The Best Luxury Hotels in Southeastern Indiana from AED 490 in 2026 | Expedia

A wooden bench in a forest with a natural backdrop of trees and foliage.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check availability on Southeastern Indiana Luxury Hotels

Tonight

21 Oct - 22 Oct

Tomorrow

22 Oct - 23 Oct

This weekend

23 Oct - 25 Oct

Next weekend

Our top choices for Southeastern Indiana luxury hotels

A classical gold statue in front of a multi-story building with large windows and a brick facade.

A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.

A steam fountain in a brick alleyway.

A cozy room with a geometric-patterned ceiling, a sofa, and a chair.

1. 21c Museum Hotel Louisville

Downtown Louisville

Museum-infused luxury awaits at this hotel with spa, restaurant, and contemporary art steps from the river.

AED 590

AED 713 total

includes taxes & fees

15 Nov - 16 Nov

A grand lobby with ornate columns, plush seating, and a chandelier.

A grand lobby with ornate ceiling, large windows, and classic furniture.

A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".

A grand lobby with ornate ceiling, multiple seating areas, and a staircase.

2. The Brown Hotel

Downtown Louisville

Elegantly designed spaces and refined comforts define this historic Louisville hotel offering a boutique feel in the city center.

AED 526

AED 619 total

includes taxes & fees

25 Oct - 26 Oct

A grand entrance with a staircase leading to a door, flanked by two lamp posts and a bench.

A covered porch with a brick wall, a wooden door, and a hanging light fixture.

A grand hallway with a wooden floor, a staircase, a chandelier, and a large mirror.

A marble countertop with a tray of colorful glassware, a bottle, and two glasses. A framed painting hangs above, and two lamps are on either side.

3. The Pepin Mansion Historic B&B

New Albany

AED 434

AED 490 total

includes taxes & fees

27 Oct - 28 Oct

A bedroom with a large bed, a wooden floor, a white door, and a painting on the wall.

A modern kitchen with a central island, wooden bar stools, a black refrigerator, and white cabinetry.

A dining area with a piano, a large woven pendant light, and a patterned rug.

A living room with a dining area, white cabinetry, a flat-screen TV, and a large patterned rug.

4. Eclectic & Unique Historic Home

New Albany

AED 643

AED 1,781 total

includes taxes & fees

26 Oct - 27 Oct

A wooden deck with a table, chairs, and a lantern.

A traditional room with a sofa, armchairs, a coffee table, and a sideboard.

A cozy porch area with wicker furniture, a ceiling fan, string lights, and a welcome sign.

A large, historic house with a green roof, multiple chimneys, and a prominent front porch.

5. Inn at Woodhaven

St. Matthews

AED 877

AED 1,018 total

includes taxes & fees

1 Nov - 2 Nov

A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.

A covered outdoor seating area with wicker furniture and a wooden railing.

A living room with a sofa, armchair, coffee table, fireplace, and large windows.

A building entrance with a dark door, a large number '1332' above it, and two large potted ferns on either side.

6. Louisville Bourbon Inn

Old Louisville

Luxurious bourbon country retreat offers elegant rooms with Egyptian cotton sheets and champagne service just minutes from downtown.

AED 1,025

AED 1,189 total

includes taxes & fees

25 Oct - 26 Oct

A modern kitchen with white cabinetry, a large island with bar stools, and a wood floor.

A hot tub with a cover, surrounded by a garden with a paved area.

A bedroom with a bed, a ceiling fan, a TV, and a window with curtains.

A modern kitchen with white cabinets, a wooden dining table, and a ceiling fan.

7. Creation Museum Hot Tub 4BR for 10

Burlington

AED 1,093

AED 2,153 total

includes taxes & fees

22 Oct - 23 Oct

View all properties

Top Southeastern Indiana Hotel Reviews

Hyatt Select Louisville North

Hyatt Select Louisville North

10/10 Excellent

"Good stay for the price, rooms looked freshly renovated."