
Search Vacation Homes in Southeast Missouri
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Check prices for these dates
In two weeks
In two months
In three months
In four months
Our top choices for Southeast Missouri vacation homes

1. The Stonehouse - Private Hot Tub - Sleeps 5
The Stonehouse - Private Hot Tub - Sleeps 5Fredericktown
9.8 out of 10, Exceptional, (8 reviews)
The price is AED 562
AED 898 total
includes taxes & fees
16 Nov - 17 Nov

2. Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations
Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stationsFarmington
9.4 out of 10, Exceptional, (11 reviews)
The price is AED 261
AED 531 total
includes taxes & fees
3 Nov - 4 Nov

3. AV Bungalows #9B
AV Bungalows #9BArcadia
10.0 out of 10, Exceptional, (2 reviews)
The price is AED 498
AED 558 total
includes taxes & fees
3 Nov - 4 Nov

4. Get Away Acres 1/2 mile off highway 60 extra sanitized
Get Away Acres 1/2 mile off highway 60 extra sanitizedEllsinore
10.0 out of 10, Exceptional, (101 reviews)
The price is AED 386
AED 452 total
includes taxes & fees
4 Nov - 5 Nov

5. "The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington
"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous FarmingtonFarmington
10.0 out of 10, Exceptional, (32 reviews)
The price is AED 511
AED 929 total
includes taxes & fees
3 Nov - 4 Nov

6. Clifford's Country Cottage
Clifford's Country CottageBonne Terre
10.0 out of 10, Exceptional, (47 reviews)
The price is AED 459
AED 535 total
includes taxes & fees
5 Nov - 6 Nov

7. Cozy Three bedroom home in Central Farmington
Cozy Three bedroom home in Central FarmingtonFarmington
9.8 out of 10, Exceptional, (37 reviews)
The price is AED 397
AED 894 total
includes taxes & fees
3 Nov - 4 Nov

8. Hunting / Fishing Cabin at Lake Wappapello
Hunting / Fishing Cabin at Lake WappapelloWilliamsville
8.0 out of 10, Very good, (1 review)
The price is AED 485
AED 869 total
includes taxes & fees
3 Nov - 4 Nov

9. Your home away from home in downtown, historic Farmington!
Your home away from home in downtown, historic Farmington!Farmington
10.0 out of 10, Exceptional, (53 reviews)
The price is AED 474
AED 885 total
includes taxes & fees
3 Nov - 4 Nov

10. The Sutton House 2 blocks from Main Street & Courthouse Square
The Sutton House 2 blocks from Main Street & Courthouse SquareIronton
10.0 out of 10, Exceptional, (65 reviews)
The price is AED 621
AED 700 total
includes taxes & fees
3 Nov - 4 Nov

11. Charming 1860s Renovated Home
Charming 1860s Renovated HomeIronton
8.0 out of 10, Very good, (20 reviews)
The price is AED 505
AED 942 total
includes taxes & fees
16 Nov - 17 Nov

12. Tiny Houses of French Village
Tiny Houses of French VillageFrench Village
10.0 out of 10, Exceptional, (6 reviews)
The price is AED 817
AED 1,250 total
includes taxes & fees
3 Nov - 4 Nov

13. Group Getaway Sleeps 8 • King Bed • Arcade • Bumper Pool • Full Kitchen
Group Getaway Sleeps 8 • King Bed • Arcade • Bumper Pool • Full KitchenFarmington
10.0 out of 10, Exceptional, (34 reviews)
The price is AED 384
AED 1,123 total
includes taxes & fees
3 Nov - 4 Nov

14. "The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC
"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, ACFarmington
10.0 out of 10, Exceptional, (11 reviews)
The price is AED 511
AED 929 total
includes taxes & fees
3 Nov - 4 Nov

15. Serenity in Town 2-bedroom, 4 beds house in charming Farmington
Serenity in Town 2-bedroom, 4 beds house in charming FarmingtonFarmington
10.0 out of 10, Exceptional, (4 reviews)
The price is AED 536
AED 1,001 total
includes taxes & fees
3 Nov - 4 Nov

16. Little Blue Cottage on Spanish
Little Blue Cottage on SpanishCape Girardeau
8.4 out of 10, Very good, (59 reviews)
The price is AED 298
AED 368 total
includes taxes & fees
3 Nov - 4 Nov

17. RUSTIC RETREAT Cozy 2 Bed 1.5 Bath Home, in Rural Farmington, Wooded Outdoor.
RUSTIC RETREAT Cozy 2 Bed 1.5 Bath Home, in Rural Farmington, Wooded Outdoor.Farmington
9.4 out of 10, Exceptional, (11 reviews)
The price is AED 584
AED 675 total
includes taxes & fees
3 Nov - 4 Nov

18. Silo Farm Haus- located in the heart of wine country!
Silo Farm Haus- located in the heart of wine country!Ste. Genevieve
10.0 out of 10, Exceptional, (159 reviews)
The price is AED 878
AED 1,360 total
includes taxes & fees
3 Nov - 4 Nov

