (24)
"We have been there three times and it was just as peaceful, clean and exactly what we needed. "
United States
Kimber L.
The price is AED 459
AED 560 total
includes taxes & fees
9 Dec - 10 Dec
Clifford's Country Cottage
Fridge, microwave, oven, stovetop
Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations

Vacation Home in Farmington

8.6 out of 10, Excellent, (4)
"Great place. "
United States
Diana
The price is AED 248
AED 505 total
includes taxes & fees
9 Dec - 10 Dec
Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations
Outdoor dining
"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington

Vacation Home in Farmington

2.0 star property
10.0 out of 10, Exceptional, (11)
"Great place and very comfortable! Hosts were super attentive when our door code didn’t work and got us sorted out right away. "
United States
Kyser B.
The price is AED 444
AED 844 total
includes taxes & fees
10 Dec - 11 Dec
"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington
Private kitchen
Cozy 1-bedroom house with AC and WiFi in charming Farmington

Vacation Home in Farmington

10.0 out of 10, Exceptional, (6)
"Absolutely LOVED it here! Hope to return in 2026. Karli made my first Vrbo experience just plain splendid!"
United States
Tru L.
The price is AED 281
AED 673 total
includes taxes & fees
9 Dec - 10 Dec
Cozy 1-bedroom house with AC and WiFi in charming Farmington
Interior
Charming 2-bedroom house with AC, WiFi in serene Van Buren

Vacation Home in Van Buren

2.0 star property
9.0 out of 10, Wonderful, (15)
"It was beautiful and homey. We really enjoyed our stay. "
United States
Jessica
The price is AED 257
AED 617 total
includes taxes & fees
9 Dec - 10 Dec
Charming 2-bedroom house with AC, WiFi in serene Van Buren
Property grounds
Get Away Acres 1/2 mile off highway 60 extra sanitized

Vacation Home in Ellsinore

10.0 out of 10, Exceptional, (95)
"We really enjoyed our stay! Host was very friendly and quick to respond to questions! We will definitely stay again!!"
United States
Anonymous traveler
The price is AED 386
AED 481 total
includes taxes & fees
1 Jan - 2 January 2026
Get Away Acres 1/2 mile off highway 60 extra sanitized
Outdoor dining
"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC

Vacation Home in Farmington

2.0 star property
10.0 out of 10, Exceptional, (8)
"It is a very nice place and very comfortable has everything you could possibly need for homeaway from home."
United States
Scott
The price is AED 444
AED 833 total
includes taxes & fees
4 Jan - 5 January 2026
"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC
Dining
Goforth into Nature, a charming 1-bdrm home in the quiet Bloomsdale countryside.

Vacation Home in Bloomsdale

10.0 out of 10, Exceptional, (6)
"What a beautiful fun stay that was a nice quick getaway for us! Everything was perfect from booking, to arrival, to overall stay, we had the best time! "
United States
Blake H.
The price is AED 614
AED 960 total
includes taxes & fees
16 Dec - 17 Dec
Goforth into Nature, a charming 1-bdrm home in the quiet Bloomsdale countryside.
Fridge, microwave, oven, stovetop
Cozy Three bedroom home in Central Farmington

Vacation Home in Farmington

9.6 out of 10, Exceptional, (29)
"House was adorable and comfortable. Location close to everything. Drive to The Landing was not bad at all. Host was friendly and available. I would stay again!"
United States
Jody C.
The price is AED 397
AED 898 total
includes taxes & fees
9 Dec - 10 Dec
Cozy Three bedroom home in Central Farmington
Property grounds
Newly remodeled house minutes away from downtown, golf courses + BIG back yard

Vacation Home in Farmington

2.0 star property
9.8 out of 10, Exceptional, (20)
"very nice house and good location . had so many things to enjoy"
United States
Peter V.
The price is AED 430
AED 840 total
includes taxes & fees
5 Jan - 6 January 2026
Newly remodeled house minutes away from downtown, golf courses + BIG back yard
Dining
Cute town house with fenced backyard

Vacation Home in Barnhart

9.6 out of 10, Exceptional, (17)
"It was a great place to stay for our needs we had our little dog with us as was there for weekend, it had a nice fenced back yard we could let her just go out didn't have to have her on leash. Was very nice inside clean well kept, beds were surprising comfortable. The host stayed in contact and answered a lot questions before we arrived which put me a ease for our trip. High recommand this place if needing to stay in the area. "
United States
Terry
The price is AED 465
AED 1,071 total
includes taxes & fees
2 Jan - 3 January 2026
Cute town house with fenced backyard
Property grounds
Pet-Friendly Downtown Ironton minutes away Elephant Rocks, Johnson Shut-ins

Vacation Home in Ironton

10.0 out of 10, Exceptional, (33)
"Very friendly, helpful host, clean and cute house. Love the area for shops, and hiking we had a wonderful stay!"
United States
beth s.
The price is AED 503
AED 892 total
includes taxes & fees
9 Dec - 10 Dec
Pet-Friendly Downtown Ironton minutes away Elephant Rocks, Johnson Shut-ins
Exterior
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

Vacation Home in Cape Girardeau

8.6 out of 10, Excellent, (35)
"Very nice house. The pool and hot tub were perfect for a short getaway. Tons of activities and games to keep the fanily entertained. Will definitely come back! "
United States
Emily D.
The price is AED 496
AED 785 total
includes taxes & fees
9 Dec - 10 Dec
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
1 bedroom, WiFi, bed sheets
AV Bungalows #9B

Vacation Home in Arcadia

10.0 out of 10, Exceptional, (2)
"My husband and I really enjoyed our stay! The Bungalow was perfect for us and will definitely be staying again when we come back to Arcadia!!"
United States
Theresa R.
The price is AED 497
AED 613 total
includes taxes & fees
9 Dec - 10 Dec
AV Bungalows #9B
Property grounds
Doc's Cottage - A-Frame in Piggott, AR

Vacation Home in Piggott

10.0 out of 10, Exceptional, (9)
"Very clean and well stocked. Host was excellent to communicate with. We would definitely stay again!"
United States
Ken R.
The price is AED 441
AED 847 total
includes taxes & fees
9 Dec - 10 Dec
Doc's Cottage - A-Frame in Piggott, AR
Living area
Modern Newly built 2-bedroom house minutes from downtown Park Hills

Vacation Home in Park Hills

8.8 out of 10, Excellent, (6)
"Stayed here as it was close to our newly purchased home. The home was comfortable and quiet. "
United States
Greg S.
The price is AED 268
AED 793 total
includes taxes & fees
14 Dec - 15 Dec
Modern Newly built 2-bedroom house minutes from downtown Park Hills
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

10/10 Excellent
"Very good hotel for the price."
Gareth 1-night trip
Posted 3 days ago
Drury Inn & Suites Jackson MO

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