The Best Luxury Hotels in Southeastern Indiana from AED 364 in 2026 | Expedia

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Our top choices for Southeastern Indiana luxury hotels

A classical gold statue in front of a multi-story building with large windows and a brick facade.

A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

A cozy room with a geometric-patterned ceiling, a sofa, and a chair.

A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.

1. 21c Museum Hotel Louisville

Downtown Louisville

Museum-infused luxury awaits at this hotel with spa, restaurant, and contemporary art steps from the river.

AED 621

AED 749 total

includes taxes & fees

25 Oct - 26 Oct

A grand lobby with ornate columns, plush seating, and a chandelier.

A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.

A grand lobby with ornate ceiling, large windows, and classic furniture.

A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".

2. The Brown Hotel

Downtown Louisville

Elegantly designed spaces and refined comforts define this historic Louisville hotel offering a boutique feel in the city center.

AED 493

AED 580 total

includes taxes & fees

25 Oct - 26 Oct

A grand entrance with a staircase leading to a door, flanked by two lamp posts and a bench.

A grand hallway with a wooden floor, a staircase, a chandelier, and a large mirror.

A covered porch with a brick wall, a wooden door, and a hanging light fixture.

A marble countertop with a tray of colorful glassware, a bottle, and two glasses. A framed painting hangs above, and two lamps are on either side.

3. The Pepin Mansion Historic B&B

New Albany

AED 322

AED 364 total

includes taxes & fees

5 Oct - 6 Oct

A bedroom with a large bed, a wooden floor, a white door, and a painting on the wall.

A dining area with a piano, a large woven pendant light, and a patterned rug.

A living room with a dining area, white cabinetry, a flat-screen TV, and a large patterned rug.

A cozy living room with a staircase, a sofa, a patterned rug, and a small table with a lamp.

4. Eclectic & Unique Historic Home

New Albany

A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.

A building entrance with a dark door, a large number '1332' above it, and two large potted ferns on either side.

A living room with a sofa, armchair, coffee table, fireplace, and large windows.

A covered outdoor seating area with wicker furniture and a wooden railing.

5. Louisville Bourbon Inn

Old Louisville

Luxurious bourbon country retreat offers elegant rooms with Egyptian cotton sheets and champagne service just minutes from downtown.

AED 1,025

AED 1,189 total

includes taxes & fees

5 Oct - 6 Oct

A wooden deck with a table, chairs, and a lantern.

A traditional room with a sofa, armchairs, a coffee table, and a sideboard.

A cozy porch area with wicker furniture, a ceiling fan, string lights, and a welcome sign.

A grand staircase with dark wood railings and a chandelier.

6. Inn at Woodhaven

St. Matthews

AED 920

AED 1,068 total

includes taxes & fees

1 Nov - 2 Nov

View all properties

Top Southeastern Indiana Hotel Reviews

Hyatt Select Louisville North

Hyatt Select Louisville North

10/10 Excellent

"The facility was immaculate. The lobby, the halls, the room, the business center, and the fitness center. We didn't see the pool, The staff was pleasant and cheerful. Definitely a place to return to."