19. 5 Charles Farms Cabin #1 - NEW CABIN - Wineries, Hiking, & Camp Cana
5 Charles Farms Cabin #1 - NEW CABIN - Wineries, Hiking, & Camp CanaSte. Genevieve
10.0 out of 10, Exceptional, (4 reviews)
The price is AED 672
AED 947 total
includes taxes & fees
5 Nov - 6 Nov

20. Peaceful, cozy 1 bdrm home w hot tub & fire pit in the quiet countryside.
Peaceful, cozy 1 bdrm home w hot tub & fire pit in the quiet countryside.Bloomsdale
10.0 out of 10, Exceptional, (20 reviews)
The price is AED 661
AED 995 total
includes taxes & fees
8 Nov - 9 Nov
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find vacation rentals that suit your style
Cabins
Cottages
Save an average of 15% on thousands of hotels when you're signed in
Top Southeast Missouri Hotel Reviews

Pear Tree Inn Cape Girardeau West
10/10 Excellent
Explore a world of travel with Expedia
- Wyndham Hotels in Caledonia
- Resorts & Hotels with Spas in Farmington
- Independent Hotels in Friedheim
- Hilton Hotels in Belleview
- Hotels near Fort Davidson State Historic Site
- Farmstay in Sedgewickville
- 5 Star Hotels in Bonne Terre
- Middle Brook Hotels
- Marriott Hotels & Resorts in Farmington
- 2 Star Hotels in Piedmont
- Cabin Rentals in Farmington
- Vacation Homes in Sturdivant
- 5 Star Hotels in Middle Brook
- Motels in Bonne Terre
- Premier Inn Hotels in Park Hills
- Cottages in Perryville
- 3 Star Hotels in Pilot Knob
- Rv Parks in Southeast Missouri
- Cabin Rentals in Southeast Missouri
- 5 Star Hotels in Van Buren
- Hotels with Bars in Farmington
- B&B in Perryville
- Family Hotels in Bonne Terre
- Motels in Van Buren
- Motels in Fredericktown
- La Quinta Inn & Suites Hotels in Southeast Missouri
- Wyndham Hotels in Fredericktown
- Wyndham Hotels in Pilot Knob
- Independent Hotels in Marble Hill
- Hotels near Twin Oaks Vineyard & Winery
- 2 Star Hotels in Lesterville
- Golf Hotels in Southeast Missouri
- Motels in Ironton
- Wyndham Hotels in Doe Run
- Wyndham Hotels in Friedheim
- Cabin Rentals in Van Buren
- Pilot Knob Hotels
- Cabin Rentals in Belleview
- Aimbridge Hospitality Hotels in Wappapello
- Vacation Homes in Leadwood
- 3 Star Hotels in Friedheim
- Apartments in Piedmont
- Farmington Hotels
- Wyndham Hotels in Park Hills
- 4 Star Hotels in Ellington
- 4 Star Hotels in Fredericktown
- B&B in Ironton
- Cottages in Caledonia
- Cabin Rentals in Park Hills
- Motels in Park Hills
- Vacation Homes in Piedmont
- Motels in Ellington
- Motels in Doe Run
- 5 Star Hotels in Arcadia
- Hotels near Bollinger Mill State Historic Site
- Wyndham Hotels in Sedgewickville
- 4 Star Hotels in Leadwood
- 2 Star Hotels in Sturdivant
- Cottages in Doe Run
- 2 Star Hotels in Lowndes
- Apartments in Lesterville
- 4 Star Hotels in Piedmont
- Cabin Rentals in Friedheim
- Hotels with Hot Tubs in Southeast Missouri
- 5 Star Hotels in Piedmont
- Winery Hotels in Southeast Missouri
- 5 Star Hotels in Friedheim
- Farmstay in Ellington
- Hotels with WiFi in Pilot Knob
- 5 Star Hotels in Flat River
- Hotels with Free Parking in Farmington
- 2 Star Hotels in Park Hills
- Pet-Friendly Hotels in Southeast Missouri
- 4 Star Hotels in Doe Run
- 2 Star Hotels in Fredericktown
- 2 Star Hotels in Pilot Knob
- Cabin Rentals in Perryville
- Vacation Homes in Van Buren
- Cottages in Ironton
- 2 Star Hotels in Black
- 5 Star Hotels in Ironton
- Hilton Hotels in Arcadia
- Vacation Homes in Friedheim
- Flights from Annapolis
- Flights to Black
- Flights from Desloge
- Flights from Fredericktown
- Flights from Bonne Terre
- Flights from Lowndes
- Flights from Leadwood
- Flights from Van Buren
- Flights from Lesterville
- Flights from Flat River
- Flights from Ironton
- Flights from Farmington
- Flights from Park Hills
- Flights from Pilot Knob
- Flights from Caledonia
- Flights from Ellington



































































