Our top choices for Upstate South Carolina hotels

The Abernathy of Clemson

Clemson

Stay close to Clemson University in a stylish hotel with a trendy bar and restaurant.

Megan

AED 560 total

includes taxes & fees

22 Jan - 23 Jan

Courtyard Marriott Clemson

Clemson

Enjoy a refreshing stay near Clemson University with pool and American dining.

Lynn

AED 565 total

includes taxes & fees

15 Feb - 16 Feb

The Inn at Patrick Square

Clemson

Book this charming hotel minutes from Clemson University with free WiFi and parking.

Joyce

AED 608 total

includes taxes & fees

22 Jan - 23 Jan

Inn @ Clemson

Clemson

Book a peaceful stay minutes from campus with free Wi-Fi and parking.

Stacey

SUN AND SAND MOTEL

Spartanburg

Enjoy Spartanburg comfort with free parking and daily housekeeping service.

Michael

AED 231 total

includes taxes & fees

31 Jan - 1 Feb

Clemson University's James F. Martin Inn

Clemson

Experience Walker Golf Course and Clemson campus just steps from this lakeside inn.

Mindi

AED 607 total

includes taxes & fees

22 Jan - 23 Jan

Holiday Inn Express & Suites Clemson by IHG

Clemson

Enjoy easy access to Clemson University and free breakfast at this welcoming hotel.

barry

AED 501 total

includes taxes & fees

15 Feb - 16 Feb

Suite, 1 King Bed with Sofa bed, Non Smoking (Efficiency) | Premium bedding, individually decorated, desk, laptop workspace

Comfort Inn & Suites Clemson - University Area

Clemson

Experience a quiet, convenient stay near Clemson University and Lake Keowee.

Anita

AED 385 total

includes taxes & fees

28 Jan - 29 Jan

Urban Boutique Hotel, BW Signature Collection

Greenville

Experience Greenville's charm at a boutique motel with free breakfast and parking.

Carl

AED 251 total

includes taxes & fees

3 Feb - 4 Feb

Woodspring Suites Greenville Airport

Greenville

Experience efficient extended stays minutes from Greenville-Spartanburg Airport.

Makiya

AED 319 total

includes taxes & fees

22 Jan - 23 Jan

Extended Stay America Premier Suites - Greenville - Spartanburg - I-85

Duncan

Modern Greville hotel with free breakfast and parking near BMW Performance Center.

Eric

AED 312 total

includes taxes & fees

23 Jan - 24 Jan

Home2 Suites by Hilton Greenville Downtown

Greenville Downtown

Enjoy a riverside stay steps from Bon Secours Wellness Arena and The Peace Center.

Robert

AED 510 total

includes taxes & fees

8 Feb - 9 Feb

Tru by Hilton Greenville Woodruff Road

Greenville

Modern Greenville hotel with pool and free breakfast near Haywood Mall.

Christopher

AED 418 total

includes taxes & fees

28 Jan - 29 Jan

Holiday Inn Greenville - Woodruff Road by IHG

Greenville

Enjoy convenient access to Greenville's attractions with fitness and dining options.

Candice

AED 457 total

includes taxes & fees

25 Jan - 26 Jan

Best Western Plus Clemson Hotel & Conference Center

Clemson

Enjoy lakeside stays close to Clemson University with 24-hour fitness center.

Regina

AED 385 total

includes taxes & fees

25 Jan - 26 Jan

Aloft Greenville Downtown

Greenville Downtown

Modern hotel in downtown Greenville with outdoor pool, bar, and convenient location.

Mike

AED 490 total

includes taxes & fees

25 Jan - 26 Jan

Hampton Inn Spartanburg-North I-85

Spartanburg

Quiet retreat with a seasonal pool and free breakfast near Spartanburg attractions.

Randall

AED 318 total

includes taxes & fees

15 Feb - 16 Feb

Four Points by Sheraton Spartanburg

Spartanburg

Ashley

AED 506 total

includes taxes & fees

1 Feb - 2 Feb

Hilton Garden Inn Spartanburg

Spartanburg

Relax in Spartanburg with a heated pool, chic bar, and attentive service.

James

AED 498 total

includes taxes & fees

29 Jan - 30 Jan

Room, 2 Queen Beds, Accessible, Non Smoking | Memory foam beds, desk, laptop workspace, iron/ironing board

WoodSpring Suites Greenville Haywood Mall

Greenville

Well-equipped extended stay hotel near Greenville's key attractions.

Alesha

AED 279 total

includes taxes & fees

22 Jan - 23 Jan

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Vacation Rentals in Upstate South Carolina

Cottage

Clemson Memorabilia House

Clemson

"We enjoyed our stay, it was the perfect size for our family of four. "

Apartment

Designer Retreat w/ Pool, Golf + Beach Access!

Salem

"Property is in a great community, and it was very clean and beautifully decorated."

Aparthotel

Apartment, 1 Bedroom | Private kitchen | Full-size fridge, microwave, oven, stovetop

Park Place Apartments by Landing

Greenville

"The facility is beautiful, but there is no visibility of staff. We had several mechanical issues with dishwasher, washing machine and the Internet. We were able to resolve the Internet issue. But the dishwasher was never fixed during the four nights we stayed and our clothes. Locked in the washer. We could not get anyone to come and fix so we had to leave our items there. It’s been two weeks and I still haven’t heard back from anyone to retrieve my belongings."

Aparthotel

Full-size fridge, microwave, oven, stovetop

stayAPT Suites Greenville-Haywood Mall

Greenville

"Great place!"

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Excellent stay."

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Lake "

Cottage

Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!

Seneca

"Beautiful and quaint cabin! Highly recommend, great view of the lake."

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Cottage

Waterfront Lake Hartwell Vacation Rental w/ Dock!

Townville

Cottage

Deck, Grill & Dock Access: Lake Keowee Retreat!

Seneca

"The best, perfect "

Cottage

8 Mi to Clemson: Peaceful Family Home w/ Yard

Seneca

"The place was all out perfect the owner was polite and perfect. It was a very peaceful place to stay thank you so much."

Cottage

Lakefront South Carolina Abode w/ Deck & Boat Dock

Fair Play

"clean room, family friendly "

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

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Stay near popular Southeastern United States attractions

Clemson University

4.7/5 (738 reviews)

Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.

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The Peace Center

4.3/5 (517 reviews)

You can make plans for a show at The Peace Center during your stay in Greenville. Amble around this family-friendly area's riverfront or attend a sporting event.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina