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Our top choices for Upstate South Carolina hotels

A modern restaurant interior with round tables and chairs, a kitchen area, and large windows offering a view of parked cars outside.

1. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Rubin

AED 304 total

includes taxes & fees

6 Dec - 7 Dec

A modern kitchen with hanging light fixtures and bar seating.

2. DoubleTree by Hilton Greenville Woodruff Road

Greenville

Angie

AED 440 total

includes taxes & fees

29 Nov - 30 Nov

A spacious lobby with a large beige sofa, a fireplace, and a modern chandelier.

3. Hilton Garden Inn Greenville

Greenville

Valerie

AED 406 total

includes taxes & fees

27 Nov - 28 Nov

A multi-level hotel lobby with a central atrium, multiple dining areas, and a reception desk.

4. Embassy Suites Greenville Golf Resort & Conference Center

Greenville

James

AED 406 total

includes taxes & fees

23 Nov - 24 Nov

A modern hotel room with a large bed, a desk, and a kitchenette.

5. Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Greenville

Maclin

AED 288 total

includes taxes & fees

23 Nov - 24 Nov

An indoor swimming pool with a tiled floor, a covered area, and a seating area with chairs.

6. Drury Inn & Suites Greenville

Greenville

ruth

AED 465 total

includes taxes & fees

22 Nov - 23 Nov

A multi-story hotel with a modern design, featuring a prominent 'La Quinta' sign, a parking lot, and a landscaped entrance area.

7. La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

Greenville

Sam

AED 389 total

includes taxes & fees

7 Dec - 8 Dec

A modern hotel room with a large bed, a desk, and a seating area with chairs and a table.

8. Hampton Inn Greenville I-385 - Woodruff Rd.

Greenville

Joseph

AED 423 total

includes taxes & fees

24 Nov - 25 Nov

A spacious lobby with a modern design, featuring a reception desk, seating area with sofas and armchairs, and a large chandelier.

9. Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Greenville

George

AED 402 total

includes taxes & fees

10 Dec - 11 Dec

A modern outdoor seating area with a glass-top coffee table, blue sofas, and orange patterned cushions.

10. Tru by Hilton Greenville Woodruff Road

Greenville

Amy

AED 456 total

includes taxes & fees

26 Nov - 27 Nov

A Holiday Inn Express & Suites with a covered entrance and a clear sky.

11. Holiday Inn Express & Suites Greenville-I-85 & Woodruff Rd by IHG

Greenville

Jammie

AED 462 total

includes taxes & fees

7 Dec - 8 Dec

A modern hotel lobby with a bar area, seating, and a reception desk.

12. Holiday Inn Greenville - Woodruff Road by IHG

Greenville

Rick

AED 429 total

includes taxes & fees

7 Dec - 8 Dec

A spacious lobby with modern furniture, a chandelier, and potted plants.

13. Hilton Greenville

Greenville

Monique

AED 430 total

includes taxes & fees

7 Dec - 8 Dec

An outdoor patio with a modern design, featuring a seating area with sofas and a fire pit, surrounded by plants and under a pergola with hanging lights.

14. SpringHill Suites by Marriott Greenville Downtown

Greenville Downtown

Deborah

AED 589 total

includes taxes & fees

15 Nov - 16 Nov

A Comfort Inn hotel with a stone facade, a clear sign indicating a 12'6" clearance, and a well-lit entrance.

15. Comfort Inn Greenville - Haywood Mall

Greenville

Paul

AED 370 total

includes taxes & fees

6 Dec - 7 Dec

A modern lobby with a reception desk, seating area, and a kitchen in the background.

16. Courtyard by Marriott Greenville Downtown

Greenville Downtown

Ray

AED 614 total

includes taxes & fees

25 Nov - 26 Nov

A covered outdoor area with a grill and seating, surrounded by brick walls and windows.

17. Homewood Suites by Hilton Greenville Downtown

Greenville Downtown

Cyrus

AED 563 total

includes taxes & fees

24 Nov - 25 Nov

18. Hyatt Place Greenville Downtown

Greenville Downtown

Tamara

AED 549 total

includes taxes & fees

29 Nov - 30 Nov

A hotel room with two beds, a bedside table, a lamp, and a window with curtains.

19. Clarion Inn

Greenville

Johnny

AED 285 total

includes taxes & fees

26 Nov - 27 Nov

A multi-story hotel with a stone facade, large windows, and outdoor seating areas.

20. Hampton Inn & Suites Greenville-Downtown-RiverPlace

Greenville Downtown

Susan

AED 607 total

includes taxes & fees

22 Nov - 23 Nov

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Vacation Rentals in Upstate South Carolina

Apartment

A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Great location-we walked to soo many shops and restaurants!"

Aparthotel

stayAPT Suites Greenville-Haywood Mall

Greenville

"Great property and cozy. Safe area and close to mall and restaurants."

Cottage

A modern living room with a ceiling fan, a sofa, a chair, and a coffee table. There is a kitchen in the background with cabinets and a countertop.

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Perfect location for getting away in a quiet cabin!"

Mobile Home

A wooden dining table with green placemats, surrounded by chairs, in a cabin with large windows and wooden walls.

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

A living room with a blue sofa, a round coffee table with a vase of flowers, a patterned rug, and a chair. There are paintings on the walls and a window with curtains.

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

A living room with a sofa, a dining table, chairs, a kitchen area, and a view through large windows.

Greer Guest House < 1 Mi to Park & Downtown Area!

Greer

"Nice place en Greenville area "

Apartment

A large house with a spacious driveway and a pond in the background.

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Cottage

A living room with a sofa, coffee table, and a dining area with chairs and a table.

1 Mi to Downtown Greer: Family Home w/ Gazebo!

Greer

"Very cute home close to everything. Super clean and spacious. Well furnished."

Cottage

A round table with a white tablecloth, surrounded by chairs, set up for a meal.

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Cottage

A spacious living room with a dining area, a leather sofa, a TV, and artwork on the walls.

Families Welcome, Fenced Yard: Inviting Greer Home

Greer

"This property is such an amazing find. Three large bedrooms, very clean and well maintained. Close to town of Greer and all amenities. Very easy check-in. Beds very comfortable. Kitchen well equipped for the week we were there."

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.

See properties

Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Top Upstate South Carolina Hotel Reviews

Mint House Greenville Downtown by Kasa

8/10 Good

"The property was as advertised, clean and walkable to the falls and downtown restaurants."

Best Western Spartanburg I-26

10/10 Excellent

"Our room was perfect! Very clean and the bed & pillows were very comfortable! Very quiet. Breakfast was substantial. Eggs, bacon, pancakes, different types of cereal and pastries. Different juices and great selection of hot beverages. The staff was very friendly and helpful. We definitely will be back."